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Volumn 2012, Issue , 2012, Pages

Recent advances in potential clinical application of ghrelin in obesity

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE; ANTIOBESITY AGENT; BIM 28163; CYT 009 GHR; EX 1350; GHRELIN; GHRELIN O ACYLTRANSFERASE; GSK 1614343; HAPTEN; JMV 2844; JMV 2866; NOX B11 2; NOX B11 3; PENTAPEPTIDE; PIPERIDINE DERIVATIVE; QUINAZOLINONE DERIVATIVE; TZP 301; UNCLASSIFIED DRUG; VACCINE; YIL 781;

EID: 84866253294     PISSN: 20900708     EISSN: 20900716     Source Type: Journal    
DOI: 10.1155/2012/535624     Document Type: Review
Times cited : (25)

References (91)
  • 1
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., Kangawa K., Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999 402 6762 656 660 2-s2.0-0033540056 10.1038/45230 (Pubitemid 129516334)
    • (1999) Nature , vol.402 , Issue.6762 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 3
    • 38849090670 scopus 로고    scopus 로고
    • Identification of the Acyltransferase that Octanoylates Ghrelin, an Appetite-Stimulating Peptide Hormone
    • DOI 10.1016/j.cell.2008.01.017, PII S0092867408001177
    • Yang J., Brown M. S., Liang G., Grishin N. V., Goldstein J. L., Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 2008 132 3 387 396 2-s2.0-38849090670 10.1016/j.cell.2008.01.017 (Pubitemid 351192001)
    • (2008) Cell , vol.132 , Issue.3 , pp. 387-396
    • Yang, J.1    Brown, M.S.2    Liang, G.3    Grishin, N.V.4    Goldstein, J.L.5
  • 4
    • 0035433977 scopus 로고    scopus 로고
    • A Preprandial Rise in Plasma Ghrelin Levels Suggests a Role in Meal Initiation in Humans
    • Cummings D. E., Purnell J. Q., Frayo R. S., Schmidova K., Wisse B. E., Weigle D. S., A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 2001 50 8 1714 1719 2-s2.0-0035433977 (Pubitemid 33641587)
    • (2001) Diabetes , vol.50 , Issue.8 , pp. 1714-1719
    • Cummings, D.E.1    Purnell, J.Q.2    Frayo, R.S.3    Schmidova, K.4    Wisse, B.E.5    Weigle, D.S.6
  • 8
    • 0033679897 scopus 로고    scopus 로고
    • Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans
    • 2-s2.0-0033679897
    • Date Y., Kojima M., Hosoda H., Sawaguchi A., Mondal M. S., Suganuma T., Matsukura S., Kangawa K., Nakazato M., Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 2000 141 11 4255 4261 2-s2.0-0033679897
    • (2000) Endocrinology , vol.141 , Issue.11 , pp. 4255-4261
    • Date, Y.1    Kojima, M.2    Hosoda, H.3    Sawaguchi, A.4    Mondal, M.S.5    Suganuma, T.6    Matsukura, S.7    Kangawa, K.8    Nakazato, M.9
  • 9
    • 0036085711 scopus 로고    scopus 로고
    • Characterisation of gastric ghrelin cells in man and other mammals: Studies in adult and fetal tissues
    • DOI 10.1007/s00418-002-0415-1
    • Rindi G., Necchi V., Savio A., Torsello A., Zoli M., Locatelli V., Raimondo F., Cocchi D., Solcia E., Characterisation of gastric ghrelin cells in man and other mammals: studies in adult and fetal tissues. Histochemistry and Cell Biology 2002 117 6 511 519 2-s2.0-0036085711 10.1007/s00418-002-0415-1 (Pubitemid 34666954)
    • (2002) Histochemistry and Cell Biology , vol.117 , Issue.6 , pp. 511-519
    • Rindi, G.1    Necchi, V.2    Savio, A.3    Torsello, A.4    Zoli, M.5    Locatelli, V.6    Raimondo, F.7    Cocchi, D.8    Solcia, E.9
  • 10
    • 0036171253 scopus 로고    scopus 로고
    • Ghrelin-producing cells exist as two types of cells, closed- and opened-type cells, in the rat gastrointestinal tract
    • DOI 10.1016/S0196-9781(01)00633-7, PII S0196978101006337
    • Sakata I., Nakamura K., Yamazaki M., Matsubara M., Hayashi Y., Kangawa K., Sakai T., Ghrelin-producing cells exist as two types of cells, closed- and opened-type cells, in the rat gastrointestinal tract. Peptides 2002 23 3 531 536 2-s2.0-0036171253 10.1016/S0196-9781(01)00633-7 (Pubitemid 34143270)
    • (2002) Peptides , vol.23 , Issue.3 , pp. 531-536
    • Sakata, I.1    Nakamura, K.2    Yamazaki, M.3    Matsubara, M.4    Hayashi, Y.5    Kangawa, K.6    Sakai, T.7
  • 11
    • 0346949031 scopus 로고    scopus 로고
    • Structural divergence of human ghrelin: Identification of multiple ghrelin-derived molecules produced by post-translational processing
    • DOI 10.1074/jbc.M205366200
