Genetic vasectomy - Overexpression of Prm1-EGFP fusion protein in elongating spermatids causes dominant male sterility in mice

Genesis

Volumn 48, Issue 3, 2010, Pages 151-160

  Haueter, Sabine ^a   Kawasumi, Miyuri ^b   Asner, Igor ^a   Brykczynska, Urszula ^c   Cinelli, Paolo ^a   Moisyadi, Stefan ^b   Bürki, Kurt ^a   Peters, Antoine H F M ^c   Pelczar, Pawel ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY OF HAWAII   (United States)

^c FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

Author keywords

Fertilization; Protamine; Spermatozoa; Transgenesis; Vasectomy

Indexed keywords

HYBRID PROTEIN; PROTAMINE; PROTAMINE P1; PROTEIN EGFP; UNCLASSIFIED DRUG;

ARTICLE; EMBRYO; GENE EXPRESSION; INTRACYTOPLASMIC SPERM INJECTION; MALE; MALE STERILITY; MOUSE; NONHUMAN; PHENOTYPE; PREIMPLANTATION EMBRYO; PRIORITY JOURNAL; PSEUDOPREGNANCY; RNA EXTRACTION; SPERMATID; SPERMATOZOON MATURATION; VASECTOMY;

ANIMALS; BLASTOCYST; BLOTTING, WESTERN; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GREEN FLUORESCENT PROTEINS; INFERTILITY, MALE; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; PEDIGREE; PROTAMINES; RECOMBINANT FUSION PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPERM INJECTIONS, INTRACYTOPLASMIC; SPERMATIDS; SPERMATOGENESIS; TESTIS; VASECTOMY;

ANIMALIA; MUS; MUS MUSCULUS;

EID: 77949409354     PISSN: 1526954X     EISSN: 1526968X     Source Type: Journal    
DOI: 10.1002/dvg.20598     Document Type: Article

References (17)

1. Bellve AR. 1979. The molecular biology of mammalian spermatogenesis, 1st ed. Finn CA. Oxford University Press. pp 159-261
2. Brugmans L, Kanaar R, Essers J. 2007. Analysis of DNA double-strand break repair pathways in mice. Mutat Res 614:95-108.
3. Brunner S, Colman D, Travis AJ, Luhmann UF, Shi W, Feil S, Imsand C, Nelson J, Grimm C, Rülicke T, Fundele R, Neidhardt J, Berger W. 2008. Overexpression of RPGR leads to male infertility in mice due to defects in flagellar assembly. Biol Reprod 79:608-617.
4. Cho C, Jung-Ha H, Willis WD, Goulding EH, Stein P, Xu Z, Schultz RM, Hecht NB, Eddy EM. 2003. Protamine 2 deficiency leads to sperm DNA damage and embryo death in mice. Biol Reprod 69:211-217.
5. Cho C, Willis WD, Goulding EH, Jung-Ha H, Choi YC, Hecht NB, Eddy EM. 2001. Haploinsufficiency of protamine-1 or -2 causes infertility in mice. Nat Genet 28:82-86.
6. Costa SL, Boekelheide K, Vanderhyden BC, Seth R, McBurney MW. 1997. Male infertility caused by epididymal dysfunction in transgenic mice expressing a dominant negative mutation of retinoic acid receptor alpha 1. Biol Reprod 56:985-990.
7. Jaroudi S, SenGupta S. 2007. DNA repair in mammalian embryos. Mutat Res 635:53-77.
8. Kai M, Irie M, Okutsu T, Inoue K, Ogonuki N, Miki H, Yokoyama M, Migishima R, Muguruma K, Fujimura H, Kohda T, Ogura A, Kaneko-Ishino T, Ishino F. 2004. The novel dominant mutation Dspd leads to a severe spermiogenesis defect in mice. Biol Reprod 70:1213-1221.
9. Kimura Y, Yanagimachi R. 1995. Intracytoplasmic sperm injection in the mouse. Biol Reprod 52:709-720.
10. Lee K, Haugen HS, Clegg CH, Braun RE. 1995. Premature translation of protamine 1 mRNA causes precocious nuclear condensation and arrests spermatid differentiation in mice. Proc Natl Acad Sci USA 92:12451-12455.
11. Magram J, Bishop JM. 1991. Dominant male sterility in mice caused by insertion of a transgene. Proc Natl Acad Sci USA 88:10327-10331.
12. Matzuk MM, Lamb DJ. 2002. Genetic dissection of mammalian fertility pathways. Nat Cell Biol Suppl. 4:41-49.
13. Meng X, Akutsu H, Schoene K, Reifsteck C, Fox EP, Olson S, Sariola H, Yanagimachi R, Baetscher M. 2002. Transgene insertion induced dominant male sterility and rescue of male fertility using round spermatid injection. Biol Reprod 66:726-734.
14. Okabe M, Ikawa M, Kominami K, Nakanishi T, Nishimune Y. 1997. 'Green mice' as a source of ubiquitous green cells. FEBS Lett 407:313-319.
15. Peschon JJ, Behringer RR, Brinster RL, Palmiter RD. 1987. Spermatid-specific expression of protamine 1 in transgenic mice. Proc Natl Acad Sci USA 84:5316-5319.
16. Rousseaux S, Reynoird N, Escoffier E, Thevenon J, Caron C, Khochbin S. 2008. Epigenetic reprogramming of the male genome during gametogenesis and in the zygote. Reprod Biomed Online 16:492-503.
17. Zhong J, Peters AH, Kafer K, Braun RE. 2001. A highly conserved sequence essential for translational repression of the protamine-1 messenger rna in murine spermatids. Biol Reprod 64:1784-1789.