-
1
-
-
33644790392
-
Specific inhibitors of Plasmodium falciparum thioredoxin reductase as potential antimalarial agents
-
Andricopulo A.D., Akoachere M.B., Krogh R., Nickel C., Mcleish M.J., Kenyon G.L., Arscott L.D., Williams C.H., Davioud-Charvet E., Becker K. Specific inhibitors of Plasmodium falciparum thioredoxin reductase as potential antimalarial agents. Bioorg. Med. Chem. Lett. 2006, 16:2283-2292.
-
(2006)
Bioorg. Med. Chem. Lett.
, vol.16
, pp. 2283-2292
-
-
Andricopulo, A.D.1
Akoachere, M.B.2
Krogh, R.3
Nickel, C.4
Mcleish, M.J.5
Kenyon, G.L.6
Arscott, L.D.7
Williams, C.H.8
Davioud-Charvet, E.9
Becker, K.10
-
2
-
-
0027430639
-
Origin of reactive oxygen species in erythrocytes infected with Plasmodium falciparum
-
Atamna H., Ginsburg H. Origin of reactive oxygen species in erythrocytes infected with Plasmodium falciparum. Mol. Biochem. Parasitol. 1993, 61:231-241.
-
(1993)
Mol. Biochem. Parasitol.
, vol.61
, pp. 231-241
-
-
Atamna, H.1
Ginsburg, H.2
-
3
-
-
0344643424
-
Plasmoredoxin, a novel redox-active protein unique for malarial parasites
-
Becker K., Kanzok S.M., Iozef R., Fischer M., Schirmer R.H., Rahlfs S. Plasmoredoxin, a novel redox-active protein unique for malarial parasites. Eur. J. Biochem. 2003, 270:1057-1064.
-
(2003)
Eur. J. Biochem.
, vol.270
, pp. 1057-1064
-
-
Becker, K.1
Kanzok, S.M.2
Iozef, R.3
Fischer, M.4
Schirmer, R.H.5
Rahlfs, S.6
-
4
-
-
0037621507
-
Glutathione - functions and metabolism in the malarial parasite Plasmodium falciparum
-
Becker K., Rahlfs S., Nickel C., Schirmer R.H. Glutathione - functions and metabolism in the malarial parasite Plasmodium falciparum. Biol. Chem. 2003, 384:551-566.
-
(2003)
Biol. Chem.
, vol.384
, pp. 551-566
-
-
Becker, K.1
Rahlfs, S.2
Nickel, C.3
Schirmer, R.H.4
-
5
-
-
1242316941
-
Oxidative stress in malaria parasite-infected erythrocytes: host-parasite interactions
-
Becker K., Tilley L., Vennerstrom J.L., Roberts D., Rogerson S., Ginsburg H. Oxidative stress in malaria parasite-infected erythrocytes: host-parasite interactions. Int. J. Parasitol. 2004, 34:163-189.
-
(2004)
Int. J. Parasitol.
, vol.34
, pp. 163-189
-
-
Becker, K.1
Tilley, L.2
Vennerstrom, J.L.3
Roberts, D.4
Rogerson, S.5
Ginsburg, H.6
-
6
-
-
0034532221
-
Kinetic characterization of glutathione reductase from the malarial parasite Plasmodium falciparum. Comparison with the human enzyme
-
Bohme C.C., Arscott L.D., Becker K., Schirmer R.H., Williams C.H. Kinetic characterization of glutathione reductase from the malarial parasite Plasmodium falciparum. Comparison with the human enzyme. J. Biol. Chem. 2000, 275:37317-37323.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 37317-37323
-
-
Bohme, C.C.1
Arscott, L.D.2
Becker, K.3
Schirmer, R.H.4
Williams, C.H.5
-
7
-
-
33746505480
-
Structural and biochemical characterization of a mitochondrial peroxiredoxin from Plasmodium falciparum
-
Boucher I.W., Mcmillan P.J., Gabrielsen M., Akerman S.E., Brannigan J.A., Schnick C., Brzozowski A.M., Wilkinson A.J., Muller S. Structural and biochemical characterization of a mitochondrial peroxiredoxin from Plasmodium falciparum. Mol. Microbiol. 2006, 61:948-959.
-
(2006)
Mol. Microbiol.
, vol.61
, pp. 948-959
-
-
Boucher, I.W.1
Mcmillan, P.J.2
Gabrielsen, M.3
Akerman, S.E.4
Brannigan, J.A.5
Schnick, C.6
Brzozowski, A.M.7
Wilkinson, A.J.8
Muller, S.9
-
8
-
-
49649107787
-
Depletion of Plasmodium berghei plasmoredoxin reveals a non-essential role for life cycle progression of the malaria parasite
-
Buchholz K., Rahlfs S., Schirmer R.H., Becker K., Matuschewski K. Depletion of Plasmodium berghei plasmoredoxin reveals a non-essential role for life cycle progression of the malaria parasite. PLoS ONE 2008, 3:e2474.
-
(2008)
PLoS ONE
, vol.3
-
-
Buchholz, K.1
Rahlfs, S.2
Schirmer, R.H.3
Becker, K.4
Matuschewski, K.5
-
9
-
-
37849030399
-
Interactions of methylene blue with human disulfide reductases and their orthologues from Plasmodium falciparum
-
Buchholz K., Schirmer R.H., Eubel J.K., Akoachere M., Dandekar T., Becker K., Gromer S. Interactions of methylene blue with human disulfide reductases and their orthologues from Plasmodium falciparum. Antimicrob. Agents Chemother. 2008, 52:183-191.
-
(2008)
Antimicrob. Agents Chemother.