    • Hosoda H., Kojima M., Mizushima T., Shimizu S., Kangawa K., Structural divergence of human ghrelin: identification of multiple ghrelin-derived molecules produced by post-translational processing. Journal of Biological Chemistry 2003 278 1 64 70 2-s2.0-0346949031 10.1074/jbc.M205366200 (Pubitemid 36043544)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.1 , pp. 64-70
    • Hosoda, H.1    Kojima, M.2    Mizushima, T.3    Shimizu, S.4    Kangawa, K.5
  • 12
    • 20244366719 scopus 로고    scopus 로고
    • Ingested medium-chain fatty acids are directly utilized for the acyl modification of ghrelin
    • DOI 10.1210/en.2004-0695
    • Nishi Y., Hiejima H., Hosoda H., Kaiya H., Mori K., Fukue Y., Yanase T., Nawata H., Kangawa K., Kojima M., Ingested medium-chain fatty acids are directly utilized for the acyl modification of ghrelin. Endocrinology 2005 146 5 2255 2264 2-s2.0-20244366719 10.1210/en.2004-0695 (Pubitemid 40577513)
    • (2005) Endocrinology , vol.146 , Issue.5 , pp. 2255-2264
    • Nishi, Y.1    Hiejima, H.2    Hosoda, H.3    Kaiya, H.4    Mori, K.5    Fukue, Y.6    Yanase, T.7    Nawata, H.8    Kangawa, K.9    Kojima, M.10
  • 14
    • 8844239339 scopus 로고    scopus 로고
    • Lysophospholipase I identified as a ghrelin deacylation enzyme in rat stomach
    • DOI 10.1016/j.bbrc.2004.10.193, PII S0006291X04025379
    • Shanado Y., Kometani M., Uchiyama H., Koizumi S., Teno N., Lysophospholipase I identified as a ghrelin deacylation enzyme in rat stomach. Biochemical and Biophysical Research Communications 2004 325 4 1487 1494 2-s2.0-8844239339 10.1016/j.bbrc.2004.10.193 (Pubitemid 39535930)
    • (2004) Biochemical and Biophysical Research Communications , vol.325 , Issue.4 , pp. 1487-1494
    • Shanado, Y.1    Kometani, M.2    Uchiyama, H.3    Koizumi, S.4    Teno, N.5
  • 15
    • 77957266562 scopus 로고    scopus 로고
    • Identification and characterization of acyl-protein thioesterase 1/lysophospholipase i as a ghrelin deacylation/lysophospholipid hydrolyzing enzyme in fetal bovine serum and conditioned medium
    • 2-s2.0-77957266562 10.1210/en.2010-0412
    • Satou M., Nishi Y., Yoh J., Hattori Y., Sugimoto H., Identification and characterization of acyl-protein thioesterase 1/lysophospholipase I as a ghrelin deacylation/lysophospholipid hydrolyzing enzyme in fetal bovine serum and conditioned medium. Endocrinology 2010 151 10 4765 4775 2-s2.0-77957266562 10.1210/en.2010-0412
    • (2010) Endocrinology , vol.151 , Issue.10 , pp. 4765-4775
    • Satou, M.1    Nishi, Y.2    Yoh, J.3    Hattori, Y.4    Sugimoto, H.5
  • 16
    • 9244225118 scopus 로고    scopus 로고
    • Ghrelin degradation by serum and tissue homogenates: Identification of the cleavage sites
    • DOI 10.1210/en.2004-0569
    • De Vriese C., Gregoire F., Lema-Kisoka R., Waelbroeck M., Robberecht P., Delporte C., Ghrelin degradation by serum and tissue homogenates: identification of the cleavage sites. Endocrinology 2004 145 11 4997 5005 2-s2.0-9244225118 10.1210/en.2004-0569 (Pubitemid 39551118)
    • (2004) Endocrinology , vol.145 , Issue.11 , pp. 4997-5005
    • De Vriese, C.1    Gregoire, F.2    Lema-Kisoka, R.3    Waelbroeck, M.4    Robberecht, P.5    Delporte, C.6
  • 17
    • 12244299859 scopus 로고    scopus 로고
    • Separate measurement of plasma levels of acylated and desacyl ghrelin in healthy subjects using a new direct ELISA assay
    • DOI 10.1210/jc.2004-1640
    • Akamizu T., Shinomiya T., Irako T., Fukunaga M., Nakai Y., Nakai Y., Kangawa K., Separate measurement of plasma levels of acylated and desacyl ghrelin in healthy subjects using a new direct ELISA assay. Journal of Clinical Endocrinology and Metabolism 2005 90 1 6 9 2-s2.0-12244299859 10.1210/jc.2004-1640 (Pubitemid 40116625)
    • (2005) Journal of Clinical Endocrinology and Metabolism , vol.90 , Issue.1 , pp. 6-9
    • Akamizu, T.1    Shinomiya, T.2    Irako, T.3    Fukunaga, M.4    Nakai, Y.5    Nakai, Y.6    Kangawa, K.7
  • 18
    • 2642570058 scopus 로고    scopus 로고
    • Optimum collection and storage conditions for ghrelin measurements: Octanoyl modification of ghrelin is rapidly hydrolyzed to desacyl ghrelin in blood samples
    • DOI 10.1373/clinchem.2003.025841
