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Volumn 11, Issue 17, 2012, Pages 3237-3249

MEK2 regulates ribonucleotide reductase activity through functional interaction with ribonucleotide reductase small subunit p53R2

Author keywords

DNA damage repair; Ionizing radiation; MEK2; p53R2; Ribonucleotide reductase

Indexed keywords

AMINO ACID; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; OXIDOREDUCTASE; RIBONUCLEOTIDE REDUCTASE; RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT P53R2; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

EID: 84866290837     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.21591     Document Type: Article
Times cited : (9)

References (42)
  • 1
    • 0035544604 scopus 로고    scopus 로고
    • Structure and function of the radical enzyme ribonucleotide reductase
    • PMID:11796141
    • Eklund H, Uhlin U, Färnegårdh M, Logan DT, Nordlund P. Structure and function of the radical enzyme ribonucleotide reductase. Prog Biophys Mol Biol 2001; 77:177-268; PMID:11796141; http://dx.doi.org/10.1016/ S0079-6107(01)00014-1
    • (2001) Prog Biophys Mol Biol , vol.77 , pp. 177-268
    • Eklund, H.1    Uhlin, U.2    Färnegårdh, M.3    Logan, D.T.4    Nordlund, P.5
  • 2
    • 33746370368 scopus 로고    scopus 로고
    • Ribonucleotide reductases
    • PMID:16756507
    • Nordlund P, Reichard P. Ribonucleotide reductases. Annu Rev Biochem 2006; 75:681-706; PMID:16756507; http://dx.doi.org/10.1146/annurev.biochem.75.103004. 142443
    • (2006) Annu Rev Biochem , vol.75 , pp. 681-706
    • Nordlund, P.1    Reichard, P.2
  • 3
    • 0018337084 scopus 로고
    • Reduction of ribonucleotides
    • PMID:382982
    • Thelander L, Reichard P. Reduction of ribonucleotides. Annu Rev Biochem 1979; 48:133-58; PMID:382982; http://dx.doi.org/10.1146/annurev.bi.48.070179. 001025
    • (1979) Annu Rev Biochem , vol.48 , pp. 133-158
    • Thelander, L.1    Reichard, P.2
  • 4
    • 0034594978 scopus 로고    scopus 로고
    • A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage
    • PMID:10716435
    • Tanaka H, Arakawa H, Yamaguchi T, Shiraishi K, Fukuda S, Matsui K, et al. A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage. Nature 2000; 404:42-9; PMID:10716435; http://dx.doi.org/10.1038/35003506
    • (2000) Nature , vol.404 , pp. 42-49
    • Tanaka, H.1    Arakawa, H.2    Yamaguchi, T.3    Shiraishi, K.4    Fukuda, S.5    Matsui, K.6
  • 5
    • 0035890408 scopus 로고    scopus 로고
    • P53R2-dependent pathway for DNA synthesis in a p53-regulated cell cycle checkpoint
    • PMID:11719458
    • Yamaguchi T, Matsuda K, Sagiya Y, Iwadate M, Fujino MA, Nakamura Y, et al. p53R2-dependent pathway for DNA synthesis in a p53-regulated cell cycle checkpoint. Cancer Res 2001; 61:8256-62; PMID:11719458
    • (2001) Cancer Res , vol.61 , pp. 8256-8262
    • Yamaguchi, T.1    Matsuda, K.2    Sagiya, Y.3    Iwadate, M.4    Fujino, M.A.5    Nakamura, Y.6
  • 6
    • 0034738967 scopus 로고    scopus 로고
    • A ribonucleotide reductase gene is a transcriptional target of p53 and p73
    • PMID:10980602
    • Nakano K, Bálint E, Ashcroft M, Vousden KH. A ribonucleotide reductase gene is a transcriptional target of p53 and p73. Oncogene 2000; 19:4283-9; PMID:10980602; http://dx.doi.org/10.1038/sj.onc.1203774
