Genomic structure, transcriptional control, and tissue distribution of HERG1 and KCNQ1 genes

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 294, Issue 3, 2008, Pages

  Luo, Xiaobin ^a,b,d   Xiao, Jiening ^a,b,d   Lin, Huixian ^a,b,d   Lu, Yanjie ^c,d   Yang, Baofeng ^c,d   Wang, Zhiguo ^a,d  

^a MONTREAL HEART INSTITUTE   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c State Province Key Laboratory of China   (China)

^d HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

human ether a go gorelated gene; Potassium channels; Promoter; Stimulating protein 1; Transcription; Voltage gated potassium channel, KQT like subfamily, member 1

Indexed keywords

ISOPROTEIN; MESSENGER RNA; POTASSIUM CHANNEL HERG; POTASSIUM CHANNEL KCNQ1; TRANSCRIPTION FACTOR SP1; VOLTAGE GATED POTASSIUM CHANNEL;

ARTICLE; CONTROLLED STUDY; CPG ISLAND; GENE CONTROL; GENE EXPRESSION PROFILING; GENE STRUCTURE; GENETIC TRANSCRIPTION; GENOMICS; HEART REPOLARIZATION; HUMAN; HUMAN TISSUE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; TISSUE DISTRIBUTION; TRANSACTIVATION; TRANSCRIPTION INITIATION SITE;

5' FLANKING REGION; BASE SEQUENCE; CELLS, CULTURED; CPG ISLANDS; DNA, COMPLEMENTARY; ETHER-A-GO-GO POTASSIUM CHANNELS; GENE EXPRESSION REGULATION; HUMANS; KCNQ1 POTASSIUM CHANNEL; LUCIFERASES; MOLECULAR SEQUENCE DATA; MYOCARDIUM; NUCLEASE PROTECTION ASSAYS; PLASMIDS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TISSUE DISTRIBUTION; TRANSFECTION;

EID: 41549148623     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01026.2007     Document Type: Article

References (38)

