Metabolism of L-arginine by myeloid-derived suppressor cells in cancer: Mechanisms of T cell suppression and therapeutic perspectives

Immunological Investigations

Volumn 41, Issue 6-7, 2012, Pages 614-634

  Raber, Patrick ^a,b   Ochoa, Augusto C ^b   Rodríguez, Paulo C ^a,b  

^a Immunology and Parasitology   (United States)

^b LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Arginine; MDSC; Tumor immunology

Indexed keywords

ARGINASE 1; ARGININE; CANCER VACCINE; CYCLIN D3; GAMMA INTERFERON; INITIATION FACTOR 2ALPHA; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; STAT1 PROTEIN; STEM CELL FACTOR; T LYMPHOCYTE RECEPTOR;

AMINO ACID METABOLISM; ARTICLE; BREAST CARCINOMA; CANCER IMMUNOTHERAPY; CANCER PATIENT; CANCER PROGNOSIS; CANCER SURVIVAL; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CELL MATURATION; CELL PROLIFERATION; CLONAL ANERGY; DELAYED HYPERSENSITIVITY; DENDRITIC CELL; DETOXIFICATION; GRANULOCYTE; HUMAN; IMMUNE DEFICIENCY; IMMUNE RESPONSE; NITROSYLATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; REGULATORY MECHANISM; REGULATORY T LYMPHOCYTE; SUPPRESSOR CELL; T LYMPHOCYTE; TREATMENT RESPONSE; TUMOR GROWTH; TUMOR MICROENVIRONMENT; UPREGULATION;

ANIMALS; ARGINASE; ARGININE; CYTOKINES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNE TOLERANCE; INFLAMMATION; MICE; MYELOID PROGENITOR CELLS; NEOPLASM PROTEINS; NEOPLASMS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 84866916560     PISSN: 08820139     EISSN: 15324311     Source Type: Journal    
DOI: 10.3109/08820139.2012.680634     Document Type: Article

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