    • (2000) Oncogene , vol.19 , pp. 4283-4289
    • Nakano, K.1    Bálint, E.2    Ashcroft, M.3    Vousden, K.H.4
  • 7
    • 0242317756 scopus 로고    scopus 로고
    • Mouse ribonucleotide reductase R2 protein: A new target for anaphase-promoting complex-Cdh1-mediated proteolysis
    • PMID:12655059
    • Chabes AL, Pfleger CM, Kirschner MW, Thelander L. Mouse ribonucleotide reductase R2 protein: a new target for anaphase-promoting complex-Cdh1-mediated proteolysis. Proc Natl Acad Sci USA 2003; 100:3925-9; PMID:12655059; http://dx.doi.org/10.1073/pnas.0330774100
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 3925-3929
    • Chabes, A.L.1    Pfleger, C.M.2    Kirschner, M.W.3    Thelander, L.4
  • 8
    • 34248583886 scopus 로고    scopus 로고
    • MAP kinase signalling pathways in cancer
    • PMID:17496922
    • Dhillon AS, Hagan S, Rath O, Kolch W. MAP kinase signalling pathways in cancer. Oncogene 2007; 26:3279-90; PMID:17496922; http://dx.doi.org/10.1038/sj. onc.1210421
    • (2007) Oncogene , vol.26 , pp. 3279-3290
    • Dhillon, A.S.1    Hagan, S.2    Rath, O.3    Kolch, W.4
  • 9
    • 0033613944 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase kinase 2 activation is essential for progression through the G2/M checkpoint arrest in cells exposed to ionizing radiation
    • PMID:9915804
    • Abbott DW, Holt JT. Mitogen-activated protein kinase kinase 2 activation is essential for progression through the G2/M checkpoint arrest in cells exposed to ionizing radiation. J Biol Chem 1999; 274:2732-42; PMID:9915804; http://dx.doi.org/10.1074/jbc.274.5.2732
    • (1999) J Biol Chem , vol.274 , pp. 2732-2742
    • Abbott, D.W.1    Holt, J.T.2
  • 10
    • 0034526814 scopus 로고    scopus 로고
    • Cisplatin-induced response of c-jun N-terminal kinase 1 and extracellular signal-regulated protein kinases 1 and 2 in a series of cisplatinresistant ovarian carcinoma cell lines
    • PMID:11170260
    • Cui W, Yazlovitskaya EM, Mayo MS, Pelling JC, Persons DL. Cisplatin-induced response of c-jun N-terminal kinase 1 and extracellular signal-regulated protein kinases 1 and 2 in a series of cisplatinresistant ovarian carcinoma cell lines. Mol Carcinog 2000; 29:219-28; PMID:11170260; http://dx.doi.org/10.1002/1098-2744(200012)29:4〈219::AIDMC1004〉3.0. CO;2-D
    • (2000) Mol Carcinog , vol.29 , pp. 219-228
    • Cui, W.1    Yazlovitskaya, E.M.2    Mayo, M.S.3    Pelling, J.C.4    Persons, D.L.5
  • 11
    • 0033625759 scopus 로고    scopus 로고
    • Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest
    • PMID:10848581
    • Wang X, McGowan CH, Zhao M, He L, Downey JS, Fearns C, et al. Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest. Mol Cell Biol 2000; 20:4543-52; PMID:10848581; http://dx.doi.org/10.1128/MCB.20.13. 4543-4552.2000
    • (2000) Mol Cell Biol , vol.20 , pp. 4543-4552
    • Wang, X.1    McGowan, C.H.2    Zhao, M.3    He, L.4    Downey, J.S.5    Fearns, C.6
  • 12
    • 34447537796 scopus 로고    scopus 로고
    • Irradiation-induced G2/M checkpoint response requires ERK1/2 activation
    • PMID:17297454
    • Yan Y, Black CP, Cowan KH. Irradiation-induced G2/M checkpoint response requires ERK1/2 activation. Oncogene 2007; 26:4689-98; PMID:17297454; http://dx.doi.org/10.1038/sj.onc.1210268
