α-Lipoic acid ameliorates impaired glucose uptake in LYRM1 overexpressing 3T3-L1 adipocytes through the IRS-1/Akt signaling pathway

Journal of Bioenergetics and Biomembranes

Volumn 44, Issue 5, 2012, Pages 579-586

  Qin, Zhen Ying ^a   Zhang, Min ^a   Guo, Xi Rong ^a   Wang, Yu Mei ^b   Zhu, Guan Zhong ^a   Ni, Yu Hui ^a   Zhao, Ya Ping ^c   Qiu, Jie ^a   Kou, Chun Zhao ^a   Qin, Rui ^a   Cao, Xin Guo ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b Huai'an Maternal and Child Health Care Center   (China)

^c The 82nd Hospital of the People's Liberation Army   (China)

Author keywords

LA; Insulin resistance; LYRM1; Mitochondrial dysfunction; Obesity

Indexed keywords

GLUCOSE TRANSPORTER 4; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SERINE; THIOCTIC ACID; TYROSINE;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; DISORDERS OF MITOCHONDRIAL FUNCTIONS; GENE; GENE OVEREXPRESSION; GLUCOSE TRANSPORT; INSULIN RESISTANCE; INSULIN SENSITIVITY; LYRM1 GENE; NONHUMAN; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION;

3T3-L1 CELLS; ANIMALS; ANTIOXIDANTS; APOPTOSIS REGULATORY PROTEINS; GENE EXPRESSION; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; HUMANS; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; MICE; PHOSPHORYLATION; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; THIOCTIC ACID;

HOMO SAPIENS;

EID: 84866739022     PISSN: 0145479X     EISSN: 15736881     Source Type: Journal    
DOI: 10.1007/s10863-012-9460-1     Document Type: Article

References (43)

