High-resolution metabolic profiling towards G protein-coupled receptors: Rapid and comprehensive screening of histamine H4 receptor ligands

Journal of Chromatography A

Volumn 1259, Issue , 2012, Pages 213-220

  Kool, J ^a   Rudebeck, A F ^a   Fleurbaaij, F ^a   Nijmeijer, S ^a   Falck, D ^a   Smits, R A ^b   Vischer, H F ^a   Leurs, R ^a   Niessen, W M A ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b Griffin Discoveries BV   (Netherlands)

Author keywords

Accurate mass; Comprehensive metabolic profiling; G protein coupled receptor; High resolution fractionation; MS MS; Selectivity

Indexed keywords

ACCURATE-MASS; G PROTEIN COUPLED RECEPTORS; HIGH RESOLUTION; METABOLIC PROFILING; MS/MS;

CATALYST SELECTIVITY; CYTOLOGY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LEAD COMPOUNDS; METABOLITES;

METABOLISM;

CLOZAPINE; G PROTEIN COUPLED RECEPTOR; HISTAMINE H4 RECEPTOR; QUINAZOLINE DERIVATIVE; QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG; VUF 10148; VUF 10519; VUF 11488;

ARTICLE; CONTROLLED STUDY; CYTOLOGY; DRUG DETERMINATION; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; FRACTIONATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LIGAND BINDING; MICROTITER PLATE ASSAY; PRIORITY JOURNAL; PROCESS OPTIMIZATION; STRUCTURE ANALYSIS; TANDEM MASS SPECTROMETRY;

CELL LINE, TUMOR; CELL MEMBRANE; CHROMATOGRAPHY, LIQUID; CLOZAPINE; DRUG DISCOVERY; HEK293 CELLS; HISTAMINE; HUMANS; LIGANDS; PIPERAZINES; QUINAZOLINONES; RADIOLIGAND ASSAY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE; TANDEM MASS SPECTROMETRY;

EID: 84866322550     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2012.03.052     Document Type: Article

References (30)

1. Kool J., Lingeman H., Niessen W., Irth H. Comb. Chem. High Throughput Screen. 2010, 13:548.
2. Mishra K.P., Ganju L., Sairam M., Banerjee P.K., Sawhney R.C. Biomed. Pharmacother. 2008, 62:94.
3. Bender A., Bojanic D., Davies J.W., Crisman T.J., Mikhailov D., Scheiber J., Jenkins J.L., Deng Z., Hill W.A., Popov M., Jacoby E., Glick M. Curr. Opin. Drug Discov. Devel. 2008, 11:327.
4. Lam K.S. Trends Microbiol. 2007, 15:279.
5. Liu S., Yi L.Z., Liang Y.Z. J. Sep. Sci. 2008, 31:2113.
6. Brack W., Klamer H.J., Lopez de Alda M., Barcelo D. Environ. Sci. Pollut. Res. Int. 2007, 14:30.
7. Kool J., Giera M., Irth H., Niessen W.M. Anal. Bioanal. Chem. 2011, 399:2655.
8. Falck D., de Vlieger J.S., Niessen W.M., Kool J., Honing M., Giera M., Irth H. Anal. Bioanal. Chem. 2010, 398:1771.
9. Marques L.A., Kool J., de Kanter F., Lingeman H., Niessen W., Irth H. J. Pharm. Biomed. Anal. 2010, 53:609.
10. Giera M., Heus F., Janssen L., Kool J., Lingeman H., Irth H. Anal. Chem. 2009, 81:5460.
11. Kool J., de Kloe G., Denker A.D., van Altena K., Smoluch M., van Iperen D., Nahar T.T., Limburg R.J., Niessen W.M., Lingeman H., Leurs R., de Esch I.J., Smit A.B., Irth H. Anal. Chem. 2011, 83:125.
12. Kool J., Heus F., de Kloe G., Lingeman H., Smit A.B., Leurs R., Edink E., De Esch I.J., Irth H., Niessen W.M. J. Biomol. Screen. 2011, 16:917.
13. Giera M., de Vlieger J.S., Lingeman H., Irth H., Niessen W.M. Rapid Commun. Mass Spectrom. 2010, 24:1439.
14. Lappano R., Maggiolini M. Nat. Rev. Drug Discov. 2011, 10:47.
15. Ballesteros J., Palczewski K. Curr. Opin. Drug Discov. Devel. 2001, 4:561.
16. Bhatt H.G., Agrawal Y.K., Raval H.G., Manna K., Desai P.R. Mini Rev. Med. Chem. 2010, 10:1293.
17. Huang J.F., Thurmond R.L. Curr. Allergy Asthma Rep. 2008, 8:21.
18. Leurs R., Vischer H.F., Wijtmans M., de Esch I.J. Trends Pharmacol. Sci. 2011, 32:250.
19. Asha S., Vidyavathi M. Appl. Biochem. Biotechnol. 2010, 160:1699.
20. S. Nijmeijer, A.F. Rudebeck, F. Fleurbaaij, R. Leurs, W.M.A. Niessen, H.F. Vischer, J. Kool, submitted for publication.
21. Smits R.A., Lim H.D., Hanzer A., Zuiderveld O.P., Guaita E., Adami M., Coruzzi G., Leurs R., de Esch I.J. J. Med. Chem. 2008, 51:2457.
22. Smits R.A., Adami M., Istyastono E.P., Zuiderveld O.P., van Dam C.M., de Kanter F.J., Jongejan A., Coruzzi G., Leurs R., de Esch I.J. J. Med. Chem. 2010, 53:2390.
23. R.A. Smits, H.D. Lim, T. van der Meer, G. Coruzzi, M. Adami, W. Baumer, K. Rossbach, I.J. de Esch, R. Leurs, submitted for publication.
24. Istyastono E.P., Nijmeijer S., Lim H.D., van de Stolpe A., Roumen L., Kooistra A.J., Vischer H.F., de Esch I.J., Leurs R., de Graaf C. J. Med. Chem. 2011, 54:8136.
25. Wijtmans M., de Graaf C., de Kloe G., Istyastono E.P., Smit J., Lim H., Boonnak R., Nijmeijer S., Smits R.A., Jongejan A., Zuiderveld O., de Esch I.J., Leurs R. J. Med. Chem. 2011, 54:1693.
26. Liu C., Ma X., Jiang X., Wilson S.J., Hofstra C.L., Blevitt J., Pyati J., Li X., Chai W., Carruthers N., Lovenberg T.W. Mol. Pharmacol. 2001, 59:420.
27. Reinen J., Kool J., Vermeulen N.P. Anal. Bioanal. Chem. 2008, 390:1987.
28. Lim H.D., van Rijn R.M., Ling P., Bakker R.A., Thurmond R.L., Leurs R. J. Pharmacol. Exp. Ther. 2005, 314:1310.
29. Kool J., de Kloe G.E., Bruyneel B., de Vlieger J.S., Retra K., Wijtmans M., van Elk R., Smit A.B., Leurs R., Lingeman H., de Esch I.J., Irth H. J. Med. Chem. 2010, 53:4720.
30. Kerns E.H., Rourick R.A., Volk K.J., Lee M.S. J. Chromatogr. B 1997, 698:133.