5-Chloroacetyl-2-amino-1,3-selenazoles attenuate microglial inflammatory responses through NF-κB inhibition

European Journal of Pharmacology

Volumn 589, Issue 1-3, 2008, Pages 53-57

  Nam, Kyong Nyon ^a   Koketsu, Mamoru ^b   Lee, Eunjoo H ^a  

^a Kyung Hee University   (South Korea)

^b GIFU UNIVERSITY   (Japan)

Author keywords

2 amino 1,3 selenazole; Akt; Brain inflammation; Microglia; NF B; Nitric oxide; TNF

Indexed keywords

2 AMINO 1,3 SELENAZOLE DERIVATIVE; 5 CHLOROACETYL 2 AMINO 1,3 SELENAZOLE; 5 CHLOROACETYL 2 MORPHOLINO 1,3 SELENAZOLE; ANTIOXIDANT; BIS(2 AMINO 5 SELENAZOYL)KETONE DERIVATIVE; CYCLOOXYGENASE 2; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; KETONE DERIVATIVE; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROSTAGLANDIN E2; PROTEIN KINASE B; SELENAZOLE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; IMMUNOMODULATION; MICROGLIA; NERVE CELL; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANIMALS, NEWBORN; ANTI-INFLAMMATORY AGENTS; CELL LINE; CELLS, CULTURED; CYCLOOXYGENASE 2; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; NEUROPROTECTIVE AGENTS; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; ORGANOSELENIUM COMPOUNDS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 47549083461     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.03.034     Document Type: Article

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