Triazole ligands reveal distinct molecular features that induce histaine H4 receptor affinity and subtly govern H4/H3 subtype selectivity

Journal of Medicinal Chemistry

Volumn 54, Issue 6, 2011, Pages 1693-1703

  Wijtmans, Maikel ^a   De Graaf, Chris ^a   De Kloe, Gerdien ^a   Istyastono, Enade P ^a   Smit, Judith ^a   Lim, Herman ^a   Boonnak, Ratchanok ^a   Nijmeijer, Saskia ^a   Smits, Rogier A ^a   Jongejan, Aldo ^a   Zuiderveld, Obbe ^a   De Esch, Iwan J P ^a   Leurs, Rob ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

1 [3 (1H IMIDAZOL 4 YL)PROPYL] 4 (CYCLOHEXYLMETHYL) 1H 1,2,3 TRIAZOLE; 1 [3 (1H IMIDAZOL 4 YL)PROPYL] 4 (CYCLOPENTYLMETHYL) 1H 1,2,3 TRIAZOLE; 1,2,3 TRIAZOLE DERIVATIVE; HISTAMINE; HISTAMINE H3 RECEPTOR; HISTAMINE H4 RECEPTOR; THIOPERAMIDE; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ALKYNES; AZIDES; CLICK CHEMISTRY; HEK293 CELLS; HUMANS; IMIDAZOLES; LIGANDS; MODELS, MOLECULAR; RADIOLIGAND ASSAY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE; RECEPTORS, HISTAMINE H3; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 79952812346     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1013488     Document Type: Article

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