, vol.52
, pp. 183-191
-
-
Buchholz, K.1
Schirmer, R.H.2
Eubel, J.K.3
Akoachere, M.4
Dandekar, T.5
Becker, K.6
Gromer, S.7
-
10
-
-
78549246255
-
Molecular genetics evidence for the in vivo roles of the two major NADPH-dependent disulfide reductases in the malaria parasite
-
Buchholz K., Putrianti E.D., Rahlfs S., Schirmer R.H., Becker K., Matuschewski K. Molecular genetics evidence for the in vivo roles of the two major NADPH-dependent disulfide reductases in the malaria parasite. J. Biol. Chem. 2010, 285:37388-37395.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 37388-37395
-
-
Buchholz, K.1
Putrianti, E.D.2
Rahlfs, S.3
Schirmer, R.H.4
Becker, K.5
Matuschewski, K.6
-
11
-
-
0031658792
-
Status of Plasmodium falciparum towards catalase
-
Clarebout G., Slomianny C., Delcourt P., Leu B., Masset A., Camus D., Dive D. Status of Plasmodium falciparum towards catalase. Br. J. Haematol. 1998, 103:52-59.
-
(1998)
Br. J. Haematol.
, vol.103
, pp. 52-59
-
-
Clarebout, G.1
Slomianny, C.2
Delcourt, P.3
Leu, B.4
Masset, A.5
Camus, D.6
Dive, D.7
-
12
-
-
10744226522
-
Mechanism-based inactivation of thioredoxin reductase from Plasmodium falciparum by Mannich bases. Implication for cytotoxicity
-
Davioud-Charvet E., Mcleish M.J., Veine D.M., Giegel D., Arscott L.D., Andricopulo A.D., Becker K., Muller S., Schirmer R.H., Williams C.H., Kenyon G.L. Mechanism-based inactivation of thioredoxin reductase from Plasmodium falciparum by Mannich bases. Implication for cytotoxicity. Biochemistry 2003, 42:13319-13330.
-
(2003)
Biochemistry
, vol.42
, pp. 13319-13330
-
-
Davioud-Charvet, E.1
Mcleish, M.J.2
Veine, D.M.3
Giegel, D.4
Arscott, L.D.5
Andricopulo, A.D.6
Becker, K.7
Muller, S.8
Schirmer, R.H.9
Williams, C.H.10
Kenyon, G.L.11
-
13
-
-
67649277651
-
A newly discovered protein export machine in malaria parasites
-
De Koning-Ward T.F., Gilson P.R., Boddey J.A., Rug M., Smith B.J., Papenfuss A.T., Sanders P.R., Lundie R.J., Maier A.G., Cowman A.F., Crabb B.S. A newly discovered protein export machine in malaria parasites. Nature 2009, 459:945-949.
-
(2009)
Nature
, vol.459
, pp. 945-949
-
-
De Koning-Ward, T.F.1
Gilson, P.R.2
Boddey, J.A.3
Rug, M.4
Smith, B.J.5
Papenfuss, A.T.6
Sanders, P.R.7
Lundie, R.J.8
Maier, A.G.9
Cowman, A.F.10
Crabb, B.S.11
-
14
-
-
84862537852
-
Peroxiredoxin systems of protozoal parasites
-
Springer, New York, USA, L.H. Flohé (Ed.)
-
Deponte M.R.S., Becker K. Peroxiredoxin systems of protozoal parasites. Peroxiredoxin Systems 2007, Springer, New York, USA. L.H. Flohé (Ed.).
-
(2007)
Peroxiredoxin Systems
-
-
Deponte, M.R.S.1
Becker, K.2
-
15
-
-
14944367451
-
Plasmodium falciparum glutaredoxin-like proteins
-
Deponte M., Becker K., Rahlfs S. Plasmodium falciparum glutaredoxin-like proteins. Biol. Chem. 2005, 386:33-40.
-
(2005)
Biol. Chem.
, vol.386
, pp. 33-40
-
-
Deponte, M.1
Becker, K.2
Rahlfs, S.3
-
16
-
-
0037101785
-
Fate of haem iron in the malaria parasite Plasmodium falciparum
-
Egan T.J., Combrinck J.M., Egan J., Hearne G.R., Marques H.M., Ntenteni S., Sewell B.T., Smith P.J., Taylor D., Van Schalkwyk D.A., Walden J.C. Fate of haem iron in the malaria parasite Plasmodium falciparum. Biochem. J. 2002, 365:343-347.
-
(2002)
Biochem. J.
, vol.365
, pp. 343-347
-
-
Egan, T.J.1
Combrinck, J.M.2
Egan, J.3
Hearne, G.R.4
Marques, H.M.5
Ntenteni, S.6
Sewell, B.T.7
Smith, P.J.8
Taylor, D.9
Van Schalkwyk, D.A.10
Walden, J.C.11
-
17
-
-
0030879653
-
Hemoglobin metabolism in the malaria parasite Plasmodium falciparum
-
Francis S.E., Sullivan D.J., Goldberg D.E. Hemoglobin metabolism in the malaria parasite Plasmodium falciparum. Annu. Rev. Microbiol. 1997, 51:97-123.
-
(1997)
Annu. Rev. Microbiol.
, vol.51
, pp. 97-123
-
-
Francis, S.E.1
Sullivan, D.J.2
Goldberg, D.E.3
-
18
-
-
70350234635
-
Inherited glutathione reductase deficiency and Plasmodium falciparum malaria - a case study
-
Gallo V., Schwarzer E., Rahlfs S., Schirmer R.H., Van Zwieten R., Roos D., Arese P., Becker K. Inherited glutathione reductase deficiency and Plasmodium falciparum malaria - a case study. PLoS ONE 2009, 4:e7303.
