Synthesis of new pyrroles of potential anti-inflammatory activity

Archiv der Pharmazie

Volumn 344, Issue 12, 2011, Pages 830-839

  Mohamed, Mosaad S ^a   Kamel, Rehab ^a   Fathallah, Samar S ^a  

^a Helwan   (Egypt)

Author keywords

Anti inflammatory activity; Pyrrole; Pyrrolo 2,3 d pyrimidine; Structure activity relationship

Indexed keywords

(1 BENZYL 3 CYANO 4,5 DIPHENYL 1H PYRROL 2 YL)CARBONOHYDRAZONOYL DICYANIDE; 1 BENZYL 2 [2 (3,5 DIAMINO 4H PYRAZOL 4 YLIDENE)HYDRAZINYL] 4,5 DIPHENYL 1H PYRROLE 3 CARBONITRILE; 2 (3,5 DIMETHYL 1H PYRAZOL 1 YL) 7 (1,5 DIMETHYL 3 OXO 2 PHENYL 2,3 DIHYDRO 1H PYRAZOL 4 YL) 5,6 DIPHENYL 3H PYRROLO[2,3 D]PYRIMIDIN 4(7H)ONE; 2 [2 (3,5 DIAMINO 4H PYRAZOL 4 YLIDENE)HYDRAZINYL] 1 (1,5 DIMETHYL 3 OXO 2 PHENYL 2,3 DIHYDRO 1H PYRAZOL 4 YL) 4,5 DIPHENYL 1H PYRROLE 3 CARBONITRILE; 2 [2 (3,5 DIAMINO 4H PYRAZOL 4 YLIDENE)HYDRAZINYL] 1 (3,4 DICHLORO PHENYL) 4 PHENYL 1H PYRROLE 3 CARBONITRILE; 2 AMINO 1 (3,4 DICHLOROPHENYL) 4 PHENYL 1H PYRROLE 3 CARBOXAMIDE; 2 AMINO 1 BENZYL 4,5 DIPHENYL 1H PYRROLE 3 CARBOXAMIDE; 7 (1,5 DIMETHYL 3 OXO 1 PHENYL 2,5 DIHYDRO 1H PYRAZOL 3 YL) 2 HYDRAZINYL 5,6 DIPHENYL 3H PYRROLO[2,3 D]PYRIMIDIN 4(7H)ONE; 7 (1,5 DIMETHYL 3 OXO 2 PHENYL 2,3 DIHYDRO 1H PYRAZOL 4 L) 5,6 DIPHENYL 2 THIOXO 2,3 DIHYDRO 1H PYRROLO[2,3 D]PYRIMIDIN 4(7H)ONE; 7 (1,5 DIMETHYL 3 OXO 2 PHENYL 2,3 DIHYDRO 1H PYRAZOL 4 YL) 2 (5 METHYL 3 OXO 2,3 DIHYDRO 1H PYRAZOL 1 YL) 5,6 DIPHENYL 3H PYRROLO[2,3 D]PYRIMIDIN 4(7H)ONE; 7 (1,5 DIMETHYL 3 OXO 2 PHENYL 2,3 DIHYDRO 1H PYRAZOL 4 YL) 2 (ETHYLTHIO) 5,6 DIPHENYL 3H PYRROLO[2,3 D]PYRIMIDIN 4(7H)ONE; 7 (3,4 DICHLOROPHENYL) 2 (5 METHYL 3 OXO 2,3 DIHYDRO 1H PYRAZOL 1 YL) 5 PHENYL 3H PYRROLO[2,3 D]PYRIMIDIN 4(7H)ONE; 7 (3,4 DICHLOROPHENYL) 2 (ETHYLTHIO) 5 PHENYL 3H PYRROLO[2,3 D]PYRIMIDIN 4(7H)ONE; 7 (3,4 DICHLOROPHENYL) 2 HYDRAZINYL 5 PHENYL 3H PYRROLO[2,3 D]PYRIMIDIN 4(7H)ONE; 7 (3,4 DICHLOROPHENYL) 5 PHENYL 2 THIOXO 2,3 DIHYDRO 1H PYRROLO[2,3 D]PYRIMIDIN 4(7H)ONE; 7 BENZYL 2 (3,5 DIMETHYL 1H PYRAZOL 1 YL) 5,6 DIPHENYL 3H PYRROLO[2,3 D]PYRIMIDIN 4(7H)ONE; 7 BENZYL 2 (ETHYLTHIO) 5,6 DIPHENYL 3H PYRROLO[2,3 D]PYRIMIDIN 4(7H)ONE; 7 BENZYL 2 HYDRAZINYL 5,6 DIPHENYL 3H PYRROLO[2,3 D]PYRIMIDIN 4(7H)ONE; 7 BENZYL 5,6 DIPHENYL 2 THIOXO 2,3 DIHYDRO 1H PYRROLO[2,3 D]PYRIMIDIN 4(7H)ONE; 8 (3,4 DICHLOROPHENYL) 3 METHYL 6 PHENYL 1H PYRROLO[2,3 D][1,2,4] TRIAZOLO[4,3 A]PYRIMIDIN 5(8H)ONE; 8 BENZYL 3 METHYL 6,7 DIPHENYL 1H PYRROLO[2,3 D][1,2,4]TRIAZOLO[4,3 A]PYRIMIDIN 5(8H)ONE; [3 CYANO 1 (1,5 DIMETHYL 3 OXO 2 PHENYL 2,3 DIHYDRO 1H PYRAZOL 4 YL) 4,5 DIPHENYL 1H PYRROL 2 YL]CARBONOHYDRAZONOYL DICYANIDE; [3 CYANO 1 (3,4 DICHLOROPHENYL) 4 PHENYL 1H PYRROL 2 YL]CARBONO HYDRAZONOYL DICYANIDE; PYRROLE DERIVATIVE; PYRROLOPYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; DRUG SYNTHESIS; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; MALE; PYRROLES; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 82955178689     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.201100056     Document Type: Article

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