    • (2007) Oncogene , vol.26 , pp. 4689-4698
    • Yan, Y.1    Black, C.P.2    Cowan, K.H.3
  • 13
    • 48549098149 scopus 로고    scopus 로고
    • Gamma-irradiation-induced DNA damage checkpoint activation involves feedback regulation between extracellular signal-regulated kinase 1/2 and BRCA1
    • PMID:18593910
    • Yan Y, Black CP, Cao PT, Haferbier JL, Kolb RH, Spieker RS, et al. Gamma-irradiation-induced DNA damage checkpoint activation involves feedback regulation between extracellular signal-regulated kinase 1/2 and BRCA1. Cancer Res 2008; 68:5113-21; PMID:18593910; http://dx.doi.org/10.1158/0008-5472.CAN-07- 5818
    • (2008) Cancer Res , vol.68 , pp. 5113-5121
    • Yan, Y.1    Black, C.P.2    Cao, P.T.3    Haferbier, J.L.4    Kolb, R.H.5    Spieker, R.S.6
  • 14
    • 0032575135 scopus 로고    scopus 로고
    • Inhibition of the mitogen activated protein (MAP) kinase cascade potentiates cell killing by low dose ionizing radiation in A431 human squamous carcinoma cells
    • PMID:9652746
    • Carter S, Auer KL, Reardon DB, Birrer M, Fisher PB, Valerie K, et al. Inhibition of the mitogen activated protein (MAP) kinase cascade potentiates cell killing by low dose ionizing radiation in A431 human squamous carcinoma cells. Oncogene 1998; 16:2787-96; PMID:9652746; http://dx.doi.org/10.1038/sj. onc.1201802
    • (1998) Oncogene , vol.16 , pp. 2787-2796
    • Carter, S.1    Auer, K.L.2    Reardon, D.B.3    Birrer, M.4    Fisher, P.B.5    Valerie, K.6
  • 15
    • 0033613250 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase kinase activity is required for the G(2)/M transition of the cell cycle in mammalian fibroblasts
    • PMID:10500177
    • Wright JH, Munar E, Jameson DR, Andreassen PR, Margolis RL, Seger R, et al. Mitogen-activated protein kinase kinase activity is required for the G(2)/M transition of the cell cycle in mammalian fibroblasts. Proc Natl Acad Sci USA 1999; 96:11335-40; PMID:10500177; http://dx.doi.org/10.1073/pnas.96.20.11335
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 11335-11340
    • Wright, J.H.1    Munar, E.2    Jameson, D.R.3    Andreassen, P.R.4    Margolis, R.L.5    Seger, R.6
  • 16
    • 77953577584 scopus 로고    scopus 로고
    • The Raf/MEK/ERK pathway can govern drug resistance, apoptosis and sensitivity to targeted therapy
    • PMID:20436278
    • Abrams SL, Steelman LS, Shelton JG, Wong EW, Chappell WH, Bäsecke J, et al. The Raf/MEK/ERK pathway can govern drug resistance, apoptosis and sensitivity to targeted therapy. Cell Cycle 2010; 9:1781-91; PMID:20436278; http://dx.doi.org/10.4161/cc.9.9.11483
    • (2010) Cell Cycle , vol.9 , pp. 1781-1791
    • Abrams, S.L.1    Steelman, L.S.2    Shelton, J.G.3    Wong, E.W.4    Chappell, W.H.5    Bäsecke, J.6
  • 17
    • 77953598922 scopus 로고    scopus 로고
    • Dominant roles of the Raf/ MEK/ERK pathway in cell cycle progression, prevention of apoptosis and sensitivity to chemotherapeutic drugs
    • PMID:20372086
    • Steelman LS, Abrams SL, Shelton JG, Chappell WH, Bäsecke J, Stivala F, et al. Dominant roles of the Raf/ MEK/ERK pathway in cell cycle progression, prevention of apoptosis and sensitivity to chemotherapeutic drugs. Cell Cycle 2010; 9:1629-38; PMID:20372086; http://dx.doi.org/10.4161/cc.9.8.11487
