Modanifil activates the histaminergic system through the orexinergic neurons

Neuroscience Letters

Volumn 483, Issue 3, 2010, Pages 193-196

  Ishizuka, Tomoko ^a,b   Murotani, Tomotaka ^a   Yamatodani, Atsushi ^a,b  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Histaminergic system; Microdialysis; Modafinil; Orexinergic neurons; Tuberomammillary nucleus

Indexed keywords

MODAFINIL; OREXIN; PROTEIN C FOS;

ARTICLE; HISTAMINE RELEASE; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; LOCOMOTION; MALE; MAMMILLARY BODY; MICRODIALYSIS; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; SYNAPTIC MEMBRANE;

ANIMALS; BENZHYDRYL COMPOUNDS; CENTRAL NERVOUS SYSTEM STIMULANTS; HISTAMINE; HYPOTHALAMIC AREA, LATERAL; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MICE, KNOCKOUT; NEURONS; NEUROPEPTIDES; PROTO-ONCOGENE PROTEINS C-FOS;

EID: 77956296410     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2010.08.005     Document Type: Article

References (31)

1. Chemelli R.M., Willie J.T., Sinton C.M., Elmquist J.K., Scammell T., Lee C., Richardson J.A., Williams S.C., Xiong Y., Kisanuki Y., Fitch T.E., Nakazato M., Hammer R.E., Saper C.B., Yanagisawa M. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 1999, 98:437-451.
2. de Saint Hilaire Z., Orosco M., Rouch C., Blanc G., Nicolaidis S. Variations in extracellular monoamines in the prefrontal cortex and medial hypothalamus after modafinil administration: a microdialysis study in rats. Neuroreport 2001, 12:3533-3537.
3. Espana R.A., Baldo B.A., Kelley A.E., Berridge C.W. Wake-promoting and sleep-suppressing actions of hypocretin (orexin): basal forebrain sites of action. Neuroscience 2001, 106:699-715.
4. Fauchey V., Jaber M., Bloch B., Le Moine C. Dopamine control of striatal gene expression during development: relevance to knockout mice for the dopamine transporter. Eur. J. Neurosci. 2000, 12:3415-3425.
5. Hara J., Beuckmann C.T., Nambu T., Willie J.T., Chemelli R.M., Sinton C.M., Sugiyama F., Yagami K., Goto K., Yanagisawa M., Sakurai T. Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity. Neuron 2001, 30:345-354.
6. Hara J., Yanagisawa M., Sakurai T. Difference in obesity phenotype between orexin-knockout mice and orexin neuron-deficient mice with same genetic background and environmental conditions. Neurosci. Lett. 2005, 380:239-242.
7. Huang Z.L., Qu W.M., Li W.D., Mochizuki T., Eguchi N., Watanabe T., Urade Y., Hayaishi O. Arousal effect of orexin A depends on activation of the histaminergic system. Proc. Natl. Acad. Sci. U.S.A. 2001, 98:9965-9970.
8. 3-inverse agonist on energy intake and hypothalamic histamine release in normal mice and leptin resistant mice with high fat diet-induced obesity. Behav. Brain Res. 2008, 118:250-254.
9. Ishizuka T., Murakami M., Yamatodani A. Involvement of central histaminergic systems in modafinil-induced but not methylphenidate-induced increases in locomotor activity in rats. Eur. J. Pharmacol. 2008, 578:209-215.
10. Ishizuka T., Sakamoto Y., Sakurai T., Yamatodani A. Modafinil increases histamine release in the anterior hypothalamus of rats. Neurosci. Lett. 2003, 339:143-146.
11. Ishizuka T., Yamamoto Y., Yamatodani A. The effect of orexin-A and -B on the histamine release in the anterior hypothalamus in rats. Neurosci. Lett. 2002, 323:93-96.
12. Lin J.S., Hou Y., Jouvet M. Potential brain neuronal targets for amphetamine-, methylphenidate-, and modafinil-induced wakefulness, evidenced by c-fos immunocytochemistry in the cat. Proc. Natl. Acad. Sci. U.S.A. 1996, 93:14128-14133.
13. Madras B.K., Xie Z., Lin Z., Jassen A., Panas H., Lynch L., Johnson R., Livni E., Spencer T.J., Bonab A.A., Miller G.M., Fischman A.J. Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro. J. Pharmacol. Exp. Ther. 2006, 319:561-569.