-
(2009)
PLoS ONE
, vol.4
-
-
Gallo, V.1
Schwarzer, E.2
Rahlfs, S.3
Schirmer, R.H.4
Van Zwieten, R.5
Roos, D.6
Arese, P.7
Becker, K.8
-
19
-
-
0030725657
-
Identification and characterization of the functional amino acids at the active site of the large thioredoxin reductase from Plasmodium falciparum
-
Gilberger T.W., Walter R.D., Muller S. Identification and characterization of the functional amino acids at the active site of the large thioredoxin reductase from Plasmodium falciparum. J. Biol. Chem. 1997, 272:29584-29589.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 29584-29589
-
-
Gilberger, T.W.1
Walter, R.D.2
Muller, S.3
-
20
-
-
0034655152
-
Deletion of the parasite-specific insertions and mutation of the catalytic triad in glutathione reductase from chloroquine-sensitive Plasmodium falciparum 3D7
-
Gilberger T.W., Schirmer R.H., Walter R.D., Muller S. Deletion of the parasite-specific insertions and mutation of the catalytic triad in glutathione reductase from chloroquine-sensitive Plasmodium falciparum 3D7. Mol. Biochem. Parasitol. 2000, 107:169-179.
-
(2000)
Mol. Biochem. Parasitol.
, vol.107
, pp. 169-179
-
-
Gilberger, T.W.1
Schirmer, R.H.2
Walter, R.D.3
Muller, S.4
-
21
-
-
0029973142
-
Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene
-
Gladyshev V.N., Jeang K.T., Stadtman T.C. Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene. Proc. Natl. Acad. Sci. U.S.A. 1996, 93:6146-6151.
-
(1996)
Proc. Natl. Acad. Sci. U.S.A.
, vol.93
, pp. 6146-6151
-
-
Gladyshev, V.N.1
Jeang, K.T.2
Stadtman, T.C.3
-
23
-
-
2542464938
-
Two enzymes in one; two yeast peroxiredoxins display oxidative stress-dependent switching from a peroxidase to a molecular chaperone function
-
Jang H.H., Lee K.O., Chi Y.H., Jung B.G., Park S.K., Park J.H., Lee J.R., Lee S.S., Moon J.C., Yun J.W., Choi Y.O., Kim W.Y., Kang J.S., Cheong G.W., Yun D.J., Rhee S.G., Cho M.J., Lee S.Y. Two enzymes in one; two yeast peroxiredoxins display oxidative stress-dependent switching from a peroxidase to a molecular chaperone function. Cell 2004, 117:625-635.
-
(2004)
Cell
, vol.117
, pp. 625-635
-
-
Jang, H.H.1
Lee, K.O.2
Chi, Y.H.3
Jung, B.G.4
Park, S.K.5
Park, J.H.6
Lee, J.R.7
Lee, S.S.8
Moon, J.C.9
Yun, J.W.10
Choi, Y.O.11
Kim, W.Y.12
Kang, J.S.13
Cheong, G.W.14
Yun, D.J.15
Rhee, S.G.16
Cho, M.J.17
Lee, S.Y.18
-
24
-
-
77956748640
-
Redox regulation of Plasmodium falciparum ornithine delta-aminotransferase
-
Jortzik E., Fritz-Wolf K., Sturm N., Hipp M., Rahlfs S., Becker K. Redox regulation of Plasmodium falciparum ornithine delta-aminotransferase. J. Mol. Biol. 2010, 402:445-459.
-
(2010)
J. Mol. Biol.
, vol.402
, pp. 445-459
-
-
Jortzik, E.1
Fritz-Wolf, K.2
Sturm, N.3
Hipp, M.4
Rahlfs, S.5
Becker, K.6
-
25
-
-
79957693495
-
Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase: a unique bifunctional enzyme from Plasmodium falciparum
-
Jortzik E., Mailu B.M., Preuss J., Fischer M., Bode L., Rahlfs S., Becker K. Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase: a unique bifunctional enzyme from Plasmodium falciparum. Biochem. J. 2011, 436:641-650.
-
(2011)
Biochem. J.
, vol.436
, pp. 641-650
-
-
Jortzik, E.1
Mailu, B.M.2
Preuss, J.3
Fischer, M.4
Bode, L.5
Rahlfs, S.6
Becker, K.7
-
26
-
-
0034704081
-
The thioredoxin system of the malaria parasite Plasmodium falciparum. Glutathione reduction revisited
-
Kanzok S.M., Schirmer R.H., Turbachova I., Iozef R., Becker K. The thioredoxin system of the malaria parasite Plasmodium falciparum. Glutathione reduction revisited. J. Biol. Chem. 2000, 275:40180-40186.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 40180-40186
-
-
Kanzok, S.M.1
Schirmer, R.H.2
Turbachova, I.3
Iozef, R.4
Becker, K.5
-
27
-
-
0035951470
-
Substitution of the thioredoxin system for glutathione reductase in Drosophila melanogaster
-
Kanzok S.M., Fechner A., Bauer H., Ulschmid J.K., Muller H.M., Botella-Munoz J., Schneuwly S., Schirmer R., Becker K. Substitution of the thioredoxin system for glutathione reductase in Drosophila melanogaster. Science 2001, 291:643-646.
-
(2001)
Science
, vol.291
, pp. 643-646
-
-
Kanzok, S.M.1
Fechner, A.2
Bauer, H.3
Ulschmid, J.K.4
Muller, H.M.5
Botella-Munoz, J.6
Schneuwly, S.7
Schirmer, R.8
Becker, K.9
-
28
-
-
0036119803
-
Thioredoxin, thioredoxin reductase, and thioredoxin peroxidase of malaria parasite Plasmodium falciparum
-
Kanzok S.M., Rahlfs S., Becker K., Schirmer R.H. Thioredoxin, thioredoxin reductase, and thioredoxin peroxidase of malaria parasite Plasmodium falciparum. Methods Enzymol. 2002, 347:370-381.
-
(2002)
Methods Enzymol.
, vol.347
, pp. 370-381
-
-
Kanzok, S.M.1
Rahlfs, S.2
Becker, K.3
Schirmer, R.H.4
-
29
-
-
0033844270
-
Molecular cloning and characterization of a peroxiredoxin from the human malaria parasite Plasmodium falciparum
-
Kawazu S., Tsuji N., Hatabu T., Kawai S., Matsumoto Y., Kano S. Molecular cloning and characterization of a peroxiredoxin from the human malaria parasite Plasmodium falciparum. Mol. Biochem. Parasitol. 2000, 109:165-169.