    • Hosoda H., Doi K., Nagaya N., Okumura H., Nakagawa E., Enomoto M., Ono F., Kangawa K., Optimum collection and storage conditions for ghrelin measurements: octanoyl modification of ghrelin is rapidly hydrolyzed to desacyl ghrelin in blood samples. Clinical Chemistry 2004 50 6 1077 1080 2-s2.0-2642570058 10.1373/clinchem.2003.025841 (Pubitemid 38725803)
    • (2004) Clinical Chemistry , vol.50 , Issue.6 , pp. 1077-1080
    • Hosoda, H.1    Doi, K.2    Nagaya, N.3    Okumura, H.4    Nakagawa, E.5    Enomoto, M.6    Ono, F.7    Kangawa, K.8
  • 19
    • 34249788733 scopus 로고    scopus 로고
    • Ghrelin interacts with human plasma lipoproteins
    • DOI 10.1210/en.2006-1281
    • De Vriese C., Hacquebard M., Gregoire F., Carpentier Y., Delporte C., Ghrelin interacts with human plasma lipoproteins. Endocrinology 2007 148 5 2355 2362 2-s2.0-34249788733 10.1210/en.2006-1281 (Pubitemid 46997038)
    • (2007) Endocrinology , vol.148 , Issue.5 , pp. 2355-2362
    • De Vriese, C.1    Hacquebard, M.2    Gregoire, F.3    Carpentier, Y.4    Delporte, C.5
  • 20
    • 50649114884 scopus 로고    scopus 로고
    • The butyrylcholinesterase knockout mouse is obese on a high-fat diet
    • 2-s2.0-50649114884 10.1016/j.cbi.2008.03.009
    • Li B., Duysen E. G., Lockridge O., The butyrylcholinesterase knockout mouse is obese on a high-fat diet. Chemico-Biological Interactions 2008 175 13 88 91 2-s2.0-50649114884 10.1016/j.cbi.2008.03.009
    • (2008) Chemico-Biological Interactions , vol.175 , Issue.13 , pp. 88-91
    • Li, B.1    Duysen, E.G.2    Lockridge, O.3
  • 22
    • 0035513696 scopus 로고    scopus 로고
    • Chronic Central Infusion of Ghrelin Increases Hypothalamic Neuropeptide Y and Agouti-Related Protein mRNA Levels and Body Weight in Rats
    • Kamegai J., Tamura H., Shimizu T., Ishii S., Sugihara H., Wakabayashi I., Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and agouti-related protein mRNA levels and body weight in rats. Diabetes 2001 50 7-12 2438 2443 2-s2.0-0035513696 (Pubitemid 33642759)
    • (2001) Diabetes , vol.50 , Issue.7-12 , pp. 2438-2443
    • Kamegai, J.1    Tamura, H.2    Shimizu, T.3    Ishii, S.4    Sugihara, H.5    Wakabayashi, I.6
  • 23
    • 0035843183 scopus 로고    scopus 로고
    • A role for ghrelin in the central regulation of feeding
    • DOI 10.1038/35051587
    • Nakazato M., Murakami N., Date Y., Kojima M., Matsuo H., Kangawa K., Matsukura S., A role for ghrelin in the central regulation of feeding. Nature 2001 409 6817 194 198 2-s2.0-0035843183 10.1038/35051587 (Pubitemid 32144284)
    • (2001) Nature , vol.409 , Issue.6817 , pp. 194-198
    • Nakazato, M.1    Murakami, N.2    Date, Y.3    Kojima, M.4    Matsuo, H.5    Kangawa, K.6    Matsukura, S.7
  • 24
    • 0035143816 scopus 로고    scopus 로고
    • Rapid publication ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway
    • Shintani M., Ogawa Y., Ebihara K., Aizawa-Abe M., Miyanaga F., Takaya K., Hayashi T., Inoue G., Hosoda K., Kojima M., Kangawa K., Nakao K., Rapid publication ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes 2001 50 2 227 232 2-s2.0-0035143816 (Pubitemid 32127276)
    • (2001) Diabetes , vol.50 , Issue.2 , pp. 227-232
    • Shintani, M.1    Ogawa, Y.2    Ebihara, K.3    Aizawa-Abe, M.4    Miyanaga, F.5    Takaya, K.6    Hayashi, T.7    Inoue, G.8    Hosoda, K.9    Kojima, M.10    Kangawa, K.11    Nakao, K.12
  • 25
    • 0034687376 scopus 로고    scopus 로고
    • Ghrelin induces adiposity in rodents
    • 2-s2.0-0034687376 10.1038/35038090
    • Tschop M., Smiley D. L., Heiman M. L., Ghrelin induces adiposity in rodents. Nature 2000 407 6806 908 913 2-s2.0-0034687376 10.1038/35038090
    • (2000) Nature , vol.407 , Issue.6806 , pp. 908-913
    • Tschop, M.1    Smiley, D.L.2    Heiman, M.L.3
  • 26
    • 0346494433 scopus 로고    scopus 로고
    • Ghrelin levels in obesity and anorexia nervosa: Effect of weight reduction or recuperation
    • DOI 10.1016/j.jpeds.2003.10.036
    • Soriano-Guillén L., Barrios V., Campos-Barros A., Argente J., Ghrelin levels in obesity and anorexia nervosa: effect of weight reduction or recuperation. Journal of Pediatrics 2004 144 1 36 42 2-s2.0-0346494433 10.1016/j.jpeds.2003.10.036 (Pubitemid 38091419)
    • (2004) Journal of Pediatrics , vol.144 , Issue.1 , pp. 36-42
