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Volumn 8, Issue 4, 2012, Pages 539-550

Insulin Sensitization Therapy and the Heart: Focus on Metformin and Thiazolidinediones

Author keywords

Chronic heart failure; Insulin resistance; Metformin; Thiazolidinedione

Indexed keywords

ANTIDIABETIC AGENT; CARVEDILOL; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INSULIN; INSULIN RECEPTOR SUBSTRATE; METFORMIN; MINERALOCORTICOID RECEPTOR; PIOGLITAZONE; RAMIPRIL; ROSIGLITAZONE;

EID: 84866616996     PISSN: 15517136     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hfc.2012.06.002     Document Type: Review
Times cited : (13)

References (98)
  • 1
    • 22244474634 scopus 로고    scopus 로고
    • Insulin resistance and risk of congestive heart failure
    • Ingelsson E., Sundstrom J., Arnlov J., et al. Insulin resistance and risk of congestive heart failure. JAMA 2005, 294:334-341.
    • (2005) JAMA , vol.294 , pp. 334-341
    • Ingelsson, E.1    Sundstrom, J.2    Arnlov, J.3
  • 2
    • 0037353460 scopus 로고    scopus 로고
    • Functional class in patients with heart failure is associated with the development of diabetes
    • Tenenbaum A., Motro M., Fisman E.Z., et al. Functional class in patients with heart failure is associated with the development of diabetes. Am J Med 2003, 114:271-275.
    • (2003) Am J Med , vol.114 , pp. 271-275
    • Tenenbaum, A.1    Motro, M.2    Fisman, E.Z.3
  • 3
    • 0030751957 scopus 로고    scopus 로고
    • Insulin resistance in chronic heart failure: relation to severity and etiology of heart failure
    • Swan J.W., Anker S.D., Walton C., et al. Insulin resistance in chronic heart failure: relation to severity and etiology of heart failure. J Am Coll Cardiol 1997, 30:527-532.
    • (1997) J Am Coll Cardiol , vol.30 , pp. 527-532
    • Swan, J.W.1    Anker, S.D.2    Walton, C.3
  • 4
    • 0033886497 scopus 로고    scopus 로고
    • Glucose and insulin abnormalities relate to functional capacity in patients with congestive heart failure
    • Suskin N., McKelvie R.S., Burns R.J., et al. Glucose and insulin abnormalities relate to functional capacity in patients with congestive heart failure. Eur Heart J 2000, 21:1368-1375.
    • (2000) Eur Heart J , vol.21 , pp. 1368-1375
    • Suskin, N.1    McKelvie, R.S.2    Burns, R.J.3
  • 5
    • 60449096969 scopus 로고    scopus 로고
    • Insulin resistance is highly prevalent and is associated with reduced exercise tolerance in nondiabetic patients with heart failure
    • AlZadjali M.A., Godfrey V., Khan F., et al. Insulin resistance is highly prevalent and is associated with reduced exercise tolerance in nondiabetic patients with heart failure. J Am Coll Cardiol 2009, 53:747-753.
    • (2009) J Am Coll Cardiol , vol.53 , pp. 747-753
    • AlZadjali, M.A.1    Godfrey, V.2    Khan, F.3
  • 6
    • 77349089728 scopus 로고    scopus 로고
    • B-type natriuretic peptide levels and insulin resistance in patients with severe ischemic myocardial dysfunction
    • Tassone F., Gianotti L., Rolfo F., et al. B-type natriuretic peptide levels and insulin resistance in patients with severe ischemic myocardial dysfunction. J Endocrinol Invest 2009, 32:805-809.
    • (2009) J Endocrinol Invest , vol.32 , pp. 805-809
    • Tassone, F.1    Gianotti, L.2    Rolfo, F.3
  • 7
    • 24944519346 scopus 로고    scopus 로고
    • Impaired insulin sensitivity as an independent risk factor for mortality in patients with stable chronic heart failure
    • Doehner W., Rauchhaus M., Ponikowski P., et al. Impaired insulin sensitivity as an independent risk factor for mortality in patients with stable chronic heart failure. J Am Coll Cardiol 2005, 46:1019-1026.
    • (2005) J Am Coll Cardiol , vol.46 , pp. 1019-1026
    • Doehner, W.1    Rauchhaus, M.2    Ponikowski, P.3
  • 8
    • 39749202265 scopus 로고    scopus 로고
    • Nature and prognostic importance of abnormal glucose tolerance and diabetes in acute heart failure
    • Berry C., Brett M., Stevenson K., et al. Nature and prognostic importance of abnormal glucose tolerance and diabetes in acute heart failure. Heart 2008, 94:296-304.
    • (2008) Heart , vol.94 , pp. 296-304
    • Berry, C.1    Brett, M.2    Stevenson, K.3
  • 9
    • 37849047917 scopus 로고    scopus 로고
    • Insulin-resistant cardiomyopathy clinical evidence, mechanisms, and treatment options
    • Witteles R.M., Fowler M.B. Insulin-resistant cardiomyopathy clinical evidence, mechanisms, and treatment options. J Am Coll Cardiol 2008, 51:93-102.
    • (2008) J Am Coll Cardiol , vol.51 , pp. 93-102
    • Witteles, R.M.1    Fowler, M.B.2
  • 10
    • 53949106519 scopus 로고    scopus 로고
    • Insulin resistance: a potential new target for therapy in patients with heart failure
    • Wong A.K., AlZadjali M.A., Choy A.M., et al. Insulin resistance: a potential new target for therapy in patients with heart failure. Cardiovasc Ther 2008, 26:203-213.
    • (2008) Cardiovasc Ther , vol.26 , pp. 203-213
    • Wong, A.K.1    AlZadjali, M.A.2    Choy, A.M.3
  • 11
    • 0025995364 scopus 로고
    • Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans
    • Anderson E.A., Hoffman R.P., Balon T.W., et al. Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans. J Clin Invest 1991, 87:2246-2252.
    • (1991) J Clin Invest , vol.87 , pp. 2246-2252
    • Anderson, E.A.1    Hoffman, R.P.2    Balon, T.W.3
  • 12
    • 0028151431 scopus 로고
    • Relation of pressor responsiveness to angiotensin II and insulin resistance in hypertension
    • Gaboury C.L., Simonson D.C., Seely E.W., et al. Relation of pressor responsiveness to angiotensin II and insulin resistance in hypertension. J Clin Invest 1994, 94:2295-2300.
