메뉴 건너뛰기




Volumn 28, Issue 21, 2009, Pages 2173-2184

Ribonucleotide reductase small subunit p53R2 suppresses MEK-ERK activity by binding to ERK kinase 2

Author keywords

ERK1 2; invasion; MEK2; P53R2; transformation

Indexed keywords

DEOXYRIBONUCLEOSIDE TRIPHOSPHATE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; PROTEIN P53; PROTEIN P53 SUBUNIT R2; RAS PROTEIN; RIBONUCLEOTIDE REDUCTASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

EID: 67349265769     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2009.84     Document Type: Article
Times cited : (30)

References (37)
  • 1
    • 10944251591 scopus 로고    scopus 로고
    • Repair and genetic consequences of endogenous DNA base damage in mammalian cells
    • Barnes DE, Lindahl T. (2004). Repair and genetic consequences of endogenous DNA base damage in mammalian cells. Annu Rev Genet 38: 445-476.
    • (2004) Annu Rev Genet , vol.38 , pp. 445-476
    • Barnes, D.E.1    Lindahl, T.2
  • 2
    • 10744222070 scopus 로고    scopus 로고
    • Adenovirus-mediated ribonucleotide reductase R1 gene therapy of human colon adenocarcinoma
    • Cao MY, Lee Y, FengNP, XiongK, Jin H, WangM et al. (2003). Adenovirus-mediated ribonucleotide reductase R1 gene therapy of human colon adenocarcinoma. Clin Cancer Res 9: 4553-4561.
    • (2003) Clin Cancer Res , vol.9 , pp. 4553-4561
    • Cao, M.Y.1    Lee, Y.2    Feng, N.P.3    Xiong, K.4    Jin, H.5    Wang, M.6
  • 3
    • 0242317756 scopus 로고    scopus 로고
    • Mouse ribonucleotide reductase R2 protein: A new target for anaphasepromotingcomplex- Cdh1-mediated proteolysis
    • Chabes AL, Pfleger CM, Kirschner MW, Thelander L. (2003). Mouse ribonucleotide reductase R2 protein: a new target for anaphasepromotingcomplex- Cdh1-mediated proteolysis. Proc Natl Acad Sci USA 100: 3925-3929.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 3925-3929
    • Chabes, A.L.1    Pfleger, C.M.2    Kirschner, M.W.3    Thelander, L.4
  • 4
    • 34447635228 scopus 로고    scopus 로고
    • Transgenic expression of human thymidylate synthase accelerates the development of hyperplasia and tumors in the endocrine pancreas
    • Chen M, Rahman L, Voeller D, Kastanos E, YangSX, Feigenbaum L et al. (2007). Transgenic expression of human thymidylate synthase accelerates the development of hyperplasia and tumors in the endocrine pancreas. Oncogene 26: 4817-4824.
    • (2007) Oncogene , vol.26 , pp. 4817-4824
    • Chen, M.1    Rahman, L.2    Voeller, D.3    Kastanos, E.4    Yang, S.X.5    Feigenbaum, L.6
  • 5
    • 51049105096 scopus 로고    scopus 로고
    • Impairment of the DNA repair and growth arrest pathways by p53R2 silencingenhances DNA damage-induced apoptosis in a p53-dependent manner in prostate cancer cells
    • Devlin HL, Mack PC, Burich RA, Gumerlock PH, KungHJ, Mudryj M et al. (2008). Impairment of the DNA repair and growth arrest pathways by p53R2 silencingenhances DNA damage-induced apoptosis in a p53-dependent manner in prostate cancer cells. Mol Cancer Res 6: 808-818.