    • Soriano-Guillen, L.1    Barrios, V.2    Campos-Barros, A.3    Argente, J.4
  • 27
    • 72449192299 scopus 로고    scopus 로고
    • Ghrelin in the regulation of body weight and metabolism
    • tschoemh@ucmail.uc.edu 10.1016/j.yfrne.2009.10.008
    • Castaeda T. R., Tong J., Datta R., Culler M., Tschöp M. H., tschoemh@ucmail.uc.edu Ghrelin in the regulation of body weight and metabolism. Frontiers in Neuroendocrinology 2010 31 1 44 60 10.1016/j.yfrne.2009.10.008
    • (2010) Frontiers in Neuroendocrinology , vol.31 , Issue.1 , pp. 44-60
    • Castaeda, T.R.1    Tong, J.2    Datta, R.3    Culler, M.4    Tschöp, M.H.5
  • 29
    • 33947590069 scopus 로고    scopus 로고
    • Elevated serum acylated (biologically active) ghrelin and resistin levels associate with pregnancy-induced weight gain and insulin resistance
    • DOI 10.1016/j.diabres.2006.09.005, PII S0168822706003883
    • Palik E., Baranyi E., Melczer Z., Audikovszky M., Szöcs A., Winkler G., Cseh K., Elevated serum acylated (biologically active) ghrelin and resistin levels associate with pregnancy-induced weight gain and insulin resistance. Diabetes Research and Clinical Practice 2007 76 3 351 357 2-s2.0-33947590069 10.1016/j.diabres.2006.09.005 (Pubitemid 46482713)
    • (2007) Diabetes Research and Clinical Practice , vol.76 , Issue.3 , pp. 351-357
    • Palik, E.1    Baranyi, E.2    Melczer, Z.3    Audikovszky, M.4    Szocs, A.5    Winkler, G.6    Cseh, K.7
  • 30
    • 33645214469 scopus 로고    scopus 로고
    • Early effects of olanzapine on serum levels of ghrelin, adiponectin and leptin in patients with schizophrenia
    • 2-s2.0-33645214469 10.1177/0269881105056647
    • Hosojima H., Togo T., Odawara T., Hasegawa K., Miura S., Kato Y., Kanai A., Kase A., Uchikado H., Hirayasu Y., Early effects of olanzapine on serum levels of ghrelin, adiponectin and leptin in patients with schizophrenia. Journal of Psychopharmacology 2006 20 1 75 79 2-s2.0-33645214469 10.1177/0269881105056647
    • (2006) Journal of Psychopharmacology , vol.20 , Issue.1 , pp. 75-79
    • Hosojima, H.1    Togo, T.2    Odawara, T.3    Hasegawa, K.4    Miura, S.5    Kato, Y.6    Kanai, A.7    Kase, A.8    Uchikado, H.9    Hirayasu, Y.10
  • 31
    • 25144497560 scopus 로고    scopus 로고
    • High-fat Diet-induced ultradian leptin and insulin hypersecretion are absent in obesity-resistant rats
    • 2-s2.0-25144497560
    • Otukonyong E. E., Dube M. G., Torto R., Kalra P. S., Kalra S. P., High-fat Diet-induced ultradian leptin and insulin hypersecretion are absent in obesity-resistant rats. Obesity Research 2005 13 6 991 999 2-s2.0-25144497560
    • (2005) Obesity Research , vol.13 , Issue.6 , pp. 991-999
    • Otukonyong, E.E.1    Dube, M.G.2    Torto, R.3    Kalra, P.S.4    Kalra, S.P.5
  • 33
    • 1842480284 scopus 로고    scopus 로고
    • Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor
    • DOI 10.1073/pnas.0305930101
    • Sun Y., Wang P., Zheng H., Smith R. G., Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor. Proceedings of the National Academy of Sciences of the United States of America 2004 101 13 4679 4684 2-s2.0-1842480284 10.1073/pnas.0305930101 (Pubitemid 38437470)
    • (2004) Proceedings of the National Academy of Sciences of the United States of America , vol.101 , Issue.13 , pp. 4679-4684
    • Sun, Y.1    Wang, P.2    Zheng, H.3    Smith, R.G.4
  • 35
    • 27344437877 scopus 로고    scopus 로고
    • A novel growth hormone secretagogue-1a receptor antagonist that blocks ghrelin-induced growth hormone secretion but induces increased body weight gain
    • DOI 10.1159/000088796
    • Halem H. A., Taylor J. E., Dong J. Z., Shen Y., Datta R., Abizaid A., Diano S., Horvath T. L., Culler M. D., A novel growth hormone secretagogue-1a receptor antagonist that blocks ghrelin-induced growth hormone secretion but induces increased body weight gain. Neuroendocrinology 2005 81 5 339 349 2-s2.0-27344437877 10.1159/000088796 (Pubitemid 41527865)
    • (2005) Neuroendocrinology , vol.81 , Issue.5 , pp. 339-349
    • Halem, H.A.1    Taylor, J.E.2    Dong, J.Z.3    Shen, Y.4    Datta, R.5    Abizaid, A.6    Diano, S.7    Horvath, T.L.8    Culler, M.D.9
  • 36
    • 67349169801 scopus 로고    scopus 로고
    • Is desacyl ghrelin a modulator of food intake?
