Variation in effects of Cs+, UL-FS-49, and ZD-7288 within sinoatrial node

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 272, Issue 6 41-6, 1997, Pages

  Nikmaram, M R ^b   Boyett, M R ^a   Kodama, I ^c   Suzuki, R ^c   Honjo, H ^c  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b IRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c NAGOYA UNIVERSITY   (Japan)

Author keywords

Cardiac; Heart; Hyperpolarization activated inward current

Indexed keywords

4 (N ETHYL N PHENYLAMINO) 1,2 DIMETHYL 6 (METHYLAMINO)PYRIMIDINIUM CHLORIDE; CESIUM; ZATEBRADINE;

ACTION POTENTIAL; ANIMAL TISSUE; ARTICLE; HYPERPOLARIZATION; NONHUMAN; PACEMAKER; PRIORITY JOURNAL; RABBIT; SINUS NODE;

EID: 33751298056     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1997.272.6.h2782     Document Type: Article

References (18)

1. CCh in frog atrium. Pflügers Arch. 397: 295-299, 1983.
2. Bleeker, W. K., A. J. C. Mackaay, M. Masson-Pevet, L. N. Bouman, and A. E. Becker. Functional and morphological organization of the rabbit sinus node. Circ. Res. 46: 11-22, 1980.
3. f) in guinea-pig dissociated sinoatrial node cells. Br. J. Pharmacol. 110: 343-349, 1993.
4. Bouman, L. N., A. J. C. Mackaay, W. K. Bleeker, and A. E. Becker. Pacemaker shift in the sinus node: effects of vagal stimulation, temperature and reduction of extracellular calcium. In: The Sinus Node, Structure, Function and Clinical Relevance, edited by F. I. M. Bonke. The Hague, Netherlands: Nijhoff, 1978, p. 245-257.
5. Boyett, M. R., A. V. Holden, H. Zhang, I. Kodama, and R. Suzuki. Atrial modulation of sinoatrial pacemaker rate. Chaos Solitons Fractals 5: 425-438, 1995.
6. Boyett, M. R., I. Kodama, H. Honjo, A. Arai, R. Suzuki, and J. Toyama. Ionic basis of the chronotropic effect of acetylcholine on the rabbit sinoatrial node. Cardiovasc. Res. 29: 867-878, 1995.
7. Briggs, I., R. E. BoSmith, and C. G. Heapy. Effects of Zeneca ZD7288 in comparison with alinidine and UL-FS 49 on guinea-pig sinoatrial node and ventricular action potentials. J. Cardiovasc. Pharmacol. 24: 380-387, 1994.
8. f. J. Physiol. (Lond.) 429: 401-409, 1990.
9. f) in sino-atrial node myocytes. Pflügers Arch. 427: 64-70, 1994.
10. DiFrancesco, D. The onset and autonomic regulation of cardiac pacemaker activity: relevance of the f current. Cardiovasc. Res. 29: 449-456, 1995.
11. f) in cells isolated from the rabbit sino-atrial node. J. Physiol. (Lond.) 377: 61-88, 1986.
12. f. J. Cardiovasc. Electrophysiol. 3: 334-344, 1992.
13. Doerr, T., and W. Trautwein. On the mechanism of the "specific bradycardic action" of the verapamil derivative UL-FS 49. Naunyn-Schmiedebergs Arch. Pharmacol. 341: 331-340, 1990.
14. f in rabbit sinoatrial node cells by zatebradine (UL-FS 49). On the mode of action of sinus node inhibitors. Circulation 88: 2389-2401, 1993.
15. f, is not required for pacemaking in single cells from the rabbit atrioventricular node. Pflügers Arch. 427: 121-128, 1994.
16. Honjo, H., and M. R. Boyett. Correlation between action potential parameters and the size of single sino-atrial node cells isolated from the rabbit heart (Abstract). J. Physiol. (Lond.) 452: 128P, 1992.
17. + current and the hyperpolarization-activated current in rabbit sinoatrial node cells depends on cell size (Abstract). J. Physiol. (Lond.) 491: 154P, 1996.
18. Honjo, H., I. Kodama, W.-J. Zang, and M. R. Boyett. Desensitization to acetylcholine in single sinoatrial node cells isolated from the rabbit heart. Am. J. Physiol. 263 (Heart Circ. Physiol. 32): H1779-H1789, 1992.