    • (1994) J Clin Invest , vol.94 , pp. 2295-2300
    • Gaboury, C.L.1    Simonson, D.C.2    Seely, E.W.3
  • 13
    • 10844250123 scopus 로고    scopus 로고
    • Insulin resistance and inflammatory activation in older patients with systolic and diastolic heart failure
    • Wisniacki N., Taylor W., Lye M., et al. Insulin resistance and inflammatory activation in older patients with systolic and diastolic heart failure. Heart 2005, 91:32-37.
    • (2005) Heart , vol.91 , pp. 32-37
    • Wisniacki, N.1    Taylor, W.2    Lye, M.3
  • 14
    • 77954370180 scopus 로고    scopus 로고
    • Acute oxidative stress can reverse insulin resistance by inactivation of cytoplasmic JNK
    • Berdichevsky A., Guarente L., Bose A. Acute oxidative stress can reverse insulin resistance by inactivation of cytoplasmic JNK. J Biol Chem 2010, 285:21581-21589.
    • (2010) J Biol Chem , vol.285 , pp. 21581-21589
    • Berdichevsky, A.1    Guarente, L.2    Bose, A.3
  • 15
    • 3042647159 scopus 로고    scopus 로고
    • Effects of angiotensin II and insulin on ERK1/2 activation in fibroblasts from hypertensive patients
    • Sartori M., Ceolotto G., Papparella I., et al. Effects of angiotensin II and insulin on ERK1/2 activation in fibroblasts from hypertensive patients. Am J Hypertens 2004, 17:604-610.
    • (2004) Am J Hypertens , vol.17 , pp. 604-610
    • Sartori, M.1    Ceolotto, G.2    Papparella, I.3
  • 16
    • 84863713121 scopus 로고    scopus 로고
    • Left ventricular function impairment in patients with normal weight obesity: contribution of abdominal fat deposition, profibrotic state, reduced insulin sensitivity and proinflammatory activation
    • Kosmala W., Jedrzejuk D., Derzhko R., et al. Left ventricular function impairment in patients with normal weight obesity: contribution of abdominal fat deposition, profibrotic state, reduced insulin sensitivity and proinflammatory activation. Circ Cardiovasc Imaging 2012, 5(3):349-356.
    • (2012) Circ Cardiovasc Imaging , vol.5 , Issue.3 , pp. 349-356
    • Kosmala, W.1    Jedrzejuk, D.2    Derzhko, R.3
  • 17
    • 33845293219 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure
    • Sokos G.G., Nikolaidis L.A., Mankad S., et al. Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure. J Card Fail 2006, 12:694-699.
    • (2006) J Card Fail , vol.12 , pp. 694-699
    • Sokos, G.G.1    Nikolaidis, L.A.2    Mankad, S.3
  • 18
    • 0025266282 scopus 로고
    • Myocardial metabolism in insulin-deficient diabetic humans without coronary artery disease
    • Avogaro A., Nosadini R., Doria A., et al. Myocardial metabolism in insulin-deficient diabetic humans without coronary artery disease. Am J Physiol 1990, 258:E606-E618.
    • (1990) Am J Physiol , vol.258
    • Avogaro, A.1    Nosadini, R.2    Doria, A.3
  • 19
    • 0035061419 scopus 로고    scopus 로고
    • A novel mouse model of lipotoxic cardiomyopathy
    • Chiu H.C., Kovacs A., Ford D.A., et al. A novel mouse model of lipotoxic cardiomyopathy. J Clin Invest 2001, 107:813-822.
    • (2001) J Clin Invest , vol.107 , pp. 813-822
    • Chiu, H.C.1    Kovacs, A.2    Ford, D.A.3
  • 20
    • 34248370974 scopus 로고    scopus 로고
    • Lipids in the heart: a source of fuel and a source of toxins
    • Park T.S., Yamashita H., Blaner W.S., et al. Lipids in the heart: a source of fuel and a source of toxins. Curr Opin Lipidol 2007, 18:277-282.
    • (2007) Curr Opin Lipidol , vol.18 , pp. 277-282
    • Park, T.S.1    Yamashita, H.2    Blaner, W.S.3
  • 21
    • 18044393847 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor agonists modulate heart function in transgenic mice with lipotoxic cardiomyopathy
    • Vikramadithyan R.K., Hirata K., Yagyu H., et al. Peroxisome proliferator-activated receptor agonists modulate heart function in transgenic mice with lipotoxic cardiomyopathy. J Pharmacol Exp Ther 2005, 313:586-593.
    • (2005) J Pharmacol Exp Ther , vol.313 , pp. 586-593
    • Vikramadithyan, R.K.1    Hirata, K.2    Yagyu, H.3
  • 22
    • 0030819144 scopus 로고    scopus 로고
    • Myocardial phosphocreatine-to-ATP ratio is a predictor of mortality in patients with dilated cardiomyopathy
    • Neubauer S., Horn M., Cramer M., et al. Myocardial phosphocreatine-to-ATP ratio is a predictor of mortality in patients with dilated cardiomyopathy. Circulation 1997, 96:2190-2196.
    • (1997) Circulation , vol.96 , pp. 2190-2196
    • Neubauer, S.1    Horn, M.2    Cramer, M.3
  • 23
    • 33947239659 scopus 로고    scopus 로고
    • The failing heart-an engine out of fuel
    • Neubauer S. The failing heart-an engine out of fuel. N Engl J Med 2007, 356:1140-1151.
    • (2007) N Engl J Med , vol.356 , pp. 1140-1151
    • Neubauer, S.1
  • 24
    • 33749453003 scopus 로고    scopus 로고
    • Decreased myocardial free fatty acid uptake in patients with idiopathic dilated cardiomyopathy: evidence of relationship with insulin resistance and left ventricular dysfunction
    • Tuunanen H., Engblom E., Naum A., et al. Decreased myocardial free fatty acid uptake in patients with idiopathic dilated cardiomyopathy: evidence of relationship with insulin resistance and left ventricular dysfunction. J Card Fail 2006, 12:644-652.