-
(2000)
Mol. Biochem. Parasitol.
, vol.109
, pp. 165-169
-
-
Kawazu, S.1
Tsuji, N.2
Hatabu, T.3
Kawai, S.4
Matsumoto, Y.5
Kano, S.6
-
30
-
-
17144413378
-
Roles of 1-Cys peroxiredoxin in haem detoxification in the human malaria parasite Plasmodium falciparum
-
Kawazu S., Ikenoue N., Takemae H., Komaki-Yasuda K., Kano S. Roles of 1-Cys peroxiredoxin in haem detoxification in the human malaria parasite Plasmodium falciparum. FEBS J. 2005, 272:1784-1791.
-
(2005)
FEBS J.
, vol.272
, pp. 1784-1791
-
-
Kawazu, S.1
Ikenoue, N.2
Takemae, H.3
Komaki-Yasuda, K.4
Kano, S.5
-
31
-
-
78651262197
-
Compartmentation of redox metabolism in malaria parasites
-
Kehr S., Sturm N., Rahlfs S., Przyborski J.M., Becker K. Compartmentation of redox metabolism in malaria parasites. PLoS Pathog. 2010, 6:e1001242.
-
(2010)
PLoS Pathog.
, vol.6
-
-
Kehr, S.1
Sturm, N.2
Rahlfs, S.3
Przyborski, J.M.4
Becker, K.5
-
32
-
-
80054711041
-
Protein s-glutathionylation in malaria parasites
-
Kehr S., Jortzik E., Delahunty C., Yates J.R., Rahlfs S., Becker K. Protein s-glutathionylation in malaria parasites. Antioxid. Redox Signal. 2011, 15:2855-2865.
-
(2011)
Antioxid. Redox Signal.
, vol.15
, pp. 2855-2865
-
-
Kehr, S.1
Jortzik, E.2
Delahunty, C.3
Yates, J.R.4
Rahlfs, S.5
Becker, K.6
-
34
-
-
0038643671
-
Disruption of the Plasmodium falciparum 2-Cys peroxiredoxin gene renders parasites hypersensitive to reactive oxygen and nitrogen species
-
Komaki-Yasuda K., Kawazu S., Kano S. Disruption of the Plasmodium falciparum 2-Cys peroxiredoxin gene renders parasites hypersensitive to reactive oxygen and nitrogen species. FEBS Lett. 2003, 547:140-144.
-
(2003)
FEBS Lett.
, vol.547
, pp. 140-144
-
-
Komaki-Yasuda, K.1
Kawazu, S.2
Kano, S.3
-
35
-
-
69449106780
-
The malarial parasite Plasmodium falciparum imports the human protein peroxiredoxin 2 for peroxide detoxification
-
Koncarevic S., Rohrbach P., Deponte M., Krohne G., Prieto J.H., Yates J., Rahlfs S., Becker K. The malarial parasite Plasmodium falciparum imports the human protein peroxiredoxin 2 for peroxide detoxification. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:13323-13328.
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 13323-13328
-
-
Koncarevic, S.1
Rohrbach, P.2
Deponte, M.3
Krohne, G.4
Prieto, J.H.5
Yates, J.6
Rahlfs, S.7
Becker, K.8
-
36
-
-
13444280474
-
Dithiol proteins as guardians of the intracellular redox milieu in parasites: old and new drug targets in trypanosomes and malaria-causing plasmodia
-
Krauth-Siegel R.L., Bauer H., Schirmer R.H. Dithiol proteins as guardians of the intracellular redox milieu in parasites: old and new drug targets in trypanosomes and malaria-causing plasmodia. Angew. Chem. Int. Ed. Engl. 2005, 44:690-715.
-
(2005)
Angew. Chem. Int. Ed. Engl.
, vol.44
, pp. 690-715
-
-
Krauth-Siegel, R.L.1
Bauer, H.2
Schirmer, R.H.3
-
37
-
-
0035815346
-
Isolation and functional analysis of two thioredoxin peroxidases (peroxiredoxins) from Plasmodium falciparum
-
Krnajski Z., Walter R.D., Muller S. Isolation and functional analysis of two thioredoxin peroxidases (peroxiredoxins) from Plasmodium falciparum. Mol. Biochem. Parasitol. 2001, 113:303-308.
-
(2001)
Mol. Biochem. Parasitol.
, vol.113
, pp. 303-308
-
-
Krnajski, Z.1
Walter, R.D.2
Muller, S.3
-
38
-
-
0037135586
-
Thioredoxin reductase is essential for the survival of Plasmodium falciparum erythrocytic stages
-
Krnajski Z., Gilberger T.W., Walter R.D., Cowman A.F., Muller S. Thioredoxin reductase is essential for the survival of Plasmodium falciparum erythrocytic stages. J. Biol. Chem. 2002, 277:25970-25975.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 25970-25975
-
-
Krnajski, Z.1
Gilberger, T.W.2
Walter, R.D.3
Cowman, A.F.4
Muller, S.5
-
39
-
-
0034161967
-
Plasmodium falciparum-infected red blood cells depend on a functional glutathione de novo synthesis attributable to an enhanced loss of glutathione
-
Luersen K., Walter R.D., Muller S. Plasmodium falciparum-infected red blood cells depend on a functional glutathione de novo synthesis attributable to an enhanced loss of glutathione. Biochem. J. 2000, 346:545-552.
-
(2000)
Biochem. J.
, vol.346
, pp. 545-552
-
-
Luersen, K.1
Walter, R.D.2
Muller, S.3
-
40
-
-
0036566055
-
Glutathione synthetase from Plasmodium falciparum
-
Meierjohann S., Walter R.D., Muller S. Glutathione synthetase from Plasmodium falciparum. Biochem. J. 2002, 363:833-838.
-
(2002)
Biochem. J.
