The novel A4435G mutation in the mitochondrial tRNAMet may modulate the phenotypic expression of the LHON-associated ND4 G11778A mutation

Investigative Ophthalmology and Visual Science

Volumn 47, Issue 2, 2006, Pages 475-483

  Qu, Jia ^a   Li, Ronghua ^b   Zhou, Xiangtian ^a   Tong, Yi ^a,c   Lu, Fan ^a   Qian, Yaping ^b   Hu, Yongwu ^a   Jun, Qin Mo ^b,d   West, Constance E ^b,d   Guan, Min Xin ^a,b,d  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^c FUJIAN MEDICAL UNIVERSITY   (China)

^d UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; MITOCHONDRIAL DNA; TRANSFER RNA METHYLTRANSFERASE; METHIONINE TRANSFER RNA; RNA; RNA, MITOCHONDRIAL;

ADOLESCENT; ARTICLE; CHINESE; CLINICAL ARTICLE; CLINICAL FEATURE; CODON; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE IDENTIFICATION; GENE LOCATION; GENE MUTATION; GENETIC ANALYSIS; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; LEBER HEREDITARY OPTIC NEUROPATHY; MALE; MITOCHONDRION; PHENOTYPE; PRIORITY JOURNAL; RNA METABOLISM; RNA STRUCTURE; STEADY STATE; ADULT; ASIAN; CHILD; GENETICS; MIDDLE AGED; MUTATION; NUCLEOTIDE SEQUENCE; ONSET AGE; PEDIGREE;

ADOLESCENT; ADULT; AGE OF ONSET; ASIAN CONTINENTAL ANCESTRY GROUP; CHILD; DNA MUTATIONAL ANALYSIS; DNA, MITOCHONDRIAL; FEMALE; HUMANS; MALE; MIDDLE AGED; MITOCHONDRIA; MUTATION; OPTIC ATROPHY, HEREDITARY, LEBER; PEDIGREE; PHENOTYPE; RNA; RNA, TRANSFER, MET;

EID: 33644868369     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.05-0665     Document Type: Article

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