Dopaminergic regulation of orexin neurons

European Journal of Neuroscience

Volumn 21, Issue 11, 2005, Pages 2993-3001

  Bubser, Michael ^a   Fadel, Jim R ^c   Jackson, Lela L ^a   Meador Woodruff, James H ^d   Jing, Deqiang ^a   Deutch, Ariel Y ^a,b  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Apomorphine; Fos; Lateral hypothalamus; Nucleus accumbens; Rat

Indexed keywords

3 (1 ADAMANTYL) 1 AMINOMETHYL 3,4 DIHYDRO 5,6 DIHYDROXY 1H 2 BENZOPYRAN; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; APOMORPHINE; DOPAMINE; DOPAMINE 1 RECEPTOR STIMULATING AGENT; DOPAMINE 2 RECEPTOR STIMULATING AGENT; HALOPERIDOL; ISOFLURANE; MESSENGER RNA; OREXIN; PROTEIN FOS;

ANIMAL CELL; ANIMAL EXPERIMENT; AROUSAL; ARTICLE; CELL ACTIVATION; CELL ACTIVITY; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DOPAMINERGIC TRANSMISSION; GENE EXPRESSION; GENE INDUCTION; HORMONAL REGULATION; HYPOTHALAMUS NUCLEUS; IN SITU HYBRIDIZATION; LOCOMOTION; MESENCEPHALON; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT; SYNAPSE;

AFFERENT PATHWAYS; ANIMALS; AROUSAL; CENTRAL NERVOUS SYSTEM STIMULANTS; DOPAMINE; DOPAMINE AGONISTS; DOPAMINE ANTAGONISTS; HYPERKINESIS; HYPOTHALAMIC AREA, LATERAL; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; NEURONS; NEUROPEPTIDES; NUCLEUS ACCUMBENS; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE; RNA, MESSENGER; SYNAPTIC TRANSMISSION;

EID: 21444446552     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2005.04121.x     Document Type: Article

References (63)