    • (2010) Cell Cycle , vol.9 , pp. 1629-1638
    • Steelman, L.S.1    Abrams, S.L.2    Shelton, J.G.3    Chappell, W.H.4    Bäsecke, J.5    Stivala, F.6
  • 18
    • 80052398902 scopus 로고    scopus 로고
    • Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells
    • PMID:21869603
    • Steelman LS, Navolanic P, Chappell WH, Abrams SL, Wong EW, Martelli AM, et al. Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells. Cell Cycle 2011; 10:3003-15; PMID:21869603; http://dx.doi.org/10.4161/cc.10.17.17119
    • (2011) Cell Cycle , vol.10 , pp. 3003-3015
    • Steelman, L.S.1    Navolanic, P.2    Chappell, W.H.3    Abrams, S.L.4    Wong, E.W.5    Martelli, A.M.6
  • 19
    • 33847066413 scopus 로고    scopus 로고
    • Extracellular signal-related kinase positively regulates ataxia telangiectasia mutated, homologous recombination repair, and the DNA damage response
    • PMID:17283137
    • Golding SE, Rosenberg E, Neill S, Dent P, Povirk LF, Valerie K. Extracellular signal-related kinase positively regulates ataxia telangiectasia mutated, homologous recombination repair, and the DNA damage response. Cancer Res 2007; 67:1046-53; PMID:17283137; http://dx.doi.org/10.1158/0008-5472.CAN-06- 2371
    • (2007) Cancer Res , vol.67 , pp. 1046-1053
    • Golding, S.E.1    Rosenberg, E.2    Neill, S.3    Dent, P.4    Povirk, L.F.5    Valerie, K.6
  • 20
    • 79851506488 scopus 로고    scopus 로고
    • ATM-dependent ERK signaling via AKT in response to DNA double-strand breaks
    • PMID:21263216
    • Khalil A, Morgan RN, Adams BR, Golding SE, Dever SM, Rosenberg E, et al. ATM-dependent ERK signaling via AKT in response to DNA double-strand breaks. Cell Cycle 2011; 10:481-91; PMID:21263216; http://dx.doi.org/10.4161/cc.10.3. 14713
    • (2011) Cell Cycle , vol.10 , pp. 481-491
    • Khalil, A.1    Morgan, R.N.2    Adams, B.R.3    Golding, S.E.4    Dever, S.M.5    Rosenberg, E.6
  • 21
    • 0037066686 scopus 로고    scopus 로고
    • ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53
    • PMID:11821415
    • Tang D, Wu D, Hirao A, Lahti JM, Liu L, Mazza B, et al. ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53. J Biol Chem 2002; 277:12710-7; PMID:11821415; http://dx.doi.org/10.1074/jbc. M111598200
    • (2002) J Biol Chem , vol.277 , pp. 12710-12717
    • Tang, D.1    Wu, D.2    Hirao, A.3    Lahti, J.M.4    Liu, L.5    Mazza, B.6
  • 22
    • 0035901496 scopus 로고    scopus 로고
    • P53 induction of heparin-binding EGF-like growth factor counteracts p53 growth suppression through activation of MAPK and PI3K/Akt signaling cascades
    • PMID:11296226
    • Fang L, Li G, Liu G, Lee SW, Aaronson SA. p53 induction of heparin-binding EGF-like growth factor counteracts p53 growth suppression through activation of MAPK and PI3K/Akt signaling cascades. EMBO J 2001; 20:1931-9; PMID:11296226; http://dx.doi.org/10.1093/emboj/20.8.1931
    • (2001) EMBO J , vol.20 , pp. 1931-1939
    • Fang, L.1    Li, G.2    Liu, G.3    Lee, S.W.4    Aaronson, S.A.5
  • 23
    • 0034682469 scopus 로고    scopus 로고
    • Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53
    • PMID:10890907
    • Lee SW, Fang L, Igarashi M, Ouchi T, Lu KP, Aaronson SA. Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53. Proc Natl Acad Sci USA 2000; 97:8302-5; PMID:10890907; http://dx.doi.org/10.1073/pnas.150024397