    • (2006) J Card Fail , vol.12 , pp. 644-652
    • Tuunanen, H.1    Engblom, E.2    Naum, A.3
  • 25
    • 0037034257 scopus 로고    scopus 로고
    • Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    • Knowler W.C., Barrett-Connor E., Fowler S.E., et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002, 346:393-403.
    • (2002) N Engl J Med , vol.346 , pp. 393-403
    • Knowler, W.C.1    Barrett-Connor, E.2    Fowler, S.E.3
  • 26
    • 10744228615 scopus 로고    scopus 로고
    • Insulin signalling and resistance in patients with chronic heart failure
    • Kemppainen J., Tsuchida H., Stolen K., et al. Insulin signalling and resistance in patients with chronic heart failure. J Physiol 2003, 550:305-315.
    • (2003) J Physiol , vol.550 , pp. 305-315
    • Kemppainen, J.1    Tsuchida, H.2    Stolen, K.3
  • 27
    • 27144466795 scopus 로고    scopus 로고
    • Effect of orlistat in obese patients with heart failure: a pilot study
    • Beck-da-Silva L., Higginson L., Fraser M., et al. Effect of orlistat in obese patients with heart failure: a pilot study. Congest Heart Fail 2005, 11:118-123.
    • (2005) Congest Heart Fail , vol.11 , pp. 118-123
    • Beck-da-Silva, L.1    Higginson, L.2    Fraser, M.3
  • 28
    • 3142781955 scopus 로고    scopus 로고
    • Prevention of type 2 diabetes mellitus through inhibition of the renin-angiotensin system
    • Scheen A.J. Prevention of type 2 diabetes mellitus through inhibition of the renin-angiotensin system. Drugs 2004, 64:2537-2565.
    • (2004) Drugs , vol.64 , pp. 2537-2565
    • Scheen, A.J.1
  • 29
    • 33846683004 scopus 로고    scopus 로고
    • Effect of ramipril on the incidence of diabetes
    • author reply: 523-4
    • Potter B.J., LeLorier J. Effect of ramipril on the incidence of diabetes. N Engl J Med 2007, 356:522-523. author reply: 523-4.
    • (2007) N Engl J Med , vol.356 , pp. 522-523
    • Potter, B.J.1    LeLorier, J.2
  • 30
    • 77951453096 scopus 로고    scopus 로고
    • Effect of valsartan on the incidence of diabetes and cardiovascular events
    • McMurray J.J., Holman R.R., Haffner S.M., et al. Effect of valsartan on the incidence of diabetes and cardiovascular events. N Engl J Med 2010, 362:1477-1490.
    • (2010) N Engl J Med , vol.362 , pp. 1477-1490
    • McMurray, J.J.1    Holman, R.R.2    Haffner, S.M.3
  • 31
    • 7744237066 scopus 로고    scopus 로고
    • Metabolic effects of carvedilol vs metoprolol in patients with type 2 diabetes mellitus and hypertension: a randomized controlled trial
    • Bakris G.L., Fonseca V., Katholi R.E., et al. Metabolic effects of carvedilol vs metoprolol in patients with type 2 diabetes mellitus and hypertension: a randomized controlled trial. JAMA 2004, 292:2227-2236.
    • (2004) JAMA , vol.292 , pp. 2227-2236
    • Bakris, G.L.1    Fonseca, V.2    Katholi, R.E.3
  • 32
    • 34250308746 scopus 로고    scopus 로고
    • Effects of metoprolol and carvedilol on pre-existing and new onset diabetes in patients with chronic heart failure: data from the Carvedilol or Metoprolol European Trial (COMET)
    • Torp-Pedersen C., Metra M., Charlesworth A., et al. Effects of metoprolol and carvedilol on pre-existing and new onset diabetes in patients with chronic heart failure: data from the Carvedilol or Metoprolol European Trial (COMET). Heart 2007, 93:968-973.
    • (2007) Heart , vol.93 , pp. 968-973
    • Torp-Pedersen, C.1    Metra, M.2    Charlesworth, A.3
  • 33
    • 79960916860 scopus 로고    scopus 로고
    • Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets
    • Luther J.M., Luo P., Kreger M.T., et al. Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets. Diabetologia 2011, 54:2152-2163.
    • (2011) Diabetologia , vol.54 , pp. 2152-2163
    • Luther, J.M.1    Luo, P.2    Kreger, M.T.3
  • 34
    • 41849126315 scopus 로고    scopus 로고
    • Spironolactone for poorly controlled hypertension in type 2 diabetes: conflicting effects on blood pressure, endothelial function, glycaemic control and hormonal profiles
    • Swaminathan K., Davies J., George J., et al. Spironolactone for poorly controlled hypertension in type 2 diabetes: conflicting effects on blood pressure, endothelial function, glycaemic control and hormonal profiles. Diabetologia 2008, 51:762-768.
    • (2008) Diabetologia , vol.51 , pp. 762-768
    • Swaminathan, K.1    Davies, J.2    George, J.3
  • 35
    • 78649370678 scopus 로고    scopus 로고
    • Effect of eplerenone versus spironolactone on cortisol and hemoglobin A(c) levels in patients with chronic heart failure
    • Yamaji M., Tsutamoto T., Kawahara C., et al. Effect of eplerenone versus spironolactone on cortisol and hemoglobin A(c) levels in patients with chronic heart failure. Am Heart J 2010, 160:915-921.
    • (2010) Am Heart J , vol.160 , pp. 915-921
    • Yamaji, M.1    Tsutamoto, T.2    Kawahara, C.3
  • 36
    • 68949163165 scopus 로고    scopus 로고
    • Losartan reduces the onset of type 2 diabetes in hypertensive Japanese patients with chronic hepatitis C
    • Arase Y., Suzuki F., Suzuki Y., et al. Losartan reduces the onset of type 2 diabetes in hypertensive Japanese patients with chronic hepatitis C. J Med Virol 2009, 81:1584-1590.