1. Akiyama, M., Yuasa, T., Hayasaka, N., Horikawa, K., Sakurai, T. & Shibata, S. (2004) Reduced food anticipatory activity in genetically orexin (hypocretin) neuron-ablated mice. Eur. J. Neurosci., 20, 3054-3062.
2. Asper, H., Baggioline, M., Bürki, H.R., Lauener, H., Ruch, W. & Stille, G. (1973) Tolerance phenomena with neuroleptics catalepsy, apomorphine stereotypies and striatal dopamine metabolism in the rat after single and repeated administration of loxapine and haloperidol. Eur. J. Pharmacol., 22, 287-294.
3. Baldo, B.A., Daniel, R.A., Berridge, C.W. & Kelley, A.E. (2003) Overlapping distributions of orexin/hypocretin- and dopamine-beta-hydroxylase immunoreactive fibers in rat brain regions mediating arousal, motivation, and stress. J. Comp. Neurol., 464, 220-237.
4. A receptor-mediated inhibition of the nucleus accumbens shell, but not by exposure to a novel environment. Eur. J. Neurosci., 19, 376-386.
5. Bouret, S.G., Draper, S.J. & Simerly, R.B. (2004) Formation of projection pathways from the arcuate nucleusof the hypothalamus to hypothalamic regions implicated in the neural control of feeding behavior in mice. J. Neurosci., 24, 2797-2805.
6. Broberger, C., De Lecea, L., Sutcliffe, J.G. & Hokfelt, T. (1998) Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: relationship to the neuropeptide Y and agouti gene-related protein systems. J. Comp. Neurol., 402, 460-474.
7. Brunetti, L., Orlando, G., Recinella, L., Michelotto, B., Ferrante, C. & Vacca, M. (2004) Resistin, but not adiponectin, inhibits dopamine and norepinephrine release in the hypothalamus. Eur. J. Pharmacol., 493, 41-44.
8. Bubser, M. & Deutch, A.Y. (1998) Thalamic paraventricular nucleus neurons collateralize to innervate the prefrontal cortex and nucleus accumbens. Brain Res., 787, 304-310.
9. Carr, K.D., Kim, G.Y. & Cabeza de Vaca, S. (2001) Rewarding and locomotor-activating effects of direct dopamine receptor agonists are augmented by chronic food restriction in rats. Psychopharmacology, 154, 420-428.
10. Damask, S.P., Bovenkerk, K.A., De la Pena, G., Hoversten, K.M., Peters, D.B., Valentine, A.M. & Meador-Woodruff, J.H. (1996) Differential effects of clozapine and haloperidol on dopamine receptor mRNA expression in rat striatum and cortex. Mol. Brain Res., 41, 241-249.
11. Espana, R.A., Baldo, B.A., Kelley, A.E. & Berridge, C.W. (2001) Wake-promoting and sleep-suppressing actions of hypocretin (orexin): basal forebrain sites of action. Neuroscience, 106, 699-715.
12. Espana, R.A., Valentino, R.J. & Berridge, C.W. (2003) Fos immunoreactivity in hypocretin-synthesizing and hypocretin-1 receptor-expressing neurons: effects of diurnal and nocturnal spontaneous waking, stress and hypocretin-1 administration. Neuroscience, 121, 201-217.
13. Estabrooke, I.V., McCarthy, M.T., Ko, E., Chou, T.C., Chemelli, R.M., Yanagisawa, M., Saper, C.B. & Scammell, T.E. (2001) Fos expression in orexin neurons varies with behavioral state. J. Neurosci., 21, 1656-1662.
14. Fadel, J., Bubser, M. & Deutch, A.Y. (2002) Differential activation of orexin neurons by antipsychotic drugs associated with weight gain. J. Neurosci., 22, 6742-6746.
15. Fadel, J. & Deutch, A.Y. (2002) Anatomical substrates of orexin-dopamine interactions: lateral hypothalamic projections to the ventral tegmental area. Neuroscience, 111, 379-387.
16. Fetissov, S.O., Meguid, M.M., Sato, T. & Zhang, L.H. (2002) Expression of dopaminergic receptors in the hypothalamus of lean and obese Zucker rats and food intake. Am. J. Physiol. Regul. Integr. Comp. Physiol., 283, R905-R910.
17. Fujiki, N., Yoshida, Y., Ripley, B., Honda, K., Mignot, E. & Nishino, S. (2001) Changes in CSF hypocretin-1 (orexin A) levels in rats across 24 hours and in response to food deprivation. Neuroreport, 12, 993-997.
18. Hagan, J.J., Leslie, R.A., Patel, S., Evans, M.L., Wattam, T.A., Holmes, S., Benham, C.D., Taylor, S.G., Routledge, C., Hemmati, P., Munton, R.P., Ashmeade, I.E., Shah, A.S., Hatcher, J.P., Hatcher, P.D., Jones, D.N., Smith, M.I., Piper, D.C., Hunter, A.J., Porter, R.A. & Upton, N. (1999) Orexin A activates locus coeruleus cell firing and increases arousal in the rat. Proc. Natl Acad. Sci. USA, 96, 10911-10916.
19. Horvath, T.L., Peyron, C., Diano, S., Ivanov, A., Aston-Jones, G., Kilduff, T.S. & van Den Pol, A.N. (1999) Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system. J. Comp. Neurol., 415, 145-159.
