Bisabolangelone isolated from Ostericum koreanum inhibits the production of inflammatory mediators by down-regulation of NF-κB and ERK MAP kinase activity in LPS-stimulated RAW264.7 cells

International Immunopharmacology

Volumn 10, Issue 2, 2010, Pages 155-162

  Jung, Hyo Won ^a,b   Mahesh, Ramalingam ^a,b   Park, Jun Hong ^c   Boo, Yong Chool ^d   Park, Kwon Moo ^d   Park, Yong Ki ^a,b  

^a Dongguk University   (South Korea)

^b Dongguk University   (South Korea)

^c Alpine Medicinal Plant Research Station   (South Korea)

^d Kyungpook National University School of Medicine   (South Korea)

Author keywords

Bisabolangelone; Inflammation; Macrophage; NF kappaB; Ostericum koreanum

Indexed keywords

ANTIINFLAMMATORY AGENT; BISABOLANGELONE; CYCLOOXYGENASE 2; CYTOKINE; HERBACEOUS AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; PROSTAGLANDIN E2; SESQUITERPENE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN; CELL STRAIN RAW 264 7; CHINESE HERB; CONTROLLED STUDY; DRUG ISOLATION; DRUG MECHANISM; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTERICUM KOREANUM; PERITONEUM MACROPHAGE; PLANT ROOT; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APIACEAE; CELL LINE; CYCLOOXYGENASE 2 INHIBITORS; CYTOKINES; DINOPROSTONE; DOWN-REGULATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; INFLAMMATION; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NF-KAPPA B; NITRIC OXIDE; PLANT EXTRACTS; PLANT ROOTS; SESQUITERPENES;

EID: 74749084919     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2009.10.010     Document Type: Article

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