ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 47, 2008, Pages 18519-18524

  Chang, Lufen ^a   Zhou, Bingsen ^a   Hu, Shuya ^a   Guo, Robin ^a   Liu, Xiyong ^a   Jones, Stephen N ^b   Yen, Yun ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

DNA damage stress; Kinase; Protein stability; Signal transduction

Indexed keywords

ALANINE; ATM PROTEIN; HETERODIMER; PROTEIN MDM2; PROTEIN P53; RIBONUCLEOTIDE REDUCTASE; SERINE;

ARTICLE; DNA DAMAGE; IN VIVO STUDY; MUTANT; MUTATION; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; STRESS; TURNOVER TIME; UBIQUITINATION;

CELL CYCLE PROTEINS; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; HUMANS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-MDM2; RIBONUCLEOTIDE REDUCTASES; SERINE; TUMOR SUPPRESSOR PROTEINS; ULTRAVIOLET RAYS;

ATAXIA TELANGIECTASIA;

EID: 57449084374     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0803313105     Document Type: Article

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