Age-related changes in natural killer cell receptors from childhood through old age

Human Immunology

Volumn 72, Issue 4, 2011, Pages 319-329

  Almeida Oliveira, Aline ^a,b   Smith Carvalho, Monique ^a   Porto, Luis Cristovão ^c   Cardoso Oliveira, Juliana ^c   Ribeiro, Aline dos Santos ^a   Falcão, Rosângela Rosa ^d   Abdelhay, Eliana ^a   Bouzas, Luis Fernando ^a   Thuler, Luiz Claudio Santos ^a   Ornellas, Maria Helena ^c   Diamond, Hilda Rachel ^a  

^a INSTITUTO NACIONAL DE CÂNCER   (Brazil)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

^c STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^d National Institute of Traumatology and Orthopedics (INTO)   (Brazil)

Author keywords

Aging; KIR; Natural killer cells; NCR; NKG2D

Indexed keywords

CD56 ANTIGEN; NATURAL KILLER CELL RECEPTOR;

ADOLESCENCE; ADOLESCENT; ADULT; ADULTHOOD; AGED; AGING; ANTIGEN EXPRESSION; ARTICLE; CHILD; CHILDHOOD; FEMALE; GENOTYPE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; NATURAL KILLER CELL; NATURAL KILLER T CELL; NORMAL HUMAN; PRIORITY JOURNAL; SENESCENCE; T LYMPHOCYTE;

ADOLESCENT; ADULT; AGE FACTORS; AGED; AGING; ANTIGENS, CD56; CHILD; CHILD, PRESCHOOL; FEMALE; GENOTYPE; HLA ANTIGENS; HUMANS; KILLER CELLS, NATURAL; LECTINS, C-TYPE; MALE; MIDDLE AGED; RECEPTORS, NATURAL KILLER CELL; T-LYMPHOCYTES; YOUNG ADULT;

EID: 79952622429     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humimm.2011.01.009     Document Type: Article

References (56)

