Stereolability of dihydroartemisinin, an antimalarial drug: A comprehensive thermodynamic investigation. Part 1

Journal of Organic Chemistry

Volumn 76, Issue 6, 2011, Pages 1751-1758

  Cabri, Walter ^b   D'Acquarica, Ilaria ^c   Simone, Patrizia ^c   Di Iorio, Marta ^c   Di Mattia, Michela ^b   Gasparrini, Francesco ^c   Giorgi, Fabrizio ^b   Mazzanti, Andrea ^a   Pierini, Marco ^c   Quaglia, Marco ^b   Villani, Claudio ^c  

^a Sigma Tau SpA   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANIONIC CHARACTER; ANTIMALARIAL DRUG; ARTEMISIA ANNUA; ARTEMISININ; DIFFERENTIAL EFFECT; DIHYDROARTEMISININ; EMPIRICAL DATA; ENDOPEROXIDES; EPIMERIZATION; EPIMERS; HEMIACETALS; INTERCONVERSIONS; LINEAR SOLVATION ENERGY RELATIONSHIPS; NMR MEASUREMENTS; POLAR MEDIA; POLAR SOLVENTS; QINGHAOSU; RATE-LIMITING STEPS; RELATIVE ABUNDANCE; SESQUITERPENE LACTONES; SPONTANEOUS PROCESS; THEORETICAL APPROACH; THERMODYNAMIC INVESTIGATION; TRANSITION STATE;

THERMODYNAMICS;

RATE CONSTANTS;

DIHYDROARTEMISININ; SOLVENT;

ACIDITY; ARTICLE; CATALYSIS; DRUG ANALYSIS; EPIMER; EPIMERIZATION; EQUILIBRIUM CONSTANT; HYDROGEN BOND; MOLECULAR MODEL; PROTON NUCLEAR MAGNETIC RESONANCE; THERMODYNAMICS;

ANTIMALARIALS; ARTEMISININS; HYDROGEN-ION CONCENTRATION; MODELS, MOLECULAR; MOLECULAR CONFORMATION; SOLVENTS; STEREOISOMERISM; THERMODYNAMICS;

EID: 79953856808     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo102391s     Document Type: Article

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