Determination of β-artemether and its main metabolite dihydroartemisinin in plasma employing liquid-phase microextraction prior to liquid chromatographic-tandem mass spectrometric analysis

Talanta

Volumn 81, Issue 3, 2010, Pages 941-947

  Magalhães, Igor R S ^a   Jabor, Valquíria A P ^a   Faria, Anizio M ^b,c   Collins, Carol H ^c   Jardim, Isabel C S F ^c   Bonato, Pierina S ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF UBERLÂNDIA   (Brazil)

^c UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Artemether; Dihydroartemisinin; Liquid chromatography mass spectrometry; Liquid phase microextraction; Plasma

Indexed keywords

LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; METABOLITES; PLASMAS; POSITIVE IONS; SILICA;

ARTEMETHER; DIHYDROARTEMISININ; ELECTROSPRAY INTERFACES; LIQUID CHROMATOGRAPHY - MASS SPECTROMETRIES; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID PHASE MICRO EXTRACTION; SOLVENT CONSUMPTION; TANDEM MASS SPECTROMETRIC ANALYSIS;

EXTRACTION;

ARTEMETHER; ARTEMISININ; ARTEMISININ DERIVATIVE; TOLUENE;

ANIMAL; CALIBRATION; CHEMICAL ANALYSIS; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; FRACTIONATION; HUMAN; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PROCEDURES; QUALITY CONTROL; RAT; REPRODUCIBILITY;

ANIMALS; ARTEMISININS; CALIBRATION; CHEMICAL FRACTIONATION; CHEMISTRY TECHNIQUES, ANALYTICAL; CHROMATOGRAPHY, LIQUID; HUMANS; LIMIT OF DETECTION; MASS SPECTROMETRY; QUALITY CONTROL; RATS; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TOLUENE;

EID: 77949304853     PISSN: 00399140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.talanta.2010.01.039     Document Type: Article

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