1. Pawelec G., Solana R. Immunosenescence. Immunol Today 1997, 18:514-516.
2. Mocchegiani E., Malavolta M. NK and NKT cell functions in immunosenescence. Aging Cell 2004, 3:177-184.
3. Robertson M.J., Ritz J. Biology and clinical relevance of human natural killer cells. Blood 1990, 76:2421-2438.
4. Almeida-Oliveira A., Diamond H.R. Antileukemic activity of natural killer cells. Rev Bras Cancerol 2008, 54:297-305.
5. Cooper M.A., Fehniger T.A., Caligiuri M.A. The biology of human natural killer-cell subsets. Trends Immunol 2001, 22:633-640.
6. Cooper M.A., Fehniger T.A., Turner S.C., Chen K.S., Ghaheri B.A., Ghayur T., et al. Human natural killer cells: a unique innate immunoregulatory role for the CD56(bright) subset. Blood 2001, 97:3146-3151.
7. Farag S.S., Fehniger T.A., Ruggeri L., Velardi A., Caligiuri M.A. Natural killer cell receptors: new biology and insights into the graft-versus-leukemia effect. Blood 2002, 100:1935-1947.
8. Almeida-Oliveira A., Diamond H.R. The relevance of natural killer (NK) cells and killer immunoglobulin-like receptors (KIR) in hematopoietic stem cell transplantation (HSCT). Rev Bras Hematologia Hemoterapia 2008, 30:320-329.
9. Huenecke S., Behl M., Fadler C., Zimmermann S.Y., Bochennek K., Tramsen L., et al. Age-matched lymphocyte subpopulation reference values in childhood and adolescence: application of exponential regression analysis. Eur J Haematol 2008, 80:532-539.
10. Sundstrom Y., Nilsson C., Lilja G., Karre K., Troye-Blomberg M., Berg L. The expression of human natural killer cell receptors in early life. Scand J Immunol 2007, 66:335-344.
11. Mavilio D., Benjamin J., Daucher M., Lombardo G., Kottilil S., Planta M.A., et al. Natural killer cells in HIV-1 infection: dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates. Proc Natl Acad Sci U S A 2003, 100:15011-15016.
12. Guma M., Angulo A., Vilches C., Gomez-Lozano N., Malats N., Lopez-Botet M. Imprint of human cytomegalovirus infection on the NK cell receptor repertoire. Blood 2004, 104:3664-3671.
13. Ballan W.M., Vu B.A., Long B.R., Loo C.P., Michaelsson J., Barbour J.D., et al. Natural killer cells in perinatally HIV-1-infected children exhibit less degranulation compared to HIV-1-exposed uninfected children and their expression of KIR2DL3, NKG2C, and NKp46 correlates with disease severity. J Immunol 2007, 179:3362-3370.
14. Verheyden S., Bernier M., Demanet C. Identification of natural killer cell receptor phenotypes associated with leukemia. Leukemia 2004, 18:2002-2007.
15. Kiladjian J.J., Bourgeois E., Lobe I., Braun T., Visentin G., Bourhis J.H., et al. Cytolytic function and survival of natural killer cells are severely altered in myelodysplastic syndromes. Leukemia 2006, 20:463-470.
16. Epling-Burnette P.K., Bai F., Painter J.S., Rollison D.E., Salih H.R., Krusch M., et al. Reduced natural killer (NK) function associated with high-risk myelodysplastic syndrome (MDS) and reduced expression of activating NK receptors. Blood 2007, 109:4816-4824.
17. Garcia-Iglesias T., Toro-Arreola A., Albarran-Somoza B., Toro-Arreola S., Sanchez-Hernandez P.E., Ramirez-Dueñas M.G., Balderas-Pena L.M., Bravo-Cuellar A., Ortiz-Lazareno P.C., Daneri-Navarro A. Low NKp30, NKp46 and NKG2D expression and reduced cytotoxic activity on NK cells in cervical cancer and precursor lesions. BMC Cancer 2009, 9:186.
18. Bruunsgaard H., Pedersen A.N., Schroll M., Skinhoj P., Pedersen B.K. Decreased natural killer cell activity is associated with atherosclerosis in elderly humans. Exp Gerontol 2001, 37:127-136.
19. Lutz C.T., Moore M.B., Bradley S., Shelton B.J., Lutgendorf S.K. Reciprocal age related change in natural killer cell receptors for MHC class I. Mech Ageing Dev 2005, 126:722-731.
20. Garff-Tavernier M., Beziat V., Decocq J., Siguret V., Gandjbakhch F., Pautas E., et al. Cells display major phenotypic and functional changes over the life span. Aging Cell 2010, 9:527-535.
21. Ligthart G.J., Corberand J.X., Fournier C., Galanaud P., Hijmans W., Kennes B., et al. Admission criteria for immunogerontological studies in man: the SENIEUR protocol. Mech Ageing Dev 1984, 28:47-55.
22. Hayhoe R.P., Henson S.M., Akbar A.N., Palmer D.B. Variation of human natural killer cell phenotypes with age: identification of a unique KLRG1-negative subset. Hum Immunol 2010, 71:676-681.
23. Cholujova D., Jakubikova J., Kubes M., Arendacka B., Sapak M., Ihnatko R., Sedlak J. Comparative study of four fluorescent probes for evaluation of natural killer cell cytotoxicity assays. Immunobiology 2008, 213:629-640.
24. Becker S., Tonn T., Fussel T., Uhrberg M., Bogdanow M., Seifried E., Seidl C. Assessment of killer cell immunoglobulinlike receptor expression and corresponding HLA class I phenotypes demonstrates heterogenous KIR expression independent of anticipated HLA class I ligands. Hum Immunol 2003, 64:183-193.
25. Tarazona R., DelaRosa O., Alonso C., Ostos B., Espejo J., Pena J., Solana R. Increased expression of NK cell markers on T lymphocytes in aging and chronic activation of the immune system reflects the accumulation of effector/senescent T cells. Mech Ageing Dev 2000, 121:77-88.
26. Maxwell L.D., Ross O.A., Curran M.D., Rea I.M., Middleton D. Investigation of KIR diversity in immunosenescence and longevity within the Irish population. Exp Gerontol 2004, 39:1223-1232.