    • (2008) Mol Cancer Res , vol.6 , pp. 808-818
    • Devlin, H.L.1    Mack, P.C.2    Burich, R.A.3    Gumerlock, P.H.4    Kung, H.J.5    Mudryj, M.6
  • 6
    • 34248583886 scopus 로고    scopus 로고
    • MAP kinase signalling pathways in cancer
    • Dhillon AS, Hagan S, Rath O, Kolch W. (2007). MAP kinase signalling pathways in cancer. Oncogene 26: 3279-3290.
    • (2007) Oncogene , vol.26 , pp. 3279-3290
    • Dhillon, A.S.1    Hagan, S.2    Rath, O.3    Kolch, W.4
  • 7
    • 0036086130 scopus 로고    scopus 로고
    • Free radicals in the physiological control of cell function
    • Droge W. (2002). Free radicals in the physiological control of cell function. Physiol Rev 82: 47-95.
    • (2002) Physiol Rev , vol.82 , pp. 47-95
    • Droge, W.1
  • 8
    • 0034759115 scopus 로고    scopus 로고
    • Regulation of MAP kinases by docking domains
    • Enslen H, Davis RJ. (2001). Regulation of MAP kinases by docking domains. Biol Cell 93: 5-14.
    • (2001) Biol Cell , vol.93 , pp. 5-14
    • Enslen, H.1    Davis, R.J.2
  • 9
    • 0030720867 scopus 로고    scopus 로고
    • The R1 component of mammalian ribonucleotide reductase has malignancy-suppressing activity as demonstrated by gene transfer experiments
    • Fan H, Huang A, Villegas C, Wright JA. (1997). The R1 component of mammalian ribonucleotide reductase has malignancy-suppressing activity as demonstrated by gene transfer experiments. Proc Natl Acad Sci USA 94: 13181-13186.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 13181-13186
    • Fan, H.1    Huang, A.2    Villegas, C.3    Wright, J.A.4
  • 10
    • 0032522647 scopus 로고    scopus 로고
    • The mammalian ribonucleotide reductase R2 component cooperates with a variety of oncogenes in mechanisms of cellular transformation
    • Fan H, Villegas C, Huang A, Wright JA. (1998). The mammalian ribonucleotide reductase R2 component cooperates with a variety of oncogenes in mechanisms of cellular transformation. Cancer Res 58: 1650-1653.
    • (1998) Cancer Res , vol.58 , pp. 1650-1653
    • Fan, H.1    Villegas, C.2    Huang, A.3    Wright, J.A.4
  • 11
    • 0030450403 scopus 로고    scopus 로고
    • Ribonucleotide reductase R2 component is a novel malignancy determinant that cooperates with activated oncogenes to determine transformation and malignant potential
    • Fan H, Villegas C, Wright JA. (1996). Ribonucleotide reductase R2 component is a novel malignancy determinant that cooperates with activated oncogenes to determine transformation and malignant potential. Proc Natl Acad Sci USA 93: 14036-14040.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 14036-14040
    • Fan, H.1    Villegas, C.2    Wright, J.A.3
  • 12
    • 33746164472 scopus 로고    scopus 로고
    • Suppression of lungtumor formation by the regulatory subunit of ribonucleotide reductase
    • Gautam A, Bepler G. (2006). Suppression of lungtumor formation by the regulatory subunit of ribonucleotide reductase. Cancer Res 66: 6497-6502.
    • (2006) Cancer Res , vol.66 , pp. 6497-6502
    • Gautam, A.1    Bepler, G.2
  • 13
    • 0038636459 scopus 로고    scopus 로고
    • RRM1-induced metastasis suppression through PTEN-regulated pathways
    • Gautam A, Li ZR, Bepler G. (2003). RRM1-induced metastasis suppression through PTEN-regulated pathways. Oncogene 22: 2135-2142.
    • (2003) Oncogene , vol.22 , pp. 2135-2142
    • Gautam, A.1    Li, Z.R.2    Bepler, G.3
  • 14
    • 33646359442 scopus 로고    scopus 로고
    • Regulation of mammalian ribonucleotide reduction and dNTP pools after DNA damage and in resting cells
    • Hakansson P, Hofer A, Thelander L. (2006). Regulation of mammalian ribonucleotide reduction and dNTP pools after DNA damage and in resting cells. J Biol Chem 281: 7834-7841.
