Using lidocaine and benzocaine to link sodium channel molecular conformations to state-dependent antiarrhythmic drug affinity

Circulation Research

Volumn 105, Issue 5, 2009, Pages 492-499

  Hanck, Dorothy A ^a   Nikitina, Elena ^a   McNulty, Megan M ^a   Fozzard, Harry A ^a   Lipkind, Gregory M ^a   Sheets, Michael F ^a,b  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Antiarrhythmic drug; Benzocaine; Gating currents; Lidocaine; Local anethestic; Voltage clamp

Indexed keywords

ANTIARRHYTHMIC AGENT; BENZOCAINE; LIDOCAINE; PHENYLALANINE; VOLTAGE GATED SODIUM CHANNEL; MUSCLE PROTEIN; SCN5A PROTEIN, HUMAN; SODIUM CHANNEL;

ARTICLE; BINDING AFFINITY; BINDING KINETICS; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING; DRUG INHIBITION; DRUG PROTEIN BINDING; ELECTRIC POTENTIAL; EMBRYO; HUMAN; HUMAN CELL; INHIBITION KINETICS; ION CURRENT; LIPOPHILICITY; MEMBRANE CURRENT; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN STABILITY; BINDING SITE; CELL LINE; CELL MEMBRANE POTENTIAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; METABOLISM; PROTEIN TERTIARY STRUCTURE;

ANTI-ARRHYTHMIA AGENTS; BENZOCAINE; BINDING SITES; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; ION CHANNEL GATING; LIDOCAINE; MEMBRANE POTENTIALS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUSCLE PROTEINS; PHENYLALANINE; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SODIUM CHANNELS; TRANSFECTION;

EID: 70149112082     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.109.198572     Document Type: Article

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