    • 2-s2.0-67349169801 10.1016/j.peptides.2009.01.019
    • Inhoff T., Wiedenmann B., Klapp B. F., Mönnikes H., Kobelt P., Is desacyl ghrelin a modulator of food intake? Peptides 2009 30 5 991 994 2-s2.0-67349169801 10.1016/j.peptides.2009.01.019
    • (2009) Peptides , vol.30 , Issue.5 , pp. 991-994
    • Inhoff, T.1    Wiedenmann, B.2    Klapp, B.F.3    Mönnikes, H.4    Kobelt, P.5
  • 37
    • 74149087844 scopus 로고    scopus 로고
    • Ghrelin, des-acyl ghrelin and nesfatin-1 in gastric X/A-like cells: Role as regulators of food intake and body weight
    • 2-s2.0-74149087844 10.1016/j.peptides.2009.11.019
    • Stengel A., Goebel M., Wang L., Taché Y., Ghrelin, des-acyl ghrelin and nesfatin-1 in gastric X/A-like cells: role as regulators of food intake and body weight. Peptides 2010 31 2 357 369 2-s2.0-74149087844 10.1016/j.peptides.2009.11.019
    • (2010) Peptides , vol.31 , Issue.2 , pp. 357-369
    • Stengel, A.1    Goebel, M.2    Wang, L.3    Taché, Y.4
  • 42
    • 28544441759 scopus 로고    scopus 로고
    • Ghrelin and a novel preproghrelin isoform are highly expressed in prostate cancer and ghrelin activates mitogen-activated protein kinase in prostate cancer
    • DOI 10.1158/1078-0432.CCR-05-0443
    • Yeh A. H., Jeffery P. L., Duncan R. P., Herington A. C., Chopin L. K., Ghrelin and a novel preproghrelin isoform are highly expressed in prostate cancer and ghrelin activates mitogen-activated protein kinase in prostate cancer. Clinical Cancer Research 2005 11 23 8295 8303 2-s2.0-28544441759 10.1158/1078-0432.CCR-05-0443 (Pubitemid 41746940)
    • (2005) Clinical Cancer Research , vol.11 , Issue.23 , pp. 8295-8303
    • Yeh, A.H.1    Jeffery, P.L.2    Duncan, R.P.3    Herington, A.C.4    Chopin, L.K.5
  • 43
    • 24044462104 scopus 로고    scopus 로고
    • Large-scale studies of the Leu72Met polymorphism of the ghrelin gene in relation to the metabolic syndrome and associated quantitative traits
    • DOI 10.1111/j.1464-5491.2005.01575.x
    • Bing C., Ambye L., Fenger M., Jorgensen T., Borch-Johnsen K., Madsbad S., Urhammer S. A., Large-scale studies of the Leu72Met polymorphism of the ghrelin gene in relation to the metabolic syndrome and associated quantitative traits. Diabetic Medicine 2005 22 9 1157 1160 2-s2.0-24044462104 10.1111/j.1464-5491. 2005.01575.x (Pubitemid 41224173)
    • (2005) Diabetic Medicine , vol.22 , Issue.9 , pp. 1157-1160
    • Bing, C.1    Ambye, L.2    Fenger, M.3    Jorgensen, T.4    Borch-Johnsen, K.5    Madsbad, S.6    Urhammer, S.A.7
  • 44
    • 0036079504 scopus 로고    scopus 로고
    • Ghrelin gene: Identification of missense variants and a frameshift mutation in extremely obese children and adolescents and healthy normal weight students
    • DOI 10.1210/jc.87.6.2716
    • Hinney A., Hoch A., Geller F., Schäfer H., Siegfried W., Goldschmidt H., Remschmidt H., Hebebrand J., Ghrelin gene: identification of missense variants and a frameshift mutation in extremely obese children and adolescents and healthy normal weight students. Journal of Clinical Endocrinology and Metabolism 2002 87 6 2716 2719 10.1210/jc.87.6.2716 (Pubitemid 34655335)
    • (2002) Journal of Clinical Endocrinology and Metabolism , vol.87 , Issue.6 , pp. 2716-2719
    • Hinney, A.1    Hoch, A.2    Geller, F.3    Schafer, H.4    Siegfried, W.5    Goldschmidt, H.6    Remschmidt, H.7    Hebebrand, J.8
  • 47
    • 4344690017 scopus 로고    scopus 로고
    • Ghrelin gene polymorphisms and ghrelin, insulin, IGF-I, leptin and anthropometric data in children and adolescents
    • DOI 10.1530/eje.0.1510127
    • Vivenza D., Rapa A., Castellino N., Bellone S., Petri A., Vacca G., Aimaretti G., Broglio F., Bona G., Ghrelin gene polymorphisms and ghrelin, insulin, IGF-I, leptin and anthropometric data in children and adolescents. European Journal of Endocrinology 2004 151 1 127 133 2-s2.0-4344690017 10.1530/eje.0.1510127 (Pubitemid 39117375)
    • (2004) European Journal of Endocrinology , vol.151 , Issue.1 , pp. 127-133
    • Vivenza, D.1    Rapa, A.2    Castellino, N.3    Bellone, S.4    Petri, A.5    Vacca, G.6    Aimaretti, G.7    Broglio, F.8    Bona, G.9
  • 50
    • 41549128569 scopus 로고    scopus 로고
    • Lack of association of ghrelin precursor gene variants and percentage body fat or serum lipid profiles
    • DOI 10.1038/oby.2007.125, PII OBY2007125
    • Martin G. R., Loredo J. C., Sun G., Lack of association of ghrelin precursor gene variants and percentage body fat or serum lipid profiles. Obesity 2008 16 4 908 912 2-s2.0-41549128569 10.1038/oby.2007.125 (Pubitemid 351465654)
    • (2008) Obesity , vol.16 , Issue.4 , pp. 908-912
    • Martin, G.R.1    Loredo, J.C.2    Sun, G.3
  • 51
    • 1542300099 scopus 로고    scopus 로고
    • Molecular screening of the ghrelin gene in Italian obese children: The Leu72Met variant is associated with an earlier onset of obesity
