Cell signalling in insulin secretion: The molecular targets of ATP, cAMP and sulfonylurea

Diabetologia

Volumn 55, Issue 8, 2012, Pages 2096-2108

  Seino, S ^a,b  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

ATP; CAMP; Epac; Incretin; Insulin secretion; Katp channel; Review; Sulfonylurea

Indexed keywords

ACETOHEXAMIDE; ADENOSINE TRIPHOSPHATE; CHLORPROPAMIDE; CYCLIC AMP; DIPEPTIDYL PEPTIDASE IV INHIBITOR; EXOCYST COMPLEX COMPONENT 3 LIKE PROTEIN; GLIBENCLAMIDE; GLICLAZIDE; GLIPIZIDE; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; GLUCOSE; INCRETIN; INSULIN; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.1; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; ISOPROTEIN; PROTEIN EPAC2A; RAP1 PROTEIN; SULFONYLUREA; TOLBUTAMIDE; TRANSIENT RECEPTOR POTENTIAL CHANNEL; UNCLASSIFIED DRUG;

CELL FUNCTION; CELLULAR DISTRIBUTION; DIABETES MELLITUS; DRUG ACTIVITY; EPAC1 GENE; EPAC2 GENE; EXOCYTOSIS; GENE; GLUCOSE INDUCED INSULIN SECRETION; INSULIN RELEASE; MICROSCOPY; MOLECULAR DYNAMICS; NONHUMAN; PANCREAS ISLET BETA CELL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; REVIEW; SIGNAL TRANSDUCTION; TOTAL INTERNAL REFLECTION FLUORESCENCE MICROSCOPY;

ADENOSINE TRIPHOSPHATE; BLOOD GLUCOSE; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DIABETES MELLITUS, TYPE 2; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; EXOCYTOSIS; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; INCRETINS; INSULIN; INSULIN-SECRETING CELLS; MALE; RECEPTORS, GLUCAGON; SIGNAL TRANSDUCTION; SULFONYLUREA COMPOUNDS;

EID: 84866370709     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2562-9     Document Type: Review

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