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Volumn 38, Issue 5, 2001, Pages 397-408

Influence of relative binding affinity on efficacy in a panel of anti-CD3 scFv immunotoxins

(9) Hexham, J Mark a Dudas, Debra a Hugo, Ron a Thompson, Jerry b King, Vicki a Dowling, Carol a Neville, David M c Digan, Mary Ellen a Lake, Phil a

a NOVARTIS PHARMA AG (Switzerland)

b PENNSYLVANIA STATE UNIVERSITY (United States)

c NATIONAL INSTITUTE OF MENTAL HEALTH (United States)

Author keywords

Affinity; Antibody engineering; CD3; Immunotoxin; Tolerance; Transplantation

Indexed keywords

BACTERIAL TOXIN; CD3 ANTIGEN; HYBRID PROTEIN; IMMUNOTOXIN; MONOCLONAL ANTIBODY; PSEUDOMONAS EXOTOXIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CELL KILLING; CONTROLLED STUDY; CORYNEBACTERIUM DIPHTHERIAE; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; TANDEM REPEAT;

ADP RIBOSE TRANSFERASES; ANTIBODIES, MONOCLONAL; ANTIBODY AFFINITY; ANTIGENS, CD3; BACTERIAL TOXINS; EXOTOXINS; HUMANS; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOTOXINS; JURKAT CELLS; U937 CELLS; VIRULENCE FACTORS;

CORYNEBACTERIUM DIPHTHERIAE; PSEUDOMONAS; PSEUDOMONAS AERUGINOSA;

EID: 0034783354 PISSN: 01615890 EISSN: None Source Type: Journal
DOI: 10.1016/S0161-5890(01)00070-0 Document Type: Article

Times cited : (38)

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