The crystal structure of Plasmodium falciparum glutamate dehydrogenase, a putative target for novel antimalarial drugs

Journal of Molecular Biology

Volumn 349, Issue 3, 2005, Pages 597-607

  Werner, Christof ^a   Stubbs, Milton T ^a,c   Krauth Siegel, R Luise ^b   Klebe, Gerhard ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Crystal structure analysis; Drug design; Glutamate dehydrogenase; Malaria; Plasmodium falciparum

Indexed keywords

AMINO ACID; ANTIMALARIAL AGENT; ANTIOXIDANT; BRIDGED COMPOUND; GLUTAMATE DEHYDROGENASE (NADP); GLUTATHIONE REDUCTASE; SODIUM CHLORIDE; THIOREDOXIN REDUCTASE;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DEVELOPING COUNTRY; DISEASE SEVERITY; DRUG TARGETING; ELECTRON; ENDEMIC DISEASE; ENZYME ACTIVE SITE; ENZYME ASSAY; ENZYME SUBUNIT; ERYTHROCYTE; ESCHERICHIA COLI; GENETIC ORGANIZATION; HOST CELL; HYDROPHOBICITY; MALARIA; MAMMAL; NONHUMAN; OLIGOMERIZATION; OXIDATIVE STRESS; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN INTERACTION; SENSITIVITY ANALYSIS; THREE DIMENSIONAL IMAGING; TROPICAL DISEASE; X RAY CRYSTALLOGRAPHY;

MAMMALIA; PLASMODIUM FALCIPARUM;

EID: 19444372583     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2005.03.077     Document Type: Article

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