Leber's hereditary optic neuropathy is associated with the T3866C mutation in mitochondrial ND1 gene in three Han Chinese families

Investigative Ophthalmology and Visual Science

Volumn 53, Issue 8, 2012, Pages 4586-4594

  Zhou, Xiangtian ^a   Qian, Yaping ^b   Zhang, Juanjuan ^a,b   Tong, Yi ^a   Jiang, Pingping ^b   Liang, Min ^a,b   Dai, Xianning ^a   Zhou, Huihui ^a   Ji, Yanchun ^b   Mo, Jun Qin ^c   Qu, Jia ^a   Guan, Min Xin ^b  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^c ZHEJIANG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE; NADH DEHYDROGENASE SUBUNIT 1, HUMAN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE;

ADOLESCENT; ADULT; AGED; ARTICLE; CHEMICAL ANALYSIS; CHILD; CHINESE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DNA POLYMORPHISM; EYE FUNDUS; FEMALE; GENE MUTATION; HUMAN; LEBER HEREDITARY OPTIC NEUROPATHY; LYMPHOBLASTOID CELL LINE; MALE; MITOCHONDRIAL GENE; MOLECULAR DIAGNOSIS; ND1 GENE; OPHTHALMOLOGY; OPTIC NERVE DISEASE; OXYGEN CONSUMPTION; PHYLOGENY; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; VISUAL IMPAIRMENT; CELL CULTURE; CHINA; COMPARATIVE STUDY; FAMILY; FOLLOW UP; GENETIC PREDISPOSITION; GENETICS; METABOLISM; MIDDLE AGED; MUTATION; NUCLEOTIDE SEQUENCE; PATHOLOGY; PEDIGREE;

ADOLESCENT; ADULT; CELLS, CULTURED; CHILD; CHILD, PRESCHOOL; CHINA; DNA MUTATIONAL ANALYSIS; DNA, MITOCHONDRIAL; FAMILY; FEMALE; FOLLOW-UP STUDIES; GENES, MITOCHONDRIAL; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; MUTATION; NADH DEHYDROGENASE; OPTIC ATROPHY, HEREDITARY, LEBER; PEDIGREE; YOUNG ADULT;

EID: 84866926775     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.11-9109     Document Type: Article

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