Activation of the hedgehog pathway in a subset of lung cancers

Cancer Letters

Volumn 244, Issue 1, 2006, Pages 53-60

  Chi, Sumin ^a   Huang, Shuhong ^b   Li, Chengxin ^a   Zhang, Xiaoli ^a   He, Nonggao ^a   Bhutani, Manoop S ^a   Jones, Dennie ^a   Castro, Claudia Y ^a   Logrono, Roberto ^a   Haque, Abida ^a   Zwischenberger, Joseph ^a   Tyring, Stephen K ^c   Zhang, Hongwei ^b   Xie, Jingwu ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b SHANDONG UNIVERSITY   (China)

^c University of Texas Health Science Center at Houston   (United States)

Author keywords

Gli1; Hedgehog; Lung cancer; PTCH1; Su(Fu)

Indexed keywords

PROTEIN; PROTEIN SU(FU); SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE ACTIVATION; GENE EXPRESSION; GENE IDENTIFICATION; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LUNG CARCINOMA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

ADENOCARCINOMA; BLOTTING, NORTHERN; BLOTTING, WESTERN; CARCINOMA, LARGE CELL; CARCINOMA, SMALL CELL; CARCINOMA, SQUAMOUS CELL; CELL PROLIFERATION; COLONY-FORMING UNITS ASSAY; FEMALE; HEDGEHOG PROTEINS; HUMANS; IMMUNOBLOTTING; IMMUNOENZYME TECHNIQUES; IN SITU HYBRIDIZATION; LUNG NEOPLASMS; MALE; ONCOGENE PROTEINS; RECEPTORS, CELL SURFACE; REPRESSOR PROTEINS; RNA, MESSENGER; RNA, NEOPLASM; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TUMOR CELLS, CULTURED;

ERINACEIDAE;

EID: 33745606922     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2005.11.036     Document Type: Article

References (33)