    • (2006) J Biol Chem , vol.281 , pp. 7834-7841
    • Hakansson, P.1    Hofer, A.2    Thelander, L.3
  • 15
    • 0042166135 scopus 로고    scopus 로고
    • Impaired function of p53R2 in Rrm2b-null mice causes severe renal failure through attenuation of dNTP pools
    • Kimura T, Takeda S, Sagiya Y, Gotoh M, Nakamura Y, Arakawa H. (2003). Impaired function of p53R2 in Rrm2b-null mice causes severe renal failure through attenuation of dNTP pools. Nat Genet 34: 440-445.
    • (2003) Nat Genet , vol.34 , pp. 440-445
    • Kimura, T.1    Takeda, S.2    Sagiya, Y.3    Gotoh, M.4    Nakamura, Y.5    Arakawa, H.6
  • 16
    • 0034667593 scopus 로고    scopus 로고
    • Meaningful relationships: The regulation of the Ras/ Raf/MEK/ERK pathway by protein interactions
    • Kolch W. (2000). Meaningful relationships: the regulation of the Ras/ Raf/MEK/ERK pathway by protein interactions. Biochem J 351(Pt 2): 289-305.
    • (2000) Biochem J , vol.351 , Issue.PART 2 , pp. 289-305
    • Kolch, W.1
  • 17
    • 33751275310 scopus 로고    scopus 로고
    • Metastasis-suppressingpotential of ribonucleotide reductase small subunit p53R2 in human cancer cells
    • Liu X, Zhou B, Xue L, Shih J, Tye K, Lin W et al. (2006). Metastasis-suppressingpotential of ribonucleotide reductase small subunit p53R2 in human cancer cells. Clin Cancer Res 12: 6337-6344.
    • (2006) Clin Cancer Res , vol.12 , pp. 6337-6344
    • Liu, X.1    Zhou, B.2    Xue, L.3    Shih, J.4    Tye, K.5    Lin, W.6
  • 18
    • 33847417505 scopus 로고    scopus 로고
    • Ribonucleotide reductase subunits M2 and p53R2 are potential biomarkers for metastasis of colon cancer
    • Liu X, Zhou B, Xue L, Yen F, Chu P, Un F et al. (2007). Ribonucleotide reductase subunits M2 and p53R2 are potential biomarkers for metastasis of colon cancer. Clin Colorectal Cancer 6: 374-381.
    • (2007) Clin Colorectal Cancer , vol.6 , pp. 374-381
    • Liu, X.1    Zhou, B.2    Xue, L.3    Yen, F.4    Chu, P.5    Un, F.6
  • 19
    • 33746539166 scopus 로고    scopus 로고
    • DNA precursor metabolism and genomic stability
    • Mathews CK. (2006). DNA precursor metabolism and genomic stability. FASEB J 20: 1300-1314.
    • (2006) FASEB J , vol.20 , pp. 1300-1314
    • Mathews, C.K.1
  • 21
    • 0034738967 scopus 로고    scopus 로고
    • A ribonucleotide reductase gene is a transcriptional target of p53 and p73
    • Nakano K, Balint E, Ashcroft M, Vousden KH. (2000). A ribonucleotide reductase gene is a transcriptional target of p53 and p73. Oncogene 19: 4283-4289.
    • (2000) Oncogene , vol.19 , pp. 4283-4289
    • Nakano, K.1    Balint, E.2    Ashcroft, M.3    Vousden, K.H.4
  • 23
    • 14644442937 scopus 로고    scopus 로고
    • Rapid development of glomerular injury and renal failure in mice lackingp53R2
    • Powell DR, Desai U, Sparks MJ, Hansen G, Gay J, Schrick J et al. (2005). Rapid development of glomerular injury and renal failure in mice lackingp53R2. Pediatr Nephrol 20: 432-440.
