Development and validation of a liquid chromatography-mass spectrometry method for the simultaneous quantification of artesunate and dihydroartemisinin in human plasma

Southeast Asian Journal of Tropical Medicine and Public Health

Volumn 39, Issue 6, 2008, Pages 963-977

  Thuy, Le Thi Diem ^a,b   Hung, Le Ngoc ^a   Danh, Phan Thong ^a   Na Bangchang, Kesara ^b,c  

^a CHO RAY HOSPITAL   (Viet Nam)

^b THAMMASAT UNIVERSITY   (Thailand)

^c Faculty of Allied Health Sciences   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 56849111997     PISSN: 01251562     EISSN: 26975718     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Angus BJ, Thaiaporn I, Chanthapadith K, Suputtamongkol Y, White NJ. Oral artesunate dose-response relationship in acute falciparum malaria. Antimicrob Agents Chemother 2002; 46: 778-82.
2. Ashton M, Hai TN, Sy ND, et al. Artemisinin pharmacokinetics is time-dependent during repeated oral administration in healthy male adults. Drug Metab Dispos 1998; 26: 25-7.
3. Barradell LB, Fitton A. Artesunate. A review of its pharmacology and therapeutic efficacy in the treatment of malaria. Drugs 1995; 50: 714-41.
4. Batty KT, Davis TM, Thu LX, Binh TQ, Anh TK, llett KF. Selective high-performance liquid chromatographic determination of artesunate and alpha- and beta-dihydroartemisinin in patients with falciparum malaria. J Chromatogr B Biomed Appl 1996; 677: 345-50.
5. Batty KT, Thu LT, Davis TM, et al. A pharmacokinetic and pharmacodynamic study of intravenous vs oral artesunate in uncomplicated falciparum malaria. Br J Clin Pharmacol 1998; 45: 123-9.
6. Edwards G. Measurement of artemisinin and its derivatives in biological fluids. Trans R Soc Trop Med Hyg 1994; 88: 37-9.
7. Grace JM, Skanchy DJ, Aguilar AJ. Metabolism of artelinic acid to dihydroqinqhaosu by human liver cytochrome P4503A. Xenobiotica 1999; 29:703-17.
8. Hassan Alin M, Björkman A, Landberg-Lindgren A, Ashton M. The effect of artemisinin, its derivatives and mefloquine against chloroquine-resistant strains of Plasmodium falciparum in vitro. Trans R Soc Trop Med Hyg 1992; 86: 365-7.
9. Karbwang J, Na-Bangchang K, Molunto P, Banmairuroi V, Congpuong K. Determination of artemether and its major metabolite, dihydroartemisinin, in plasma using high-performance liquid chromatography with electrochemical detection. J Chromatogr B Biomed Sci Appl 1997; 690: 259-65.
10. Karunajeewa HA, llett KF, Dufall K, et al. Disposition of artesunate and dihydroartemisinin after administration of artesunate suppositories in children from Papua New Guinea with uncomplicated malaria. Antimicrob Agents Chemother 2004; 48: 2966-72.
11. Khanh NX, de Vries PJ, Ha LD, van Boxtel CJ, Koopmans R, Kager PA. Declining concentrations of dihydroartemisinin in plasma during 5-day oral treatment with artesunate for falciparum malaria. Antimicrob Agents Chemother 1999; 43: 690-2.
12. Klayman DL. Qinghaosu (artemisinin): an antimalarial drug from China. Science 1985; 228: 1049-55.
13. Mohamed SS, Khalid SA, Ward SA, et al. Simultaneous determination of artemether and its major metabolite dihydroartemisinin in plasma by gas chromatography-mass spectrometryselected ion monitoring. J Chromatogr B Biomed Sci Appl 1999; 731: 251-60.
14. Na-Bangchang K, Congpuong K, Hung LN, Molunto P, Karbwang J. Simple high-performance liquid chromatographic method with electrochemical detection for the simultaneous determination of artesunate and dihydroartemisinin in biological fluids. J Chromatogr B Biomed Sci Appl 1998; 708: 201-7.
15. Naik H, Murry DJ, Kirsch LE, Fleckenstein L. Development and validation of a high-performance liquid chromatography-mass spectroscopy assay for determination of artesunate and dihydroartemisinin in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci 2005:816:233-42.
16. Nealon C, Dzeing A, Müller-Römer U, et al. Intramuscular bioavailability and clinical efficacy of artesunate in Gabonese children with severe malaria. Antimicrob Agents Chemother 2002; 46: 3933-9.
17. Newton P, Suputtamongkol Y, Teja-lsavadharm P, et al. Antimalarial bioavailability and disposition of artesunate in acute falciparum malaria. Antimicrob Agents Chemother 2000; 44: 972-7.
18. Olliaro PL, Nair NK, Sathasivam K, Mansor SM, Navaratnam V. Pharmacokinetics of artesunate after single oral administration to rats. BMC Pharmacol 2001; 1: 12.
19. Taylor RB, Awad Ml, Reid RG, Moody RR. Determination of sodium artesunate in plasma using ion-pairing high-performance liquid chromatography. J Chromatogr B Biomed Sci App 2000;744:415-21.
20. Teja-lsavadharm P, Watt G, Eamsila C, et al. Comparative pharmacokinetics and effect kinetics of orally administered artesunate in healthy volunteers and patients with uncomplicated falciparum malaria. Am J Trop Med Hyg 2001; 65: 717-21.
21. van Agtmael MA, Butter JJ, Portier EJ, van Boxtel CJ. Validation of an improved reversed-phase high-performance liquid chromatography assay with reductive electrochemical detection for the determination of artemisinin derivatives in man. Ther Drug Monit 1998; 20: 109-16.
22. White NJ, van Vugt M, Ezzet F. Clinical pharmacokinetics and pharmacodynamics of artemetherlumefantrine. Clin Pharmacokinet 1999; 37: 105-25.
23. White NJ. Clinical pharmacokinetics and pharmacodynamics of artemisinin and derivatives. Trans R Soc Trop Med Hyg 1994; 88: 41-3.