Investigating the efficiency of novel metallo-phthalocyanine PDT-induced cell death in MCF-7 breast cancer cells

Photodiagnosis and Photodynamic Therapy

Volumn 9, Issue 3, 2012, Pages 215-224

  Horne, Tamarisk Kerry ^a   Abrahamse, Heidi ^a   Cronjé, Marianne J ^a  

^a UNIVERSITY OF JOHANNESBURG   (South Africa)

Author keywords

Cell death; MCF 7; Photodynamic therapy; Phthalocyanines

Indexed keywords

ALPCSMIX; ETOPOSIDE; GEPCSMIX; PHTHALOCYANINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL ENERGY; CELL FUNCTION; CELL RESPIRATION; CELL STRAIN MCF 7; CELL STRESS; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG MECHANISM; IN VITRO STUDY; INFRARED RADIATION; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL;

APOPTOSIS; HUMANS; INDOLES; MCF-7 CELLS; METALS; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS;

EID: 84865962640     PISSN: 15721000     EISSN: 18731597     Source Type: Journal    
DOI: 10.1016/j.pdpdt.2011.12.008     Document Type: Article

References (75)

1. Cahill D.P., Kinzler K.W., Vogelstein B., Lengauer C. Genetic instability and Darwinian selection in tumors. Trends Cell Biol 1999, 9(12):M57-M60.
2. Hanahan D., Weinberg R.A. The hallmarks of cancer. Cell 2000, 100:57-70.
3. Hartwell L.H., Kastan M.B. Cell cycle control and cancer. Science 1994, 266(5192):1821-1828.
4. Heppner G.H., Miller F.R. The cellular basis of tumor progression. Int Rev Cytol 1998, 177:1-56.
5. Desany B., Zhang Z. Bioinformatics and cancer target discovery. Drug Discov Today 2004, 9(18):795-802.
6. Deveraux Q.L., Aza-Blanc P. Exposing oncogenic dependencies for cancer drug target discovery and validation using RNAi. Semin Cancer Biol 2003, 13:293-300.
7. Felipe A., Vicente R., Villalonga N., et al. Potassium channels: new targets in cancer therapy. Cancer Detect Prev 2006, 30:375-385.
8. Newell D.R. How to develop a successful cancer drug-molecules to medicines or targets to treatments?. Eur J Cancer 2005, 41:676-682.
9. Wachtel M., Schäfer B.W. Targets for cancer therapy in childhood sarcomas. Cancer Treat Rev 2010, 36:318-327.
10. Henwood J.M., Brogden R.N. Etoposide: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in combination chemotherapy of cancer. Drugs 1990, 39(3):438-490.
11. Montecucco A., Biamonti G. Cellular response to etoposide treatment. Cancer Lett 2007, 252:9-18. [mini-review].
12. Coley H.M. Mechanisms and consequences of chemotherapy resistance in breast cancer. Eur J Cancer Suppl 2009, 7(1):3-7.
13. Lario A.P., García C.B., Elizondo M.E., Lobo C. Expression of proteins associated with multidrug resistance to chemotherapy in lung cancer. Arch Broncopneumol 2007, 43(9):479-484.
14. Osborne C.K., Shou J., Massarweh S., Schiff R. Crosstalk between estrogen receptor and growth factor receptor pathways as a cause for endocrine therapy resistance in breast cancer. Clin Cancer Res 2005, 11:865-870.
15. Castano A.P., Demidova T.N., Hamblin M.R. Mechanisms on photodynamic therapy. Part 1. Photosensitizers, photochemistry and cellular localization. J Photodiagn Photodyn Ther 2004, 2:1-23.
16. Dougherty T.J., Gomer C.J., Henderson B.W., et al. Photodynamic therapy. J Natl Cancer Inst 1998, 90(12):889-905.
17. Ochsner M. Photophysical and photobiological processes in the photodynamic therapy of tumors. J Photochem Photobiol B 1997, 39(1):1-18.
18. Abrahamse H., Kresfelder T., Horne T., Nyokong T., Cronje M.J. Apoptotic inducing ability of a novel photosensitizing agent, Ge sulfophthalocyanine, on oesophageal and breast cancer cell lines. Proc SPIE 2006, 6139:17-28.