    • DOI 10.1038/sj.ijo.0802572
    • Miraglia D. G., emanuele.miraglia@unina2.it Santoro N., Cirillo G., Raimondo P., Grandone A., D'Aniello A., Di Nardo M., Perrone L., Molecular screening of the ghrelin gene in Italian obese children: the Leu72Met variant is associated with an earlier onset of obesity. International Journal of Obesity 2004 28 3 447 450 10.1038/sj.ijo.0802572 (Pubitemid 38296960)
    • (2004) International Journal of Obesity , vol.28 , Issue.3 , pp. 447-450
    • Miraglia Del Giudice, E.1    Santoro, N.2    Cirillo, G.3    Raimondo, P.4    Grandone, A.5    D'Aniello, A.6    Di Nardo, M.7    Perrone, L.8
  • 53
  • 54
    • 0036896934 scopus 로고    scopus 로고
    • Fasting plasma ghrelin levels are negatively correlated with insulin resistance and PAI-1, but not with leptin, in obese children and adolescents
    • Ikezaki A., Hosoda H., Ito K., Iwama S., Miura N., Matsuoka H., Kondo C., Kojima M., Kangawa K., Sugihara S., Fasting plasma ghrelin levels are negatively correlated with insulin resistance and PAI-1, but not with leptin, in obese children and adolescents. Diabetes 2002 51 12 3408 3411 2-s2.0-0036896934 (Pubitemid 35403443)
    • (2002) Diabetes , vol.51 , Issue.12 , pp. 3408-3411
    • Ikezaki, A.1    Hosoda, H.2    Ito, K.3    Iwama, S.4    Miura, N.5    Matsuoka, H.6    Kondo, C.7    Kojima, M.8    Kangawa, K.9    Sugihara, S.10
  • 55
    • 0141643291 scopus 로고    scopus 로고
    • Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes
    • DOI 10.2337/diabetes.52.10.2546
    • Pöykkö S. M., seppo.poykko@ppshp.fi Kellokoski E., Hörkkö S., Kauma H., Kesäniemi Y. A., Ukkola O., Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes. Diabetes 2003 52 10 2546 2553 10.2337/diabetes.52.10.2546 (Pubitemid 37210544)
    • (2003) Diabetes , vol.52 , Issue.10 , pp. 2546-2553
    • Poykko, S.M.1    Kellokoski, E.2    Horkko, S.3    Kauma, H.4    Kesaniemi, Y.A.5    Ukkola, O.6
  • 56
    • 72949115929 scopus 로고    scopus 로고
    • Acylated and nonacylated ghrelin levels and their associations with insulin resistance in obese and normal weight children with metabolic syndrome
    • 2-s2.0-72949115929 10.1530/EJE-09-0375
    • Pacifico L., Poggiogalle E., Costantino F., Anania C., Ferraro F., Chiarelli F., Chiesa C., Acylated and nonacylated ghrelin levels and their associations with insulin resistance in obese and normal weight children with metabolic syndrome. European Journal of Endocrinology 2009 161 6 861 870 2-s2.0-72949115929 10.1530/EJE-09-0375
    • (2009) European Journal of Endocrinology , vol.161 , Issue.6 , pp. 861-870
    • Pacifico, L.1    Poggiogalle, E.2    Costantino, F.3    Anania, C.4    Ferraro, F.5    Chiarelli, F.6    Chiesa, C.7
  • 57
    • 79960333463 scopus 로고    scopus 로고
    • Ghrelin and glucose homeostasis
    • p.delhanty@erasmusmc.nl 10.1016/j.peptides.2011.03.001
    • Delhanty P. J., p.delhanty@erasmusmc.nl van der Lely A. J., Ghrelin and glucose homeostasis. Peptides 2011 32 11 2309 2318 10.1016/j.peptides.2011.03. 001
    • (2011) Peptides , vol.32 , Issue.11 , pp. 2309-2318
    • Delhanty, P.J.1    Van Der Lely, A.J.2
  • 58
    • 79958016808 scopus 로고    scopus 로고
    • Effect of ghrelin on glucose-insulin homeostasis: Therapeutic implications
    • 234709 10.1155/2010/234709
    • Sangiao-Alvarellos S., Cordido F., Effect of ghrelin on glucose-insulin homeostasis: therapeutic implications. International Journal of Peptides 2010 2010 25 234709 10.1155/2010/234709
    • (2010) International Journal of Peptides , vol.2010 , pp. 25
    • Sangiao-Alvarellos, S.1    Cordido, F.2
  • 60
    • 67649210216 scopus 로고    scopus 로고
    • Ghrelin O-acyltransferase (GOAT) has a preference for n-hexanoyl-CoA over n-octanoyl-CoA as an acyl donor
    • 2-s2.0-67649210216 10.1016/j.bbrc.2009.06.001
    • Ohgusu H., Shirouzu K., Nakamura Y., Nakashima Y., Ida T., Sato T., Kojima M., Ghrelin O-acyltransferase (GOAT) has a preference for n-hexanoyl-CoA over n-octanoyl-CoA as an acyl donor. Biochemical and Biophysical Research Communications 2009 386 1 153 158 2-s2.0-67649210216 10.1016/j.bbrc.2009.06.001
    • (2009) Biochemical and Biophysical Research Communications , vol.386 , Issue.1 , pp. 153-158
    • Ohgusu, H.1    Shirouzu, K.2    Nakamura, Y.3    Nakashima, Y.4    Ida, T.5    Sato, T.6    Kojima, M.7
  • 61
    • 43849098185 scopus 로고    scopus 로고
    • Structure and function of Ghrelin
    • 2-s2.0-43849098185 10.1007/4002007049
    • Kojima M., Kangawa K., Structure and function of Ghrelin. Results and Problems in Cell Differentiation 2008 46 89 115 2-s2.0-43849098185 10.1007/4002007049
    • (2008) Results and Problems in Cell Differentiation , vol.46 , pp. 89-115
    • Kojima, M.1    Kangawa, K.2
  • 62
    • 33746739498 scopus 로고    scopus 로고
    • Ghrelin and the short- and long-term regulation of appetite and body weight
