Molecular insights into the local anesthetic receptor within voltage-gated sodium channels using hydroxylated analogs of mexiletine

Frontiers in Pharmacology

Volumn 3 FEB, Issue , 2012, Pages

  Desaphy, Jean François ^a   Dipalma, Antonella ^a   Costanza, Teresa ^a   Carbonara, Roberta ^a   Dinardo, Maria Maddalena ^a   Catalano, Alessia ^a   Carocci, Alessia ^a   Lentini, Giovanni ^a   Franchini, Carlo ^a   Camerino, Diana Conte ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

hNav1.4; Local anesthetic receptor; Mexiletine analogs; Sodium channel

Indexed keywords

DRUG RECEPTOR; LOCAL ANESTHETIC RECEPTOR; MEXILETINE; PHENYLALANINE; SODIUM CHANNEL NAV1.4; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG DETERMINATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IC 50; LIPOPHILICITY; MOLECULAR DYNAMICS; PHARMACOPHORE; PROTEIN EXPRESSION; PROTEIN FUNCTION; STATIC ELECTRICITY;

EID: 84865959412     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2012.00017     Document Type: Article

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