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Volumn 11, Issue , 2012, Pages 157-171

Haploinsufficiency of tumor suppressor genes is driven by the cumulative effect of micrornas, microrna binding site polymorphisms and microrna polymorphisms: An in silico approach

Author keywords

Cancer; Haploin sufficiency; MicroRNA; miR SNPs; Single nucleotide polymorphism; Tumor suppressor genes

Indexed keywords

MESSENGER RNA; MICRORNA;

EID: 84866040731     PISSN: None     EISSN: 11769351     Source Type: Journal    
DOI: 10.4137/CIN.S10176     Document Type: Article
Times cited : (13)

References (59)
  • 1
    • 19344366193 scopus 로고    scopus 로고
    • Many ribosomal protein genes are cancer genes in zebrafish
    • Amsterdam A, Sadler KC, et al. Many ribosomal protein genes are cancer genes in zebrafish. PLoS Biol. 2004;2(5):E139.
    • (2004) PLoS Biol , vol.2 , Issue.5
    • Amsterdam, A.1    Sadler, K.C.2
  • 2
    • 78649634206 scopus 로고    scopus 로고
    • Germline DICER1 mutations and familial cystic nephroma
    • Bahubeshi A, Bal N, et al. Germline DICER1 mutations and familial cystic nephroma. J Med Genet. 2010;47(12):863-866.
    • (2010) J Med Genet , vol.47 , Issue.12 , pp. 863-866
    • Bahubeshi, A.1    Bal, N.2
  • 3
    • 73849128091 scopus 로고    scopus 로고
    • A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome
    • Barlow JL, Drynan LF, et al. A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome. Nat Med. 2010;16(1):59-66.
    • (2010) Nat Med , vol.16 , Issue.1 , pp. 59-66
    • Barlow, J.L.1    Drynan, L.F.2
  • 4
    • 77649191497 scopus 로고    scopus 로고
    • Identification of DOK genes as lung tumor suppressors
    • Berger AH, Niki M, et al. Identification of DOK genes as lung tumor suppressors. Nat Genet. 2010;42(3):216-223.
    • (2010) Nat Genet , vol.42 , Issue.3 , pp. 216-223
    • Berger, A.H.1    Niki, M.2
  • 5
    • 0033988241 scopus 로고    scopus 로고
    • Variation in microdeletions of the cyclic AMP-responsive element-binding protein gene at chromosome band 16p13.3 in the Rubinstein-Taybi syndrome
    • Blough RI, Petrij F, et al. Variation in microdeletions of the cyclic AMP-responsive element-binding protein gene at chromosome band 16p13.3 in the Rubinstein-Taybi syndrome. Am J Med Genet. 2000;90(1):29-34.
    • (2000) Am J Med Genet , vol.90 , Issue.1 , pp. 29-34
    • Blough, R.I.1    Petrij, F.2
  • 6
    • 0033741837 scopus 로고    scopus 로고
    • Evidence for Msh2 haploinsufficiency in mice revealed by MNU-induced sister-chromatid exchange analysis
    • Bouffer SD, Hofand N, et al. Evidence for Msh2 haploinsufficiency in mice revealed by MNU-induced sister-chromatid exchange analysis. Br J Cancer. 2000;83(10):1291-1294.
    • (2000) Br J Cancer , vol.83 , Issue.10 , pp. 1291-1294
    • Bouffer, S.D.1    Hofand, N.2
  • 7
    • 65949104846 scopus 로고    scopus 로고
    • Identification of copy number abnormalities and inactivating mutations in two negative regulators of nuclear factor-kappaB signaling pathways in Waldenstrom's macroglobulinemia
    • Braggio E, Keats JJ, et al. Identification of copy number abnormalities and inactivating mutations in two negative regulators of nuclear factor-kappaB signaling pathways in Waldenstrom's macroglobulinemia. Cancer Res. 2009;69(8):3579-3588.
