Molecular determinants of state-dependent block of voltage-gated sodium channels by pilsicainide

British Journal of Pharmacology

Volumn 160, Issue 6, 2010, Pages 1521-1533

  Desaphy, J F ^a   Dipalma, A ^a   Costanza, T ^a   Bruno, C ^a   Lentini, G ^a   Franchini, C ^a   George, A L ^b   Conte Camerino, D ^a  

^a UNIVERSITY OF BARI   (Italy)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

anti arrhythmics; hNav1.4; local anaesthetic receptor; open channel block; paramyotonia congenita; pilsicainide; pKa; state dependent block; voltage gated sodium channels

Indexed keywords

FLECAINIDE; MEXILETINE; PILSICAINIDE; VOLTAGE GATED SODIUM CHANNEL; LIDOCAINE; MUSCLE PROTEIN; NERVE PROTEIN; SCN1A PROTEIN, HUMAN; SCN4A PROTEIN, HUMAN; SCN5A PROTEIN, HUMAN; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT; SODIUM CHANNEL NAV1.1; SODIUM CHANNEL NAV1.4; SODIUM CHANNEL NAV1.5;

ACTION POTENTIAL; ANESTHESIA; ARTICLE; BINDING AFFINITY; CHANNEL GATING; CONTROLLED STUDY; DRUG EFFECT; HUMAN; HUMAN CELL; PATCH CLAMP; PH; PRIORITY JOURNAL; SKELETAL MUSCLE; ANALOGS AND DERIVATIVES; BRAIN; CELL LINE; COMPARATIVE STUDY; DRUG EFFECTS; HEART; METABOLISM; PATCH CLAMP TECHNIQUE;

BRAIN; CELL LINE; FLECAINIDE; HEART; HUMANS; LIDOCAINE; MEXILETINE; MUSCLE PROTEINS; MUSCLE, SKELETAL; NAV1.1 VOLTAGE-GATED SODIUM CHANNEL; NAV1.4 VOLTAGE-GATED SODIUM CHANNEL; NAV1.5 VOLTAGE-GATED SODIUM CHANNEL; NERVE TISSUE PROTEINS; PATCH-CLAMP TECHNIQUES; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS;

EID: 77954042073     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.00816.x     Document Type: Article

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