Targeting Hedgehog signaling and understanding refractory response to treatment with Hedgehog pathway inhibitors

Drug Resistance Updates

Volumn 15, Issue 4, 2012, Pages 211-222

  Queiroz, Karla C S ^a   Spek, C Arnold ^a   Peppelenbosch, Maikel P ^b  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Drug resistance; Hh pathway; PDA; PI3K mTOR pathway; SMO antagonists; Stromal depletion

Indexed keywords

ANTINEOPLASTIC AGENT; BEVACIZUMAB; BMS 833923; BORTEZOMIB; CARBOPLATIN; CETUXIMAB; CISPLATIN; CYCLOPAMINE; DASATINIB; DEXAMETHASONE; ERISMODEGIB; ERLOTINIB; ETOPOSIDE; GEMCITABINE; GOSERELIN; IMATINIB; LENALIDOMIDE; LEQ 506; LEUPRORELIN; N (6,7 DIHYDRO 6 OXO 5H DIBENZ[B,D]AZEPIN 7 YL) 2,2 DIMETHYL N' (2,2,3,3,3 PENTAFLUOROPROPYL)PROPANEDIAMIDE; NILOTINIB; ORAL CONTRACEPTIVE AGENT; PACLITAXEL; PF 04449913; PROTEIN INHIBITOR; RAPAMYCIN; ROSIGLITAZONE; SARIDEGIB; SONIC HEDGEHOG PROTEIN; SONIC HEDGEHOG PROTEIN INHIBITOR; TAK 441; UNCLASSIFIED DRUG; UNINDEXED DRUG; VISMODEGIB;

ACINAR CELL CARCINOMA; BASAL CELL CARCINOMA; BREAST CANCER; CANCER GROWTH; CANCER RESISTANCE; CARCINOGENESIS; CHEMORADIOTHERAPY; COLON CANCER; COLORECTAL CANCER; ESOPHAGEAL ADENOCARCINOMA; HEAD AND NECK CANCER; HUMAN; LEUKEMIA; LUNG SMALL CELL CANCER; MEDULLOBLASTOMA; MOLECULARLY TARGETED THERAPY; MULTIPLE MYELOMA; NONHUMAN; OVARY CANCER; PANCREAS CANCER; PANCREAS CARCINOMA; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN BINDING; PROTEIN EXPRESSION; REVIEW; RHABDOMYOSARCOMA; SIGNAL TRANSDUCTION; SOLID TUMOR; TREATMENT RESPONSE;

EID: 84865986389     PISSN: 13687646     EISSN: 15322084     Source Type: Journal    
DOI: 10.1016/j.drup.2012.05.002     Document Type: Article

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