    • (2009) Cancer Res , vol.69 , Issue.8 , pp. 3579-3588
    • Braggio, E.1    Keats, J.J.2
  • 8
    • 70349454058 scopus 로고    scopus 로고
    • Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model
    • Bric A, Miething C, et al. Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model. Cancer Cell. 2009;16(4):324-335.
    • (2009) Cancer Cell , vol.16 , Issue.4 , pp. 324-335
    • Bric, A.1    Miething, C.2
  • 9
    • 65549092592 scopus 로고    scopus 로고
    • Clusterin, a haploinsufficient tumor suppressor gene in neuroblastomas
    • Chayka O, Corvetta D, et al. Clusterin, a haploinsufficient tumor suppressor gene in neuroblastomas. J Natl Cancer Inst. 2009;101(9):663-677.
    • (2009) J Natl Cancer Inst , vol.101 , Issue.9 , pp. 663-677
    • Chayka, O.1    Corvetta, D.2
  • 10
    • 0037179848 scopus 로고    scopus 로고
    • A possible tumor suppressor role of the KLF5 transcription factor in human breast cancer
    • Chen C, Bhalala HV, et al. A possible tumor suppressor role of the KLF5 transcription factor in human breast cancer. Oncogene. 2002;21(43): 6567-6572.
    • (2002) Oncogene , vol.21 , Issue.43 , pp. 6567-6572
    • Chen, C.1    Bhalala, H.V.2
  • 11
    • 54549102143 scopus 로고    scopus 로고
    • Identification of human haploinsufficient genes and their genomic proximity to segmental duplications
    • Dang VT, Kassahn KS, et al. Identification of human haploinsufficient genes and their genomic proximity to segmental duplications. Eur J Hum Genet. 2008;16(11):1350-1357.
    • (2008) Eur J Hum Genet , vol.16 , Issue.11 , pp. 1350-1357
    • Dang, V.T.1    Kassahn, K.S.2
  • 12
    • 0031984094 scopus 로고    scopus 로고
    • Mouse models for hereditary nonpolyposis colorectal cancer
    • de Wind N, Dekker M, et al. Mouse models for hereditary nonpolyposis colorectal cancer. Cancer Res. 1998;58(2):248-255.
    • (1998) Cancer Res , vol.58 , Issue.2 , pp. 248-255
    • de Wind, N.1    Dekker, M.2
  • 13
    • 0032578544 scopus 로고    scopus 로고
    • Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inficted by low-level radiation
    • DeWeese TL, Shipman JM, et al. Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inficted by low-level radiation. Proc Natl Acad Sci U S A. 1998;95(20): 11915-11920.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , Issue.20 , pp. 11915-11920
    • Deweese, T.L.1    Shipman, J.M.2
  • 14
    • 84855447125 scopus 로고    scopus 로고
    • FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas
    • Duan S, Cermak L, et al. FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas. Nature. 2012;481(7379):90-93.
    • (2012) Nature , vol.481 , Issue.7379 , pp. 90-93
    • Duan, S.1    Cermak, L.2
  • 15
    • 0242610857 scopus 로고    scopus 로고
    • Nbn heterozygosity renders mice susceptible to tumor formation and ionizing radiation-induced tumorigenesis
    • Dumon-Jones V, Frappart PO, et al. Nbn heterozygosity renders mice susceptible to tumor formation and ionizing radiation-induced tumorigenesis. Cancer Res. 2003;63(21):7263-7269.
    • (2003) Cancer Res , vol.63 , Issue.21 , pp. 7263-7269
    • Dumon-Jones, V.1    Frappart, P.O.2
  • 16
    • 38349088899 scopus 로고    scopus 로고
    • Identifcation of RPS14 as a 5q- syndrome gene by RNA interference screen
    • Ebert BL, Pretz J, et al. Identifcation of RPS14 as a 5q- syndrome gene by RNA interference screen. Nature. 2008;451(7176):335-339.
