Coordinate regulation of TPL-2 and NF-κB signaling in macrophages by NF-κB1 p105

Molecular and Cellular Biology

Volumn 32, Issue 17, 2012, Pages 3438-3451

  Yang, Huei Ting ^a   Papoutsopoulou, Stamatia ^a   Belich, Monica ^a,b   Brender, Christine ^a,c   Janzen, Julia ^a   Gantke, Thorsten ^a   Handley, Matt ^a,d   Ley, Steven C ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c NOVO NORDISK A S   (Denmark)

^d Venner Shipley LLP   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; CYSTINE; FLAGELLIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12P35; INTERLEUKIN 12P40; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; LYSINE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; NUCLEAR FACTOR KAPPA B1; PROTEIN; PROTEIN P105; PROTEIN SERINE THREONINE KINASE; PROTEIN TUMOR PROGRESSION LOCUS 2; RESIQUIMOD; SERINE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CPG ISLAND; ENZYME ACTIVATION; GENE TRANSLOCATION; INNATE IMMUNITY; INTRACELLULAR SIGNALING; MACROPHAGE; MOUSE; MUTATION; NEGATIVE FEEDBACK; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION;

AMINO ACID SUBSTITUTION; ANIMALS; CELLS, CULTURED; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; I-KAPPA B KINASE; INTERLEUKIN-12 SUBUNIT P35; INTERLEUKIN-12 SUBUNIT P40; LIPOPOLYSACCHARIDES; MACROPHAGES; MAP KINASE KINASE KINASES; MICE; NF-KAPPA B; NF-KAPPA B P50 SUBUNIT; PROTO-ONCOGENE PROTEINS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTORS;

MUS;

EID: 84866299927     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.00564-12     Document Type: Article

References (47)