27. Borrego F., Alonso M.C., Galiani M.D., Carracedo J., Ramirez R., Ostos B., et al. NK phenotypic markers and IL2 response in NK cells from elderly people. Exp Gerontol 1999, 34:253-265.
28. Lemster B.H., Michel J.J., Montag D.T., Paat J.J., Studenski S.A., Newman A.B., Vallejo A.N. Induction of CD56 and TCR-independent activation of T cells with aging. J Immunol 2008, 180:1979-1990.
29. Abedin S., Michel J.J., Lemster B., Vallejo A.N. Diversity of NKR expression in aging T cells and in T cells of the aged: the new frontier into the exploration of protective immunity in the elderly. Exp Gerontol 2005, 40:537-548.
30. Groh V., Rhinehart R., Randolph-Habecker J., Topp M.S., Riddell S.R., Spies T. Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells. Nat Immunol 2001, 2:255-260.
31. Kronenberg M., Gapin L. The unconventional lifestyle of NKT cells. Nat Rev Immunol 2002, 2:557-568.
32. Kronenberg M. Toward an understanding of NKT cell biology: progress and paradoxes. Annu Rev Immunol 2005, 23:877-900.
33. Norris S., Doherty D.G., Collins C., McEntee G., Traynor O., Hegarty J.E., O'Farrelly C. Natural T cells in the human liver: cytotoxic lymphocytes with dual T cell and natural killer cell phenotype and function are phenotypically heterogenous and include Valpha24-JalphaQ and gammadelta T cell receptor bearing cells. Hum Immunol 1999, 60:20-31.
34. Emoto M., Kaufmann S.H., Liver N.K.T. Cells: an account of heterogeneity. Trends Immunol 2003, 24:364-369.
35. Kenna T., Golden-Mason L., Porcelli S.A., Koezuka Y., Hegarty J.E., O'Farrelly C., Doherty D.G. NKT cells from normal and tumor-bearing human livers are phenotypically and functionally distinct from murine NKT cells. J Immunol 2003, 171:1775-1779.
36. van der Vliet H.J., von Blomberg B.M., Nishi N., Reijm M., Voskuyl A.E., van Bodegraven A.A., et al. (alpha24+) Vbeta11+ NKT cell numbers are decreased in a wide variety of diseases that are characterized by autoreactive tissue damage. Clin Immunol 2001, 100:144-148.
37. Zeng W., Maciejewski J.P., Chen G., Risitano A.M., Kirby M., Kajigaya S., Young N.S. Selective reduction of natural killer T cells in the bone marrow of aplastic anaemia. Br J Haematol 2002, 119:803-809.
38. Facchini A., Mariani E., Mariani A.R., Papa S., Vitale M., Manzoli F.A. Increased number of circulating Leu 11+ (CD 16) large granular lymphocytes and decreased NK activity during human ageing. Clin Exp Immunol 1987, 68:340-347.
39. Vitale M., Zamai L., Neri L.M., Galanzi A., Facchini A., Rana R., et al. The impairment of natural killer function in the healthy aged is due to a postbinding deficient mechanism. Cell Immunol 1992, 145:1-10.
40. Krishnaraj R. Senescence and cytokines modulate the NK cell expression. Mech Ageing Dev 1997, 96:89-101.
41. Chidrawar S.M., Khan N., Chan Y.L., Nayak L., Moss P.A. Ageing is associated with a decline in peripheral blood CD56bright NK cells. Immun Ageing 2006, 3:10.
42. Rink L., Cakman I., Kirchner H. Altered cytokine production in the elderly. Mech Ageing Dev 1998, 102:199-209.
43. Krishnaraj R., Bhooma T. Cytokine sensitivity of human NK cells during immunosenescence. 2. IL2-induced interferon gamma secretion. Immunol Lett 1996, 50:59-63.
44. Loza M.J., Perussia B. The IL-12 signature: NK cell terminal CD56+high stage and effector functions. J Immunol 2004, 172:88-96.
45. +CCR7+ NK helper cells. J Exp Med 2005, 202:941-953.
46. Chan A., Hong D.L., Atzberger A., Kollnberger S., Filer A.D., Buckley C.D., et al. CD56bright human NK cells differentiate into CD56dim cells: role of contact with peripheral fibroblasts. J Immunol 2007, 179:89-94.
47. - Killer Ig-like Receptor NK Cells Display longer Telomeres and Acquire Features of CD56dim NK Cells upon activation. J Immunol 2007, 178:4947-4955.
48. Gardiner C.M. Killer cell immunoglobulin-like receptors on NK cells: the how, where and why. Int J Immunogenet 2008, 35:1-8.
49. Kimoto Y., Horiuchi T., Tsukamoto H., Kiyohara C., Mitoma H., Uchino A., et al. Association of killer cell immunoglobulin-like receptor 2DL5 with systemic lupus erythematosus and accompanying infections. Rheumatol Oxf 2010, 49:1346-1353.
50. Parham P., Abi-Rached L., Matevosyan L., Moesta A.K., Norman P.J., Older Aguilar A.M., Guethlein L.A. Primate-specific regulation of natural killer cells. J Med Primatol 2010, 39:194-212.
51. Moretta A., Bottino C., Vitale M., Pende D., Cantoni C., Mingari M.C., et al. Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu Rev Immunol 2001, 19:197-223.
52. Walzer T., Dalod M., Robbins S.H., Zitvogel L., Vivier E. Natural-killer cells and dendritic cells: "L'Union fait la force.". Blood 2005, 106:2252-2258.
53. O'Connor G.M., Hart O.M., Gardiner C.M. Putting the natural killer cell in its place. Immunology 2006, 117:1-10.
54. Moretta L., Ferlazzo G., Bottino C., Vitale M., Pende D., Mingari M.C., Moretta A. Effector and regulatory events during natural killer-dendritic cell interactions. Immunol Rev 2006, 214:219-228.
55. Dorshkind K., Montecino-Rodriguez E., Signer R.A. The ageing immune system: is it ever too old to become young again?. Nat Rev Immunol 2009, 9:57-62.
56. Agrawal A., Agrawal S., Tay J., Gupta S. Biology of dendritic cells in aging. J Clin Immunol 2008, 28:14-20.