Marine algal toxin azaspiracid is an open-state blocker of hERG potassium channels

Chemical Research in Toxicology

Volumn 25, Issue 9, 2012, Pages 1975-1984

  Twiner, Michael J ^a   Doucette, Gregory J ^b   Rasky, Andrew ^a   Huang, Xi Ping ^c   Roth, Bryan L ^c   Sanguinetti, Michael C ^d  

^a UNIVERSITY OF MICHIGAN DEARBORN   (United States)

^b CENTER FOR COASTAL ENVIRONMENTAL HEALTH AND BIOMOLECULAR RESEARCH   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZASPIRACID; AZASPIRACID 1; AZASPIRACID 2; AZASPIRACID 3; DOFETILIDE; POTASSIUM CHANNEL HERG; THALLIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; CYTOPLASM; HUMAN; HUMAN CELL; IC 50; ION CURRENT; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; POTASSIUM CURRENT; VOLTAGE CLAMP; XENOPUS;

ANIMALS; ETHER-A-GO-GO POTASSIUM CHANNELS; HEK293 CELLS; HUMANS; IONS; MARINE TOXINS; MUTATION; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN BINDING; RECOMBINANT PROTEINS; SPIRO COMPOUNDS; THALLIUM; TRANSFECTION; XENOPUS LAEVIS;

ALGAE; DINOPHYCEAE; MAMMALIA; MUS;

EID: 84866402236     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx300283t     Document Type: Article

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