    • (2008) Nature , vol.451 , Issue.7176 , pp. 335-339
    • Ebert, B.L.1    Pretz, J.2
  • 17
    • 1942437456 scopus 로고    scopus 로고
    • Bim is a suppressor of Myc-induced mouse B cell leukemia
    • Egle A, Harris AW, et al. Bim is a suppressor of Myc-induced mouse B cell leukemia. Proc Natl Acad Sci U S A. 2004;101(16):6164-6169.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.16 , pp. 6164-6169
    • Egle, A.1    Harris, A.W.2
  • 18
    • 4143051517 scopus 로고    scopus 로고
    • ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background
    • Fang Y, Tsao CC, et al. ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background. EMBO J. 2004;23(15):3164-3174.
    • (2004) EMBO J , vol.23 , Issue.15 , pp. 3164-3174
    • Fang, Y.1    Tsao, C.C.2
  • 19
    • 8644290828 scopus 로고    scopus 로고
    • Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development
    • Gale NW, Dominguez MG, et al. Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development. Proc Natl Acad Sci U S A. 2004;101(45):15949-15954.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.45 , pp. 15949-15954
    • Gale, N.W.1    Dominguez, M.G.2
  • 20
    • 34548312368 scopus 로고    scopus 로고
    • Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response
    • Gorrini C, Squatrito M, et al. Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response. Nature. 2007;448(7157):1063-1067.
    • (2007) Nature , vol.448 , Issue.7157 , pp. 1063-1067
    • Gorrini, C.1    Squatrito, M.2
  • 21
    • 0037144601 scopus 로고    scopus 로고
    • Enhanced tumor formation in mice heterozygous for Blm mutation
    • Goss KH, Risinger MA, et al. Enhanced tumor formation in mice heterozygous for Blm mutation. Science. 2002;297(5589):2051-2053.
    • (2002) Science , vol.297 , Issue.5589 , pp. 2051-2053
    • Goss, K.H.1    Risinger, M.A.2
  • 22
    • 77957969004 scopus 로고    scopus 로고
    • MicroRNA biogenesis takes another single hit from microsatellite instability
    • Grosshans H, Bussing I. MicroRNA biogenesis takes another single hit from microsatellite instability. Cancer Cell. 2010;18(4):295-297.
    • (2010) Cancer Cell , vol.18 , Issue.4 , pp. 295-297
    • Grosshans, H.1    Bussing, I.2
  • 23
    • 33847046849 scopus 로고    scopus 로고
    • Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
    • Hellstrom M, Phng LK, et al. Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature. 2007;445(7129): 776-780.
    • (2007) Nature , vol.445 , Issue.7129 , pp. 776-780
    • Hellstrom, M.1    Phng, L.K.2
  • 24
    • 0037102446 scopus 로고    scopus 로고
    • Prostatic intraepithelial neoplasia in mice with conditional disruption of the retinoid X receptor alpha allele in the prostate epithelium
    • Huang J, Powell WC, et al. Prostatic intraepithelial neoplasia in mice with conditional disruption of the retinoid X receptor alpha allele in the prostate epithelium. Cancer Res. 2002;62(16):4812-4819.
    • (2002) Cancer Res , vol.62 , Issue.16 , pp. 4812-4819
    • Huang, J.1    Powell, W.C.2
  • 25
    • 0035890273 scopus 로고    scopus 로고
    • Dmp1 is haplo-insufficient for tumor suppression and modifies the frequencies of Arf and p53 mutations in Myc-induced lym-phomas
    • Inoue K, Zindy F, et al. Dmp1 is haplo-insufficient for tumor suppression and modifies the frequencies of Arf and p53 mutations in Myc-induced lym-phomas. Genes Dev. 2001;15(22):2934-2939.