1. (2002) Fact sheets from the surgeon general's call to action to prevent and decrease overweight and obesity. W V Med J 98(6): p 234-43
2. Bashan N et al (2009) Positive and negative regulation of insulin signaling by reactive oxygen and nitrogen species. Physiol Rev 89(1):27-71
3. Biewenga GP, Haenen GR, Bast A (1997) The pharmacology of the antioxidant lipoic acid. Gen Pharmacol 29(3):315-331
4. Bloch-Damti A et al (2006) Differential effects of IRS1 phosphorylated on Ser307 or Ser632 in the induction of insulin resistance by oxidative stress. Diabetologia 49(10):2463-2473
5. Boden G (2011) Obesity, insulin resistance and free fatty acids. Curr Opin Endocrinol Diabetes Obes 18(2):139-143
6. Bonnard C et al (2008) Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice. J Clin Invest 118(2):789-800
7. Bournat JC, Brown CW (2010) Mitochondrial dysfunction in obesity. Curr Opin Endocrinol Diabetes Obes 17(5):446-452
8. Cao XG et al (2010) Overexpression of LYRM1 induces mitochondrial impairment in 3T3-L1 adipocytes. Mol Genet Metab 101(4):395-399
9. Ceddia RB et al (2005) Globular adiponectin increases GLUT4 translocation and glucose uptake but reduces glycogen synthesis in rat skeletal muscle cells. Diabetologia 48(1):132-139
10. Choksi KB et al (2004) Oxidatively damaged proteins of heart mitochondrial electron transport complexes. Biochim Biophys Acta 1688(2):95-101
11. Demozay D et al (2008) FALDH reverses the deleterious action of oxidative stress induced by lipid peroxidation product 4-hydroxynonenal on insulin signaling in 3T3-L1 adipocytes. Diabetes 57(5):1216-1226
12. Estrada DE et al (1996) Stimulation of glucose uptake by the natural coenzyme alpha-lipoic acid/thioctic acid: participation of elements of the insulin signaling pathway. Diabetes 45(12):1798-1804
13. Forstermann U (2008) Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies. Nat Clin Pract Cardiovasc Med 5(6):338-349
14. Giovannone B et al (2000) Insulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential. Diabetes Metabol Res Rev 16(6):434-441
15. Houstis N, Rosen ED, Lander ES (2006) Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 440(7086):944-948
16. Kanzaki M (2006) Insulin receptor signals regulating GLUT4 translocation and actin dynamics. Endocr J 53(3):267-293
17. Kim JA, Wei Y, Sowers JR (2008) Role of mitochondrial dysfunction in insulin resistance. Circ Res 102(4):401-414
18. Konrad D (2005) Utilization of the insulin-signaling network in the metabolic actions of alpha-lipoic acid-reduction or oxidation? Antioxid Redox Signal 7(7-8):1032-1039
19. Konrad T et al (1999) Alpha-Lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with type 2 diabetes. Diabetes Care 22(2):280-287
20. Kou C et al (2011) Over-expression of LYRM1 inhibits glucose transport in rat skeletal muscles via attenuated phosphorylation of PI3K (p85) and Akt. Mol Cell Biochem 348(1-2):149-154
21. Lowell BB, Shulman GI (2005) Mitochondrial dysfunction and type 2 diabetes. Science 307(5708):384-387
22. Lu H et al (2010) Molecular and metabolic evidence for mitochondrial defects associated with beta-cell dysfunction in a mouse model of type 2 diabetes. Diabetes 59(2):448-459
23. Maddux BA et al (2001) Protection against oxidative stress-induced insulin resistance in rat L6 muscle cells by mircomolar concentrations of alpha-lipoic acid. Diabetes 50(2):404-410
24. Maxwell DP, Wang Y, McIntosh L (1999) The alternative oxidase lowers mitochondrial reactive oxygen production in plant cells. Proc Natl Acad Sci U S A 96(14):8271-8276
25. Moini H et al (2002) R-alpha-lipoic acid action on cell redox status, the insulin receptor, and glucose uptake in 3T3-L1 adipocytes. Arch Biochem Biophys 397(2):384-391
26. Nishikawa T et al (2000) Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 404(6779):787-790
27. Patti ME, Corvera S (2010) The role of mitochondria in the pathogenesis of type 2 diabetes. Endocr Rev 31(3):364-395
28. Pershadsingh HA (2007) Alpha-lipoic acid: physiologic mechanisms and indications for the treatment of metabolic syndrome. Expet Opin Investig Drugs 16(3):291-302
29. Poh ZX, Goh KP (2009) A current update on the use of alpha lipoic acid in the management of type 2 diabetes mellitus. Endocr Metab Immune Disord Drug Targets 9(4):392-398
30. Qiu J et al (2007) Identification of differentially expressed genes in omental adipose tissues of obese patients by suppression subtractive hybridization. Biochem Biophys Res Commun 352(2):469-478
31. Qiu J et al (2009) LYRM1, a novel gene promotes proliferation and inhibits apoptosis of preadipocytes. Eur J Endocrinol 160(2):177-184
32. Rudich A et al (1999) Lipoic acid protects against oxidative stress induced impairment in insulin stimulation of protein kinase B and glucose transport in 3T3-L1 adipocytes. Diabetologia 42(8):949-957
33. Saltiel AR, Kahn CR (2001) Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414(6865):799-806
34. Schrauwen P, Hesselink MK (2004) Oxidative capacity, lipotoxicity, and mitochondrial damage in type 2 diabetes. Diabetes 53(6):1412-1417
35. Shay KP, Hagen TM (2009) Age-associated impairment of Akt phosphorylation in primary rat hepatocytes is remediated by alphalipoic acid through PI3 kinase, PTEN, and PP2A. Biogerontology 10(4):443-456
36. Shen W et al (2008) R-alpha-lipoic acid and acetyl-L-carnitine complementarily promote mitochondrial biogenesis in murine 3T3-L1 adipocytes. Diabetologia 51(1):165-174
37. Shibata M et al (2010) Paraquat-induced oxidative stress represses phosphatidylinositol 3-kinase activities leading to impaired glucose uptake in 3T3-L1 adipocytes. J Biol Chem 285(27):20915-20925
38. Student AK, Hsu RY, Lane MD (1980) Induction of fatty acid synthetase synthesis in differentiating 3T3-L1 preadipocytes. J Biol Chem 255(10):4745-4750
39. Turner N, Heilbronn LK (2008) Is mitochondrial dysfunction a cause of insulin resistance? Trends Endocrinol Metabol 19(9):324-330
40. Walley AJ, Asher JE, Froguel P (2009) The genetic contribution to non-syndromic human obesity. Nat Rev Genet 10(7):431-442
41. Wang X et al (2012) Glucose oxidase induces insulin resistance via influencing multiple targets in vitro and in vivo: the central role of oxidative stress. Biochimie
42. Yaworsky K et al (2000) Engagement of the insulin-sensitive pathway in the stimulation of glucose transport by alpha-lipoic acid in 3T3-L1 adipocytes. Diabetologia 43(3):294-303
43. Zhang M et al (2012) Regulation of LYRM1 gene expression by free fatty acids, adipokines, and rosiglitazone in 3T3-L1 adipocytes. Exp Diabetes Res 2012:820989