    • (2005) Pediatr Nephrol , vol.20 , pp. 432-440
    • Powell, D.R.1    Desai, U.2    Sparks, M.J.3    Hansen, G.4    Gay, J.5    Schrick, J.6
  • 24
    • 1842685083 scopus 로고    scopus 로고
    • Thymidylate synthase as an oncogene: A novel role for an essential DNA synthesis enzyme
    • Rahman L, Voeller D, Rahman M, Lipkowitz S, Allegra C, Barrett JC et al. (2004). Thymidylate synthase as an oncogene: a novel role for an essential DNA synthesis enzyme. Cancer Cell 5: 341-351.
    • (2004) Cancer Cell , vol.5 , pp. 341-351
    • Rahman, L.1    Voeller, D.2    Rahman, M.3    Lipkowitz, S.4    Allegra, C.5    Barrett, J.C.6
  • 26
    • 0034594978 scopus 로고    scopus 로고
    • A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage
    • Tanaka H, Arakawa H, Yamaguchi T, Shiraishi K, Fukuda S, Matsui K et al. (2000). A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage. Nature 404: 42-49.
    • (2000) Nature , vol.404 , pp. 42-49
    • Tanaka, H.1    Arakawa, H.2    Yamaguchi, T.3    Shiraishi, K.4    Fukuda, S.5    Matsui, K.6
  • 27
    • 31544442476 scopus 로고    scopus 로고
    • Transcriptional responses to ionizingradiation reveal that p53R2 protects against radiation-induced mutagenesis in human lymphoblastoid cells
    • Tsai MH, Chen X, Chandramouli GV, Chen Y, Yan H, Zhao S et al. (2006). Transcriptional responses to ionizingradiation reveal that p53R2 protects against radiation-induced mutagenesis in human lymphoblastoid cells. Oncogene 25: 622-632.
    • (2006) Oncogene , vol.25 , pp. 622-632
    • Tsai, M.H.1    Chen, X.2    Chandramouli, G.V.3    Chen, Y.4    Yan, H.5    Zhao, S.6
  • 28
    • 0032928614 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase: Conservation of a three-kinase module from yeast to human
    • Widmann C, Gibson S, Jarpe MB, Johnson GL. (1999). Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol Rev 79: 143-180.
    • (1999) Physiol Rev , vol.79 , pp. 143-180
    • Widmann, C.1    Gibson, S.2    Jarpe, M.B.3    Johnson, G.L.4
  • 29
    • 42349085603 scopus 로고    scopus 로고
    • Broad overexpression of ribonucleotide reductase genes in mice specifically induces lungneoplasms
    • Xu X, Page JL, Surtees JA, Liu H, Lagedrost S, Lu Y et al. (2008). Broad overexpression of ribonucleotide reductase genes in mice specifically induces lungneoplasms. Cancer Res 68: 2652-2660.
    • (2008) Cancer Res , vol.68 , pp. 2652-2660
    • Xu, X.1    Page, J.L.2    Surtees, J.A.3    Liu, H.4    Lagedrost, S.5    Lu, Y.6
  • 30
    • 33846418710 scopus 로고    scopus 로고
    • Ribonucleotide reductase small subunit p53R2 facilitates p21 induction of G1 arrest under UV irradiation
    • Xue L, Zhou B, Liu X, HeungY, Chau J, Chu E et al. (2007). Ribonucleotide reductase small subunit p53R2 facilitates p21 induction of G1 arrest under UV irradiation. Cancer Res 67: 16-21.
    • (2007) Cancer Res , vol.67 , pp. 16-21
    • Xue, L.1    Zhou, B.2    Liu, X.3    Heung, Y.4    Chau, J.5    Chu, E.6
  • 31
    • 0037374051 scopus 로고    scopus 로고
    • Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits
    • Xue L, Zhou B, Liu X, Qiu W, Jin Z, Yen Y. (2003). Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits. Cancer Res 63: 980-986.
