Ghrelin neutralization by a ribonucleic acid-SPM ameliorates obesity in diet-induced obese mice

Endocrinology

Volumn 147, Issue 3, 2006, Pages 1517-1526

  Shearman, Lauren P ^a   Wang, Sheng Ping ^a   Helmling, Steffen ^b   Stribling, D Sloan ^a   Mazur, Paul ^a   Ge, Lan ^a   Wang, Liyang ^a   Klussmann, Sven ^b   Macintyre, D Euan ^a   Howard, Andrew D ^a   Strack, Alison M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NOXXON PHARMA AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GHRELIN; OLIGONUCLEOTIDE; RNA DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BODY WEIGHT; CELL CULTURE; CONTROLLED STUDY; DIET; DRUG INFUSION; ENERGY BALANCE; FEEDING; FOOD INTAKE; HYPOPHYSIS; HYPOTHALAMUS; IC 50; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RECEPTOR AFFINITY; WEIGHT REDUCTION;

ANIMALS; ANTI-OBESITY AGENTS; BEHAVIOR, ANIMAL; BETA-LACTAMASES; BODY WEIGHT; CHO CELLS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEEDING BEHAVIOR; GENES, REPORTER; HUMANS; INHIBITORY CONCENTRATION 50; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; NFATC TRANSCRIPTION FACTORS; OBESITY; OLIGONUCLEOTIDES; PEPTIDE HORMONES; PEPTIDES; POLYETHYLENE GLYCOLS; PROTEIN BINDING; RADIOIMMUNOASSAY; RNA; TIME FACTORS;

EID: 32644448802     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2005-0993     Document Type: Article

References (34)