    • (2001) Genes Dev , vol.15 , Issue.22 , pp. 2934-2939
    • Inoue, K.1    Zindy, F.2
  • 26
    • 34447308515 scopus 로고    scopus 로고
    • Ddb2 is a haploinsuffcient tumor suppressor and controls spontaneous germ cell apoptosis
    • Itoh T, Iwashita S, et al. Ddb2 is a haploinsuffcient tumor suppressor and controls spontaneous germ cell apoptosis. Hum Mol Genet. 2007;16(13): 1578-1586.
    • (2007) Hum Mol Genet , vol.16 , Issue.13 , pp. 1578-1586
    • Itoh, T.1    Iwashita, S.2
  • 27
    • 0028307836 scopus 로고
    • Tumour predisposition in mice heterozygous for a targeted mutation in Nf1
    • Jacks T, Shih TS, et al. Tumour predisposition in mice heterozygous for a targeted mutation in Nf1. Nat Genet. 1994;7(3):353-361.
    • (1994) Nat Genet , vol.7 , Issue.3 , pp. 353-361
    • Jacks, T.1    Shih, T.S.2
  • 28
    • 0037732510 scopus 로고    scopus 로고
    • p21Cip1 nullizygosity increases tumor metastasis in irradiated mice
    • Jackson RJ, Engelman RW, et al. p21Cip1 nullizygosity increases tumor metastasis in irradiated mice. Cancer Res. 2003;63(12):3021-3025.
    • (2003) Cancer Res , vol.63 , Issue.12 , pp. 3021-3025
    • Jackson, R.J.1    Engelman, R.W.2
  • 29
    • 77954661062 scopus 로고    scopus 로고
    • Deletions of the transcription factor Ikaros in myeloproliferative neoplasms
    • Jager R, Gisslinger H, et al. Deletions of the transcription factor Ikaros in myeloproliferative neoplasms. Leukemia. 2010;24(7):1290-1298.
    • (2010) Leukemia , vol.24 , Issue.7 , pp. 1290-1298
    • Jager, R.1    Gisslinger, H.2
  • 30
    • 23044434841 scopus 로고    scopus 로고
    • Increased chromosome instability but not cancer predisposition in haploinsuffcient Bub3 mice
    • Kalitsis P, Fowler KJ, et al. Increased chromosome instability but not cancer predisposition in haploinsuffcient Bub3 mice. Genes Chromosomes Cancer. 2005;44(1):29-36.
    • (2005) Genes Chromosomes Cancer , vol.44 , Issue.1 , pp. 29-36
    • Kalitsis, P.1    Fowler, K.J.2
  • 31
    • 0037162498 scopus 로고    scopus 로고
    • Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression
    • Kucherlapati M, Yang K, et al. Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression. Proc Natl Acad Sci U S A. 2002;99(15):9924-9929.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.15 , pp. 9924-9929
    • Kucherlapati, M.1    Yang, K.2
  • 32
    • 72549115018 scopus 로고    scopus 로고
    • Dicer1 functions as a haploinsufficient tumor suppressor
    • Kumar MS, Pester RE, et al. Dicer1 functions as a haploinsufficient tumor suppressor. Genes Dev. 2009;23(23):2700-2704.
    • (2009) Genes Dev , vol.23 , Issue.23 , pp. 2700-2704
    • Kumar, M.S.1    Pester, R.E.2
  • 33
    • 3142552523 scopus 로고    scopus 로고
    • Chk1 is haploinsufficient for multiple functions critical to tumor suppression
    • Lam MH, Liu Q, et al. Chk1 is haploinsufficient for multiple functions critical to tumor suppression. Cancer Cell. 2004;6(1):45-59.
    • (2004) Cancer Cell , vol.6 , Issue.1 , pp. 45-59
    • Lam, M.H.1    Liu, Q.2
  • 34
    • 35148886223 scopus 로고    scopus 로고
    • Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer
    • Mallakin A, Sugiyama T, et al. Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer. Cancer Cell. 2007;12(4):381-394.