    • (2009) J Med Virol , vol.81 , pp. 1584-1590
    • Arase, Y.1    Suzuki, F.2    Suzuki, Y.3
  • 37
    • 0033659881 scopus 로고    scopus 로고
    • Unraveling the mechanism of action of thiazolidinediones
    • Kahn C.R., Chen L., Cohen S.E. Unraveling the mechanism of action of thiazolidinediones. J Clin Invest 2000, 106:1305-1307.
    • (2000) J Clin Invest , vol.106 , pp. 1305-1307
    • Kahn, C.R.1    Chen, L.2    Cohen, S.E.3
  • 38
    • 12344316682 scopus 로고    scopus 로고
    • Thiazolidinediones: a review of their mechanisms of insulin sensitization, therapeutic potential, clinical efficacy, and tolerability
    • Vasudevan A.R., Balasubramanyam A. Thiazolidinediones: a review of their mechanisms of insulin sensitization, therapeutic potential, clinical efficacy, and tolerability. Diabetes Technol Ther 2004, 6:850-863.
    • (2004) Diabetes Technol Ther , vol.6 , pp. 850-863
    • Vasudevan, A.R.1    Balasubramanyam, A.2
  • 39
    • 0037076294 scopus 로고    scopus 로고
    • Structure, endothelial function, cell growth, and inflammation in blood vessels of angiotensin II-infused rats: role of peroxisome proliferator-activated receptor-gamma
    • Diep Q.N., El Mabrouk M., Cohn J.S., et al. Structure, endothelial function, cell growth, and inflammation in blood vessels of angiotensin II-infused rats: role of peroxisome proliferator-activated receptor-gamma. Circulation 2002, 105:2296-2302.
    • (2002) Circulation , vol.105 , pp. 2296-2302
    • Diep, Q.N.1    El Mabrouk, M.2    Cohn, J.S.3
  • 40
    • 33845400193 scopus 로고    scopus 로고
    • Effect of pioglitazone compared with glimepiride on carotid intima-media thickness in type 2 diabetes: a randomized trial
    • Mazzone T., Meyer P.M., Feinstein S.B., et al. Effect of pioglitazone compared with glimepiride on carotid intima-media thickness in type 2 diabetes: a randomized trial. JAMA 2006, 296:2572-2581.
    • (2006) JAMA , vol.296 , pp. 2572-2581
    • Mazzone, T.1    Meyer, P.M.2    Feinstein, S.B.3
  • 41
    • 0034858843 scopus 로고    scopus 로고
    • Ca(2+)-sensitizing effect is involved in the positive inotropic effect of troglitazone
    • Furuse Y., Ogino K., Shimoyama M., et al. Ca(2+)-sensitizing effect is involved in the positive inotropic effect of troglitazone. Br J Pharmacol 2001, 133:1307-1313.
    • (2001) Br J Pharmacol , vol.133 , pp. 1307-1313
    • Furuse, Y.1    Ogino, K.2    Shimoyama, M.3
  • 42
    • 0035199792 scopus 로고    scopus 로고
    • Pioglitazone improves left ventricular diastolic function and decreases collagen accumulation in prediabetic stage of a type II diabetic rat
    • Tsuji T., Mizushige K., Noma T., et al. Pioglitazone improves left ventricular diastolic function and decreases collagen accumulation in prediabetic stage of a type II diabetic rat. J Cardiovasc Pharmacol 2001, 38:868-874.
    • (2001) J Cardiovasc Pharmacol , vol.38 , pp. 868-874
    • Tsuji, T.1    Mizushige, K.2    Noma, T.3
  • 43
    • 0037066014 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma plays a critical role in inhibition of cardiac hypertrophy in vitro and in vivo
    • Asakawa M., Takano H., Nagai T., et al. Peroxisome proliferator-activated receptor gamma plays a critical role in inhibition of cardiac hypertrophy in vitro and in vivo. Circulation 2002, 105:1240-1246.
    • (2002) Circulation , vol.105 , pp. 1240-1246
    • Asakawa, M.1    Takano, H.2    Nagai, T.3
  • 44
    • 52749098189 scopus 로고    scopus 로고
    • Differential roles of cardiomyocyte and macrophage peroxisome proliferator-activated receptor gamma in cardiac fibrosis
    • Caglayan E., Stauber B., Collins A.R., et al. Differential roles of cardiomyocyte and macrophage peroxisome proliferator-activated receptor gamma in cardiac fibrosis. Diabetes 2008, 57:2470-2479.
    • (2008) Diabetes , vol.57 , pp. 2470-2479
    • Caglayan, E.1    Stauber, B.2    Collins, A.R.3
  • 45
    • 70350496807 scopus 로고    scopus 로고
    • In vivo metabolic phenotyping of myocardial substrate metabolism in rodents: differential efficacy of metformin and rosiglitazone monotherapy
    • Shoghi K.I., Finck B.N., Schechtman K.B., et al. In vivo metabolic phenotyping of myocardial substrate metabolism in rodents: differential efficacy of metformin and rosiglitazone monotherapy. Circ Cardiovasc Imaging 2009, 2:373-381.
    • (2009) Circ Cardiovasc Imaging , vol.2 , pp. 373-381
    • Shoghi, K.I.1    Finck, B.N.2    Schechtman, K.B.3
  • 46
    • 48749116551 scopus 로고    scopus 로고
    • Pioglitazone induces lipid accumulation in the rat heart despite concomitant reduction in plasma free fatty acid availability
    • Baranowski M., Blachnio-Zabielska A., Zabielski P., et al. Pioglitazone induces lipid accumulation in the rat heart despite concomitant reduction in plasma free fatty acid availability. Arch Biochem Biophys 2008, 477:86-91.
    • (2008) Arch Biochem Biophys , vol.477 , pp. 86-91
    • Baranowski, M.1    Blachnio-Zabielska, A.2    Zabielski, P.3
  • 47
    • 84859534676 scopus 로고    scopus 로고
    • Metformin prevents the development of chronic heart failure in the SHHF rat model
    • Cittadini A., Napoli R., Monti M.G., et al. Metformin prevents the development of chronic heart failure in the SHHF rat model. Diabetes 2012, 61(4):944-953.