1. Howard AD, Feighner SD, Cully DF, Arena JP, Liberator PA, Rosenblum CI, Hamelin M, Hreniuk DL, Palyha OC, Anderson J, Paress PS, Diaz C, Chou M, Liu KK, McKee KK, Pong SS, Chaung LY, Elbrecht A, Dashkevicz M, Heavens R, Rigby M, Sirinathsinghji DJ, Dean DC, Melillo DG, Patchett AA, Nargund R, Griffin PR, DeMartino JA, Gupta SK, Schaeffer JA, Smith RG, Van der Ploeg LHT 1996 A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 273:974-977
2. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K 1999 Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656-660
3. Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, Matsukura S 2001 A role for ghrelin in the central regulation of feeding. Nature 409:194-198
4. Wren AM, Small CJ, Ward HL, Murphy KG, Dakin CL, Taheri S, Kennedy AR, Roberts GH, Morgan DGA, Ghatei MA, Bloom SR 2000 The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 141:4325-4328
5. Wren AM, Small CJ, Abbott CR, Dhillo WS, Seal LJ, Cohen MA, Batterham RL, Taheri S, Stanley SA, Ghatei MA, Bloom SR 2001 Ghrelin causes hyperphagia and obesity in rats. Diabetes 50:2540-2547
6. Tschöp M, Smiley DL, Heiman ML 2000 Ghrelin induces adiposity in rodents. Nature 407:908-913
7. Sun Y, Wang P, Zheng H, Smith RG 2004 Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor. Proc Natl Acad Sci USA 101:4679-4684
8. Wortley KE, Anderson K, Garcia K, Murray JD, Malinova L, Liu R, Moncrieffe M, Thabet K, Cox HJ, Yancopoulos GD, Wiegand SJ, Sleeman MW 2004 Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference. Proc Natl Acad Sci USA 101:8227-8232
9. Chen HY, Trumbauer ME, Chen AS, Weingarth DT, Adams JR, Frasier EG, Shen Z, Marsh DJ, Feighner SD, Guan XM, Ye Z, Nargund RP, Smith RG, Van der Ploeg LHT, Howard AD, MacNeil DJ, Qian S 2004 Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein. Endocrinology 145:2607-2612
10. Toshinai K, Date Y, Mrakami N, Shimada M, Modal MS, Shimbara T, Guan J-L, Wang Q-P, Funahashi H, Sakurai T, Shioda S, Matsukura S, Kangawa K, Nakazato M 2003 Ghrelin-induced food intake is mediated via the orexin pathway. Endocrinology 144:1506-1512
11. Tschöp M, Wawarta R, Riepl RL, Friedrich S, Bidlingmaier M, Landgraf R, Folwaczny C 2001 Postprandial decrease of circulating human ghrelin levels. J Endocrinol Invest 24:RC19-RC21
12. Wren AM, Seal LJ, Cohen MA, Byrnes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA, Bloom SR 2001 Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 86:5992-5995
13. Cummings DE, Weigle DS, Frayo RS, Breen PA, Ma MK, Dellinger EP, Purnell JQ 2002 Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med 346:1623-1630
14. Cummings DE, Clement K, Purnell JQ, Vaisse C, Foster KE, Frayo RS, Schwartz MW, Basdevant A, Weigle DS 2002 Elevated plasma ghrelin levels in Prader Willi syndrome. Nat Med 8:643-644
15. Helmling S, Maasch C, Eulberg D, Buchner K, Schröder W, Lange C, Vonhoff S, Wlotzka B, Tschop MH, Rosewicz S, Klussmann S 2004 Inhibition of ghrelin action in vitro and in vivo by an RNA-SPM. Proc Natl Acad Sci USA 101:13174-13179
16. Kobelt P, Helmling S, Stengel A, Wlotzka B, Andresen V, Klapp BF, Wiedenmann B, Klussmann S, Monnikes H 30 June 2005 Anti-ghrelin SPIEGELMER NOX-B11 inhibits neurostimulatory and orexigenic effects of peripheral ghrelin in rats. Gut 10.1136/gut2004.061010
17. Nargund R, Ye Z, Tata J, Lu Z, Hong Q, Bakshi R, Mosley R, Feighner S, Pong S, Cheng K, Schleim K, Jacks T, Hickey G, Tamvakopoulos C, Cowell L, Howard A, Smith R, Patchett A, L-166446, a second generation growth hormone secretagogue. Proc 222nd American Chemical Society Meeting, Chicago, IL, 2001 (Abstract MEDI-184)
18. Wlotzka B, Leva S, Eschgfaller B, Burmeister J, Kleinjung F, Kaduk C, Muhn P, Hess-Stumpp H, Klussmann S 2002 In vivo properties of an anti-GnRH SPM: an example of an oligonucleotide-based therapeutic substance class. Proc Natl Acad Sci USA 99:8898-8902
19. Hill SJ, Baker JG, Rees S 2001 Reporter-gene systems for the study of G-protein-coupled receptors. Curr Opin Pharmacol 1:526-532
20. Murakami N, Hayashida T, Kuroiwa T, Nakahara K, Ida T, Mondal MS, Nakazato M, Kojima M, Kangawa K 2002 Role for central ghrelin in food intake and secretion profile of stomach ghrelin in rats. J Endocrinol 174:283-288
21. Shuto Y, Shibasaki T, Otagiri A, Kuriyama H, Ohata H, Tamura H, Kamegai J, Sugihara H, Oikawa S, Wakabayashi I 2002 Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity. J Clin Invest 109:1429-1436
22. Asakawa A, Inui A, Kaga T, Katsurra G, Fujimiya M, Fujino MA, Kasuga M 2003 Antagonism of ghrelin receptor reduces food intake and body weight gain in mice. Gut 52:947-952
23. Sun Y, Ahmed S, Smith RG 2003 Deletion of ghrelin impairs neither growth nor appetite. Mol Cell Biol 23:7973-7981
24. Date Y, Kojima M, Hosoda H, Sawaguchi A, Modal MS, Suganuma T, Matsukura S, Kangawa K, Nakazato M 2000 Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 141:4255-4261
25. Date Y, Murakami N, Toshinai K, Matsukura S, Nijima A, Matsuo H, Kangawa K, Nakazato M 2002 The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats. Gastroenterology 123:1120-1128
26. Cowley MA, Smith RG, Diano S, Tschop M, Pronchuk N, Grove KL, Strasburger CJ, Bidlingmaier M, Esterman M, Heiman ML, Garcia-Segura LM, Nillni EA, Mendez P, Low MJ, Sotonyi P, Friedman JM, Liu H, Pinto S, Colmers WF, Cone RD, Horvath TL 2003 The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 37:649-661
27. Mozid AM, Tringali G, Forsling ML, Hendricks MS, Ajodha S, Edwards R, Navarra P, Grossman AB, Korbonits M 2003 Ghrelin is released from rat hypothalamic explants and stimulates corticotrophin-releasing hormone and arginine-vasopressin. Horm Metab Res 335:455-459
28. Jeffery PL, Duncan RP, Yeh AH, Jaskolski RA, Hammond DS, Herington AC, Chopin LK 2005 Expression of the ghrelin axis in the mouse: an exon 4-deleted mouse proghrelin variant encodes a novel C terminal peptide. Endocrinology 146:432-440
29. Bluher S, Ziotopoulou M, Bullen Jr JW, Moschos SJ, Ungsunan L, Kokkotou E, Maratos-Flier E, Mantzoros CS 2004 Responsiveness to peripherally administered melanocortins in lean and obese mice. Diabetes 53:82-90
30. Wei W, Qi X, Reed J, Wang H-Q, Wang G, Englander EW, Greeley Jr GH 6 October 2005 Effect of chronic hyperghrelinemia on ingestive action of ghrelin. Am J Physiol Regul Integr Comp Physiol 10.1152/ajpregu.00331.2005
31. Tang-Christensen M, Vrang N, Ortman S, Bidlingmaier M, Horvath TL, Tschop M 2004 Central administration of ghrelin and agouti-related protein (83-132) increases food intake and decreases spontaneous locomotor activity in rats. Endocrinology 145:4645-4652
32. Jonsson L, Skarphedinsson JO, Skuladottir GV, Watanobe H, Schioth HB 2002 Food conversion is transiently affected during 4-week chronic administration of melanocortin agonist and antagonist in rats. J Endocrinol 173:517-523
33. Chelikani PK, Haver AC, Reeve Jr JR, Keire DA, Reidelberger RD 6 October 2005 Daily, intermittent intravenous infusion of peptide YY [3-36] reduces daily food intake and adiposity in rats. Am J Physiol Regul Integr Comp Physiol 10.1152/ajpregu.00674.2005
34. Pittner RA, Moore CX, Bhavsar SP, Gedulin BR, Smith PA, Jodka CM, Parkes DG, Paterniti JR, Srivastava VP, Young AA 2004 Effects of PYY [3-36] in rodent models of diabetes and obesity. Int J Obes Relat Metab Disord 28:963-971