Glutathione reductase-catalyzed cascade of redox reactions to bioactivate potent antimalarial 1,4-naphthoquinones - A new strategy to combat malarial parasites

Journal of the American Chemical Society

Volumn 133, Issue 30, 2011, Pages 11557-11571

  Müller, Tobias ^a   Johann, Laure ^a,b   Jannack, Beate ^a   Brückner, Margit ^a   Lanfranchi, Don Antoine ^b   Bauer, Holger ^a   Sanchez, Cecilia ^a   Yardley, Vanessa ^c   Deregnaucourt, Christiane ^d   Schrével, Joseph ^d   Lanzer, Michael ^a   Schirmer, R Heiner ^a   Davioud Charvet, Elisabeth ^a,b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^d MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1 ,4-NAPHTHOQUINONES; ANTIMALARIAL ACTIVITY; BENZYLIC; BIOACTIVATION; CYCLERS; CYTOSOLS; GLUTATHIONES; HUMAN PATHOGENS; MALARIA PARASITE; MALARIAL PARASITES; MODE OF ACTION; NANOMOLAR CONCENTRATION; NEW STRATEGY; PARASITE-; PLASMODIUM FALCIPARUM; RED BLOOD CELL; REDOX EQUILIBRIUM;

BIOMOLECULES; BLOOD; CATALYSIS; CELL CULTURE; CELLS; ENZYME ACTIVITY; KETONES; MAMMALS; METABOLISM; METABOLITES; PORPHYRINS;

REDOX REACTIONS;

1,4 NAPHTHOQUINONE DERIVATIVE; 2 DIFLUOROMENADIONE; 3 (ALPHA METHYLBENZYL)MENADIONE DERIVATIVE; 3 (PHENYLHYDROXYMETHYL)MENADIONE; 3 BENZOYLDIFLUOROMENADIONE; 3 BENZOYLMENADIONE DERIVATIVE; 3 BENZOYLPLUMBAGIN DERIVATIVE; 3 BENZYLDIFLUOROMENADIONE; 3 BENZYLMENADIONE DERIVATIVE; 3 BENZYLPLUMAGIN DERIVATIVE; 6 METHYLQUINOLINE 5,8 DIONE; ANTIMALARIAL AGENT; CHLOROQUINE; DIFLUOROMETHYLMENADIONE; GLUTATHIONE REDUCTASE; MENADIONE; PLUMBAGIN; SUICIDE SUBSTRATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYSIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG TARGETING; ENZYME ACTIVITY; MALARIA; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION; PARASITE; PARASITE DEVELOPMENT; PARASITEMIA; PH; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PROTON NUCLEAR MAGNETIC RESONANCE; TREATMENT OUTCOME; TROPHOZOITE;

ANIMALS; ANTIMALARIALS; BIOCATALYSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE REDUCTASE; HUMANS; MICE; MOLECULAR STRUCTURE; NAPHTHOQUINONES; OXIDATION-REDUCTION; PARASITIC SENSITIVITY TESTS; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79960849123     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja201729z     Document Type: Article

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