    • (2012) Diabetes , vol.61 , Issue.4 , pp. 944-953
    • Cittadini, A.1    Napoli, R.2    Monti, M.G.3
  • 48
    • 77951628147 scopus 로고    scopus 로고
    • Effects of pioglitazone on intramyocellular fat metabolism in patients with type 2 diabetes mellitus
    • Bajaj M., Baig R., Suraamornkul S., et al. Effects of pioglitazone on intramyocellular fat metabolism in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab 2010, 95:1916-1923.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 1916-1923
    • Bajaj, M.1    Baig, R.2    Suraamornkul, S.3
  • 49
    • 65449182043 scopus 로고    scopus 로고
    • Pioglitazone improves cardiac function and alters myocardial substrate metabolism without affecting cardiac triglyceride accumulation and high-energy phosphate metabolism in patients with well-controlled type 2 diabetes mellitus
    • van der Meer R.W., Rijzewijk L.J., de Jong H.W., et al. Pioglitazone improves cardiac function and alters myocardial substrate metabolism without affecting cardiac triglyceride accumulation and high-energy phosphate metabolism in patients with well-controlled type 2 diabetes mellitus. Circulation 2009, 119:2069-2077.
    • (2009) Circulation , vol.119 , pp. 2069-2077
    • van der Meer, R.W.1    Rijzewijk, L.J.2    de Jong, H.W.3
  • 50
    • 34247153877 scopus 로고    scopus 로고
    • A randomized, placebo-controlled trial assessing the effects of rosiglitazone on echocardiographic function and cardiac status in type 2 diabetic patients with New York Heart Association functional class I or II heart failure
    • Dargie H.J., Hildebrandt P.R., Riegger G.A., et al. A randomized, placebo-controlled trial assessing the effects of rosiglitazone on echocardiographic function and cardiac status in type 2 diabetic patients with New York Heart Association functional class I or II heart failure. J Am Coll Cardiol 2007, 49:1696-1704.
    • (2007) J Am Coll Cardiol , vol.49 , pp. 1696-1704
    • Dargie, H.J.1    Hildebrandt, P.R.2    Riegger, G.A.3
  • 51
    • 0036833805 scopus 로고    scopus 로고
    • A comparison of the effects of rosiglitazone and glyburide on cardiovascular function and glycemic control in patients with type 2 diabetes
    • St John Sutton M., Rendell M., Dandona P., et al. A comparison of the effects of rosiglitazone and glyburide on cardiovascular function and glycemic control in patients with type 2 diabetes. Diabetes Care 2002, 25:2058-2064.
    • (2002) Diabetes Care , vol.25 , pp. 2058-2064
    • St John Sutton, M.1    Rendell, M.2    Dandona, P.3
  • 52
    • 47849123996 scopus 로고    scopus 로고
    • Pioglitazone and heart failure: results from a controlled study in patients with type 2 diabetes mellitus and systolic dysfunction
    • Giles T.D., Miller A.B., Elkayam U., et al. Pioglitazone and heart failure: results from a controlled study in patients with type 2 diabetes mellitus and systolic dysfunction. J Card Fail 2008, 14:445-452.
    • (2008) J Card Fail , vol.14 , pp. 445-452
    • Giles, T.D.1    Miller, A.B.2    Elkayam, U.3
  • 53
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • Nissen S.E., Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med 2007, 356:2457-2471.
    • (2007) N Engl J Med , vol.356 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 54
    • 77955285732 scopus 로고    scopus 로고
    • Rosiglitazone revisited: an updated meta-analysis of risk for myocardial infarction and cardiovascular mortality
    • Nissen S.E., Wolski K. Rosiglitazone revisited: an updated meta-analysis of risk for myocardial infarction and cardiovascular mortality. Arch Intern Med 2010, 170:1191-1201.
    • (2010) Arch Intern Med , vol.170 , pp. 1191-1201
    • Nissen, S.E.1    Wolski, K.2
  • 55
    • 34548580881 scopus 로고    scopus 로고
    • Long-term risk of cardiovascular events with rosiglitazone: a meta-analysis
    • Singh S., Loke Y.K., Furberg C.D. Long-term risk of cardiovascular events with rosiglitazone: a meta-analysis. JAMA 2007, 298:1189-1195.
    • (2007) JAMA , vol.298 , pp. 1189-1195
    • Singh, S.1    Loke, Y.K.2    Furberg, C.D.3
  • 56
    • 34548590934 scopus 로고    scopus 로고
    • Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: a meta-analysis of randomized trials
    • Lincoff A.M., Wolski K., Nicholls S.J., et al. Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: a meta-analysis of randomized trials. JAMA 2007, 298:1180-1188.
    • (2007) JAMA , vol.298 , pp. 1180-1188
    • Lincoff, A.M.1    Wolski, K.2    Nicholls, S.J.3
  • 57
    • 84874776852 scopus 로고    scopus 로고
    • McEvoy B. Pioglitazone and rosiglitazone cardiovascular safety meta-analysis. Presented at Joint Meeting of the Endocrinologic and Metabolic Drugs Advisory Committee and the Drug Safety and Risk Management Advisory Committee. Gaithersburg, July 13-14, 2010. Available at: Accessed January 23, 2011.
    • McEvoy B. Pioglitazone and rosiglitazone cardiovascular safety meta-analysis. Presented at Joint Meeting of the Endocrinologic and Metabolic Drugs Advisory Committee and the Drug Safety and Risk Management Advisory Committee. Gaithersburg, July 13-14, 2010. Available at: Accessed January 23, 2011. http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/EndocrinologicandMetabolicDrugsAdvisoryCommittee/UCM224739.pdf.
  • 58
    • 34648832073 scopus 로고    scopus 로고
    • Congestive heart failure and cardiovascular death in patients with prediabetes and type 2 diabetes given thiazolidinediones: a meta-analysis of randomised clinical trials
    • Lago R.M., Singh P.P., Nesto R.W. Congestive heart failure and cardiovascular death in patients with prediabetes and type 2 diabetes given thiazolidinediones: a meta-analysis of randomised clinical trials. Lancet 2007, 370:1129-1136.
    • (2007) Lancet , vol.370 , pp. 1129-1136
    • Lago, R.M.1    Singh, P.P.2    Nesto, R.W.3
  • 59
    • 77954988618 scopus 로고    scopus 로고
    • Risk of acute myocardial infarction, stroke, heart failure, and death in elderly Medicare patients treated with rosiglitazone or pioglitazone
    • Graham D.J., Ouellet-Hellstrom R., MaCurdy T.E., et al. Risk of acute myocardial infarction, stroke, heart failure, and death in elderly Medicare patients treated with rosiglitazone or pioglitazone. JAMA 2010, 304:411-418.