1. Aoki M, et al. 1993. The human cot proto-oncogene encodes two protein serine/threonine kinases with different transforming activities by alternative initiation of translation. J. Biol. Chem. 268:22723-22732.
2. Babu GR, et al. 2006. Phosphorylation of NF-κB1/p105 by oncoprotein kinase Tpl2: implications for a novel mechanism of Tpl2 regulation. Biochim. Biophys. Acta 1763:174-181.
3. Banerjee A, et al. 2008. NF-κB1 and c-Rel cooperate to promote the survival of TLR4-activated B cells by neutralizing Bim via distinct mechanisms. Blood 112:5063-5073.
4. Beinke S, et al. 2003. NF-κB p105 negatively regulates TPL-2 MEK kinase activity. Mol. Cell. Biol. 23:4739-4752.
5. Beinke S, Ley SC. 2004. Functions of NF-κB1 and NF-κB2 in immune cell biology. Biochem. J. 382:393-409.
6. Beinke S, et al. 2004. Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IκB kinase-induced proteolysis of NF-κB1 p105. Mol. Cell. Biol. 24:9658-9667.
7. Belich MP, Salmeron A, Johnston LH, Ley SC. 1999. TPL-2 kinase regulates the proteolysis of the NF-κB inhibitory protein NF-κB1 p105. Nature 397:363-368.
8. Ceci JD, et al. 1997. TPL-2 is an oncogenic kinase that is activated by carboxy-terminal truncation. Gene Dev. 11:688-700.
9. β-TrCP-independent processing. Mol. Cell. Biol. 24: 475-486.
10. Dumitru CD, et al. 2000. TNFα induction by LPS is regulated posttranscriptionally via a TPL2/ERK-dependent pathway. Cell 103:1071-1083.
11. Eliopoulos AG, Dumitru CD, Wang C-C, Cho J, Tsichlis PN. 2002. Induction of COX-2 by LPS in macrophages is regulated by TPL2-dependent CREB activation signals. EMBO J. 21:4831-4840.
12. Eliopoulos AG, Wang C-C, Dumitru CD, Tsichlis PN. 2003. TPL-2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40. EMBO J. 22:3855-3864.
13. Gantke T, Sriskantharajah S, Ley SC. 2011. Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase. Cell Res. 21: 131-145.
14. Gantke T, Sriskantharajah S, Sadowski M, Ley SC. 2012. IκB kinase regulation of the TPL-2/ERK MAPK pathway. Immunol. Rev. 246:168-182.
15. George D, Salmeron A. 2009. Cot/TPL-2 protein kinase as a target for the treatment of inflammatory disease. Curr. Top. Med. Chem. 9:611-622.
16. Ghosh S, May MJ, Kopp EB. 1998. NF-κB and Rel proteins: evolutionary conserved mediators of immune responses. Annu. Rev. Immunol. 16: 225-260.
17. Heissmeyer V, Krappmann D, Hatada EN, Scheidereit C. 2001. Shared pathways of IκB kinase-induced SCFβTrCP-mediated ubiquitination and degradation for the NF-κB precursor p105 and IκBα. Mol. Cell. Biol. 21:1024-1035.
18. Heissmeyer V, Krappmann D, Wulczyn FG, Scheidereit C. 1999. NF-κB p105 is a target on IκB kinases and controls signal induction of BCL-3-p50 complexes. EMBO J. 18:4766-4788.
19. Ishikawa H, et al. 1998. Chronic inflammation and susceptibility to bacterial infections in mice lacking the polypeptide (p)105 precursor (NF-κB1) but expressing p50. J. Exp. Med. 187:985-996.
20. Kabouridis PS, Magee AI, Ley SC. 1997. S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes. EMBO J. 16:4983-4998.
21. Kaiser F, et al. 2009. TPL-2 negatively regulates interferon-beta production in macrophages and myeloid dendritic cells. J. Exp. Med. 206:1863-1871.
22. Karin M, Ben-Neriah Y. 2000. Phosphorylation meets ubiquitination: the control of NF-κB activity. Annu. Rev. Immunol. 18:621-663.
23. Kawai T, Akira S. 2010. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat. Immunol. 11:373-384.
24. Kollet JI, Petro TM. 2006. IRF-1 and NF-κB p50/cRel bind to distinct regions of the proximal murine IL-12 p35 promoter during costimulation with IFN-γ and LPS. Mol. Immunol. 43:623-633.
25. Kravtsova-Ivantsiv Y, Cohen S, Ciechanover A. 2009. Modification by single ubiquitin moieties rather than polyubiquitination is sufficient for proteasomal processing of the p105 NF-κB precursor. Mol. Cell 33:496-504.
26. Lang V, et al. 2003. βTrCP-mediated proteolysis of NF-κB1 p105 requires phosphorylation of p105 serines 927 and 932. Mol. Cell. Biol. 23: 402-413.
27. Lang V, et al. 2004. ABIN-2 forms a ternary complex with TPL-2 and NF-κB1 p105 and is essential for TPL-2 protein stability. Mol. Cell. Biol. 24:5235-5248.
28. Medzhitov R, Horng T. 2009. Transcriptional control of the inflammatory response. Nat. Rev. Immunol. 9:692-703.
29. Mielke LA, et al. 2009. Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 production. J. Immunol. 183:7984-7993.
30. βTrCP ubiquitin ligase-mediated processing of NF-κB p105 requires phosphorylation of its C-terminus by IκB kinase. EMBO J. 19:2580-2591.
31. Papoutsopoulou S, et al. 2006. ABIN-2 is required for optimal activation of the TPL-2/ERK MAP kinase pathway in innate immune responses. Nat. Immunol. 7:606-615.
32. Robinson MJ, Beinke S, Kouroumalis A, Tsichlis PN, Ley SC. 2007. Phosphorylation of TPL-2 on serine 400 is essential for lipopolysaccharide activation of extracellular signal-regulated kinase in macrophages. Mol. Cell. Biol. 27:7355-7364.
33. Rousseau S, et al. 2008. TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF alpha in LPS-stimulated macrophages. J. Cell Sci. 121:149-154.
34. Salmeron A, et al. 1996. Activation of MEK-1 and SEK-1 by Tpl-2 protooncoprotein, a novel MAP kinase kinase kinase. EMBO J. 15:817-826.
35. Salmeron A, et al. 2001. Direct phosphorylation of NF-κB p105 by the IκB kinase complex on serine 927 is essential for signal-induced p105 proteolysis. J. Biol. Chem. 276:22215-22222.
36. Sanjabi S, Hoffmann A, Liou H-C, Baltimore D, Smale ST. 2000. Selective requirement for c-Rel during IL-12 p40 gene induction in macrophages. Proc. Natl. Acad. Sci. U. S. A. 97:12705-12710.
37. Savinova OV, Hoffmann A, Ghosh G. 2009. The Nfkb1 and Nfkb2 proteins p105 and p100 function as the core of high-molecular-weight heterogeneous complexes. Mol. Cell 34:591-602.
38. Sha WC, Lious H-C, Tuomanen EI, Baltimore D. 1995. Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses. Cell 80:321-330.
39. Smale ST. 2010. Selective transcription in response to an inflammatory stimulus. Cell 140:833-844.
40. Sriskantharajah S, et al. 2009. Proteolysis of NF-kB1 p105 is essential for T cell antigen receptor-induced proliferation. Nat. Immunol. 10:38-47.
41. Trinchieri G. 2003. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3:133-146.
42. Vallabhapurapu S, Karin M. 2009. Regulation and function of NF-κB transcription factors in the immune system. Annu. Rev. Immunol. 27: 693-733.
43. Verstrepen L, Carpentier I, Verhelst K, Beyaert R. 2009. ABINs: A20 binding inhibitors of NF-κB and apoptosis signaling. Biochem. Pharm. 78:105-114.
44. Warren MK, Vogel SN. 1985. Bone marrow-derived macrophages: development and regulation of differentiation markers by colonystimulating factor and interferons. J. Immunol. 134:982-989.
45. Waterfield M, Jin W, Reiley W, Zhang MY, Sun S-C. 2004. IKκ kinase is an essential component of the TPL-2 signaling pathway. Mol. Cell. Biol. 24:6040-6048.
46. Waterfield MR, Zhang M, Norman LP, Sun S-C. 2003. NF-κB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the TPL-2 kinase. Mol. Cell 11:685-694.
47. Yamamoto M, et al. 2004. Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IκBξ. Nature 430:218-222.