    • DOI 10.1016/j.physbeh.2006.05.022, PII S0031938406002307
    • Cummings D. E., Ghrelin and the short- and long-term regulation of appetite and body weight. Physiology and Behavior 2006 89 1 71 84 2-s2.0-33746739498 10.1016/j.physbeh.2006.05.022 (Pubitemid 44164467)
    • (2006) Physiology and Behavior , vol.89 , Issue.1 , pp. 71-84
    • Cummings, D.E.1
  • 64
    • 57749084282 scopus 로고    scopus 로고
    • Influence of chronic undernutrition and leptin on GOAT mRNA levels in rat stomach mucosa
    • carlos.dieguez@usc.es 10.1677/JME-08-0102
    • González C. R., Vázquez M. J., López M., Diéguez C., carlos.dieguez@usc.es Influence of chronic undernutrition and leptin on GOAT mRNA levels in rat stomach mucosa. Journal of Molecular Endocrinology 2008 41 5-6 415 421 10.1677/JME-08-0102
    • (2008) Journal of Molecular Endocrinology , vol.41 , Issue.5-6 , pp. 415-421
    • González, C.R.1    Vázquez, M.J.2    López, M.3    Diéguez, C.4
  • 69
    • 63849244534 scopus 로고    scopus 로고
    • An acyl-ghrelin-specific neutralizing antibody inhibits the acute ghrelin-mediated orexigenic effects in mice
    • 2-s2.0-63849244534 10.1124/mol.108.052852
    • Lu S. C., Xu J., Chinookoswong N., Liu S., Steavenson S., Gegg C., Brankow D., Lindberg R., Veniant M., Gu W., An acyl-ghrelin-specific neutralizing antibody inhibits the acute ghrelin-mediated orexigenic effects in mice. Molecular Pharmacology 2009 75 4 901 907 2-s2.0-63849244534 10.1124/mol.108.052852
    • (2009) Molecular Pharmacology , vol.75 , Issue.4 , pp. 901-907
    • Lu, S.C.1    Xu, J.2    Chinookoswong, N.3    Liu, S.4    Steavenson, S.5    Gegg, C.6    Brankow, D.7    Lindberg, R.8    Veniant, M.9    Gu, W.10
  • 70
    • 0038304457 scopus 로고    scopus 로고
    • Antagonism of ghrelin receptor reduces food intake and body weight gain in mice
    • DOI 10.1136/gut.52.7.947
    • Asakawa A., Inui A., Kaga T., Katsuura G., Fujimiya M., Fujino M. A., Kasuga M., Antagonism of ghrelin receptor reduces food intake and body weight gain in mice. Gut 2003 52 7 947 952 2-s2.0-0038304457 10.1136/gut.52.7.947 (Pubitemid 36765284)
    • (2003) Gut , vol.52 , Issue.7 , pp. 947-952
    • Asakawa, A.1    Inui, A.2    Kaga, T.3    Katsuura, G.4    Fujimiya, M.5    Fujino, M.A.6    Kasuga, M.7
  • 72
    • 33646800511 scopus 로고    scopus 로고
    • Anti-ghrelin Spiegelmer NOX-B11 inhibits neurostimulatory and orexigenic effects of peripheral ghrelin in rats
    • DOI 10.1136/gut.2004.061010
    • Kobelt P., Helmling S., Stengel A., Wlotzka B., Andresen V., Klapp B. F., Wiedenmann B., Klussmann S., Mönnikes H., Anti-ghrelin Spiegelmer NOX-B11 inhibits neurostimulatory and orexigenic effects of peripheral ghrelin in rats. Gut 2006 55 6 788 792 2-s2.0-33646800511 10.1136/gut.2004.061010 (Pubitemid 43764547)
    • (2006) Gut , vol.55 , Issue.6 , pp. 788-792
    • Kobelt, P.1    Helmling, S.2    Stengel, A.3    Wlotzka, B.4    Andresen, V.5    Klapp, B.F.6    Wiedenmann, B.7    Klussmann, S.8    Monnikes, H.9
  • 74
    • 36949026161 scopus 로고    scopus 로고
    • The anti-ghrelin spiegelmer NOX-B11-3 blocks ghrelin- but not fasting-induced neuronal activation in the hypothalamic arcuate nucleus
    • DOI 10.1111/j.1365-2826.2007.01619.x
    • Becskei C., Bilik K. U., Klussmann S., Jarosch F., Lutz T. A., Riediger T., The anti-ghrelin spiegelmer NOX-B11-3 blocks ghrelin- but not fasting-induced neuronal activation in the hypothalamic arcuate nucleus. Journal of Neuroendocrinology 2008 20 1 85 92 2-s2.0-36949026161 10.1111/j.1365-2826. 2007.01619.x (Pubitemid 350239152)
    • (2008) Journal of Neuroendocrinology , vol.20 , Issue.1 , pp. 85-92
    • Becskei, C.1    Bilik, K.U.2    Klussmann, S.3    Jarosch, F.4    Lutz, T.A.5    Riediger, T.6
  • 75
    • 7644219561 scopus 로고    scopus 로고
    • Feeding response to ghrelin agonist and antagonist in lean and obese Zucker rats
    • DOI 10.1016/j.lfs.2004.09.001, PII S0024320504008306
    • Beck B., Richy S., Stricker-Krongrad A., Feeding response to ghrelin agonist and antagonist in lean and obese Zucker rats. Life Sciences 2004 76 4 473 478 2-s2.0-7644219561 10.1016/j.lfs.2004.09.001 (Pubitemid 39458314)
    • (2004) Life Sciences , vol.76 , Issue.4 , pp. 473-478
    • Beck, B.1    Richy, S.2    Stricker-Krongrad, A.3
  • 79
    • 37649022059 scopus 로고    scopus 로고
    • Trisubstituted 1,2,4-triazoles as ligands for the ghrelin receptor: On the significance of the orientation and substitution at position 3
    • 2-s2.0-37649022059 10.1016/j.bmcl.2007.10.113
    • Moulin A., Demange L., Ryan J., M'Kadmi C., Galleyrand J. C., Martinez J., Fehrentz J. A., Trisubstituted 1,2,4-triazoles as ligands for the ghrelin receptor: on the significance of the orientation and substitution at position 3. Bioorganic and Medicinal Chemistry Letters 2008 18 1 164 168 2-s2.0-37649022059 10.1016/j.bmcl.2007.10.113