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 8302-8305
    • Lee, S.W.1    Fang, L.2    Igarashi, M.3    Ouchi, T.4    Lu, K.P.5    Aaronson, S.A.6
  • 24
    • 0035798630 scopus 로고    scopus 로고
    • Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells
    • PMID:11517226
    • Guittet O, Håkansson P, Voevodskaya N, Fridd S, Gräslund A, Arakawa H, et al. Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells. J Biol Chem 2001; 276:40647-51; PMID:11517226; http://dx.doi.org/10.1074/jbc.M106088200
    • (2001) J Biol Chem , vol.276 , pp. 40647-40651
    • Guittet, O.1    Håkansson, P.2    Voevodskaya, N.3    Fridd, S.4    Gräslund, A.5    Arakawa, H.6
  • 25
    • 0034594895 scopus 로고    scopus 로고
    • P53 sends nucleotides to repair DNA
    • PMID:10716425
    • Lozano G, Elledge SJ. p53 sends nucleotides to repair DNA. Nature 2000; 404:24-5; PMID:10716425; http://dx.doi.org/10.1038/35003670
    • (2000) Nature , vol.404 , pp. 24-25
    • Lozano, G.1    Elledge, S.J.2
  • 26
    • 31544442476 scopus 로고    scopus 로고
    • Transcriptional responses to ionizing radiation reveal that p53R2 protects against radiation-induced mutagenesis in human lymphoblastoid cells
    • PMID:16247478
    • Tsai MH, Chen X, Chandramouli GV, Chen Y, Yan H, Zhao S, et al. Transcriptional responses to ionizing radiation reveal that p53R2 protects against radiation-induced mutagenesis in human lymphoblastoid cells. Oncogene 2006; 25:622-32; PMID:16247478
    • (2006) Oncogene , vol.25 , pp. 622-632
    • Tsai, M.H.1    Chen, X.2    Chandramouli, G.V.3    Chen, Y.4    Yan, H.5    Zhao, S.6
  • 27
    • 33646359442 scopus 로고    scopus 로고
    • Regulation of mammalian ribonucleotide reduction and dNTP pools after DNA damage and in resting cells
    • PMID:16436374
    • Håkansson P, Hofer A, Thelander L. Regulation of mammalian ribonucleotide reduction and dNTP pools after DNA damage and in resting cells. J Biol Chem 2006; 281:7834-41; PMID:16436374; http://dx.doi.org/10.1074/jbc. M512894200
    • (2006) J Biol Chem , vol.281 , pp. 7834-7841
    • Håkansson, P.1    Hofer, A.2    Thelander, L.3
  • 28
    • 34548216886 scopus 로고    scopus 로고
    • Cell cycle- and ribonucleotide reductase-driven changes in mtDNA copy number influence mtDNA Inheritance without compromising mitochondrial gene expression
    • PMID:17721079
    • Lebedeva MA, Shadel GS. Cell cycle- and ribonucleotide reductase-driven changes in mtDNA copy number influence mtDNA Inheritance without compromising mitochondrial gene expression. Cell Cycle 2007; 6:2048-57; PMID:17721079; http://dx.doi.org/10.4161/cc.6.16.4572
    • (2007) Cell Cycle , vol.6 , pp. 2048-2057
    • Lebedeva, M.A.1    Shadel, G.S.2
  • 29
    • 34249811206 scopus 로고    scopus 로고
    • Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion
    • PMID:17486094
    • Bourdon A, Minai L, Serre V, Jais JP, Sarzi E, Aubert S, et al. Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion. Nat Genet 2007; 39:776-80; PMID:17486094; http://dx.doi.org/10.1038/ng2040
    • (2007) Nat Genet , vol.39 , pp. 776-780
    • Bourdon, A.1    Minai, L.2    Serre, V.3    Jais, J.P.4    Sarzi, E.5    Aubert, S.6
  • 30
    • 36749022214 scopus 로고    scopus 로고