, vol.363
, pp. 833-838
-
-
Meierjohann, S.1
Walter, R.D.2
Muller, S.3
-
41
-
-
41249085856
-
Reactive oxygen species modulate Anopheles gambiae immunity against bacteria and Plasmodium
-
Molina-Cruz A., Dejong R.J., Charles B., Gupta L., Kumar S., Jaramillo-Gutierrez G., Barillas-Mury C. Reactive oxygen species modulate Anopheles gambiae immunity against bacteria and Plasmodium. J. Biol. Chem. 2008, 283:3217-3223.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 3217-3223
-
-
Molina-Cruz, A.1
Dejong, R.J.2
Charles, B.3
Gupta, L.4
Kumar, S.5
Jaramillo-Gutierrez, G.6
Barillas-Mury, C.7
-
42
-
-
47749090916
-
The aza-analogues of 1,4-naphthoquinones are potent substrates and inhibitors of plasmodial thioredoxin and glutathione reductases and of human erythrocyte glutathione reductase
-
Morin C., Besset T., Moutet J.C., Fayolle M., Bruckner M., Limosin D., Becker K., Davioud-Charvet E. The aza-analogues of 1,4-naphthoquinones are potent substrates and inhibitors of plasmodial thioredoxin and glutathione reductases and of human erythrocyte glutathione reductase. Org. Biomol. Chem. 2008, 6:2731-2742.
-
(2008)
Org. Biomol. Chem.
, vol.6
, pp. 2731-2742
-
-
Morin, C.1
Besset, T.2
Moutet, J.C.3
Fayolle, M.4
Bruckner, M.5
Limosin, D.6
Becker, K.7
Davioud-Charvet, E.8
-
43
-
-
79960849123
-
Glutathione reductase-catalyzed cascade of redox reactions to bioactivate potent antimalarial 1,4-naphthoquinones - a new strategy to combat malarial parasites
-
Muller T., Johann L., Jannack B., Bruckner M., Lanfranchi D.A., Bauer H., Sanchez C., Yardley V., Deregnaucourt C., Schrevel J., Lanzer M., Schirmer R.H., Davioud-Charvet E. Glutathione reductase-catalyzed cascade of redox reactions to bioactivate potent antimalarial 1,4-naphthoquinones - a new strategy to combat malarial parasites. J. Am. Chem. Soc. 2011, 133:11557-11571.
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 11557-11571
-
-
Muller, T.1
Johann, L.2
Jannack, B.3
Bruckner, M.4
Lanfranchi, D.A.5
Bauer, H.6
Sanchez, C.7
Yardley, V.8
Deregnaucourt, C.9
Schrevel, J.10
Lanzer, M.11
Schirmer, R.H.12
Davioud-Charvet, E.13
-
44
-
-
27244433433
-
15N sequence-specific resonance assignment and secondary structure of Plasmodium falciparum thioredoxin
-
15N sequence-specific resonance assignment and secondary structure of Plasmodium falciparum thioredoxin. J. Biomol. NMR 2005, 32:340.
-
(2005)
J. Biomol. NMR
, vol.32
, pp. 340
-
-
Munte, C.E.1
Becker, K.2
Schirmer, R.H.3
Kalbitzer, H.R.4
-
45
-
-
70449532447
-
NMR assignments of oxidised thioredoxin from Plasmodium falciparum
-
Munte C.E., Becker K., Schirmer R.H., Kalbitzer H.R. NMR assignments of oxidised thioredoxin from Plasmodium falciparum. Biomol. NMR Assign. 2009, 3:159-161.
-
(2009)
Biomol. NMR Assign.
, vol.3
, pp. 159-161
-
-
Munte, C.E.1
Becker, K.2
Schirmer, R.H.3
Kalbitzer, H.R.4
-
46
-
-
84856679687
-
Global malaria mortality between 1980 and 2010: a systematic analysis
-
Murray C.J., Rosenfeld L.C., Lim S.S., Andrews K.G., Foreman K.J., Haring D., Fullman N., Naghavi M., Lozano R., Lopez A.D. Global malaria mortality between 1980 and 2010: a systematic analysis. Lancet 2012, 379:413-431.
-
(2012)
Lancet
, vol.379
, pp. 413-431
-
-
Murray, C.J.1
Rosenfeld, L.C.2
Lim, S.S.3
Andrews, K.G.4
Foreman, K.J.5
Haring, D.6
Fullman, N.7
Naghavi, M.8
Lozano, R.9
Lopez, A.D.10
-
47
-
-
28244462440
-
Plasmodium falciparum 2-Cys peroxiredoxin reacts with plasmoredoxin and peroxynitrite
-
Nickel C., Trujillo M., Rahlfs S., Deponte M., Radi R., Becker K. Plasmodium falciparum 2-Cys peroxiredoxin reacts with plasmoredoxin and peroxynitrite. Biol. Chem. 2005, 386:1129-1136.
-
(2005)
Biol. Chem.
, vol.386
, pp. 1129-1136
-
-
Nickel, C.1
Trujillo, M.2
Rahlfs, S.3
Deponte, M.4
Radi, R.5
Becker, K.6
-
48
-
-
33746785955
-
Thioredoxin networks in the malarial parasite Plasmodium falciparum
-
Nickel C., Rahlfs S., Deponte M., Koncarevic S., Becker K. Thioredoxin networks in the malarial parasite Plasmodium falciparum. Antioxid. Redox Signal. 2006, 8:1227-1239.
-
(2006)
Antioxid. Redox Signal.
, vol.8
, pp. 1227-1239
-
-
Nickel, C.1
Rahlfs, S.2
Deponte, M.3
Koncarevic, S.4
Becker, K.5
-
49
-
-
79955660777
-
Branched tricarboxylic acid metabolism in Plasmodium falciparum
-
Olszewski K.L., Mather M.W., Morrisey J.M., Garcia B.A., Vaidya A.B., Rabinowitz J.D., Llinas M. Branched tricarboxylic acid metabolism in Plasmodium falciparum. Nature 2010, 466:774-778.
