Chronic effects in mice caused by oral administration of sublethal doses of azaspiracid, a new marine toxin isolated from mussels

Toxicon

Volumn 40, Issue 2, 2002, Pages 193-203

  Ito, Emiko ^a   Satake, Masayuki ^b   Ofuji, Katsuya ^b   Higashi, Morihiro ^c   Harigaya, Kenichi ^c   McMahon, Terry ^d   Yasumoto, Takeshi ^e  

^a CHIBA UNIVERSITY   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

^c CHIBA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d MARINE INSTITUTE   (Ireland)

^e JAPAN FOOD RESEARCH LABORATORIES   (Japan)

Author keywords

Azaspiracid; Chronic poisoning

Indexed keywords

AZASPIRACID; MARINE TOXIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL INFILTRATION; CHRONIC TOXICITY; CONTROLLED STUDY; CONVALESCENCE; DISEASE SEVERITY; DOSE RESPONSE; EDEMA; EROSION; GASTROINTESTINAL HEMORRHAGE; INTERSTITIAL PNEUMONIA; INTESTINE INJURY; INTESTINE VILLUS; LIVER HYPERPLASIA; LUNG ALVEOLUS WALL; LUNG TUMOR; LYMPHOCYTE; MALE; MOUSE; MUSSEL; NONHUMAN; PRIORITY JOURNAL; SMALL INTESTINE; SPLEEN; STOMACH; THYMUS;

ADMINISTRATION, ORAL; ANIMALS; BIVALVIA; DIGESTIVE SYSTEM; IMMUNOHISTOCHEMISTRY; LIVER; LUNG; MALE; MARINE TOXINS; MICE; MICE, INBRED ICR; NEOPLASMS; ORGAN SIZE; SPIRO COMPOUNDS; SPLEEN; THYMUS GLAND;

EID: 0036027438     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(01)00226-4     Document Type: Article

References (10)

1. Multiple organ damage caused by a new toxin azaspiracid, isolated from mussels produced in Ireland
2. A new shellfish toxic syndrome in Europe
3. Winter toxicity of unknown aetiology in mussels
4. Re-occurrence of winter toxicity
5. A soluble protein characteristic of the nervous system
6. Two analogs of azaspiracid isolated from mussels, Mytilus edulis, involved in human intoxication in Ireland
7. Structures of azaspiracid analogs, azaspiracid-4 and azaspiracid-5, causative toxins of azaspiracid poisoning in Europe
8. New toxic event caused by Irish mussels
9. Azaspiracid, a new marine toxin having unique spiro ring assemblies, isolated from Irish mussels, Mytilus edulis
10. Okadaic acid: An additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter