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Volumn 42, Issue 2, 2003, Pages 123-137

Clinical pharmacokinetic profile of modafinil

Author keywords

[No Author keywords available]

Indexed keywords

CLOMIPRAMINE; CYCLOSPORIN; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; DEXAMPHETAMINE; DRUG METABOLITE; ETHINYLESTRADIOL; METHYLPHENIDATE; MODAFINIL; MODAFINIL ACID; MODAFINIL SULFONE; NORCLOMIPRAMINE; TRIAZOLAM; UNCLASSIFIED DRUG; WARFARIN;

EID: 0037275524     PISSN: 03125963     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003088-200342020-00002     Document Type: Review
Times cited : (215)

References (35)
  • 1
    • 0030775911 scopus 로고    scopus 로고
    • Modafinil induces wakefulness without intensifying motor activity or subsequent rebound hypersomnolence in the rat
    • Edgar DM, Seidel WF. Modafinil induces wakefulness without intensifying motor activity or subsequent rebound hypersomnolence in the rat. J Pharmacol Exp Ther 1997; 283: 757-69
    • (1997) J Pharmacol Exp Ther , vol.283 , pp. 757-769
    • Edgar, D.M.1    Seidel, W.F.2
  • 2
    • 0031574307 scopus 로고    scopus 로고
    • Modafinil: An antinarcoleptic drug with a different neurochemical profile to damphetamine and dopamine uptake blockers
    • Ferraro L, Antonelli T, O'Connor WT, et al. Modafinil: an antinarcoleptic drug with a different neurochemical profile to damphetamine and dopamine uptake blockers. Biol Psychiatry 1997; 42: 1181-3
    • (1997) Biol Psychiatry , vol.42 , pp. 1181-1183
    • Ferraro, L.1    Antonelli, T.2    O'Connor, W.T.3
  • 3
    • 0028876379 scopus 로고
    • Non-amphetaminic mechanism of stimulant locomotor effect of modafinil in mice
    • Simon P, Hemet C, Ramassamy C, et al. Non-amphetaminic mechanism of stimulant locomotor effect of modafinil in mice. Eur Neuropsychopharmacol 1995; 5: 509-14
    • (1995) Eur Neuropsychopharmacol , vol.5 , pp. 509-514
    • Simon, P.1    Hemet, C.2    Ramassamy, C.3
  • 4
    • 0028245420 scopus 로고
    • Lack of pre-synaptic dopaminergic involvement in modafinil activity in anaesthetized mice: In vivo voltammetry studies
    • De Sereville JE, Boer C, Rambert FA, et al. Lack of pre-synaptic dopaminergic involvement in modafinil activity in anaesthetized mice: in vivo voltammetry studies. Neuropharmacology 1994; 33: 755-61
    • (1994) Neuropharmacology , vol.33 , pp. 755-761
    • De Sereville, J.E.1    Boer, C.2    Rambert, F.A.3
  • 5
    • 0028015747 scopus 로고
    • Modafinil binds to the dopamine uptake carrier site with low affinity
    • Mignot E, Nishino S, Guilleminault C, et al. Modafinil binds to the dopamine uptake carrier site with low affinity. Sleep 1994; 17: 436-7
    • (1994) Sleep , vol.17 , pp. 436-437
    • Mignot, E.1    Nishino, S.2    Guilleminault, C.3
  • 6
    • 0026675087 scopus 로고
    • Role of catecholamines in the modafinil and amphetamine induced wakefulness, a comparative pharmacological study in the cat
    • Lin JS, Roussel B, Akaoka H, et al. Role of catecholamines in the modafinil and amphetamine induced wakefulness, a comparative pharmacological study in the cat. Brain Res 1992; 591: 319-26
    • (1992) Brain Res , vol.591 , pp. 319-326
    • Lin, J.S.1    Roussel, B.2    Akaoka, H.3
  • 7
    • 0026099256 scopus 로고
    • Effect of modafinil and amphetamine on the rat catecholaminergic neuron activity
    • Akaoka H, Roussel B, Lin JS, et al. Effect of modafinil and amphetamine on the rat catecholaminergic neuron activity. Neurosci Lett 1991; 123: 20-2
    • (1991) Neurosci Lett , vol.123 , pp. 20-22
    • Akaoka, H.1    Roussel, B.2    Lin, J.S.3
  • 8
    • 0032544057 scopus 로고    scopus 로고
    • Brain regional substrates for the actions of the novel wake-promoting agent modafinil in the rat: Comparison with amphetamine
    • Engber TM, Dennis SA, Jones BE, et al. Brain regional substrates for the actions of the novel wake-promoting agent modafinil in the rat: comparison with amphetamine. Neuroscience 1998; 87: 905-11
    • (1998) Neuroscience , vol.87 , pp. 905-911
    • Engber, T.M.1    Dennis, S.A.2    Jones, B.E.3
  • 9
    • 0030477691 scopus 로고    scopus 로고
    • Potential brain neuronal targets for amphetamine-, methylphenidate-, and modafinil-induced wakefulness, evidenced by c-fos immunocytochemistry in the cat
    • Lin JS, Hou Y, Jouvet M. Potential brain neuronal targets for amphetamine-, methylphenidate-, and modafinil-induced wakefulness, evidenced by c-fos immunocytochemistry in the cat. Proc Natl Acad Sci U S A 1996; 93: 14128-33
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 14128-14133
    • Lin, J.S.1    Hou, Y.2    Jouvet, M.3
  • 10
    • 0034668848 scopus 로고    scopus 로고
    • Hypothalamic arousal regions are activated during modafinil-induced wakefulness
    • Scammell TE, Estabrooke IV, McCarthy MT, et al. Hypothalamic arousal regions are activated during modafinil-induced wakefulness. J Neurosci 2000; 20: 8620-8
    • (2000) J Neurosci , vol.20 , pp. 8620-8628
    • Scammell, T.E.1    Estabrooke, I.V.2    McCarthy, M.T.3
  • 11
    • 0032979760 scopus 로고    scopus 로고
    • Open-label, single-dose pharmacokinetic study of modafinil tablets: Influence of age and gender in normal subjects
    • Wong YN, King SP, Simcoe D, et al. Open-label, single-dose pharmacokinetic study of modafinil tablets: influence of age and gender in normal subjects. J Clin Pharmacol 1999; 39: 281-8
    • (1999) J Clin Pharmacol , vol.39 , pp. 281-288
    • Wong, Y.N.1    King, S.P.2    Simcoe, D.3
  • 12
    • 0031943018 scopus 로고    scopus 로고
    • Single-dose pharmacokinetics of modafinil and methylphenidate given alone or in combination in healthy male volunteers
    • Wong YN, King SP, Laughton WB, et al. Single-dose pharmacokinetics of modafinil and methylphenidate given alone or in combination in healthy male volunteers. J Clin Pharmacol 1998; 38: 276-82
    • (1998) J Clin Pharmacol , vol.38 , pp. 276-282
    • Wong, Y.N.1    King, S.P.2    Laughton, W.B.3
  • 13
    • 0342545934 scopus 로고    scopus 로고
    • Randomized trial of modafinil as a treatment for the excessive daytime somnolence of narcolepsy
    • US Modafinil in Narcolepsy Multicenter Study Group. Randomized trial of modafinil as a treatment for the excessive daytime somnolence of narcolepsy. Neurology 2000; 54: 1166-75
    • (2000) Neurology , vol.54 , pp. 1166-1175
  • 14
    • 2642638767 scopus 로고    scopus 로고
    • Randomized trial of modafinil for the treatment of pathological somnolence in narcolepsy
    • US Modafinil in Narcolepsy Multicenter Study Group. Randomized trial of modafinil for the treatment of pathological somnolence in narcolepsy. Ann Neurol 1998; 43: 88-97
    • (1998) Ann Neurol , vol.43 , pp. 88-97
  • 15
    • 0030816557 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled crossover trial of modafinil in the treatment of excessive daytime sleepiness in narcolepsy
    • Broughton RJ, Fleming JA, George CF, et al. Randomized, double-blind, placebo-controlled crossover trial of modafinil in the treatment of excessive daytime sleepiness in narcolepsy. Neurology 1997; 49: 444-51
    • (1997) Neurology , vol.49 , pp. 444-451
    • Broughton, R.J.1    Fleming, J.A.2    George, C.F.3
  • 16
    • 0027399874 scopus 로고
    • Effects of modafinil on symptomatology of human narcolepsy
    • Boivin DB, Montplaisir J, Petit D, et al. Effects of modafinil on symptomatology of human narcolepsy. Clin Neuropharmacol 1993; 16: 46-53
    • (1993) Clin Neuropharmacol , vol.16 , pp. 46-53
    • Boivin, D.B.1    Montplaisir, J.2    Petit, D.3
  • 17
    • 0023769647 scopus 로고