20. Isaac, S.O. & Berridge, C.W. (2003) Wake-promoting actions of dopamine D1 and D2 receptor stimulation. J. Pharmacol. Exp. Ther., 307, 386-394.
21. Kafetzopoulos, E. (1986) Effects of amphetamine and apomorphine on locomotor activity after kainic acid lesion of the nucleus accumbens septi in the rat. Psychopharmacology, 88, 271-274.
22. Klemm, N., Murrin, L.C. & Kuhar, M.J. (1979) Neuroleptic and dopamine receptors: autoradiographic localization of [3H]spiperone in rat brain. Brain Res., 169, 1-9.
23. Köhler, C., Haglund, L., Ögren, S.-O. & Ängeby, T. (1981) Regional blockade by neuroleptic drugs of in vivo 3H-spiperone binding in the rat brain. Relation to blockade of apomorphine induced hyperactivity and stereotypies. J. Neural Transm., 52, 163-173.
24. Korotkova, T.M., Sergeeva, O.A., Eriksson, K.S., Haas, H.L. & Brown, R.E. (2003) Excitation of ventral tegmental area dopaminergic and nondopaminergic neurons by orexins/hypocretins. J. Neurosci., 23, 7-11.
25. Kropf, W., Kuschinsky, K. & Krieglstein, J. (1989) Apomorphine-induced alterations in cortical EEG activity of rats. Involvement of D-1 and D-2 dopamine receptors. Naunyn-Schmiedeberg's Arch. Pharmacol., 340, 718-725.
26. de Lecea, L., Kilduff, T.S., Peyron, C., Gao, X., Foye, P.E., Danielson, P.E., Fukuhara, C., Battenberg, E.L., Gautvik, V.T., Bartlett, F.S., Frankel, W.N., van den Pol, A.N., Bloom, F.E., Gautvik, K.M. & Sutcliffe, J.G. (1998) The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc. Natl Acad. Sci. USA, 95, 322-327.
27. Lee, S.K. & Hollenbeck, P.J. (2003) Organization and translation of mRNA in sympathetic axons. J. Cell Sci., 116, 4467-4478.
28. Lee, T.L., Hsu, C.T., Yen, S.T., Lai, C.W. & Cheng, J.T. (1998) Activation of beta3-adrenoceptors by exogenous dopamine to lower glucose uptake into rat adipocytes. J. Auton. Nerv. Syst., 74, 86-90.
29. Leibowitz, S.F., Jhanwar-Uniyal, M., Dvorkin, B. & Makman, M.H. (1982) Distribution of alpha-adrenergic, beta-adrenergic and dopaminergic receptors in discrete hypothalamic areas of rat. Brain Res., 233, 97-114.
30. Li, Y. & van den Pol, A.N. (2005) Direct and indirect inhibition by catecholamines of hypocretin/orexin neurons. J. Neurosci., 25, 173-183.
31. Lu, X.Y., Bagnol, D., Burke, S., Akil, H. & Watson, S.J. (2000) Differential distribution and regulation of OX1 and OX2 orexin/hypocretin receptor messenger RNA in the brain upon fasting. Horm. Behav., 37, 335-344.
32. Mansour, A., Meador-Woodruff, J.H., Bunzow, J.R., Civelli, O., Akil, H. & Watson, S.J. (1990) Localization of dopamine D2 receptor mRNA and D1 and D2 receptor binding in the rat brain and pituitary: an in situ hybridization-receptor autoradiographic analysis. J. Neurosci., 10, 2587-2600.
33. Mansour, A., Meador-Woodruff, J.H., Zhou, Q.Y., Civelli, O., Akil, H. & Watson, S.J. (1991) A comparison of D1 receptor binding and mRNA in rat brain using receptor autoradiographic and in situ hybridization techniques. Neuroscience, 45, 359-371.
34. Marcus, J.N., Aschkenasi, C.J., Lee, C.E., Chemelli, R.M., Saper, C.B., Yanagisawa, M. & Elmquist, J.K. (2001) Differential expression of orexin receptors 1 and 2 in the rat brain. J. Comp. Neurol., 435, 6-25.
35. Meister, B. (2000) Control of food intake via leptin receptors in the hypothalamus. Vitam. Horm., 59, 265-304.
36. Meller, E., Bohmaker, K., Goldstein, M. & Friedhoff, A.J. (1985) Inactivation of D1 and D2 dopamine receptors by N-ethoxycarbonyl-2-ethoxy-1,2- dihydroquinoline in vivo: selective protection by neuroleptics. J. Pharmacol. Exp. Ther., 233, 656-662.
37. Millan, M.J., Maiofiss, L., Cussac, D., Audinot, V., Boutin, J.A. & Newman-Tancredi, A. (2002) Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes. J. Pharmacol. Exp. Ther., 303, 791-804.
38. Murphy, J.A., Deurveilher, S. & Semba, K. (2003) Stimulant doses of caffeine induce c-FOS activation in orexin/hypocretin-containing neurons in rat. Neuroscience, 121, 269-275.
39. Nakamura, T., Uramura, K., Nambu, T., Yada, T., Goto, K., Yanagisawa, M. & Sakurai, T. (2000) Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system. Brain Res., 873, 181-187.
40. Nakano, S., Hara, C. & Ogawa, N. (1980) Orcadian rhythm of apomorphine-induced stereotypy in rats. Pharmacol. Biochem. Behav., 12, 459-461.
41. Nasello, A.G., Tieppo, C.A. & Felicio, L.F. (1995) Apomorphine-induced yawning in the rat: influence of fasting and time of day. Physiol. Behav., 57, 967-971.