19. Xue L.Y., Chiu S.M., Oleinick N.L. Photodynamic therapy-induced death of MCF-7 human breast cancer cells: a role for caspase-3 in the late steps of apoptosis but not for critical lethal event. J Exp Cell Res 2001, 263(1):145-155.
20. Yang X.H., Sladek T.L., Liu X., Butler B.R., Froelich C.J., Thor A.D. Reconstitution of caspase-3 sensitizes MCF-7 breast cancer cells to doxorubicin- and etoposide-induced apoptosis. Cancer Res 2001, 61:348-354.
21. Ricci M.S., Zong W.-X. Chemotherapeutic approaches for targeting cell death pathways. Oncologist 2006, 11:342-357.
22. Vargas-Roig L.M., Gago F.E., Tello O., Aznar J.C., Ciocca D.R. Heat shock protein expression and drug resistance in breast cancer patients treated with induction chemotherapy. Int J Cancer 1998, 73:468-475.
23. Vladimirov Y.A., Osipov A.N., Klebanov G.I. Photobiological principles of therapeutic applications of laser radiation. Biochemistry (Mosc) 2004, 69(1):81-90.
24. Pinheiro A.L.B., Nascimento S.C., de Barros A.L., et al. Effects of low-level laser therapy on malignant cells: in vitro study. J Clin Laser Med Surg 2002, 20(1):23-26.
25. Xu T., Li Y., Wu X. Application of lower fluence rate for less microvascular damage and greater cell-killing during photodynamic therapy. Lasers Med Sci 2004, 19(3):150-154.
26. Lam M., Oleinick N.L., Nieminen A.-L. Photodynamic therapy-induced apoptosis in epidermoid carcinoma cells. Reactive oxygen species and mitochondrial inner membrane permeabilization. J Biol Chem 2001, 276(50):47379-54738.
27. Huang H.-F., Chen Y.-Z., Wu Y. ZnPcS2P2-based photodynamic therapy induces mitochondria-dependent apoptosis in K562 cells. Acta Biochim Biophys Sin 2005, 37(7):488-494.
28. Kessel D., Luo Y. Photodynamic therapy: a mitochondrial inducer of apoptosis. Cell Death Differ 1999, 6:28-35.
29. Medina W.S.G., dos Santos N.A.G., Curti C., Tedesco A.C., dos Santos A.C. Effects of zinc phthalocyanine tetrasulfonate-based photodynamic therapy on rat brain isolated mitochondria. Chem Biol Interact 2009, 179:402-406.
30. Hsieh Y.-J., Wu C.-C., Chang C.-J., Yu J.-S. Subcellular localization of photofrin1 determines the death phenotype of human epidermoid carcinoma A431 cells triggered by photodynamic therapy: when plasma membranes are the main targets. J Cell Physiol 2003, 194:363-375.
31. Grebenova D., Kuzelova K., Smetanab K., et al. Mitochondrial and endoplasmic reticulum stress-induced apoptotic pathways are activated by 5-aminolevulinic acid-based photodynamic therapy in HL60 leukemia cells. J Photochem Photobiol B 2003, 69:71-85.
32. Dummin H., Cernay T.H., Zimmermann H.W. Selective photosensitization of mitochondria in HeLa cells by cationic Zn (II) phthalocyanines with lipophilic side-chains. J Photochem Photobiol B 1997, 37:219-229.
33. Fabris C., Valduga G., Miotto G., et al. Photosensitization with zinc (II) phthalocyanine as a switch in the decision between apoptosis and necrosis. Cancer Res 2001, 61:7495-7500.
34. Plaetzer K., Kiesslich T., Krammer B., Hammerl P. Characterization of the cell death modes and the associated changes in cellular energy supply in response to AlPcS4-PDT. J Photochem Photobiol Sci 2002, 1:172-177.
35. Maman N., Dhami S., Phillips D., Brault D. Kinetic and equilibrium studies of incorporation of di-sulfonated aluminium phthalocyanine into unicellular vesicles. Biochim Biophys Acta 1999, 1420:168-178.