    • Successful treatment of idiopathic hypersomnia and narcolepsy with modafinil
    • Bastuji H, Jouvet M. Successful treatment of idiopathic hypersomnia and narcolepsy with modafinil. Prog Neuropsychopharmacol Biol Psychiatry 1988; 12: 695-700
    • (1988) Prog Neuropsychopharmacol Biol Psychiatry , vol.12 , pp. 695-700
    • Bastuji, H.1    Jouvet, M.2
  • 18
    • 0031893206 scopus 로고    scopus 로고
    • Modafinil: A review of its pharmacology and clinical efficacy in the management of narcolepsy
    • McClellan KJ, Spencer CM. Modafinil: a review of its pharmacology and clinical efficacy in the management of narcolepsy. CNS Drugs 1998; 9: 311-24
    • (1998) CNS Drugs , vol.9 , pp. 311-324
    • McClellan, K.J.1    Spencer, C.M.2
  • 19
    • 0033063439 scopus 로고    scopus 로고
    • Determination of the d- and l-enantiomers of modafinil in human plasma utilizing liquid-liquid extraction and high-performance liquid chromatography
    • Gorman SH. Determination of the d- and l-enantiomers of modafinil in human plasma utilizing liquid-liquid extraction and high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl 1999; 730: 1-7
    • (1999) J Chromatogr B Biomed Sci Appl , vol.730 , pp. 1-7
    • Gorman, S.H.1
  • 20
    • 0036164944 scopus 로고    scopus 로고
    • Determination of modafinil, modafinil acid, and modafinil sulfone in human plasma utilizing liquid-liquid extraction and high performance liquid chromatography
    • Gorman SH. Determination of modafinil, modafinil acid, and modafinil sulfone in human plasma utilizing liquid-liquid extraction and high performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci 2002; 767: 269-76
    • (2002) J Chromatogr B Analyt Technol Biomed Life Sci , vol.767 , pp. 269-276
    • Gorman, S.H.1
  • 21
    • 0032549477 scopus 로고    scopus 로고
    • High-performance liquid chromatographic determination of modafinil and its two metabolites in human plasma using solid-phase extraction
    • Burnat P, Robles F, Do B. High-performance liquid chromatographic determination of modafinil and its two metabolites in human plasma using solid-phase extraction. J Chromatogr B Biomed Sci Appl 1998; 706: 295-304
    • (1998) J Chromatogr B Biomed Sci Appl , vol.706 , pp. 295-304
    • Burnat, P.1    Robles, F.2    Do, B.3
  • 22
    • 0028265592 scopus 로고
    • Simultaneous determination of modafinil and its acid metabolite by high-performance liquid chromatography in human plasma
    • Moachon G, Matinier D. Simultaneous determination of modafinil and its acid metabolite by high-performance liquid chromatography in human plasma. J Chromatogr B Biomed Appl 1994; 654: 91-6
    • (1994) J Chromatogr B Biomed Appl , vol.654 , pp. 91-96
    • Moachon, G.1    Matinier, D.2
  • 24
    • 0030479311 scopus 로고    scopus 로고
    • Pharmacokinetic profile of modafinil
    • Moachon G, Kanmacher I, Clenet M, et al. Pharmacokinetic profile of modafinil. Drugs Today 1996; 32: 327-37
    • (1996) Drugs Today , vol.32 , pp. 327-337
    • Moachon, G.1    Kanmacher, I.2    Clenet, M.3
  • 25
    • 0032924254 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled, ascending-dose evaluation of the pharmacokinetics and tolerability of modafinil tablets in healthy male volunteers
    • Wong YN, Simcoe D, Hartman LN, et al. A double-blind, placebo-controlled, ascending-dose evaluation of the pharmacokinetics and tolerability of modafinil tablets in healthy male volunteers. J Clin Pharmacol 1999; 39: 30-40
    • (1999) J Clin Pharmacol , vol.39 , pp. 30-40
    • Wong, Y.N.1    Simcoe, D.2    Hartman, L.N.3
  • 26
    • 3543144715 scopus 로고    scopus 로고
    • Comparison of the single-dose pharmacokinetics and tolerability of modafinil and dextroamphetamine administered alone or in combination in healthy male volunteers