    • (2007) Cancer Cell , vol.12 , Issue.4 , pp. 381-394
    • Mallakin, A.1    Sugiyama, T.2
  • 35
    • 0030924657 scopus 로고    scopus 로고
    • The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation
    • McClatchey AI, Saotome I, et al. The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation. Genes Dev. 1997;11(10):1253-1265.
    • (1997) Genes Dev , vol.11 , Issue.10 , pp. 1253-1265
    • McClatchey, A.I.1    Saotome, I.2
  • 36
    • 2942746374 scopus 로고    scopus 로고
    • Involvement of mammalian Mus81 in genome integrity and tumor suppression
    • McPherson JP, Lemmers B, et al. Involvement of mammalian Mus81 in genome integrity and tumor suppression. Science. 2004;304(5678):1822-1826.
    • (2004) Science , vol.304 , Issue.5678 , pp. 1822-1826
    • McPherson, J.P.1    Lemmers, B.2
  • 37
    • 61349127117 scopus 로고    scopus 로고
    • A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function
    • Melo SA, Ropero S, et al. A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. Nat Genet. 2009;41(3): 365-370.
    • (2009) Nat Genet , vol.41 , Issue.3 , pp. 365-370
    • Melo, S.A.1    Ropero, S.2
  • 38
    • 0035905811 scopus 로고    scopus 로고
    • MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells
    • Michel LS, Liberal V, et al. MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells. Nature. 2001; 409(6818):355-359.
    • (2001) Nature , vol.409 , Issue.6818 , pp. 355-359
    • Michel, L.S.1    Liberal, V.2
  • 39
    • 43049139905 scopus 로고    scopus 로고
    • BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros
    • Mullighan CG, Miller CB, et al. BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros. Nature. 2008;453(7191):110-114.
    • (2008) Nature , vol.453 , Issue.7191 , pp. 110-114
    • Mullighan, C.G.1    Miller, C.B.2
  • 40
    • 54049148638 scopus 로고    scopus 로고
    • KIF1Bbeta functions as a haploinsufficient tumor suppressor gene mapped to chromosome 1p36.2 by inducing apopto-tic cell death
    • Munirajan AK, Ando K, et al. KIF1Bbeta functions as a haploinsufficient tumor suppressor gene mapped to chromosome 1p36.2 by inducing apopto-tic cell death. J Biol Chem. 2008;283(36):24426-24434.
    • (2008) J Biol Chem , vol.283 , Issue.36 , pp. 24426-24434
    • Munirajan, A.K.1    Ando, K.2
  • 41
    • 78650893211 scopus 로고    scopus 로고
    • DICER1 mutations in familial multino-dular goiter with and without ovarian Sertoli-Leydig cell tumors
    • Rio Frio T, Bahubeshi A, et al. DICER1 mutations in familial multino-dular goiter with and without ovarian Sertoli-Leydig cell tumors. JAMA. 2011;305(1):68-77.
    • (2011) JAMA , vol.305 , Issue.1 , pp. 68-77
    • Rio Frio, T.1    Bahubeshi, A.2
  • 42
    • 79953278448 scopus 로고    scopus 로고
    • Monoallelic deletion of the microRNA biogenesis gene Dgcr8 produces deficits in the development of excitatory synaptic transmission in the prefrontal cortex
    • Schofeld CM, Hsu R, et al. Monoallelic deletion of the microRNA biogenesis gene Dgcr8 produces deficits in the development of excitatory synaptic transmission in the prefrontal cortex. Neural Dev. 2011;6:11.
    • (2011) Neural Dev , vol.6 , pp. 11
    • Schofeld, C.M.1    Hsu, R.2
  • 43
    • 48549086260 scopus 로고    scopus 로고
    • Haploinsufficiency of the maspin tumor suppressor gene leads to hyperplastic lesions in prostate
    • Shao LJ, Shi H Y, et al. Haploinsufficiency of the maspin tumor suppressor gene leads to hyperplastic lesions in prostate. Cancer Res. 2008;68(13): 5143-5151.
