Pharmacological characterization of the ghrelin receptor antagonist, GSK1614343 in rat RC-4B/C cells natively expressing GHS type 1a receptors

European Journal of Pharmacology

Volumn 650, Issue 1, 2011, Pages 178-183

  Perdonà, Elisabetta ^a,b   Faggioni, Federico ^a   Buson, Alberto ^a   Sabbatini, Fabio Maria ^a   Corti, Corrado ^a   Corsi, Mauro ^a  

^a GSK   (Italy)

^b Aptuit Inc   (United States)

Author keywords

Ghrelin; GHS1a receptor; GSK1614343; RC 4B C cells; YIL 781

Indexed keywords

6 [(4 FLUOROPHENYL)OXY] 2 METHYL 3 [[1 (METHYLETHYL) 3 PIPERIDINYL]METHYL] 4(3H) QUINAZOLINONE; CALCIUM ION; GHRELIN; GHRELIN RECEPTOR; GHRELIN RECEPTOR ANTAGONIST; GSK 1614343; HORMONE RECEPTOR BLOCKING AGENT; INOSITOL PHOSPHATE; N' [3,5 BIS(TRIFLUOROMETHYL)PHENYL] 2 [HEXAHYDROPYRROLO[1,2 A]PYRAZIN 2(1H) YL] 2 (3 PYRIDINYL)ETHANOHYDRAZIDE; UNCLASSIFIED DRUG; YIL 781;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CELL STRAIN RC 4B/C; CONTROLLED STUDY; DRUG ACTIVITY; HYPOPHYSIS ADENOMA; IC 50; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TUMOR CELL; TUMOR CELL LINE;

AMINO ACID SEQUENCE; ANIMALS; AZABICYCLO COMPOUNDS; BACULOVIRIDAE; CALCIUM; CELL LINE, TUMOR; GENE EXPRESSION REGULATION; HUMANS; HYDRAZINES; INOSITOL PHOSPHATES; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS, GENETIC; PYRROLES; RATS; RECEPTORS, GHRELIN;

EID: 78649738318     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.10.042     Document Type: Article

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