    • Wong YN, Wang L, Hartman L, et al. Comparison of the single-dose pharmacokinetics and tolerability of modafinil and dextroamphetamine administered alone or in combination in healthy male volunteers. J Clin Pharmacol 1998; 38: 971-8
    • (1998) J Clin Pharmacol , vol.38 , pp. 971-978
    • Wong, Y.N.1    Wang, L.2    Hartman, L.3
  • 27
    • 0034916291 scopus 로고    scopus 로고
    • Steady-state pharmacokinetics and tolerability of modafinil given alone or in combination with methylphenidate in healthy volunteers
    • Hellriegel ET, Arora S, Nelson M, et al. Steady-state pharmacokinetics and tolerability of modafinil given alone or in combination with methylphenidate in healthy volunteers. J Clin Pharmacol 2001; 41: 895-904
    • (2001) J Clin Pharmacol , vol.41 , pp. 895-904
    • Hellriegel, E.T.1    Arora, S.2    Nelson, M.3
  • 28
    • 0036210247 scopus 로고    scopus 로고
    • Steady-state pharmacokinetics and tolerability of modafinil administered alone or in combination with dextroamphetamine in healthy volunteers
    • Hellriegel ET, Arora S, Nelson M, et al. Steady-state pharmacokinetics and tolerability of modafinil administered alone or in combination with dextroamphetamine in healthy volunteers. J Clin Pharmacol 2002; 42: 450-60
    • (2002) J Clin Pharmacol , vol.42 , pp. 450-460
    • Hellriegel, E.T.1    Arora, S.2    Nelson, M.3
  • 29
    • 0036157193 scopus 로고    scopus 로고
    • Effect of modafinil at steady state on the single-dose pharmacokinetic profile of warfarin in healthy volunteers
    • Robertson P, Hellriegel ET, Arora S, et al. Effect of modafinil at steady state on the single-dose pharmacokinetic profile of warfarin in healthy volunteers. J Clin Pharmacol 2002; 42: 205-14
    • (2002) J Clin Pharmacol , vol.42 , pp. 205-214
    • Robertson, P.1    Hellriegel, E.T.2    Arora, S.3
  • 30
    • 0036161693 scopus 로고    scopus 로고
    • Effect of modafinil on the pharmacokinetics of ethinyl estradiol and triazolam in healthy volunteers
    • Robertson P, Hellriegel ET, Arora S, et al. Effect of modafinil on the pharmacokinetics of ethinyl estradiol and triazolam in healthy volunteers. Clin Pharmacol Ther 2002; 71: 46-56
    • (2002) Clin Pharmacol Ther , vol.71 , pp. 46-56
    • Robertson, P.1    Hellriegel, E.T.2    Arora, S.3
  • 32
    • 0022197022 scopus 로고
    • Aging and drug disposition: An update
    • Schmucker DL. Aging and drug disposition: an update. Pharmacol Rev 1985; 37: 133-48
    • (1985) Pharmacol Rev , vol.37 , pp. 133-148
    • Schmucker, D.L.1
  • 33
    • 0034048206 scopus 로고    scopus 로고
    • In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil
    • Robertson P, DeCory HH, Madan A, et al. In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil. Drug Metab Dispos 2000; 28: 664-71
    • (2000) Drug Metab Dispos , vol.28 , pp. 664-671
    • Robertson, P.1    DeCory, H.H.2    Madan, A.3
  • 34
    • 0031589905 scopus 로고    scopus 로고
    • Gelineau syndrome in a patient with renal transplantation: Evidence of cyclosporine-modafinil interaction
    • Le Cacheux P, Charasse C, Mourtada R, et al. Gelineau syndrome in a patient with renal transplantation: evidence of cyclosporine-modafinil interaction [letter]. Presse Med 1997; 26: 466
    • (1997) Presse Med , vol.26 , pp. 466
    • Le Cacheux, P.1    Charasse, C.2    Mourtada, R.3
  • 35
    • 19244386201 scopus 로고    scopus 로고
    • Interaction of modafinil and clomipramine as comedication in a narcoleptic patient
    • Grözinger M, Hartter S, Hiemke C, et al. Interaction of modafinil and clomipramine as comedication in a narcoleptic patient. Clin Neuropharmacol 1998; 21: 127-9
    • (1998) Clin Neuropharmacol , vol.21 , pp. 127-129
    • Grözinger, M.1    Hartter, S.2    Hiemke, C.3


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