Antibody internalization after cell surface antigen binding is critical for immunotoxin development

Bioconjugate Chemistry

Volumn 20, Issue 10, 2009, Pages 1975-1982

  Kuo, Shu Ru ^a   Alfano, Randall W ^a   Frankel, Arthur E ^a   Liu, Jen Sing ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; BIOSYNTHESIS; CELL DEATH; CELL MEMBRANES; EFFICIENCY; SURFACE PLASMON RESONANCE;

'CURRENT; ANTIGEN BINDING; BINDING SPECIFICITIES; CELL SURFACES; DIPHTHERIA TOXIN; HIGH AFFINITY; IMMUNOTOXINS; PRODUCTION YIELD; SURFACE ANTIGEN; SURFACE BINDING;

MONOCLONAL ANTIBODIES;

ANTIBODY CONJUGATE; CD123 ANTIGEN; HYBRID PROTEIN; IMMUNOTOXIN; MONOCLONAL ANTIBODY; PROTEIN DTG1; PROTEIN DTG2; PROTEIN DTG3; PROTEIN G; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANTIBODY PRODUCTION; ANTIGEN BINDING; APOPTOSIS; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DRUG POTENCY; HUMAN; HUMAN CELL; HYBRIDOMA; INTERNALIZATION; NONHUMAN; PROTEIN DOMAIN; PROTEIN SYNTHESIS INHIBITION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGEN-ANTIBODY REACTIONS; ANTIGENS, SURFACE; CRICETINAE; DIPHTHERIA TOXIN; HUMANS; HYBRIDOMAS; IMMUNOASSAY; IMMUNOGLOBULIN G; IMMUNOTOXINS; LEUKEMIA; MICE; MOLECULAR TARGETED THERAPY; RECOMBINANT FUSION PROTEINS;

EID: 70350323728     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc900333j     Document Type: Article

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