    • (2010) JAMA , vol.304 , pp. 411-418
    • Graham, D.J.1    Ouellet-Hellstrom, R.2    MaCurdy, T.E.3
  • 60
    • 77958189793 scopus 로고    scopus 로고
    • Risk of cardiovascular events and all-cause mortality in patients treated with thiazolidinediones in a managed-care population
    • Wertz D.A., Chang C.L., Sarawate C.A., et al. Risk of cardiovascular events and all-cause mortality in patients treated with thiazolidinediones in a managed-care population. Circ Cardiovasc Qual Outcomes 2010, 3:538-545.
    • (2010) Circ Cardiovasc Qual Outcomes , vol.3 , pp. 538-545
    • Wertz, D.A.1    Chang, C.L.2    Sarawate, C.A.3
  • 61
    • 82555175836 scopus 로고    scopus 로고
    • Risk of death and cardiovascular outcomes with thiazolidinediones: a study with the general practice research database and secondary care data
    • Gallagher A.M., Smeeth L., Seabroke S., et al. Risk of death and cardiovascular outcomes with thiazolidinediones: a study with the general practice research database and secondary care data. PLoS One 2011, 6:e28157.
    • (2011) PLoS One , vol.6
    • Gallagher, A.M.1    Smeeth, L.2    Seabroke, S.3
  • 62
    • 0036872996 scopus 로고    scopus 로고
    • Addressing the insulin resistance syndrome: a role for the thiazolidinediones
    • Zimmet P. Addressing the insulin resistance syndrome: a role for the thiazolidinediones. Trends Cardiovasc Med 2002, 12:354-362.
    • (2002) Trends Cardiovasc Med , vol.12 , pp. 354-362
    • Zimmet, P.1
  • 63
    • 10744221639 scopus 로고    scopus 로고
    • Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association
    • Nesto R.W., Bell D., Bonow R.O., et al. Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association. Diabetes Care 2004, 27:256-263.
    • (2004) Diabetes Care , vol.27 , pp. 256-263
    • Nesto, R.W.1    Bell, D.2    Bonow, R.O.3
  • 64
    • 37849035246 scopus 로고    scopus 로고
    • Weighing up the cardiovascular benefits of thiazolidinedione therapy: the impact of increased risk of heart failure
    • Erdmann E., Wilcox R.G. Weighing up the cardiovascular benefits of thiazolidinedione therapy: the impact of increased risk of heart failure. Eur Heart J 2008, 29:12-20.
    • (2008) Eur Heart J , vol.29 , pp. 12-20
    • Erdmann, E.1    Wilcox, R.G.2
  • 65
    • 33845234619 scopus 로고    scopus 로고
    • Effect of various diuretic treatments on rosiglitazone-induced fluid retention
    • Karalliedde J., Buckingham R., Starkie M., et al. Effect of various diuretic treatments on rosiglitazone-induced fluid retention. J Am Soc Nephrol 2006, 17:3482-3490.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 3482-3490
    • Karalliedde, J.1    Buckingham, R.2    Starkie, M.3
  • 66
    • 48649107300 scopus 로고    scopus 로고
    • Effects of ramipril and rosiglitazone on cardiovascular and renal outcomes in people with impaired glucose tolerance or impaired fasting glucose: results of the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) trial
    • Dagenais G.R., Gerstein H.C., Holman R., et al. Effects of ramipril and rosiglitazone on cardiovascular and renal outcomes in people with impaired glucose tolerance or impaired fasting glucose: results of the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) trial. Diabetes Care 2008, 31:1007-1014.
    • (2008) Diabetes Care , vol.31 , pp. 1007-1014
    • Dagenais, G.R.1    Gerstein, H.C.2    Holman, R.3
  • 67
    • 34250865768 scopus 로고    scopus 로고
    • Rosiglitazone evaluated for cardiovascular outcomes-an interim analysis
    • Home P.D., Pocock S.J., Beck-Nielsen H., et al. Rosiglitazone evaluated for cardiovascular outcomes-an interim analysis. N Engl J Med 2007, 357:28-38.
    • (2007) N Engl J Med , vol.357 , pp. 28-38
    • Home, P.D.1    Pocock, S.J.2    Beck-Nielsen, H.3
  • 68
    • 26244453309 scopus 로고    scopus 로고
    • Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial
    • Dormandy J.A., Charbonnel B., Eckland D.J., et al. Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial. Lancet 2005, 366:1279-1289.
    • (2005) Lancet , vol.366 , pp. 1279-1289
    • Dormandy, J.A.1    Charbonnel, B.2    Eckland, D.J.3
  • 69
    • 77954667427 scopus 로고    scopus 로고
    • Different effects of thiazolidinediones on cardiovascular risk in patients with type 2 diabetes mellitus: pioglitazone versus rosiglitazone
    • Simo R., Rodriguez A., Caveda E. Different effects of thiazolidinediones on cardiovascular risk in patients with type 2 diabetes mellitus: pioglitazone versus rosiglitazone. Curr Drug Saf 2010, 5:234-244.
    • (2010) Curr Drug Saf , vol.5 , pp. 234-244
    • Simo, R.1    Rodriguez, A.2    Caveda, E.3
  • 71
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group. Lancet 1998, 352:854-865.
    • (1998) Lancet , vol.352 , pp. 854-865
  • 72
    • 53949091640 scopus 로고    scopus 로고
    • The phantom of lactic acidosis due to metformin in patients with diabetes
    • Misbin R. The phantom of lactic acidosis due to metformin in patients with diabetes. Diabetes Care 2002, 25:2244-2248.
    • (2002) Diabetes Care , vol.25 , pp. 2244-2248
    • Misbin, R.1
  • 73
    • 0344420380 scopus 로고    scopus 로고
    • Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus: systematic review and meta-analysis
    • Salpeter S.R., Greyber E., Pasternak G.A., et al. Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus: systematic review and meta-analysis. Arch Intern Med 2003, 163:2594-2602.