1. Arcangeli A. Expression and role of hERG channels in cancer cells. Novartis Found Symp 266: 225-232, 2005.
2. Arcangeli A, Rosati B, Cherubini A, Crociani O, Fontana L, Ziller C, Wanke E, Olivotto M. HERG- and IRK-like inward rectifier currents are sequentially expressed during neuronal development of neural crest cells and their derivatives. Eur J Neurosci 9: 2596-2604, 1997.
3. Bevilacqua A, Fiorenza MT, Mangia F. A developmentally regulated GAGA box-binding factor and Sp1 are required for transcription of the hsp70.1 gene at the onset of mouse zygotic genome activation. Development 127: 1541-1551, 2000.
4. + current highly conserved in tumors of different histogenesis: a selective advantage for cancer cells? Cancer Res 58: 815-822, 1998.
5. Black AR, Black JD, Azizkhan-Clifford J. Sp1 and kruppel-like factor family of transcription factors in cell growth regulation and cancer. J Cell Physiol 188: 143-160, 2001.
6. Claycomb WC, Lanson NA Jr, Stallworth BS, Egeland DB, Delcarpio JB, Bahinski A, Izzo NJ Jr. HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte. Proc Natl Acad Sci USA 95: 2979-2984, 1998.
7. + channels for cancer therapy. J Exp Ther Oncol 4: 161-166, 2004.
8. Crociani O, Guasti L, Balzi M, Becchetti A, Wanke E, Olivotto M, Wymore RS, Arcangeli A. Cell cycle-dependent expression of HERG1 and HERG1B isoforms in tumor cells. J Biol Chem 278: 2947-2955, 2003.
9. Demolombe S, Baro I, Pereon Y, Bliek J, Mohammad-Panah R, Pollard H, Morid S, Mannens M, Wilde A, Barhanin J, Charpentier F, Escande D. A dominant negative isoform of the long QT syndrome 1 gene product. J Biol Chem 273: 6837-6843, 1998.
10. Demolombe S, Lande G, Charpentier F, van Roon MA, van den Hoff MJ, Toumaniantz G, Baro I, Guihard G, Le Berre N, Corbier A, de Bakker J, Opthof T, Wilde A, Moorman AF, Escande D. Transgenic mice overexpressing human KvLQT1 dominant-negative isoform. Part I: phenotypic characterization. Cardiovasc Res 50: 314-27, 2001.
11. Jones EM, Roti Roti EC, Wang J, Delfosse SA, Robertson GA. Cardiac IKr channels minimally comprise hERG 1a and 1b subunits. J Biol Chem 279: 44690-44694, 2004.
12. Jump DB, Badin MV, Thelen A. The CCAAT box binding factor, NF-Y, is required for thyroid hormone regulation of rat liver S14 gene transcription. J Biol Chem 272: 27778-27786, 1997.
13. Kadonaga JT, Courey AJ, Ladika J, Tjian R. Distinct regions of Sp1 modulate DNA binding and transcriptional activation. Science 242: 1566-1570, 1988.
14. + channel in mouse and human hearts. Circ Res 81: 719-726, 1997.
15. + channel gene mediates cell-growth signals on activation of oncoproteins Sp1 and NF-κB and inactivation of tumor suppressor Nkx3.1. J Cell Physiol 212: 137-147, 2007.
16. + current. Circ Res 81: 870-878, 1997.
17. Lundquist AL, Turner CL, Ballester LY, George AL Jr. Expression and transcriptional control of human KCNE genes. Genomics 87: 119-128, 2006.
18. Ks-encoding genes and potential implications in regional heterogeneity of their expressions. J Cell Physiol 212: 358-367, 2007.
19. Morgan WD, Williams GT, Morimoto RI, Greene J, Kingston RE, Tjian R. Two transcriptional activators, CCAAT-box-binding transcription factor and heat shock transcription factor, interact with a human hsp70 gene promoter. Mol Cell Biol 7: 1129-1138, 1987.
20. Pereon Y, Demolombe S, Baro I, Drouin E, Charpentier F, Escande D. Differential expression of KvLQT1 isoforms across the human ventricular wall. Am J Physiol Heart Circ Physiol 278: H1908-H1915, 2000.
21. Pugh BF, Tjian R. Mechanism of transcriptional activation by Sp1: evidence for coactivators. Cell 61: 1187-1197, 1990.
22. Ks in canine hypertrophied hearts. Cardiovasc Res 57: 486-496, 2003.
23. Kr in the heart. Novartis Found Symp 266: 4-15, 2005.
24. Samson SL, Wong NC. Role of Sp1 in insulin regulation of gene expression. J Mol Endocrinol 29: 265-279, 2002.
25. VLQT1 and minK (IsK) proteins to form cardiac IKs potassium channel. Nature 384: 80-83, 1996.
26. Kr potassium channel. Cell 81: 299-307, 1995.
27. Takai D, Jones PA. Comprehensive analysis of CpG islands in human chromosomes 21 and 22. Proc Natl Acad Sci USA 99: 3740-3745, 2002.
28. Teodoridis JM, Strathdee G, Brown R. Epigenetic silencing mediated by CpG island methylation: potential as a therapeutic target and as a biomarker. Drug Resistance Updates 7: 267-278, 2004.
29. Ks are larger in right than left canine ventricular midmyocardium. Circulation 99: 206-210, 1999.
30. + channel: a regulator of tumor cell apoptosis and proliferation. Cancer Res 62: 4843-4848, 2002.
31. + currents in fetal mouse ventricular myocytes. Am J Physiol Heart Circ Physiol 270: H2088-H2093, 1996.
32. + channels in mouse heart. Circ Res 79: 79-85, 1996.
33. + channels in regulating tumor cell proliferation and apoptosis. Pflügers Arch 448: 274-286, 2004.
34. Wyse BD, Linas SL, Thekkumkara TJ. Functional role of a novel cis-acting element (GAGA box) in human type-1 angiotensin II receptor gene transcription. J Mol Endocrinol 25: 97-108, 2000.
35. Yagi H, Kato T, Nagata T, Habu T, Nozaki M, Matsushiro A, Nishimune Y, Morita T. Regulation of the mouse histone H2A.X gene promoter by the transcription factor E2F and CCAAT binding protein. J Biol Chem 270: 18759-18765, 1995.
36. Yamashitaa R, Suzukic Y, Suganoc S, Nakai K. Genome-wide analysis reveals strong correlation between CpG islands with nearby transcription start sites of genes and their tissue specificity. Gene 350: 129-136, 2005.
37. + current in cardiac cells. Circ Res 80: 782-789, 1997.
38. Yue L, Wang Z, Rindt H, Nattel S. Molecular evidence for a role of Shaw (Kv3) potassium channel subunits in potassium currents of dog atrium. J Physiol 527: 467-478, 2000.