Synthesis and QSAR of Quinazoline Sulfonamides As Highly Potent Human Histamine H4 Receptor Inverse Agonists

Journal of Medicinal Chemistry

Volumn 53, Issue 6, 2010, Pages 2390-2400

  Smits, Rogier A ^a   Adami, Maristella ^b   Istyastono, Enade P ^a   Zuiderveld, Obbe P ^a   Van Dam, Cindy M E ^a   De Kanter, Frans J J ^a   Jongejan, Aldo ^a   Coruzzi, Gabriella ^b   Leurs, Rob ^a   De Esch, Iwan J P ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b UNIVERSITY OF PARMA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 (6 CHLORO 2 (4 METHYLPIPERAZIN 1 YL)QUINAZOLINE 4 AMINO) N PHENYLETHANESULFONAMIDE; 2 (6 CHLORO 2 (4 METHYLPIPERAZIN 1 YL)QUINAZOLINE 4 AMINO) N,N DIMETHYLETHANESULFONAMIDE; 2 AMINOETHANESULFONAMIDE; 2 PHTHALIMIDOETHANE N METHYLSULFONAMIDE; 2 PHTHALIMIDOETHANE N PHENYLSULFONAMIDE; 2 PHTHALIMIDOETHANESULFONAMIDE; 2,4,6,7 TETRACHLOROQUINAZOLINE; 3 [6 CHLORO 2 (4 METHYLPIPERAZIN 1 YL)QUINAZOLINE 4 AMINO] N METHYLPROPANESULFONAMIDE; 6,7 DICHLOROQUINAZOLIN 2,4(1H,3H)DIONE; HISTAMINE H4 RECEPTOR; QUINAZOLINE DERIVATIVE; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; DRUG PROTEIN BINDING; DRUG SYNTHESIS; HUMAN; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BINDING, COMPETITIVE; CARRAGEENAN; EDEMA; HUMANS; KINETICS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; QUINAZOLINES; RATS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE; SULFONAMIDES;

EID: 77949816697     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm901379s     Document Type: Article

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