Leber's hereditary optic neuropathy affects only female matrilineal relatives in two Chinese families

Investigative Ophthalmology and Visual Science

Volumn 51, Issue 10, 2010, Pages 4906-4912

  Qu, Jia ^a   Wang, Ying ^b   Tong, Yi ^a,b,c   Zhou, Xiangtian ^a   Zhao, Fuxin ^a   Yang, Li ^d   Zhang, Shoukang ^b   Zhang, Juanjuan ^a   West, Constance E ^d,e   Guan, Min Xin ^a,d,e  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b INSTITUTE OF CHINESE MATERIA MEDICA   (China)

^c FUJIAN MEDICAL UNIVERSITY   (China)

^d CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^e UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA; NADH DEHYDROGENASE SUBUNIT 4; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE;

ARTICLE; BLINDNESS; CHINESE; CLINICAL ARTICLE; CO3 GENE; CYTB GENE; DISEASE SEVERITY; DNA SEQUENCE; FEMALE; GENE; HUMAN; LEBER HEREDITARY OPTIC NEUROPATHY; MALE; MISSENSE MUTATION; MITOCHONDRIAL GENOME; MUTATIONAL ANALYSIS; ND4 GENE; ND6 GENE; NUCLEOTIDE SEQUENCE; ONSET AGE; PEDIGREE ANALYSIS; PENETRANCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; VISUAL IMPAIRMENT; ADOLESCENT; ADULT; ANIMAL; ASIAN; CHINA; GENETIC PREDISPOSITION; GENETICS; PEDIGREE; PHYLOGENY; SEX DIFFERENCE;

ADOLESCENT; ADULT; AGE OF ONSET; ANIMALS; ASIAN CONTINENTAL ANCESTRY GROUP; CHINA; DNA MUTATIONAL ANALYSIS; DNA, MITOCHONDRIAL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME, MITOCHONDRIAL; HUMANS; MALE; NADH DEHYDROGENASE; OPTIC ATROPHY, HEREDITARY, LEBER; PEDIGREE; PHYLOGENY; POLYMERASE CHAIN REACTION; SEX FACTORS; YOUNG ADULT;

EID: 77957229097     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.09-5027     Document Type: Article

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