    • (2003) Cancer Res , vol.63 , pp. 980-986
    • Xue, L.1    Zhou, B.2    Liu, X.3    Qiu, W.4    Jin, Z.5    Yen, Y.6
  • 32
    • 33644505450 scopus 로고    scopus 로고
    • Structurally dependent redox property of ribonucleotide reductase subunit p53R2
    • Xue L, Zhou B, Liu X, WangT, Shih J, Qi C et al. (2006). Structurally dependent redox property of ribonucleotide reductase subunit p53R2. Cancer Res 66: 1900-1905.
    • (2006) Cancer Res , vol.66 , pp. 1900-1905
    • Xue, L.1    Zhou, B.2    Liu, X.3    Wang, T.4    Shih, J.5    Qi, C.6
  • 33
    • 0035890408 scopus 로고    scopus 로고
    • p53R2-dependent pathway for DNA synthesis in a p53-regulated cell cycle checkpoint
    • Yamaguchi T, Matsuda K, Sagiya Y, Iwadate M, Fujino MA, Nakamura Y et al. (2001). p53R2-dependent pathway for DNA synthesis in a p53-regulated cell cycle checkpoint. Cancer Res 61: 8256-8262.
    • (2001) Cancer Res , vol.61 , pp. 8256-8262
    • Yamaguchi, T.1    Matsuda, K.2    Sagiya, Y.3    Iwadate, M.4    Fujino, M.A.5    Nakamura, Y.6
  • 34
    • 30944447568 scopus 로고    scopus 로고
    • The extracellular signal-regulated kinase: Multiple substrates regulate diverse cellular functions
    • Yoon S, Seger R. (2006). The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions. Growth Factors 24: 21-44.
    • (2006) Growth Factors , vol.24 , pp. 21-44
    • Yoon, S.1    Seger, R.2
  • 35
    • 33644518370 scopus 로고    scopus 로고
    • Disruption of the p53-p53r2 DNA repair system in ulcerative colitis contributes to colon tumorigenesis
    • Yoshida T, Haga S, Numata Y, Yamashita K, Mikami T, Ogawa T et al. (2006). Disruption of the p53-p53r2 DNA repair system in ulcerative colitis contributes to colon tumorigenesis. Int J Cancer 118: 1395-1403.
    • (2006) Int J Cancer , vol.118 , pp. 1395-1403
    • Yoshida, T.1    Haga, S.2    Numata, Y.3    Yamashita, K.4    Mikami, T.5    Ogawa, T.6
  • 36
    • 33847107236 scopus 로고    scopus 로고
    • DNA synthesis and repair genes RRM1 and ERCC1 in lung cancer
    • ZhengZ, Chen T, Li X, Haura E, Sharma A, Bepler G. (2007). DNA synthesis and repair genes RRM1 and ERCC1 in lung cancer. N Engl J Med 356: 800-808.
    • (2007) N Engl J Med , vol.356 , pp. 800-808
    • Zheng, Z.1    Chen, T.2    Li, X.3    Haura, E.4    Sharma, A.5    Bepler, G.6
  • 37
    • 0031938457 scopus 로고    scopus 로고
    • Overexpression of transfected human ribonucleotide reductase M2 subunit in human cancer cells enhances their invasive potential
    • Zhou BS, Tsai P, Ker R, Tsai J, Ho R, Yu J et al. (1998). Overexpression of transfected human ribonucleotide reductase M2 subunit in human cancer cells enhances their invasive potential. Clin Exp Metastasis 16: 43-49.
    • (1998) Clin Exp Metastasis , vol.16 , pp. 43-49
    • Zhou, B.S.1    Tsai, P.2    Ker, R.3    Tsai, J.4    Ho, R.5    Yu, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.