    • The DNA damage response: Ten years after
    • PMID:18082599
    • Harper JW, Elledge SJ. The DNA damage response: ten years after. Mol Cell 2007; 28:739-45; PMID:18082599; http://dx.doi.org/10.1016/j.molcel.2007.11.015
    • (2007) Mol Cell , vol.28 , pp. 739-745
    • Harper, J.W.1    Elledge, S.J.2
  • 31
    • 33847737716 scopus 로고    scopus 로고
    • DNA damage checkpoints: From initiation to recovery or adaptation
    • PMID:17303408
    • Bartek J, Lukas J. DNA damage checkpoints: from initiation to recovery or adaptation. Curr Opin Cell Biol 2007; 19:238-45; PMID:17303408; http://dx.doi.org/10.1016/j.ceb.2007.02.009
    • (2007) Curr Opin Cell Biol , vol.19 , pp. 238-245
    • Bartek, J.1    Lukas, J.2
  • 32
    • 18844376884 scopus 로고    scopus 로고
    • BRCA1-mediated G2/M cell cycle arrest requires ERK1/2 kinase activation
    • PMID:15735702
    • Yan Y, Spieker RS, Kim M, Stoeger SM, Cowan KH. BRCA1-mediated G2/M cell cycle arrest requires ERK1/2 kinase activation. Oncogene 2005; 24:3285-96; PMID:15735702; http://dx.doi.org/10.1038/sj.onc.1208492
    • (2005) Oncogene , vol.24 , pp. 3285-3296
    • Yan, Y.1    Spieker, R.S.2    Kim, M.3    Stoeger, S.M.4    Cowan, K.H.5
  • 33
    • 0037423223 scopus 로고    scopus 로고
    • Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductase
    • PMID:12581528
    • Chabes A, Georgieva B, Domkin V, Zhao X, Rothstein R, Thelander L. Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductase. Cell 2003; 112:391-401; PMID:12581528; http://dx.doi.org/10.1016/S0092-8674(03)00075-8
    • (2003) Cell , vol.112 , pp. 391-401
    • Chabes, A.1    Georgieva, B.2    Domkin, V.3    Zhao, X.4    Rothstein, R.5    Thelander, L.6
  • 34
    • 17044378618 scopus 로고    scopus 로고
    • Ddb1 controls genome stability and meiosis in fission yeast
    • PMID:15805471
    • Holmberg C, Fleck O, Hansen HA, Liu C, Slaaby R, Carr AM, et al. Ddb1 controls genome stability and meiosis in fission yeast. Genes Dev 2005; 19:853-62; PMID:15805471; http://dx.doi.org/10.1101/gad.329905
    • (2005) Genes Dev , vol.19 , pp. 853-862
    • Holmberg, C.1    Fleck, O.2    Hansen, H.A.3    Liu, C.4    Slaaby, R.5    Carr, A.M.6
  • 35
    • 34848835736 scopus 로고    scopus 로고
    • Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis
    • PMID:17786248
    • Eaton JS, Lin ZP, Sartorelli AC, Bonawitz ND, Shadel GS. Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis. J Clin Invest 2007; 117:2723-34; PMID:17786248; http://dx.doi.org/10.1172/JCI31604
    • (2007) J Clin Invest , vol.117 , pp. 2723-2734
    • Eaton, J.S.1    Lin, Z.P.2    Sartorelli, A.C.3    Bonawitz, N.D.4    Shadel, G.S.5
  • 36
    • 47749107178 scopus 로고    scopus 로고
    • Essential role of Chk1 in S phase progression through regulation of RNR2 expression
    • PMID:18616928
    • Naruyama H, Shimada M, Niida H, Zineldeen DH, Hashimoto Y, Kohri K, et al. Essential role of Chk1 in S phase progression through regulation of RNR2 expression. Biochem Biophys Res Commun 2008; 374:79-83; PMID:18616928; http://dx.doi.org/10.1016/j.bbrc.2008.06.112
    • (2008) Biochem Biophys Res Commun , vol.374 , pp. 79-83
    • Naruyama, H.1    Shimada, M.2    Niida, H.3    Zineldeen, D.H.4    Hashimoto, Y.5    Kohri, K.6
  • 37
