The case for the funny current and the calcium clock

Heart Rhythm

Volumn 9, Issue 4, 2012, Pages 616-618

  Rosen, Michael R ^a   Nargeot, Joel ^b   Salama, Guy ^c  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b UNIV MONTPELLIER   (France)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; IVABRADINE;

BRADYCARDIA; CALCIUM CURRENT; GENE EXPRESSION; GENE MUTATION; HEART ATRIOVENTRICULAR NODE; HEART RATE; HEART VENTRICLE TACHYCARDIA; HYPERPOLARIZATION; MONOCYTE; NONHUMAN; NOTE; PRIORITY JOURNAL; SINUS NODE; SINUS TACHYCARDIA; SODIUM CALCIUM EXCHANGE;

EID: 84859419659     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2011.10.008     Document Type: Article

References (28)

1. D. DiFrancesco, D. Noble The funny current has a major pacemaking role in the sinus node Heart Rhythm 2011
2. V. Maltsev, E. Lakatta The funny current in the context of the coupled clock pacemaker system Heart Rhythm 2011
3. D. DiFrancesco, J.A. Camm Heart rate lowering by specific and selective I(f) current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease Drugs 64 2004 1757 1765 (Pubitemid 39215187)
4. f inhibitor, in stable angina: a randomized, double-blind, multicentered, placebo-controlled trial Circulation 107 2003 817 823 (Pubitemid 36241038)
5. A.N. Plotnikov, A. Bucchi, I. Shlapakova HCN212-channel biological pacemakers manifesting ventricular tachyarrhythmias are responsive to treatment with I(f) blockade Heart Rhythm 5 2008 282 288
6. J. Alig, L. Marger, P. Mesirca, H. Ehmke, M.E. Mangoni, D. Isbrandt Control of heart rate by cAMP sensitivity of HCN channels Proc Natl Acad Sci U S A 106 2009 12189 12194
7. M. Baruscotti, A. Bucchi, C. Viscomi Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene HCN4 Proc Natl Acad Sci U S A 108 2011 1705 1710
8. I.R. Efimov, V.V. Federov, B. Joung, S.-F. Lin Mapping cardiac pacemaker circuits methodological puzzles of the sinoatrial node optical mapping Circ Res 106 2010 255 271
9. Y. Yaniv, V.A. Maltsev, A.L. Escobar, H.A. Spurgeon, B.D. Ziman, M.D. Stern, E.G. Lakatta Beat-to-beat Ca(2+)-dependent regulation of sinoatrial nodal pacemaker cell rate and rhythm J Mol Cell Cardiol 2011 Sep 14 [Epub ahead of print]
10. M. Vassalle Analysis of cardiac pacemaker potential using a "voltage clamp" technique Am J Physiol 210 1966 1335 1341
11. D. Noble, R.W. Tsien The kinetics and rectifier properties of the slow potassium current in cardiac Purkinje fibres J Physiol 195 1968 185 214
12. D. DiFrancesco Characterization of the pace-maker current kinetics in calf Purkinje fibres J Physiol 48 1984 341 367
13. f: origins and developments Prog Biophys Mol Biol 46 1985 163 183
14. D. DiFrancesco Characterization of single pacemaker channels in cardiac sino-atrial node cells Nature 324 1986 470 473
15. dd) of cardiac Purkinje fibers J Biomed Sci 14 2007 699 716 (Pubitemid 47573149)
16. 2+ channels in cardiac pacemaker activity Proc Natl Acad Sci U S A 100 2003 5543 5548 (Pubitemid 36542741)
17. S.M. Baig, A. Koschak, A. Lieb Loss of Ca(v)1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness Nat Neurosci 14 2011 77 84
18. M.E. Mangoni, A. Traboulsie, A.L. Leoni Bradycardia and slowing of the atrioventricular conduction in mice lacking CaV3.1/alpha1G T-type calcium channels Circ Res 98 2006 1422 1430 (Pubitemid 43948067)
19. G. Deleuze, F. Guattari What Is Philosophy? H. Tomlinson and G. Burchell, trans 1994 Columbia University Press New York
20. A. Szent-Gyorgi quoted by Rosen MR. Letter to the editor Cardiovasc Res 27 1993 2082
21. C. Thollon, C. Cambarrat, J. Vian, J.-F. Prost, J.L. Peglion, J.P. Vilaine Electrophysiological effects of S 16257 a novel sino-atrial node modulator, on rabbit and guinea-pig cardiac preparations: comparison with UL-FS 49 Br J Pharmacol 112 1994 37 42 (Pubitemid 24151700)
22. P. Bois, J. Bescond, B. Renaudon, J. Lenfant Mode of action of bradycardic agent, S 16257, on ionic currents of rabbit sinoatrial node cells Br J Pharmacol 118 1996 1051 1057 (Pubitemid 26261281)
23. F. Custodis, M. Baumhkel, N. Schlimmer Heart rate reduction by ivabradine reduces oxidative stress, improves endothelial function, and prevents atherosclerosis in apolipoprotein E-deficient mice Circulation 117 2008 2377 2387 (Pubitemid 351653554)
24. A. Bucchi, A. Tognati, R. Milanesi, D. DiFrancesco Properties of ivabradine-induced block of HCN1 and HCN4 pacemaker channels J Physiol 572 2006 335 346
25. E.A. Sosunov, E.P. Anyukhovsky, M.R. Rosen Differential effects of ivabradine and ryanodine on automaticity of canine sinoatrial node and Purkinje fibers [abstract] Heart Rhythm 8 2011 S395
26. E.G. Lakatta, D. Difrancesco What keeps us ticking: a funny current, a calcium clock, or both? J Mol Cell Cardiol 47 2009 157 170
27. f, in rat ventricle cells Pflugers Arch 433 1997 533 535 (Pubitemid 27065342)
28. E.R. Kandel Genes, nerve cells, and the remembrance of things past J Neuropsychiatry Clin Neurosci 1 1989 103 125 (Pubitemid 19247955)