    • (2008) Bioorganic and Medicinal Chemistry Letters , vol.18 , Issue.1 , pp. 164-168
    • Moulin, A.1    Demange, L.2    Ryan, J.3    M'Kadmi, C.4    Galleyrand, J.C.5    Martinez, J.6    Fehrentz, J.A.7
  • 83
    • 78649738318 scopus 로고    scopus 로고
    • Pharmacological characterization of the ghrelin receptor antagonist, GSK1614343 in rat RC-4B/C cells natively expressing GHS type 1a receptors
    • 2-s2.0-78649738318 10.1016/j.ejphar.2010.10.042
    • Perdonà E., Faggioni F., Buson A., Sabbatini F. M., Corti C., Corsi M., Pharmacological characterization of the ghrelin receptor antagonist, GSK1614343 in rat RC-4B/C cells natively expressing GHS type 1a receptors. European Journal of Pharmacology 2011 650 1 178 183 2-s2.0-78649738318 10.1016/j.ejphar.2010.10.042
    • (2011) European Journal of Pharmacology , vol.650 , Issue.1 , pp. 178-183
    • Perdonà, E.1    Faggioni, F.2    Buson, A.3    Sabbatini, F.M.4    Corti, C.5    Corsi, M.6
  • 86
    • 67649124250 scopus 로고    scopus 로고
    • Targeting the ghrelin receptor to regulate food intake
    • 2-s2.0-67649124250 10.1016/j.regpep.2009.04.002
    • Depoortere I., Targeting the ghrelin receptor to regulate food intake. Regulatory Peptides 2009 156 13 13 23 2-s2.0-67649124250 10.1016/j.regpep.2009. 04.002
    • (2009) Regulatory Peptides , vol.156 , Issue.13 , pp. 13-23
    • Depoortere, I.1
  • 87
    • 0242330291 scopus 로고    scopus 로고
    • High Constitutive Signaling of the Ghrelin Receptor - Identification of a Potent Inverse Agonist
    • DOI 10.1210/me.2003-0069
    • Holst B., Cygankiewicz A., Jensen T. H., Ankersen M., Schwartz T. W., High constitutive signaling of the ghrelin receptoridentification of a potent inverse agonist. Molecular Endocrinology 2003 17 11 2201 2210 2-s2.0-0242330291 10.1210/me.2003-0069 (Pubitemid 37352532)
    • (2003) Molecular Endocrinology , vol.17 , Issue.11 , pp. 2201-2210
    • Holst, B.1    Cygankiewicz, A.2    Jensen, T.H.3    Ankersen, M.4    Schwartz, T.W.5
  • 88
    • 36849039489 scopus 로고    scopus 로고
    • Importance of constitutive activity and arrestin-independent mechanisms for intracellular trafficking of the ghrelin receptor
    • DOI 10.1210/me.2007-0254
    • Holliday N. D., Holst B., Rodionova E. A., Schwartz T. W., Cox H. M., Importance of constitutive activity and arrestin-independent mechanisms for intracellular trafficking of the ghrelin receptor. Molecular Endocrinology 2007 21 12 3100 3112 2-s2.0-36849039489 10.1210/me.2007-0254 (Pubitemid 350223518)
    • (2007) Molecular Endocrinology , vol.21 , Issue.12 , pp. 3100-3112
    • Holliday, N.D.1    Holst, B.2    Rodionova, E.A.3    Schwartz, T.W.4    Cox, H.M.5
  • 89
    • 1342264249 scopus 로고    scopus 로고
    • Constitutive ghrelin receptor activity as a signaling set-point in appetite regulation
    • DOI 10.1016/j.tips.2004.01.010
    • Holst B., Schwartz T. W., Constitutive ghrelin receptor activity as a signaling set-point in appetite regulation. Trends in Pharmacological Sciences 2004 25 3 113 117 2-s2.0-1342264249 10.1016/j.tips.2004.01.010 (Pubitemid 38264498)
    • (2004) Trends in Pharmacological Sciences , vol.25 , Issue.3 , pp. 113-117
    • Holst, B.1    Schwartz, T.W.2
  • 90
    • 33747603675 scopus 로고    scopus 로고
    • Ghrelin receptor inverse agonists: Identification of an active peptide core and its interaction epitopes on the receptor
    • DOI 10.1124/mol.106.024422
    • Holst B., Lang M., Brandt E., Bach A., Howard A., Frimurer T. M., Beck-Sickinger A., Schwartz T. W., Ghrelin receptor inverse agonists: identification of an active peptide core and its interaction epitopes on the receptor. Molecular Pharmacology 2006 70 3 936 946 2-s2.0-33747603675 10.1124/mol.106.024422 (Pubitemid 44268450)
    • (2006) Molecular Pharmacology , vol.70 , Issue.3 , pp. 936-946
    • Holst, B.1    Lang, M.2    Brandt, E.3    Bach, A.4    Howard, A.5    Frimurer, T.M.6    Beck-Sickinger, A.7    Schwartz, T.W.8
  • 91
    • 79952138344 scopus 로고    scopus 로고
    • Bitter taste receptors and α -gustducin regulate the secretion of ghrelin with functional effects on food intake and gastric emptying
    • 2-s2.0-79952138344 10.1073/pnas.1011508108
    • Janssen S., Laermans J., Verhulst P. J., Thijs T., Tack J., Depoortere I., Bitter taste receptors and α -gustducin regulate the secretion of ghrelin with functional effects on food intake and gastric emptying. Proceedings of the National Academy of Sciences of the United States of America 2011 108 5 2094 2099 2-s2.0-79952138344 10.1073/pnas.1011508108
    • (2011) Proceedings of the National Academy of Sciences of the United States of America , vol.108 , Issue.5 , pp. 2094-2099
    • Janssen, S.1    Laermans, J.2    Verhulst, P.J.3    Thijs, T.4    Tack, J.5    Depoortere, I.6


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