    • (2008) Cancer Res , vol.68 , Issue.13 , pp. 5143-5151
    • Shao, L.J.1    Shi, H.Y.2
  • 44
    • 0033778728 scopus 로고    scopus 로고
    • E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice
    • Smits R, Ruiz P, et al. E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice. Gastroenterology. 2000;119(4):1045-1053.
    • (2000) Gastroenterology , vol.119 , Issue.4 , pp. 1045-1053
    • Smits, R.1    Ruiz, P.2
  • 45
    • 0032830638 scopus 로고    scopus 로고
    • Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia
    • Song WJ, Sullivan MG, et al. Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia. Nat Genet. 1999;23(2):166-175.
    • (1999) Nat Genet , vol.23 , Issue.2 , pp. 166-175
    • Song, W.J.1    Sullivan, M.G.2
  • 46
    • 77958558613 scopus 로고    scopus 로고
    • TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs
    • Su X, Chakravarti D, et al. TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs. Nature. 2010;467(7318):986-990.
    • (2010) Nature , vol.467 , Issue.7318 , pp. 986-990
    • Su, X.1    Chakravarti, D.2
  • 47
    • 0031801253 scopus 로고    scopus 로고
    • Submicroscopic deletion of chromosome 16p13.3 in patients with Rubinstein-Taybi syndrome
    • Taine L, Goizet C, et al. Submicroscopic deletion of chromosome 16p13.3 in patients with Rubinstein-Taybi syndrome. Am J Med Genet. 1998;78(3): 267-270.
    • (1998) Am J Med Genet , vol.78 , Issue.3 , pp. 267-270
    • Taine, L.1    Goizet, C.2
  • 48
    • 1542366109 scopus 로고    scopus 로고
    • Roles of MGMT and MLH1 proteins in alkylation-induced apoptosis and mutagenesis
    • Takagi Y, Takahashi M, et al. Roles of MGMT and MLH1 proteins in alkylation-induced apoptosis and mutagenesis. DNA Repair (Amst). 2003; 2(10):1135-1146.
    • (2003) DNA Repair (Amst) , vol.2 , Issue.10 , pp. 1135-1146
    • Takagi, Y.1    Takahashi, M.2
  • 49
    • 0030923585 scopus 로고    scopus 로고
    • Abnormal skeletal patterning in embryos lacking a single Cbp allele: A partial similarity with Rubinstein-Taybi syndrome
    • Tanaka Y, Naruse I, et al. Abnormal skeletal patterning in embryos lacking a single Cbp allele: a partial similarity with Rubinstein-Taybi syndrome. Proc Natl Acad Sci USA. 1997;94(19):10215-10220.
    • (1997) Proc Natl Acad Sci USA , vol.94 , Issue.19 , pp. 10215-10220
    • Tanaka, Y.1    Naruse, I.2
  • 50
    • 34547192721 scopus 로고    scopus 로고
    • Haploinsuffciency of Mdm2 and Mdm4 in tumo-rigenesis and development
    • Terzian T, Wang Y, et al. Haploinsuffciency of Mdm2 and Mdm4 in tumo-rigenesis and development. Mol Cell Biol. 2007;27(15):5479-485.
    • (2007) Mol Cell Biol , vol.27 , Issue.15 , pp. 5479-5485
    • Terzian, T.1    Wang, Y.2
  • 51
    • 33644817540 scopus 로고    scopus 로고
    • Atm heterozygous deficiency enhances development of mammary carcinomas in p53 heterozygous knockout mice
    • Umesako S, Fujisawa K, et al. Atm heterozygous deficiency enhances development of mammary carcinomas in p53 heterozygous knockout mice. Breast Cancer Res. 2005;7(1):R164-R170.