-
(2010)
Nature
, vol.466
, pp. 774-778
-
-
Olszewski, K.L.1
Mather, M.W.2
Morrisey, J.M.3
Garcia, B.A.4
Vaidya, A.B.5
Rabinowitz, J.D.6
Llinas, M.7
-
50
-
-
77956245794
-
Glutathione reductase-null malaria parasites have normal blood stage growth but arrest during development in the mosquito
-
Pastrana-Mena R., Dinglasan R.R., Franke-Fayard B., Vega-Rodriguez J., Fuentes-Caraballo M., Baerga-Ortiz A., Coppens I., Jacobs-Lorena M., Janse C.J., Serrano A.E. Glutathione reductase-null malaria parasites have normal blood stage growth but arrest during development in the mosquito. J. Biol. Chem. 2010, 285:27045-27056.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 27045-27056
-
-
Pastrana-Mena, R.1
Dinglasan, R.R.2
Franke-Fayard, B.3
Vega-Rodriguez, J.4
Fuentes-Caraballo, M.5
Baerga-Ortiz, A.6
Coppens, I.7
Jacobs-Lorena, M.8
Janse, C.J.9
Serrano, A.E.10
-
51
-
-
84855760118
-
Dissecting the role of glutathione biosynthesis in Plasmodium falciparum
-
Patzewitz E.M., Wong E.H., Muller S. Dissecting the role of glutathione biosynthesis in Plasmodium falciparum. Mol. Microbiol. 2012, 83:304-318.
-
(2012)
Mol. Microbiol.
, vol.83
, pp. 304-318
-
-
Patzewitz, E.M.1
Wong, E.H.2
Muller, S.3
-
52
-
-
0035081036
-
Thioredoxin peroxidases of the malarial parasite Plasmodium falciparum
-
Rahlfs S., Becker K. Thioredoxin peroxidases of the malarial parasite Plasmodium falciparum. Eur. J. Biochem. 2001, 268:1404-1409.
-
(2001)
Eur. J. Biochem.
, vol.268
, pp. 1404-1409
-
-
Rahlfs, S.1
Becker, K.2
-
53
-
-
0035813229
-
Plasmodium falciparum possesses a classical glutaredoxin and a second, glutaredoxin-like protein with a PICOT homology domain
-
Rahlfs S., Fischer M., Becker K. Plasmodium falciparum possesses a classical glutaredoxin and a second, glutaredoxin-like protein with a PICOT homology domain. J. Biol. Chem. 2001, 276:37133-37140.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 37133-37140
-
-
Rahlfs, S.1
Fischer, M.2
Becker, K.3
-
54
-
-
0346651484
-
Plasmodium falciparum thioredoxins and glutaredoxins as central players in redox metabolism
-
Rahlfs S., Nickel C., Deponte M., Schirmer R.H., Becker K. Plasmodium falciparum thioredoxins and glutaredoxins as central players in redox metabolism. Redox. Rep. 2003, 8:246-250.
-
(2003)
Redox. Rep.
, vol.8
, pp. 246-250
-
-
Rahlfs, S.1
Nickel, C.2
Deponte, M.3
Schirmer, R.H.4
Becker, K.5
-
55
-
-
79951643450
-
Multiple functions of peroxiredoxins: peroxidases, sensors and regulators of the intracellular messenger HO, and protein chaperones
-
Rhee S.G., Woo H.A. Multiple functions of peroxiredoxins: peroxidases, sensors and regulators of the intracellular messenger HO, and protein chaperones. Antioxid. Redox Signal. 2011, 15:781-794.
-
(2011)
Antioxid. Redox Signal.
, vol.15
, pp. 781-794
-
-
Rhee, S.G.1
Woo, H.A.2
-
56
-
-
79953219814
-
A genome-wide chromatin-associated nuclear peroxiredoxin from the malaria parasite Plasmodium falciparum
-
Richard D., Bartfai R., Volz J., Ralph S.A., Muller S., Stunnenberg H.G., Cowman A.F. A genome-wide chromatin-associated nuclear peroxiredoxin from the malaria parasite Plasmodium falciparum. J. Biol. Chem. 2011, 286:11746-11755.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 11746-11755
-
-
Richard, D.1
Bartfai, R.2
Volz, J.3
Ralph, S.A.4
Muller, S.5
Stunnenberg, H.G.6
Cowman, A.F.7
-
57
-
-
40149085227
-
New uses for old drugs. Auranofin, a clinically established antiarthritic metallodrug, exhibits potent antimalarial effects in vitro: mechanistic and pharmacological implications
-
Sannella A.R., Casini A., Gabbiani C., Messori L., Bilia A.R., Vincieri F.F., Majori G., Severini C. New uses for old drugs. Auranofin, a clinically established antiarthritic metallodrug, exhibits potent antimalarial effects in vitro: mechanistic and pharmacological implications. FEBS Lett. 2008, 582:844-847.
-
(2008)
FEBS Lett.
, vol.582
, pp. 844-847
-
-
Sannella, A.R.1
Casini, A.2
Gabbiani, C.3
Messori, L.4
Bilia, A.R.5
Vincieri, F.F.6
Majori, G.7
Severini, C.8
-
58
-
-
0037427472
-
Glutathione reductase of the malarial parasite Plasmodium falciparum: crystal structure and inhibitor development
-
Sarma G.N., Savvides S.N., Becker K., Schirmer M., Schirmer R.H., Karplus P.A. Glutathione reductase of the malarial parasite Plasmodium falciparum: crystal structure and inhibitor development. J. Mol. Biol. 2003, 328:893-907.
-
(2003)
J. Mol. Biol.
, vol.328
, pp. 893-907
-
-
Sarma, G.N.1
Savvides, S.N.2
Becker, K.3
Schirmer, M.4
Schirmer, R.H.5
Karplus, P.A.6
-
59
-
-
13444265992
-
Crystal structure of a novel Plasmodium falciparum 1-Cys peroxiredoxin
-
Sarma G.N., Nickel C., Rahlfs S., Fischer M., Becker K., Karplus P.A. Crystal structure of a novel Plasmodium falciparum 1-Cys peroxiredoxin. J. Mol. Biol. 2005, 346:1021-1034.