    • 67650531172 scopus 로고    scopus 로고
    • Implication of checkpoint kinase-dependent upregulation of ribonucleotide reductase R2 in DNA damage response
    • PMID:19416980
    • Zhang YW, Jones TL, Martin SE, Caplen NJ, Pommier Y. Implication of checkpoint kinase-dependent upregulation of ribonucleotide reductase R2 in DNA damage response. J Biol Chem 2009; 284:18085-95; PMID:19416980; http://dx.doi.org/10.1074/jbc.M109.003020
    • (2009) J Biol Chem , vol.284 , pp. 18085-18095
    • Zhang, Y.W.1    Jones, T.L.2    Martin, S.E.3    Caplen, N.J.4    Pommier, Y.5
  • 38
    • 0037374051 scopus 로고    scopus 로고
    • Wildtype p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits
    • PMID:12615712
    • Xue L, Zhou B, Liu X, Qiu W, Jin Z, Yen Y. Wildtype p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits. Cancer Res 2003; 63:980-6; PMID:12615712
    • (2003) Cancer Res , vol.63 , pp. 980-986
    • Xue, L.1    Zhou, B.2    Liu, X.3    Qiu, W.4    Jin, Z.5    Yen, Y.6
  • 39
    • 57449084374 scopus 로고    scopus 로고
    • ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage
    • PMID:19015526
    • Chang L, Zhou B, Hu S, Guo R, Liu X, Jones SN, et al. ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage. Proc Natl Acad Sci USA 2008; 105:18519-24; PMID:19015526; http://dx.doi.org/10.1073/pnas.0803313105
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 18519-18524
    • Chang, L.1    Zhou, B.2    Hu, S.3    Guo, R.4    Liu, X.5    Jones, S.N.6
  • 40
    • 53349151829 scopus 로고    scopus 로고
    • Dif1 is a DNA-damage-regulated facilitator of nuclear import for ribonucleotide reductase
    • PMID:18851834
    • Lee YD, Wang J, Stubbe J, Elledge SJ. Dif1 is a DNA-damage-regulated facilitator of nuclear import for ribonucleotide reductase. Mol Cell 2008; 32:70-80; PMID:18851834; http://dx.doi.org/10.1016/j.molcel.2008.08.018
    • (2008) Mol Cell , vol.32 , pp. 70-80
    • Lee, Y.D.1    Wang, J.2    Stubbe, J.3    Elledge, S.J.4
  • 41
    • 67349265769 scopus 로고    scopus 로고
    • Ribonucleotide reductase small subunit p53R2 suppresses MEK-ERK activity by binding to ERK kinase 2
    • PMID:19398949
    • Piao C, Jin M, Kim HB, Lee SM, Amatya PN, Hyun JW, et al. Ribonucleotide reductase small subunit p53R2 suppresses MEK-ERK activity by binding to ERK kinase 2. Oncogene 2009; 28:2173-84; PMID:19398949; http://dx.doi.org/10.1038/ onc.2009.84
    • (2009) Oncogene , vol.28 , pp. 2173-2184
    • Piao, C.1    Jin, M.2    Kim, H.B.3    Lee, S.M.4    Amatya, P.N.5    Hyun, J.W.6
  • 42
    • 0034885982 scopus 로고    scopus 로고
    • Thymidylate synthase (TS) and ribonucleotide reductase (RNR) may be involved in acquired resistance to 5-fluorouracil (5-FU) in human cancer xenografts in vivo
    • PMID:11527696
    • Fukushima M, Fujioka A, Uchida J, Nakagawa F, Takechi T. Thymidylate synthase (TS) and ribonucleotide reductase (RNR) may be involved in acquired resistance to 5-fluorouracil (5-FU) in human cancer xenografts in vivo. Eur J Cancer 2001; 37:1681-7; PMID:11527696; http://dx.doi.org/10.1016/S0959-8049(01) 00174-5
    • (2001) Eur J Cancer , vol.37 , pp. 1681-1687
    • Fukushima, M.1    Fujioka, A.2    Uchida, J.3    Nakagawa, F.4    Takechi, T.5


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