    • (2005) Breast Cancer Res , vol.7 , Issue.1
    • Umesako, S.1    Fujisawa, K.2
  • 52
    • 77954609243 scopus 로고    scopus 로고
    • Haploinsufficiency of the IKZF1 (IKAROS) tumor suppressor gene cooperates with BCR-ABL in a transgenic model of acute lymphoblastic leukemia
    • Virely C, Moulin S, et al. Haploinsufficiency of the IKZF1 (IKAROS) tumor suppressor gene cooperates with BCR-ABL in a transgenic model of acute lymphoblastic leukemia. Leukemia. 2010;24(6):1200-1204.
    • (2010) Leukemia , vol.24 , Issue.6 , pp. 1200-1204
    • Virely, C.1    Moulin, S.2
  • 53
    • 0033588843 scopus 로고    scopus 로고
    • Developmental defects and tumor predisposition in Rb mutant mice
    • Vooijs M, Berns A. Developmental defects and tumor predisposition in Rb mutant mice. Oncogene. 1999;18(38):5293-5303.
    • (1999) Oncogene , vol.18 , Issue.38 , pp. 5293-5303
    • Vooijs, M.1    Berns, A.2
  • 54
    • 27644593844 scopus 로고    scopus 로고
    • 53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice
    • Ward IM, Diflippantonio S, et al. 53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice. Mol Cell Biol. 2005;25(22):10079-10086.
    • (2005) Mol Cell Biol , vol.25 , Issue.22 , pp. 10079-10086
    • Ward, I.M.1    Diflippantonio, S.2
  • 55
    • 36749057932 scopus 로고    scopus 로고
    • The protective effect of A20 on atherosclerosis in apolipoprotein E-defcient mice is associated with reduced expression of NF-kappaB target genes
    • Wolfrum S, Teupser D, et al. The protective effect of A20 on atherosclerosis in apolipoprotein E-defcient mice is associated with reduced expression of NF-kappaB target genes. Proc Natl Acad Sci U S A. 2007;104(47):18601-18606.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.47 , pp. 18601-18606
    • Wolfrum, S.1    Teupser, D.2
  • 56
    • 0034611611 scopus 로고    scopus 로고
    • Haploid loss of the tumor suppressor Smad4/ Dpc4 initiates gastric polyposis and cancer in mice
    • Xu X, Brodie SG, et al. Haploid loss of the tumor suppressor Smad4/ Dpc4 initiates gastric polyposis and cancer in mice. Oncogene. 2000;19(15): 1868-1874.
    • (2000) Oncogene , vol.19 , Issue.15 , pp. 1868-1874
    • Xu, X.1    Brodie, S.G.2
  • 57
    • 0036569924 scopus 로고    scopus 로고
    • Deficiency of Retinoblastoma gene in mouse embryonic stem cells leads to genetic instability
    • Zheng L, Flesken-Nikitin A, et al. Deficiency of Retinoblastoma gene in mouse embryonic stem cells leads to genetic instability. Cancer Res. 2002; 62(9):2498-2502.
    • (2002) Cancer Res , vol.62 , Issue.9 , pp. 2498-2502
    • Zheng, L.1    Flesken-Nikitin, A.2
  • 58
    • 79953306829 scopus 로고    scopus 로고
    • The telomerase inhibitor PinX1 is a major haploin-sufficient tumor suppressor essential for chromosome stability in mice
    • Zhou XZ, Huang P, et al. The telomerase inhibitor PinX1 is a major haploin-sufficient tumor suppressor essential for chromosome stability in mice. J Clin Invest. 2011;121(4):1266-1282.
    • (2011) J Clin Invest , vol.121 , Issue.4 , pp. 1266-1282
    • Zhou, X.Z.1    Huang, P.2
  • 59
    • 0037012848 scopus 로고    scopus 로고
    • Neurofbromas in NF1: Schwann cell origin and role of tumor environment
    • Zhu Y, Ghosh P, et al. Neurofbromas in NF1: Schwann cell origin and role of tumor environment. Science. 2002;296(5569):920-922.
    • (2002) Science , vol.296 , Issue.5569 , pp. 920-922
    • Zhu, Y.1    Ghosh, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.