Insulin Resistance Is Highly Prevalent and Is Associated With Reduced Exercise Tolerance in Nondiabetic Patients With Heart Failure

Journal of the American College of Cardiology

Volumn 53, Issue 9, 2009, Pages 747-753

  ALZadjali, Matlooba A ^a   Godfrey, Valerie ^a   Khan, Faisel ^a   Choy, AnnaMaria ^a   Doney, Alexander S ^a   Wong, Aaron K ^a   Petrie, John R ^a   Struthers, Allan D ^a   Lang, Chim C ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

endothelial dysfunction; exercise capacity; heart failure; insulin resistance

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LEPTIN; TRIACYLGLYCEROL;

ADULT; AGED; ARTICLE; BODY MASS; CARDIOPULMONARY EXERCISE TEST; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; EXERCISE TOLERANCE; FEMALE; HEART FAILURE; HUMAN; HYPEREMIA; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; OXYGEN CONSUMPTION; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE;

CHOLESTEROL, HDL; COHORT STUDIES; ENDOTHELIUM, VASCULAR; EXERCISE TOLERANCE; FEMALE; HEART FAILURE; HUMANS; INSULIN RESISTANCE; LEPTIN; LOGISTIC MODELS; MALE; OXYGEN CONSUMPTION; PREVALENCE; TRIGLYCERIDES; UNITED STATES;

EID: 60449096969     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2008.08.081     Document Type: Article

References (27)

1. Coats A.J.S., and Anker S. Insulin resistance in chronic heart failure. J Cardiovasc Pharmacol 35 (2000) S9-S14
2. Paolisso G., De Riu S., Marrazzo G., Verza M., Varricchio M., and D'Onofrio F. Insulin resistance and hyperinsulinemia in patients with chronic congestive heart failure. Metabolism 40 (1991) 972-977
3. Paolisso G., Taglimonte M.R., Rizzo M.R., et al. Prognostic importance of insulin-mediated glucose uptake in aged patients with congestive heart failure secondary to mitral and/or aortic valve disease. Am J Cardiol 83 (1999) 1338-1344
4. Swan J.W., Anker S.D., Walton C., et al. Insulin resistance in chronic heart failure relation to severity and etiology of heart failure. J Am Coll Cardiol 30 (1997) 527-532
5. Nikolaidis L.A., Sturzu A., Stolarski C., Elahi D., Shen Y.T., and Shannon R.P. The development of myocardial insulin resistance in conscious dogs with advanced dilated cardiomyopathy. Cardiovasc Res 61 (2004) 297-306
6. Tenenbaum A., and Fisman E.Z. Impaired glucose metabolism in patients with heart failure: pathophysiology and possible treatment strategies. Am J Cardiovasc Drugs 4 (2004) 269-280
7. Kostis J.B., and Sanders M. The association of heart failure with insulin resistance and development of type 2 diabetes. Am J Hypertens 18 (2005) 731-737
8. Duncan M.H., Singh B.M., Wise P.H., Carter G., and Alaqhband-Zadeh J. A simple measure of insulin resistance. Lancet 346 (1995) 120-121
9. Remme W.J., and Swedberg K. Guidelines for the diagnosis and treatment of chronic heart failure. Eur Heart J 22 (2001) 1527-1560
10. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 27 Suppl 1 (2004) S5-S10
11. Sloan A.W. Estimation of body fat in young men. J Appl Physiol 23 (1967) 311-315
12. Durnin J.V.G.A., and Womersley L. Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. Br J Nutr 32 (1974) 77-97
13. Suskin N., McKelvie R.S., Burns R.J., et al. Glucose and insulin abnormalities relate to functional capacity in patients with congestive heart failure. Eur Heart J 21 (2000) 1368-1375
14. Lang C.C., Karlin P., Haythe J., Tsao L., and Mancini D.M. Ease of noninvasive measurement of cardiac output coupled with peak VO2 determination at rest and during exercise in patients with heart failure. Am J Cardiol 99 (2007) 404-405
15. Bonetti P.O., Pumper G.M., Higano S.T., Holmes Jr. D.R., Kuvin J.T., and Lerman A. Noninvasive identification of patients with early coronary atherosclerosis by assessment of digital reactive hyperemia. J Am Coll Cardiol 44 (2004) 2137-2141
16. Bonetti P.O., Barsness G.W., Keelan P.C., et al. Enhanced external counterpulsation improves endothelial function in patients with symptomatic coronary artery disease. J Am Coll Cardiol 41 (2003) 1761-1768
17. Hamburg N.M., Keyes M.J., Larson M.G., et al. Cross-sectional relations of digital vascular function to cardiovascular risk factors in the Framingham Heart Study. Circulation 19 (2008) 2467-2474
18. Taniguchi A., Fukushima M., Ohya M., et al. Interleukin 6, adiponectin, leptin, and insulin resistance in nonobese Japanese type2 diabetic patients. Metabolism 55 (2006) 258-262
19. Rask-Madsen C., Dominguez N., Ihlemann N., et al. Tumor necrosis factor-a inhibits insulin's stimulating effect on glucose uptake and endothelium-dependent vasodilation in humans. Circulation 108 (2003) 1815-1821
20. Hsueh W.A., and Quinones M.J. Role of endothelial dysfunction in insulin resistance. Am J Cardiol 92 (2003) 10J-17J
21. Salmenniemi U., Ruotsalainen E., Pihlajamaki J., et al. Multiple abnormalities in glucose and energy metabolism and coordinated changes in levels of adiponectin, cytokines, and adhesion molecules in subjects with metabolic syndrome. Circulation 110 (2004) 3842-3848
22. Cohen B., Novick D., and Rubinstein M. Modulation of insulin activities by leptin. Science 274 (1996) 1185-1188
23. Doehner W., Rauchhaus M., Godsland I.F., et al. Insulin resistance in moderate chronic heart failure is related to hyperleptinaemia, but not to norepinephrine or TNF-alpha. Int J Cardiol 83 (2002) 73-81
24. Wilson J.R., and Mancini D.M. Factors contributing to the exercise limitation of heart failure. J Am Coll Cardiol 22 Suppl A (1993) 93A-98A
25. Banerjee S., and Peterson L.R. Myocardial metabolism and cardiac performance in obesity and insulin resistance. Curr Cardiol Rep 9 (2007) 143-149
26. Hambrecht R., Fiehn E., Weigl C., et al. Regular physical exercise corrects endothelial dysfunction and improves exercise capacity in patients with chronic heart failure. Circulation 98 (1998) 2709-2715
27. Maiorana A., O'Driscoll G., Cheetham C., et al. The effect of combined aerobic and resistance exercise training on vascular function in type 2 diabetes. J Am Coll Cardiol 38 (2001) 860-866