    • (2003) Arch Intern Med , vol.163 , pp. 2594-2602
    • Salpeter, S.R.1    Greyber, E.2    Pasternak, G.A.3
  • 74
    • 0032917623 scopus 로고    scopus 로고
    • Lactic acidosis in metformin-treated patients: prognostic value of arterial lactate levels and plasma metformin concentrations
    • Lalau J., Race J. Lactic acidosis in metformin-treated patients: prognostic value of arterial lactate levels and plasma metformin concentrations. Drug Saf 1999, 20:377-384.
    • (1999) Drug Saf , vol.20 , pp. 377-384
    • Lalau, J.1    Race, J.2
  • 75
    • 1242340408 scopus 로고    scopus 로고
    • Metformin and lactic acidosis: cause or coincidence? a review of case reports
    • Stades A., Heikens J., Erkeleens D., et al. Metformin and lactic acidosis: cause or coincidence? a review of case reports. J Intern Med 2004, 255:179-187.
    • (2004) J Intern Med , vol.255 , pp. 179-187
    • Stades, A.1    Heikens, J.2    Erkeleens, D.3
  • 76
    • 0034901899 scopus 로고    scopus 로고
    • Contraindications to metformin therapy in patients with type 2 diabetes-a population-based study of adherence to prescribing guidelines
    • Emslie-Smith A.M., Boyle D.I., Evans J.M., et al. Contraindications to metformin therapy in patients with type 2 diabetes-a population-based study of adherence to prescribing guidelines. Diabet Med 2001, 18:483-488.
    • (2001) Diabet Med , vol.18 , pp. 483-488
    • Emslie-Smith, A.M.1    Boyle, D.I.2    Evans, J.M.3
  • 77
    • 13444272949 scopus 로고    scopus 로고
    • Thiazolidinediones, metformin, and outcomes in older patients with diabetes and heart failure: an observational study
    • Masoudi F.A., Inzucchi S.E., Wang Y., et al. Thiazolidinediones, metformin, and outcomes in older patients with diabetes and heart failure: an observational study. Circulation 2005, 111:583-590.
    • (2005) Circulation , vol.111 , pp. 583-590
    • Masoudi, F.A.1    Inzucchi, S.E.2    Wang, Y.3
  • 78
    • 34548603259 scopus 로고    scopus 로고
    • Benefits and harms of antidiabetic agents in patients with diabetes and heart failure: systematic review
    • Eurich D.T., McAlister F.A., Blackburn D.F., et al. Benefits and harms of antidiabetic agents in patients with diabetes and heart failure: systematic review. BMJ 2007, 335:497.
    • (2007) BMJ , vol.335 , pp. 497
    • Eurich, D.T.1    McAlister, F.A.2    Blackburn, D.F.3
  • 79
    • 25644439280 scopus 로고    scopus 로고
    • Evaluating the safety of diabetes drugs: perspective of a Food and Drug Administration insider
    • Misbin R.I. Evaluating the safety of diabetes drugs: perspective of a Food and Drug Administration insider. Diabetes Care 2005, 28:2573-2576.
    • (2005) Diabetes Care , vol.28 , pp. 2573-2576
    • Misbin, R.I.1
  • 80
    • 77549084869 scopus 로고    scopus 로고
    • Metformin therapy and outcomes in patients with advanced systolic heart failure and diabetes
    • Shah D.D., Fonarow G.C., Horwich T.B. Metformin therapy and outcomes in patients with advanced systolic heart failure and diabetes. J Card Fail 2010, 16:200-206.
    • (2010) J Card Fail , vol.16 , pp. 200-206
    • Shah, D.D.1    Fonarow, G.C.2    Horwich, T.B.3
  • 81
    • 77956074249 scopus 로고    scopus 로고
    • Treatment of type 2 diabetes and outcomes in patients with heart failure: a nested case-control study from the U.K. General Practice Research Database
    • MacDonald M.R., Eurich D.T., Majumdar S.R., et al. Treatment of type 2 diabetes and outcomes in patients with heart failure: a nested case-control study from the U.K. General Practice Research Database. Diabetes Care 2010, 33:1213-1218.
    • (2010) Diabetes Care , vol.33 , pp. 1213-1218
    • MacDonald, M.R.1    Eurich, D.T.2    Majumdar, S.R.3
  • 82
    • 78649664499 scopus 로고    scopus 로고
    • Metformin use and mortality among patients with diabetes and atherothrombosis
    • Roussel R., Travert F., Pasquet B., et al. Metformin use and mortality among patients with diabetes and atherothrombosis. Arch Intern Med 2010, 170:1892-1899.
    • (2010) Arch Intern Med , vol.170 , pp. 1892-1899
    • Roussel, R.1    Travert, F.2    Pasquet, B.3
  • 83
    • 79952260043 scopus 로고    scopus 로고
    • Metformin use and mortality in ambulatory patients with diabetes and heart failure
    • Aguilar D., Chan W., Bozkurt B., et al. Metformin use and mortality in ambulatory patients with diabetes and heart failure. Circ Heart Fail 2011, 4:53-58.
    • (2011) Circ Heart Fail , vol.4 , pp. 53-58
    • Aguilar, D.1    Chan, W.2    Bozkurt, B.3
  • 84
    • 21544465051 scopus 로고    scopus 로고
    • Insulin-sensitizing antihyperglycemic drugs and mortality after acute myocardial infarction: insights from the National Heart Care Project
    • Inzucchi S.E., Masoudi F.A., Wang Y., et al. Insulin-sensitizing antihyperglycemic drugs and mortality after acute myocardial infarction: insights from the National Heart Care Project. Diabetes Care 2005, 28:1680-1689.
    • (2005) Diabetes Care , vol.28 , pp. 1680-1689
    • Inzucchi, S.E.1    Masoudi, F.A.2    Wang, Y.3
  • 85
    • 84866625785 scopus 로고    scopus 로고
    • Metformin therapy and prognosis of patients with heart failure and new-onset diabetes mellitus. A propensity-matched study in the community
    • [Epub ahead of print]
    • Romero S.P., Andrey J.L., Garcia-Egido A., et al. Metformin therapy and prognosis of patients with heart failure and new-onset diabetes mellitus. A propensity-matched study in the community. Int J Cardiol 2011, [Epub ahead of print].