-
(2005)
J. Mol. Biol.
, vol.346
, pp. 1021-1034
-
-
Sarma, G.N.1
Nickel, C.2
Rahlfs, S.3
Fischer, M.4
Becker, K.5
Karplus, P.A.6
-
60
-
-
0037169547
-
Crystal structure of the antioxidant enzyme glutathione reductase inactivated by peroxynitrite
-
Savvides S.N., Scheiwein M., Bohme C.C., Arteel G.E., Karplus P.A., Becker K., Schirmer R.H. Crystal structure of the antioxidant enzyme glutathione reductase inactivated by peroxynitrite. J. Biol. Chem. 2002, 277:2779-2784.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 2779-2784
-
-
Savvides, S.N.1
Scheiwein, M.2
Bohme, C.C.3
Arteel, G.E.4
Karplus, P.A.5
Becker, K.6
Schirmer, R.H.7
-
61
-
-
84855432506
-
Simultaneous inhibition of glutathione- and thioredoxin-dependent metabolism is necessary to potentiate 17AAG-induced cancer cell killing via oxidative stress
-
Scarbrough P.M., Mapuskar K.A., Mattson D.M., Gius D., Watson W.H., Spitz D.R. Simultaneous inhibition of glutathione- and thioredoxin-dependent metabolism is necessary to potentiate 17AAG-induced cancer cell killing via oxidative stress. Free. Radic. Biol. Med. 2012, 52:436-443.
-
(2012)
Free. Radic. Biol. Med.
, vol.52
, pp. 436-443
-
-
Scarbrough, P.M.1
Mapuskar, K.A.2
Mattson, D.M.3
Gius, D.4
Watson, W.H.5
Spitz, D.R.6
-
62
-
-
33748233963
-
Disulfide-reductase inhibitors as chemotherapeutic-agents - the design of drugs for trypanosomiasis and malaria
-
Schirmer R.H., Muller J.G., Krauthsiegel R.L. Disulfide-reductase inhibitors as chemotherapeutic-agents - the design of drugs for trypanosomiasis and malaria. Angew. Chem. 1995, 34:141-154.
-
(1995)
Angew. Chem.
, vol.34
, pp. 141-154
-
-
Schirmer, R.H.1
Muller, J.G.2
Krauthsiegel, R.L.3
-
63
-
-
84859780613
-
Structural insights into thioredoxin-2: a component of malaria parasite protein secretion machinery
-
Sharma A., Dixit S. Structural insights into thioredoxin-2: a component of malaria parasite protein secretion machinery. Sci. Rep. 2011, 1:179.
-
(2011)
Sci. Rep.
, vol.1
, pp. 179
-
-
Sharma, A.1
Dixit, S.2
-
64
-
-
3342882808
-
Identification of a mitochondrial superoxide dismutase with an unusual targeting sequence in Plasmodium falciparum
-
Sienkiewicz N., Daher W., Dive D., Wrenger C., Viscogliosi E., Wintjens R., Jouin H., Capron M., Muller S., Khalife J. Identification of a mitochondrial superoxide dismutase with an unusual targeting sequence in Plasmodium falciparum. Mol. Biochem. Parasitol. 2004, 137:121-132.
-
(2004)
Mol. Biochem. Parasitol.
, vol.137
, pp. 121-132
-
-
Sienkiewicz, N.1
Daher, W.2
Dive, D.3
Wrenger, C.4
Viscogliosi, E.5
Wintjens, R.6
Jouin, H.7
Capron, M.8
Muller, S.9
Khalife, J.10
-
65
-
-
79960555563
-
Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development
-
Storm J., Perner J., Aparicio I., Patzewitz E.M., Olszewski K., Llinas M., Engel P.C., Muller S. Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development. Malar. J. 2011, 10:193.
-
(2011)
Malar. J.
, vol.10
, pp. 193
-
-
Storm, J.1
Perner, J.2
Aparicio, I.3
Patzewitz, E.M.4
Olszewski, K.5
Llinas, M.6
Engel, P.C.7
Muller, S.8
-
66
-
-
59749092672
-
Compounds structurally related to ellagic acid show improved antiplasmodial activity
-
Sturm N., Hu Y., Zimmermann H., Fritz-Wolf K., Wittlin S., Rahlfs S., Becker K. Compounds structurally related to ellagic acid show improved antiplasmodial activity. Antimicrob. Agents Chemother. 2009, 53:622-630.
-
(2009)
Antimicrob. Agents Chemother.
, vol.53
, pp. 622-630
-
-
Sturm, N.1
Hu, Y.2
Zimmermann, H.3
Fritz-Wolf, K.4
Wittlin, S.5
Rahlfs, S.6
Becker, K.7
-
67
-
-
66349103376
-
Identification of proteins targeted by the thioredoxin superfamily in Plasmodium falciparum
-
Sturm N., Jortzik E., Mailu B.M., Koncarevic S., Deponte M., Forchhammer K., Rahlfs S., Becker K. Identification of proteins targeted by the thioredoxin superfamily in Plasmodium falciparum. PLoS Pathog. 2009, 5:e1000383.
-
(2009)
PLoS Pathog.
, vol.5
-
-
Sturm, N.1
Jortzik, E.2
Mailu, B.M.3
Koncarevic, S.4
Deponte, M.5
Forchhammer, K.6
Rahlfs, S.7
Becker, K.8
-
68
-
-
0035831464
-
The putative glutathione peroxidase gene of Plasmodium falciparum codes for a thioredoxin peroxidase
-
Sztajer H., Gamain B., Aumann K.D., Slomianny C., Becker K., Brigelius-Flohe R., Flohe L. The putative glutathione peroxidase gene of Plasmodium falciparum codes for a thioredoxin peroxidase. J. Biol. Chem. 2001, 276:7397-7403.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 7397-7403
-
-
Sztajer, H.1
Gamain, B.2
Aumann, K.D.3
Slomianny, C.4
Becker, K.5
Brigelius-Flohe, R.6
Flohe, L.7
-
69
-
-
33751181030
-
On the potential of thioredoxin reductase inhibitors for cancer therapy
-
Urig S., Becker K. On the potential of thioredoxin reductase inhibitors for cancer therapy. Semin. Cancer Biol. 2006, 16:452-465.
