Rapid identification of phase I and II metabolites of artemisinin antimalarials using LTQ-Orbitrap hybrid mass spectrometer in combination with online hydrogen/deuterium exchange technique

Journal of Mass Spectrometry

Volumn 46, Issue 8, 2011, Pages 725-733

  Liu, Tian ^a   Du, Fuying ^a   Wan, Yakun ^b   Zhu, Fanping ^a   Xing, Jie ^a  

^a SHANDONG UNIVERSITY   (China)

^b SOUTHEAST UNIVERSITY   (China)

Author keywords

artemisinin antimalarials; H D exchange; high resolution LC MS n; LTQ Orbitrap; metabolite identification

Indexed keywords

ARTEMISININ; H/D EXCHANGE; HIGH RESOLUTION; LTQ-ORBITRAP; METABOLITE IDENTIFICATION;

BIOMOLECULES; BODY FLUIDS; DEUTERIUM; HYDROXYLATION; MASS SPECTROMETERS; MASS SPECTROMETRY; METABOLITES; RATS;

METABOLISM;

ANTIMALARIAL AGENT; ARTEMISININ; DEUTERIUM; DIHYDROARTEMISININ; DRUG METABOLITE; HYDROGEN; QING HAO SU; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOTRANSFORMATION; DRUG BILE LEVEL; DRUG BLOOD LEVEL; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG STRUCTURE; DRUG TRANSFORMATION; DRUG URINE LEVEL; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MALARIA; MALE; MASS SPECTROMETER; MASS SPECTROMETRY; MULTIDRUG RESISTANCE; NONHUMAN; ONLINE ANALYSIS; PLASMA; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE;

ANIMALS; ANTIMALARIALS; ARTEMISININS; BILE; BIOTRANSFORMATION; CHROMATOGRAPHY, LIQUID; DEUTERIUM EXCHANGE MEASUREMENT; HUMANS; HYDROXYLATION; MALE; MASS SPECTROMETRY; MICROSOMES, LIVER; RATS; RATS, WISTAR;

RATTUS;

EID: 79960508944     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.1943     Document Type: Article

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