Mechanisms of β-adrenergic modulation of IKs in the guinea-pig ventricle: Insights from experimental and model-based analysis

Biophysical Journal

Volumn 96, Issue 9, 2009, Pages 3862-3872

  Severi, Stefano ^a   Corsi, Cristiana ^a   Rocchetti, Marcella ^b   Zaza, Antonio ^b  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR; INTERMEDIATE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; ISOPRENALINE; MONOMER; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; DELAYED RECTIFIER POTASSIUM CHANNEL; POTASSIUM;

ANIMAL CELL; ARTICLE; CONDUCTANCE; CONTROLLED STUDY; DENSITY; ELECTRIC POTENTIAL; EXPERIMENTAL MODEL; GUINEA PIG; HEART MUSCLE CELL; HEART VENTRICLE; HODGKIN HUXLEY EQUATION; KINETICS; MODULATION; NONHUMAN; PROBABILITY; REPOLARIZATION; STEADY STATE; TEMPERATURE; TIME; ACTION POTENTIAL; ANALYSIS OF VARIANCE; ANIMAL; BIOLOGICAL MODEL; CHANNEL GATING; COMPUTER SIMULATION; DRUG EFFECT; ELECTRIC CONDUCTIVITY; HEART VENTRICLE FUNCTION; METABOLISM; PATCH CLAMP; PHYSIOLOGY;

CAVIA;

ACTION POTENTIALS; ADRENERGIC BETA-AGONISTS; ANALYSIS OF VARIANCE; ANIMALS; COMPUTER SIMULATION; DELAYED RECTIFIER POTASSIUM CHANNELS; ELECTRIC CONDUCTIVITY; GUINEA PIGS; ION CHANNEL GATING; ISOPROTERENOL; KINETICS; MARKOV CHAINS; MODELS, BIOLOGICAL; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; POTASSIUM; RECEPTORS, ADRENERGIC, BETA; VENTRICULAR FUNCTION;

EID: 67650348213     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2009.02.017     Document Type: Article

References (29)

1. Sanguinetti, M. C., N. K. Jurkiewicz, A. Scott, and P. K. Siegl. 1991. Isoproterenol antagonizes prolongation of refractory period by the class III antiarrhythmic agent E-4031 in guinea pig myocytes. Mechanism of action. Circ. Res. 68:77-84.
2. Marx, S. O., J. Kurokawa, S. Reiken, H. Motoike, J. D'Armiento, et al. 2002. Requirement of a macromolecular signaling complex for β adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel. Science. 295:496-499.
3. Ks to canine ventricular repolarization: key role for β-adrenergic receptor stimulation. Circulation. 107:2753-2760.
4. Ks pore demonstrates two MinK subunits in each channel complex. Neuron. 40:15-23.
5. + channel complexes. Proc. Natl. Acad. Sci. USA. 105:1478-1482.
6. Wang, Q., M. E. Curran, I. Splawski, T. C. Burn, J. M. Millholland, et al. 1996. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nat. Genet. 12:17-23.
7. Schwartz, P. J., S. G. Priori, C. Spazzolini, A. J. Moss, G. M. Vincent, et al. 2001. Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias. Circulation. 103:89-95.
8. Rocchetti, M., V. Freli, V. Perego, C. Altomare, G. Mostacciuolo, et al. 2006. Rate dependency of β-adrenergic modulation of repolarizing currents in the guinea-pig ventricle. J. Physiol. 574:183-193.
9. Rocchetti, M., A. Besana, G. B. Gurrola, L. D. Possani, and A. Zaza. 2001. Rate dependency of delayed rectifier currents during the guinea-pig ventricular action potential. J. Physiol. 534:721-732.
10. Ks participation in cardiac repolarization and repolarization reserve. Circulation. 112:1384-1391.
11. Tzounopoulos, T., J. Maylie, and J. P. Adelman. 1998. Gating of I(sK) channels expressed in Xenopus oocytes. Biophys. J. 74:2299-2305.
12. Ks current (hKCNQ1/hKCNE1) stably expressed in HEK-293 cells. Am. J. Physiol. Heart Circ. Physiol. 295:H1867-H1881.
13. Terrenoire, C., C. E. Clancy, J. W. Cormier, K. J. Sampson, and R. S. Kass. 2005. Autonomic control of cardiac action potentials: role of potassium channel kinetics in response to sympathetic stimulation. Circ. Res. 96:e25-e34.
14. 2+ currents in cardiac myocytes: old story, new insights. Prog. Biophys. Mol. Biol. 91:1-82.
15. Faber, G. M., and Y. Rudy. 2000. Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study. Biophys. J. 78:2392-2404.
16. Aizawa, Y., K. Ueda, F. Scornik, J. M. Cordeiro, Y. Wu, et al. 2007. A novel mutation in KCNQ1 associated with a potent dominant negative effect as the basis for the LQT1 form of the long QT syndrome. J. Cardiovasc. Electrophysiol. 18:972-977.
17. K by protein kinases A and C. Am. J. Physiol. Cell Physiol. 261:C1081-C1090.
18. + current, on repolarization in human and guinea pig ventricular myocytes. Cardiovasc. Res. 38:441-450.
19. 2-adrenergic receptors cAMP-dependent protein kinase phosphorylates and modulates slow delayed rectifier potassium channels expressed in murine heart: evidence for receptor/ channel co-localization. J. Biol. Chem. 279:40778-40787.
20. + channels involved in long QT syndromes, are targets for calcium channel blockers. Mol. Pharmacol. 54:695-703.
21. Ks blockade at high heart rate in guinea pig and rabbit: implications for arrhythmogenesis in humans. Circulation. 104:951-956.
22. Saucerman, J. J., S. N. Healy, M. E. Belik, J. L. Puglisi, and A. D. McCulloch. 2004. Proarrhythmic consequences of a KCNQ1 AKAP-binding domain mutation: computational models of whole cells and heterogeneous tissue. Circ. Res. 95:1216-1224.
23. + hchannels. Proceedings of the National Academy of Sciences of the United States of America. 100:2935-2940.
24. Moreno, A. P., J. C. Saez, G. I. Fishman, and D. C. Spray. 1994. Human connexin43 gap junction channels. Regulation of unitary conductances by phosphorylation. Circ. Res. 74:1050-1057.
25. 2+/ calmodulin-kinase II enhances channel conductance of alpha-amino-3-hydroxy-5- methyl-4-isoxazolepropionate type glutamate receptors. Proc. Natl. Acad. Sci. USA. 96:3269-3274.
26. Carter, S., J. Colyer, and R. Sitsapesan. 2006. Maximum phosphorylation of the cardiac ryanodine receptor at serine-2809 by protein kinase A produces unique modifications to channel gating and conductance not observed at lower levels of phosphorylation. Circ. Res. 98:1506-1513.
27. Seebohm, G., N. Strutz-Seebohm, R. Birkin, G. Dell, C. Bucci, et al. 2007. Regulation of endocytic recycling of KCNQ1/KCNE1 potassium channels. Circ. Res. 100:686-692.
28. Ks in dog ventricular muscle and Purkinje fibre repolarization. J. Physiol. 523:67-81.
29. Iost, N., L. Virag, M. Opincariu, J. Szecsi, A. Varro, et al. 1998. Delayed rectifier potassium current in undiseased human ventricular myocytes. Cardiovasc. Res. 40:508-515.