36. Stylli S.S., Hill J.S., Sawyer W.H., Kaye A.H. Phthalocyanine photosensitizers for the treatment of brain tumors. J Clin Neurosci 1995, 2(1):64-72.
37. Almeida R.D., Gomes E.R., Carvalho A.P., Duarte C.B. Calpains are activated by photodynamic therapy but do not contribute to tumor cell death. Cancer Lett 2004, 216(2):183-189.
38. Kolárová H, Kubinek R, Lenobel R, et al. In vitro photodynamic therapy with phthalocyanines on the MCF7 cancer cells, ; 2004 [accessed 07.11.2007]. http://www.photobiology.com/photobiology99/contrib/kolarova/index.
39. Snyder J.W., Greco W.R., Bellnier D.A., Vaughan L., Henderson B.W. Photodynamic therapy: a means to enhanced drug delivery to tumors. Cancer Res 2003, 63(23):8126-8131.
40. Usuda J., Chiu S.M., Azizuddin K., et al. Promotion of photodynamic therapy-induced apoptosis by the mitochondrial protein smac/DIABLO: dependence on Bax. J Photochem Photobiol 2002, 76(2):217-223.
41. Nagy B., Yeh W.-C., Mak T.W., Chiu S.-M., Separovic D. FADD null mouse embryonic fibroblasts undergo apoptosis after photosensitization with the silicon phthalocyanine Pc 4. Arch Biochem Biophys 2001, 385(1):194-202.
42. Agostinis P., Buytaert E., Breyssens H., Hendrickx N. Regulatory pathways in photodynamic therapy induced apoptosis. Photochem Photobiol Sci 2004, 3(8):721-729.
43. Mallouk Y., Vayssier-Taussat M., Bonventre J.V., Polla B.S. Heat shock protein 70 and ATP as partners in cell homeostasis. Int J Mol Med 1999, 4(5):463-474.
44. Weizman E., Rothmann C., Greenbaum L., et al. Mitochondrial localization and photodamage during photodynamic therapy with tetraphenylporphines. J Photochem Photobiol B 2000, 59:92-102.
45. Moor A.C. Signaling pathways in cell death and survival after photodynamic therapy. J Photochem Photobiol B 2000, 57(1):1-13.
46. Kessel D., Luo Y., Deng Y., Chang C.K. The role of subcellular localization in initiation of apoptosis by photodynamic therapy. J Photochem Photobiol 1997, 65:442-446.
47. Girotti A.W. Photodynamic lipid peroxidation in biological systems. J Photochem Photobiol 1990, 51(4):497-509.
48. Nicotera P., Leist M., Ferrando-May E. Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis. Toxicol Lett 1998, 102-103:139-142.
49. Xue L.Y., Agarwal M.L., Varnes M.E. Elevation of GRP-78 and loss of HSP-70 following photodynamic treatment of V79 cells: sensitization by nigericin. J Photochem Photobiol 1995, 62(1):135-143.
50. Nylandsted J., Gyrd-Hansen M., Danielewicz A., et al. Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization. J Exp Med 2004, 200:425-435.
51. Castano A.P., Demidova T.N., Hamblin M.R. Mechanisms in photodynamic therapy. Part 3. Photosensitizer pharmacokinetics, biodistribution, tumor localization and modes of tumor destruction. J Photodiagn Photodyn Ther 2005, 2:91-106.
52. Nguyen J.T., Wells J.A. Direct activation of the apoptosis machinery as a mechanism to target cancer cells. Proc Natl Acad Sci USA 2003, 100(13):7533-7538.
53. Arrigo A.P. Small stress proteins: chaperones that act as regulators of intracellular redox state and programmed cell death. J Biol Chem 1998, 379:19-26.
54. 2+ mediated endogenous endonucleases activation in apoptotic thymocytes. J Immunol 1995, 155(11):5133-5139.
55. Gorman A.M., Heavey G., Creagh E., Cotter T.G., Samali A. Antioxidant-mediated inhibition of the heat shock response leads to apoptosis. FEBS Lett 1999, 445:93-102.