42. Nisoli, E., Tonello, C., Memorandum, M. & Carruba, M.O. (1992) Biochemical and functional identification of a novel dopamine receptor subtype in rat brown adipose tissue. Its role in modulating sympathetic stimulation-induced thermogenesis. J. Pharmacol. Exp. Ther., 263, 823-829.
43. Olszewski, P.K., Li, D., Grace, M.K., Billington, C.J., Kotz, C.M. & Levine, A.S. (2003) Neural basis of orexigenic effects of ghrelin acting within lateral hypothalamus. Peptides, 24, 597-602.
44. Paxinos, G. & Watson, C. (1986) The Rat Brain in Stereotaxic Coordinates. Academic Press, San Diego, CA.
45. Peyron, C., Tighe, D.K., van den Pol, A.N., de Lecea, L., Heller, H.C., Sutcliffe, J.G. & Kilduff, T.S. (1998) Neurons containing hypocretin (orexin) project to multiple neuronal systems. J. Neurosci., 18, 9996-10015.
46. Ritter, L.M. & Meador-Woodruff, J.H. (1997) Antipsychotic regulation of hippocampal dopamine receptor messenger RNA expression. Biol. Psychiatry, 42, 155-164.
47. Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R.M., Tanaka, H., Williams, S.C., Richardson, J.A., Kozlowski, G.P., Wilson, S., Arch., J.R., Buckingham, R.E., Haynes, A.C., Carr, S.A., Annan, R.S., McNulty, D.E., Liu, W.S., Terrett, J.A., Elshourbagy, N.A., Bergsma, D.J. & Yanagisawa, M. (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell, 92, 573-585.
48. Saller, C.F., Kreamer, L.D., Adamovage, L.A. & Salama, A.I. (1989) Dopamine receptor occupancy in vivo: measurement using N-ethoxycarbonyl-2- ethoxy-1,2-dihydroquinoline (EEDQ). Life Sci., 45, 917-929.
49. Satoh, S., Matsumura, H., Nakajima, T., Nakahama, K., Kanbayashi, T., Nishino, S., Yoneda, H. & Shigeyoshi, Y. (2003) Inhibition of rostral basal forebrain neurons promotes wakefulness and induces FOS in orexin neurons. Eur. J. Neurosci., 17, 1635-1645.
50. Savasta, M., Dubois, A. & Scatton, B. (1986) Autoradiographic localization of D1 dopamine receptors in the rat brain with [3H]SCH 23390. Brain Res., 375, 291-301.
51. Scammell, T.E., Estabrooke, I.V., McCarthy, M.T., Chemelli, R.M., Yanagisawa, M., Miller, M.S. & Saper, C.B. (2000) Hypothalamic arousal regions are activated during modafinil-induced wakefulness. J. Neurosci., 20, 8620-8628.
52. Steward, O. & Schuman. E.M. (2001) Protein synthesis at synaptic sites on dendrites. Annu. Rev. Neurosci., 24, 299-325.
53. Stratford, T.R. & Kelley, A.E. (1999) Evidence of a functional relationship between the nucleus accumbens shell and lateral hypothalamus subserving the control of feeding behavior. J. Neurosci., 19, 11040-11048.
54. 2+ signaling in dopamine neurons of the ventral tegmental area. Neuroreport, 12, 1885-1889.
55. Usuda, I., Tanaka, K. & Chiba, T. (1998) Efferent projections of the nucleus accumbens in the rat with special reference to subdivision of the nucleus: biotinylated dextran amine study. Brain Res., 797, 73-93.
56. Weissenbom, R. & Winn, P. (1992) Regulatory behavior, exploration and locomotion following NMDA or 6-OHDA lesions in the rat nucleus accumbens. Behav. Brain Res., 51, 127-137.
57. Winsky-Sommerer, R., Boutrel, B. & de Lecea, L. (2003) The role of the hypocretinergic system in the integration of networks that dictate the states of arousal. Drug News Perspect., 16, 504-512.
58. Wisor, J.P., Nishino, S., Sora, I., Uhl, G.H., Mignot, E. & Edgar, D.M. (2001) Dopaminergic role in stimulant-induced wakefulness. J. Neurosci., 21, 1787-1794.
59. Wolf, H.K., Buslei, R., Schmidt-Kastner, R., Schmidt-Kastner, P.K., Pietsch, T., Wiestler, O.D. & Blumcke, I. (1996) NeuN: a useful neuronal marker for diagnostic histopathology. J. Histochem. Cytochem., 44, 1167-1171.
60. Zahm, D.S. & Heimer, L. (1993) Specificity in the efferent projections of the nucleus accumbens in the rat: comparison of the rostral pole projection patterns with those of the core and shell. J. Comp. Neurol., 327, 220-232.
61. Zeitzer, J.M., Buckmaster, C.L., Lyons, D.M. & Mignot, E. (2004) Locomotor-dependent and -independent components to hypocretin-1 (orexin A) regulation in sleep-wake consolidating monkeys. J. Physiol. (Lond.), 557, 1045-1053.
62. Zhang, W., Klimek, V., Farley, J.T., Zhu, M.Y. & Ordway, G.A. (1999) Alpha2C adrenoceptors inhibit adenylyl cyclase in mouse striatum: potential activation by dopamine. J. Pharmacol Exp. Ther., 289, 1286-1292.
63. Zheng, H., Corkern, M., Stoyanova, I., Patterson, L.M., Tian, R. & Berthoud, H.R. (2003) Peptides that regulate food intake: appetite-inducing accumbens manipulation activates hypothalamic orexin neurons and inhibits POMC neurons. Am. J. Physiol. Regul. Integr. Comp. Physiol., 284, R1436-R1444.