14. Marcus J.N., Aschkenasi C.J., Lee C.E., Chemelli R.M., Saper C.B., Yanagisawa M., Elmquist J.K. Differential expression of orexin receptors 1 and 2 in the rat brain. J. Comp. Neurol. 2001, 435:6-25.
15. Mieda M., Yanagisawa M. Sleep, feeding, and neuropeptides: roles of orexins and orexin receptors. Curr. Opin. Neurobiol. 2002, 12:339-345.
16. Mignot E., Nishino S., Guilleminault C., Dement W.C. Modafinil binds to the dopamine uptake carrier site with low affinity. Sleep 1994, 17:436-437.
17. Mochizuki T., Yamatodani A., Okakura K., Takemura M., Inagaki N., Wada H. In vivo release of neuronal histamine in the hypothalamus of rats measured by microdialysis. Naunyn Schmiedebergs Arch. Pharmacol. 1991, 343:190-195.
18. Murillo-Rodríguez E., Haro R., Palomero-Rivero M., Millán-Aldaco D., Drucker-Colín R. Modafinil enhances extracellular levels of dopamine in the nucleus accumbens and increases wakefulness in rats. Behav. Brain Res. 2007, 176:353-357.
19. Nishino S., Ripley B., Overeem S., Lammers G.J., Mignot E. Hypocretin (orexin) deficiency in human narcolepsy. Lancet 2000, 355:39-40.
20. Okakura K., Yamatodani A., Mochizuki T., Horii A., Wada H. Glutamatergic regulation of histamine release from rat hypothalamus. Eur. J. Pharmacol. 1992, 213:189-192.
21. Peyron C., Tighe D.K., van den Pol A.N., de Lecea L., Heller H.C., Sutcliffe J.G., Kilduff T.S. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J. Neurosci. 1998, 18:9996-10015.
22. Rao Y., Liu Z.W., Borok E., Rabenstein R.L., Shanabrough M., Lu M., Picciotto M.R., Horvath T.L., Gao X.B. Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin/orexin neurons. J. Clin. Invest. 2007, 117:4022-4033.
23. Scammell T.E., Estabrooke I.V., McCarthy M.T., Chemelli R.M., Yanagisawa M., Miller M.S., Saper C.B. Hypothalamic arousal regions are activated during modafinil-induced wakefulness. J. Neurosci. 2000, 20:8620-8628.
24. Stone E.A., Cotecchia S., Lin Y., Quartermain D. Role of brain alpha 1B-adrenoceptors in modafinil-induced behavioral activity. Synapse 2002, 46:269-270.
25. Torrealba F., Yanagisawa M., Saper C.B. Colocalization of orexin A and glutamate immunoreactivity in axon terminals in the tuberomammillary nucleus in rats. Neuroscience 2003, 119:1033-1044.
26. Watanabe T., Taguchi Y., Shiosaka S., Tanaka J., Kubota H., Terano Y., Tohyama M., Wada H. Distribution of the histaminergic neuron system in the central nervous system of rats; a fluorescent immunohistochemical analysis with histidine decarboxylase as a marker. Brain Res. 1984, 295:13-25.
27. Willie J.T., Renthal W., Chemelli R.M., Miller M.S., Scammell T.E., Yanagisawa M., Sinton C.M. Modafinil more effectively induces wakefulness in orexin-null mice than in wild-type littermates. Neuroscience 2005, 130:983-995.
28. Wisor J.P., Eriksson K.S. Dopaminergic-adrenergic interactions in the wake promoting mechanism of modafinil. Neuroscience 2005, 132:1027-1034.
29. Wisor J.P., Nishino S., Sora I., Uhl G.H., Mignot E., Edgar D.M. Dopaminergic role in stimulant-induced wakefulness. J. Neurosci. 2001, 21:1787-1794.
30. Yamatodani A., Fukuda H., Wada H., Iwaeda T., Watanabe T. High-performance liquid chromatographic determination of plasma and brain histamine without previous purification of biological samples: cation-exchange chromatography coupled with post-column derivatization fluorometry. J. Chromatogr. 1985, 344:115-123.
31. Yamatodani A., Mochizuki T., Mammoto T. New vistas on histamine arousal hypothesis: microdialysis studies. Methods Find. Exp. Clin. Pharmacol. 1996, 18:113-117.