1. Warburton D., Zhao J., Berberich M.A., and Bernfield M. Molecular embryology of the lung: then, now, and in the future. Am. J. Physiol. 276 (1999) L697-L704
2. Pepicelli C.V., Lewis P.M., and McMahon A.P. Sonic hedgehog regulates branching morphogenesis in the mammalian lung. Curr. Biol. 8 (1998) 1083-1086
3. Motoyama J., Liu J., Mo R., Ding Q., Post M., and Hui C.C. Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Nat. Genet. 20 (1998) 54-57
4. Litingtung Y., Lei L., Westphal H., and Chiang C. Sonic hedgehog is essential to foregut development. Nat. Genet. 20 (1998) 58-61
5. Pasca di Magliano M., and Hebrok M. Hedgehog signalling in cancer formation and maintenance. Nat. Rev. Cancer 3 (2003) 903-911
6. Xie J. Hedgehog signaling in prostate cancer. Future Oncol. 1 (2005) 331-338
7. Toftgard R. Hedgehog signalling in cancer. Cell. Mol. Life Sci. 57 (2000) 1720-1731
8. Epstein Jr. E. Genetic determinants of basal cell carcinoma risk. Med. Pediatr. Oncol. 36 (2001) 555-558
9. Hahn H., Wicking C., Zaphiropoulous P.G., Gailani M.R., Shanley S., Chidambaram A., et al. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 85 (1996) 841-851
10. Johnson R.L., Rothman A.L., Xie J., Goodrich L.V., Bare J.W., Bonifas J.M., et al. Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science 272 (1996) 1668-1671
11. Reifenberger J., Wolter M., Knobbe C.B., Kohler B., Schonicke A., Scharwachter C., et al. Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas. Br. J. Dermatol. 152 (2005) 43-51
12. Taylor M.D., Liu L., Raffel C., Hui C.C., Mainprize T.G., Zhang X., et al. Mutations in SUFU predispose to medulloblastoma. Nat. Genet. 31 (2002) 306-310
13. Xie J., Johnson R.L., Zhang X., Bare J.W., Waldman F.M., Cogen P.H., et al. Mutations of the PATCHED gene in several types of sporadic extracutaneous tumors. Cancer Res. 57 (1997) 2369-2372
14. Xie J., Murone M., Luoh S.M., Ryan A., Gu Q., Zhang C., et al. Activating smoothened mutations in sporadic basal-cell carcinoma. Nature 391 (1998) 90-92
15. Xie J., Johnson R.L., Zhang X., Bare J.W., Waldman F.M., Cogen P.H., et al. Mutations of the PATCHED gene in several types of sporadic extracutaneous tumors. Cancer Res. 57 (1997) 2369-2372
16. Berman D.M., Karhadkar S.S., Hallahan A.R., Pritchard J.I., Eberhart C.G., Watkins D.N., et al. Medulloblastoma growth inhibition by hedgehog pathway blockade. Science 297 (2002) 1559-1561
17. Watkins D.N., Berman D.M., Burkholder S.G., Wang B., Beachy P.A., and Baylin S.B. Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature 422 (2003) 313-317
18. Berman D.M., Karhadkar S.S., Maitra A., Montes De Oca R., Gerstenblith M.R., Briggs K., et al. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature 425 (2003) 846-851
19. Fan L., Pepicelli C.V., Dibble C.C., Catbagan W., Zarycki J.L., Laciak R., et al. Hedgehog signaling promotes prostate xenograft tumor growth. Endocrinology 145 (2004) 3961-3970
20. Karhadkar S.S., Steven Bova G., Abdallah N., Dhara S., Gardner D., Maitra A., et al. Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature 431 (2004) 707-712
21. Sanchez P., Hernandez A.M., Stecca B., Kahler A.J., DeGueme A.M., Barrett A., et al. Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling. Proc. Natl Acad. Sci. USA 101 (2004) 12561-12566
22. Sheng T., Li C., Zhang X., Chi S., He N., Chen K., et al. Activation of the hedgehog pathway in advanced prostate cancer. Mol. Cancer 3 (2004) 29
23. Thayer S.P., Di Magliano M.P., Heiser P.W., Nielsen C.M., Roberts D.J., Lauwers G.Y., et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 425 (2003) 851-856
24. Haque A.K., Au W., Cajas-Salazar N., Khan S., Ginzel A.W., Jones D.V., et al. CYP2E1 polymorphism, cigarette smoking, p53 expression, and survival in non-small cell lung cancer: a long term follow-up study. Appl. Immunohistochem. Mol. Morphol. 12 (2004) 315-322
25. Xie J. Identifying biomarkers of lung cancer in the post-genomic era. Curr. Pharmacogenomics 3 (2005) 265-274
26. Ma X., Sheng T., Zhang Y., Zhang X., He J., Huang S., et al. Hedgehog signaling is activated in subsets of esophageal cancers. Int. J. Cancer 118 (2006) 139-148
27. Ma X., Chen K., Huang S., Zhang X., Sheng T., Adegboyega P., et al. Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas. Carcinogenesis (2005)
28. He N., Li C., Zhang X., Sheng T., Chi S., Chen K., et al. Regulation of lung cancer cell growth and invasiveness by beta-TRCP. Mol. Carcinog. 42 (2005) 18-28
29. Xie J., Aszterbaum M., Zhang X., Bonifas J.M., Zachary C., Epstein E., et al. A role of PDGFRalpha in basal cell carcinoma proliferation. Proc. Natl Acad. Sci. USA 98 (2001) 9255-9259
30. Li C., Chi S., He N., Zhang X., Guicherit O., Wagner R., et al. IFNalpha induces Fas expression and apoptosis in hedgehog pathway activated BCC cells through inhibiting Ras-Erk signaling. Oncogene 23 (2004) 1608-1617
31. Athar M., Li C., Tang X., Chi S., Zhang X., Kim A.L., et al. Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of fas expression and apoptosis. Cancer Res. 64 (2004) 7545-7552
32. Kogerman P., Grimm T., Kogerman L., Krause D., Unden A.B., Sandstedt B., et al. Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1. Nat. Cell Biol. 1 (1999) 312-319
33. Stone D.M., Murone M., Luoh S., Ye W., Armanini M.P., Gurney A., et al. Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli. J. Cell Sci. 112 Pt 23 (1999) 4437-4448