    • (2011) Int J Cardiol
    • Romero, S.P.1    Andrey, J.L.2    Garcia-Egido, A.3
  • 86
    • 34548791255 scopus 로고    scopus 로고
    • Establishing pragmatic estimated GFR thresholds to guide metformin prescribing
    • Shaw J.S., Wilmot R.L., Kilpatrick E.S. Establishing pragmatic estimated GFR thresholds to guide metformin prescribing. Diabet Med 2007, 24:1160-1163.
    • (2007) Diabet Med , vol.24 , pp. 1160-1163
    • Shaw, J.S.1    Wilmot, R.L.2    Kilpatrick, E.S.3
  • 87
    • 61349138261 scopus 로고    scopus 로고
    • Metformin treatment in diabetes and heart failure: when academic equipoise meets clinical reality
    • Eurich D.T., Tsuyuki R.T., Majumdar S.R., et al. Metformin treatment in diabetes and heart failure: when academic equipoise meets clinical reality. Trials 2009, 10:12.
    • (2009) Trials , vol.10 , pp. 12
    • Eurich, D.T.1    Tsuyuki, R.T.2    Majumdar, S.R.3
  • 88
    • 0035312620 scopus 로고    scopus 로고
    • Improved endothelial function with metformin in type 2 diabetes mellitus
    • Mather K.J., Verma S., Anderson T.J. Improved endothelial function with metformin in type 2 diabetes mellitus. J Am Coll Cardiol 2001, 37:1344-1350.
    • (2001) J Am Coll Cardiol , vol.37 , pp. 1344-1350
    • Mather, K.J.1    Verma, S.2    Anderson, T.J.3
  • 89
    • 71049169591 scopus 로고    scopus 로고
    • Metformin inhibits nuclear factor kappaB activation and decreases serum high-sensitivity C-reactive protein level in experimental atherogenesis of rabbits
    • Li S.N., Wang X., Zeng Q.T., et al. Metformin inhibits nuclear factor kappaB activation and decreases serum high-sensitivity C-reactive protein level in experimental atherogenesis of rabbits. Heart Vessels 2009, 24:446-453.
    • (2009) Heart Vessels , vol.24 , pp. 446-453
    • Li, S.N.1    Wang, X.2    Zeng, Q.T.3
  • 90
    • 77952741468 scopus 로고    scopus 로고
    • Metformin reduces intracellular reactive oxygen species levels by upregulating expression of the antioxidant thioredoxin via the AMPK-FOXO3 pathway
    • Hou X., Song J., Li X.N., et al. Metformin reduces intracellular reactive oxygen species levels by upregulating expression of the antioxidant thioredoxin via the AMPK-FOXO3 pathway. Biochem Biophys Res Commun 2010, 396:199-205.
    • (2010) Biochem Biophys Res Commun , vol.396 , pp. 199-205
    • Hou, X.1    Song, J.2    Li, X.N.3
  • 92
    • 33745684376 scopus 로고    scopus 로고
    • AMPK activation restores the stimulation of glucose uptake in an in vitro model of insulin-resistant cardiomyocytes via the activation of protein kinase B
    • Bertrand L., Ginion A., Beauloye C., et al. AMPK activation restores the stimulation of glucose uptake in an in vitro model of insulin-resistant cardiomyocytes via the activation of protein kinase B. Am J Physiol Heart Circ Physiol 2006, 291:H239-H250.
    • (2006) Am J Physiol Heart Circ Physiol , vol.291
    • Bertrand, L.1    Ginion, A.2    Beauloye, C.3
  • 93
    • 79251477152 scopus 로고    scopus 로고
    • Metformin improves cardiac function in rats via activation of AMP-activated protein kinase
    • Wang X.F., Zhang J.Y., Li L., et al. Metformin improves cardiac function in rats via activation of AMP-activated protein kinase. Clin Exp Pharmacol Physiol 2011, 38:94-101.
    • (2011) Clin Exp Pharmacol Physiol , vol.38 , pp. 94-101
    • Wang, X.F.1    Zhang, J.Y.2    Li, L.3
  • 94
    • 66349105917 scopus 로고    scopus 로고
    • Metformin prevents progression of heart failure in dogs: role of AMP-activated protein kinase
    • Sasaki H., Asanuma H., Fujita M., et al. Metformin prevents progression of heart failure in dogs: role of AMP-activated protein kinase. Circulation 2009, 119:2568-2577.
    • (2009) Circulation , vol.119 , pp. 2568-2577
    • Sasaki, H.1    Asanuma, H.2    Fujita, M.3
  • 95
    • 61949300140 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure
    • Gundewar S., Calvert J.W., Jha S., et al. Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure. Circ Res 2009, 104:403-411.
    • (2009) Circ Res , vol.104 , pp. 403-411
    • Gundewar, S.1    Calvert, J.W.2    Jha, S.3
  • 96
    • 33644747421 scopus 로고    scopus 로고
    • Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase
    • Davis B.J., Xie Z., Viollet B., et al. Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase. Diabetes 2006, 55:496-505.
    • (2006) Diabetes , vol.55 , pp. 496-505
    • Davis, B.J.1    Xie, Z.2    Viollet, B.3
  • 97
    • 34248589911 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) regulatory cascade in cardiac physiology and disease
    • Finck B.N., Kelly D.P. Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) regulatory cascade in cardiac physiology and disease. Circulation 2007, 115:2540-2548.
    • (2007) Circulation , vol.115 , pp. 2540-2548
    • Finck, B.N.1    Kelly, D.P.2
  • 98
    • 10244225267 scopus 로고    scopus 로고
    • Enhancement of insulin-stimulated myocardial glucose uptake in patients with type 2 diabetes treated with rosiglitazone
    • Hallsten K., Virtanen K.A., Lonnqvist F., et al. Enhancement of insulin-stimulated myocardial glucose uptake in patients with type 2 diabetes treated with rosiglitazone. Diabet Med 2004, 21:1280-1287.
    • (2004) Diabet Med , vol.21 , pp. 1280-1287
    • Hallsten, K.1    Virtanen, K.A.2    Lonnqvist, F.3


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