56. Gomer C.J., Ryter S.W., Ferrario A., Rucker N., Wong S., Fisher A.M. Photodynamic therapy-mediated oxidative stress can induce expression of heat shock proteins. Cancer Res 1996, 56(10):2355-2360.
57. Curry P.M., Levy J.G. Stress protein expression in murine tumor cells following photodynamic therapy with benzoporphyrin derivative. J Photochem Photobiol 1993, 58(3):374-379.
58. Huerta S., Goulet A.J., Huerta-Yepez S., Livingston E.H. Screening and detection of apoptosis review. J Surg Res 2007, 139:143-156.
59. Beere H.M., Wolf B.B., Cain K., et al. Heat shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nat Cell Biol 2000, 2:469-475.
60. Beere H.M. The stress of dying: the role of heat shock proteins in the regulation of apoptosis. J Cell Sci 2004, 117:2641-2651.
61. Gurbuxani S., Schmitt E., Cance C., et al. Heat shock protein 70 binding inhibits nuclear import of apoptosis-inducing-factor. Oncogene 2003, 22(43):6669-6678.
62. Li C.-Y., Lee J.-S., Ko Y.-G., Kim J.-I., Seo J.-S. Heat shock protein 70 inhibits apoptosis downstream of cytochrome c release and upstream of caspase-3 activation. J Biol Chem 2000, 275(33):25665-25671.
63. Nonaka M., Ikeda H., Inokuchi T. Inhibitory effect of heat shock protein 70 on apoptosis induced by photodynamic therapy in vitro. J Photochem Photobiol 2004, 79:94-98.
64. Deane E.E., Woo N.Y.S. Impact of heavy metals and organochlorines on hsp70 and hsc70 gene expression in black sea bream fibroblasts. Aquat Toxicol 2006, 79:9-15.
65. Urani C., Calini V., Melchioretto P., et al. Different induction of metallothionines and Hsp70 and presence of the membrane transporter ZnT-1 in HepG2 cells exposed to copper and zinc. Toxicol In Vitro 2003, 17:553-559.
66. Ali S.M., Olivo M., Yuen G.Y., Chee S.K. Photodynamic induced apoptosis of human nasopharyngeal carcinoma cells using hypocrellins. Int J Oncol 2001, 19(3):633-643.
67. Benjamin C.W., Hiebsch R.R., Jones D.A. Caspase activation in MCF7 cells responding to etoposide treatment. Mol Pharmacol 1998, 53:446-450.
68. Reck M., Groth G., Buchholtz E., Goetz E., Gatzemeier U., Manegold C. Topotecan and etoposide as first-line therapy for extensive disease small cell lung cancer: a phase II trial of a platinum-free regimen. Lung Cancer 2004, 48:409-413.
69. Samantas E., Skarlos D.V., Pectasides D., et al. Combination chemotherapy with low doses of weekly Carboplatin and oral Etoposide in poor risk small cell lung cancer. Lung Cancer 1999, 23:159-168.
70. Mascaux C., Paesmans M., Berghmans T., et al. A systematic review of the role of etoposide and cisplatin in the chemotherapy of small cell lung cancer with methodology assessment and meta-analysis. Lung Cancer 2000, 30:23-36.
71. Holdenrieder S., Stieber P. Apoptotic markers in cancer. Clin Biochem 2004, 37:605-617.
72. Granville D.J., Carthy C.M., Jiang H., et al. Rapid cytochrome c release, activation of caspases 3, 6, 7 and 8 followed by Bap31 cleavage in HeLa cells treated with photodynamic therapy. FEBS Lett 1998, 437:5-10.
73. Lemasters J.J., Nieminen A.-L., Qian T., et al. The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. Biochim Biophys Acta 1998, 1366:177-196.
74. Li R., Bounds D.J., Granville D., et al. Rapid induction of apoptosis in human keratinocytes with the photosensitizer QLT0074 via a direct mitochondrial action. Apoptosis 2003, 8(3):269-275.
75. Orrenius S., Gogvadze B., Zhivotovsky B. Mitochondrial oxidative stress: implications for cell death. Annu Rev Pharmacol Toxicol 2007, 47:147-183.