-
(2006)
Semin. Cancer Biol.
, vol.16
, pp. 452-465
-
-
Urig, S.1
Becker, K.2
-
70
-
-
61449205182
-
The glutathione biosynthetic pathway of Plasmodium is essential for mosquito transmission
-
Vega-Rodriguez J., Franke-Fayard B., Dinglasan R.R., Janse C.J., Pastrana-Mena R., Waters A.P., Coppens I., Rodriguez-Orengo J.F., Srinivasan P., Jacobs-Lorena M., Serrano A.E. The glutathione biosynthetic pathway of Plasmodium is essential for mosquito transmission. PLoS Pathog. 2009, 5:e1000302.
-
(2009)
PLoS Pathog.
, vol.5
-
-
Vega-Rodriguez, J.1
Franke-Fayard, B.2
Dinglasan, R.R.3
Janse, C.J.4
Pastrana-Mena, R.5
Waters, A.P.6
Coppens, I.7
Rodriguez-Orengo, J.F.8
Srinivasan, P.9
Jacobs-Lorena, M.10
Serrano, A.E.11
-
71
-
-
19444372583
-
The crystal structure of Plasmodium falciparum glutamate dehydrogenase, a putative target for novel antimalarial drugs
-
Werner C., Stubbs M.T., Krauth-Siegel R.L., Klebe G. The crystal structure of Plasmodium falciparum glutamate dehydrogenase, a putative target for novel antimalarial drugs. J. Mol. Biol. 2005, 349:597-607.
-
(2005)
J. Mol. Biol.
, vol.349
, pp. 597-607
-
-
Werner, C.1
Stubbs, M.T.2
Krauth-Siegel, R.L.3
Klebe, G.4
-
72
-
-
84873982712
-
-
WHO, World Malaria Report 2011
-
WHO, 2011. World Malaria Report 2011. http://www.who.int/malaria/world_malaria_report_2011/9789241564403_eng.pdf.
-
(2011)
-
-
-
73
-
-
0033781942
-
Thioredoxin reductase two modes of catalysis have evolved
-
Williams C.H., Arscott L.D., Muller S., Lennon B.W., Ludwig M.L., Wang P.F., Veine D.M., Becker K., Schirmer R.H. Thioredoxin reductase two modes of catalysis have evolved. Eur. J. Biochem. 2000, 267:6110-6117.
-
(2000)
Eur. J. Biochem.
, vol.267
, pp. 6110-6117
-
-
Williams, C.H.1
Arscott, L.D.2
Muller, S.3
Lennon, B.W.4
Ludwig, M.L.5
Wang, P.F.6
Veine, D.M.7
Becker, K.8
Schirmer, R.H.9
-
74
-
-
0242668686
-
Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling
-
Wood Z.A., Poole L.B., Karplus P.A. Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling. Science 2003, 300:650-653.
-
(2003)
Science
, vol.300
, pp. 650-653
-
-
Wood, Z.A.1
Poole, L.B.2
Karplus, P.A.3
-
75
-
-
0038408998
-
Isocitrate dehydrogenase of Plasmodium falciparum
-
Wrenger C., Muller S. Isocitrate dehydrogenase of Plasmodium falciparum. Eur. J. Biochem. 2003, 270:1775-1783.
-
(2003)
Eur. J. Biochem.
, vol.270
, pp. 1775-1783
-
-
Wrenger, C.1
Muller, S.2
-
76
-
-
13844267219
-
Expression of mRNAs and proteins for peroxiredoxins in Plasmodium falciparum erythrocytic stage
-
Yano K., Komaki-Yasuda K., Kobayashi T., Takemae H., Kita K., Kano S., Kawazu S. Expression of mRNAs and proteins for peroxiredoxins in Plasmodium falciparum erythrocytic stage. Parasitol. Int. 2005, 54:35-41.
-
(2005)
Parasitol. Int.
, vol.54
, pp. 35-41
-
-
Yano, K.1
Komaki-Yasuda, K.2
Kobayashi, T.3
Takemae, H.4
Kita, K.5
Kano, S.6
Kawazu, S.7
-
77
-
-
33744546817
-
2-Cys peroxiredoxin TPx-1 is involved in gametocyte development in Plasmodium berghei
-
Yano K., Komaki-Yasuda K., Tsuboi T., Torii M., Kano S., Kawazu S. 2-Cys peroxiredoxin TPx-1 is involved in gametocyte development in Plasmodium berghei. Mol. Biochem. Parasitol. 2006, 148:44-51.
-
(2006)
Mol. Biochem. Parasitol.
, vol.148
, pp. 44-51
-
-
Yano, K.1
Komaki-Yasuda, K.2
Tsuboi, T.3
Torii, M.4
Kano, S.5
Kawazu, S.6
-
78
-
-
43049127225
-
Disruption of the Plasmodium berghei 2-Cys peroxiredoxin TPx-1 gene hinders the sporozoite development in the vector mosquito
-
Yano K., Otsuki H., Arai M., Komaki-Yasuda K., Tsuboi T., Torii M., Kano S., Kawazu S. Disruption of the Plasmodium berghei 2-Cys peroxiredoxin TPx-1 gene hinders the sporozoite development in the vector mosquito. Mol. Biochem. Parasitol. 2008, 159:142-145.
-
(2008)
Mol. Biochem. Parasitol.
, vol.159
, pp. 142-145
-
-
Yano, K.1
Otsuki, H.2
Arai, M.3
Komaki-Yasuda, K.4
Tsuboi, T.5
Torii, M.6
Kano, S.7
Kawazu, S.8
|