Synthesis and evaluation of curcumin analogues as cytotoxic agents

Medicinal Chemistry Research

Volumn 19, Issue 5, 2010, Pages 413-430

  Fadda, Ahmed A ^a   Badria, Farid A ^b   El Attar, Khaled M ^a  

^a Mansoura University   (Egypt)

^b MANSOURA UNIVERSITY   (Egypt)

Author keywords

Antitumor; Ehrlich ascites in vitro; Hydroxycurcuminoids; Synthesis

Indexed keywords

(1,3) 4 (4 HYDROXY 3 METHOXYPHENYL) 1 [6 (4 HYDROXY 3 METHOXYPHENYL) 2 THIOXO 2,3,4,5 TETRAHYDROPYRIMIDINE 4 YL] 1 [2 (4 NITROPHENYL)HYDRAZANO] BUT 3 ENE 2 ONE; 1,7 BIS (4 HYDROXY 3 METHOXYPHENYL) 4 [(4 NITROPHENYL)HYDRAZONO]HEPTA 1,6 DIENE 3,5 DIONE; 2,10 DIACETYL 6 [(4 CHLOROPHENYL)HYDRAZONO] 3,9 BIS (4 HYDROXY 3 METHOXYPHENYL) 5,7 DIOXO UNDECANEDIONIC ACID DIETHYL ESTER; 3,5 BIS [BETA [3 (4 CHLOROPHENYLAZO) 4 HYDROXY 5 METHOXYPHENYL]ETHYNYL] PYRAZOLE 1 FORMYL; 3,5 BIS [BETA [5 (4 CHLOROPHENYLAZO) 4 HYDROXY 3 METHOXYPHENYL]ETHYNYL] 1H PYRAZOLE; 3,5 BIS [BETA [5 (4 CHLOROPHENYLAZO) 4 HYDROXY 3 METHOXYPHENYL]ETHYNYL] 2 HYDROXYMETHYLPYRAZOLE; 4 (4 CHLOROPHENYLAZO) 1,7 BIS (4 HYDROXY 3 METHOXYPHENYL)HEPTA 1,6 DIENE 3,5 DIONE; 4 (4 HYDROXY 3 METHOXYPHENYL) 6 [[6 (4 HYDROXY 3 METHOXYPHENYL) 2 THIOXO 1,2,5,6 TETRAHYDROPYRIMIDINE 4 YL]] [[2 (4 NITROPHENYL) HYDRAZONO]METHYL] 5,6 DIHYDROPYRIMIDINE 2(1H) THIONE; 4 (4 METHOXYPHENYLAZO) 1,7 BIS (4 HYDROXY 3 METHOXYPHENYL)HEPTA 1,6 DIENE 3,5 DIONE; 4 (P TOLYLAZO) 1,7 BIS (4 HYDROXY 3 METHOXYPHENYL)HEPTA 1,6 DIENE 3,5 DIONE; 4 (PHENYLAZO) 1,7 BIS (4 HYDROXY 3 METHOXYPHENYL)HEPTA 1,6 DIENE 3,5 DIONE; 4,4',2,2' (1 BROMO 1H PYRAZOLE 3,5 DIYL) BIS (ETHANE 2,1 DIYL) BIS (2 METHOXYPHENOL); 4,4',2,2' (1 CHLOROACETYL 1H PYRAZOLE 3,5 DIYL) BIS (ETHANE 2,1 DIYL) BIS (2 METHOXYPHENOL); 4,4',2,2' (1 HYDRAZINYL 1H PYRAZOLE 3,5 DIYL) BIS (ETHANE 2,1 DIYL) BIS (2 METHOXYPHENOL); 4,4',2,2' (1 NITROSYL 1H PYRAZOLE 3,5 DIYL) BIS (ETHANE 2,1 DIYL) BIS (2 METHOXYPHENOL); 4,4',2,2' (1H PYRAZOLE 3,5 DIYL) BIS (ETHANE 2,1 DIYL) BIS [2 (4 CHLOROPHENYL)]DIAZENYL 6 METHOXYPHENOL; 5 (4 HYDROXY 3 METHOXYPHENYL) 3 [[5 (4 HYDROXY 3 METHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL]] [(4 NITROPHENYLAZO)METHYL] 4,5 DIHYDRO 1H PYRAZOLE; 6,7 DIBROMO 1,7 BIS [3 (4 NITROPHENYLAZO) 4 HYDROXY 5 METHOXY]HEPTA 1 ENE 3,5 DIONE; ANTINEOPLASTIC AGENT; CURCUMIN; CYTOTOXIC AGENT; ETHYL 6 [2 (4 CHLOROPHENYL)HYDRAZONO] [4 (4 HYDROXY 3 METHOXYPHENYL) 6 1,4 DIHYDROPYRIDIN 2 YL ] 4 (4 HYDROXY 3 METHOXYPHENYL) 2 METHYL 1,4 DIHYDROPYRIDINE 3 CARBOXYLATE; FLUOROURACIL; N [BIS [5 (4 HYDROXY 3 METHOXYPHENYL) 2,5 DIHYDROISOXAZOL 3 YL] METHYLENE] N' (4 NITROPHENYL)HYDRAZINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; EHRLICH ASCITES TUMOR; IN VITRO STUDY; IN VIVO CULTURE; MALE; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

EID: 77953321535     PISSN: 10542523     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00044-009-9199-3     Document Type: Article

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