Tumor progression through epigenetic gene silencing of O 6-methylguanine-DNA methyltransferase in human biliary tract cancers

Annals of Surgical Oncology

Volumn 12, Issue 5, 2005, Pages 1-10

  Koga, Yasuo ^a   Kitajima, Yoshihiko ^a   Miyoshi, Atsushi ^a   Sato, Ken ^a   Kitahara, Kenji ^a   Soejima, Hidenobu ^a   Miyazaki, Kohji ^a  

^a SAGA UNIVERSITY   (Japan)

Author keywords

Biliary tract cancer; DNA alkylation; DNA repair gene; Gene mutation; MGMT; Multigene methylation

Indexed keywords

BETA CATENIN; DEATH ASSOCIATED PROTEIN KINASE; K RAS PROTEIN; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PARAFFIN; PROTEIN P16INK4A; PROTEIN P53; UVOMORULIN; CTNNB1 PROTEIN, HUMAN; CYTOSKELETON PROTEIN; TRANSACTIVATOR PROTEIN;

ADULT; AGED; ARTICLE; BILIARY TRACT CANCER; CANCER SURGERY; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; EPIGENETICS; FEMALE; GENE FREQUENCY; GENE MUTATION; GENE SEQUENCE; GENE SILENCING; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; METHYLATION; POLYMERASE CHAIN REACTION; PROMOTER REGION; PROTEIN EXPRESSION; TREATMENT OUTCOME; TUMOR GROWTH; BILE DUCT TUMOR; DISEASE COURSE; DNA METHYLATION; GALLBLADDER TUMOR; GENETIC EPIGENESIS; GENETICS; HEPATIC DUCT; METABOLISM; MIDDLE AGED; NUCLEOTIDE SEQUENCE; ONCOGENE RAS; PATHOLOGY; PHYSIOLOGY; PROGNOSIS;

AGED; AGED, 80 AND OVER; BETA CATENIN; BILE DUCT NEOPLASMS; BILE DUCTS, EXTRAHEPATIC; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYTOSKELETAL PROTEINS; DISEASE PROGRESSION; DNA METHYLATION; DNA MUTATIONAL ANALYSIS; EPIGENESIS, GENETIC; FEMALE; GALLBLADDER NEOPLASMS; GENE SILENCING; GENES, RAS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; PROGNOSIS; PROMOTER REGIONS (GENETICS); TRANS-ACTIVATORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84866250145     PISSN: 10689265     EISSN: None     Source Type: Journal    
DOI: 10.1245/ASO.2005.07.020     Document Type: Article

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